Ulta Lab Tests

All Immunity and Titer Tests

All Immunity and Titer Tests brings together the blood tests used to document vaccine immunity, check past infection, and screen immune function. Common reasons to test include school or employment requirements, health-care onboarding, travel, proof of hepatitis B response, TB screening before certain medicines, or evaluation of frequent infections.

A proactive plan starts by matching the exact titers you need (MMR, varicella, hepatitis B, tetanus/diphtheria). For past exposure questions, add COVID-19 antibodies (spike ± nucleocapsid). For tuberculosis screening, choose a TB blood test (IGRA) such as QuantiFERON or T-SPOT. When infections are frequent or severe, add immunoglobulins (IgG/IgA/IgM), IgG subclasses, pneumococcal serotype responses, lymphocyte subsets, and complement. These labs support screening, documentation, and monitoring, but they do not diagnose active illness or replace clinical evaluation.

Signs, Symptoms & Related Situations

  • Documentation & compliance

    • School, healthcare employment, immigration, travel, volunteer clearance

    • Proof of immunity: MMR, varicella, hepatitis B, tetanus/diphtheria (± pertussis per program)

  • Exposure & pre-treatment

    • TB screening for close contacts or before immunosuppressive therapy

    • COVID-19 antibody testing for past infection or vaccine response (not for current illness)

  • Frequent or unusual infections

    • Recurrent sinus/ear/chest infections, pneumonia, poor vaccine responses

  • Family planning

    • Rubella or varicella IgG status before pregnancy (clinician-guided)

  • Urgent care now

    • Trouble breathing, chest pain, confusion, severe dehydration, or rapidly worsening symptoms

Testing choices and symptoms should be reviewed with a qualified clinician.

Why These Tests Matter

What testing can do

  • Provide proof of immunity for schools, employers, and programs

  • Detect TB infection (latent or active) via IGRA screening; unaffected by BCG vaccination

  • Characterize immune status (immunoglobulins, subclasses, functional antibody) and guide next steps

What testing cannot do

  • Diagnose active infection or confirm contagiousness

  • Guarantee lifelong protection—antibodies can wane and cutoffs vary by disease/assay

  • Replace vaccinations/boosters, imaging, or clinician judgment when indicated

What These Tests Measure (at a glance)

  • Vaccine/Exposure Titers (IgG): Measles, Mumps, Rubella; Varicella-Zoster; Hepatitis B surface antibody (anti-HBs); Tetanus/Diphtheria; Hepatitis A IgG; others as requested.

  • COVID-19 Antibodies: Spike (S) IgG for vaccine response/previous exposure; Nucleocapsid (N) IgG for prior infection; some panels include surrogate neutralizing activity.

  • TB Blood Tests (IGRAs): QuantiFERON-TB Gold Plus or T-SPOT.TB—single visit, not affected by BCG; results are positive/negative/indeterminate and require clinical follow-up.

  • Immunoglobulin Profile: IgG/IgA/IgM (± IgE); low levels can signal immune deficits, high levels may reflect inflammation.

  • IgG Subclasses (1–4): supportive when total IgG is normal but infections persist; interpret with functional antibody testing.

  • Functional Antibody Testing: Pneumococcal serotype IgG before/after vaccination to assess antibody production.

  • Lymphocyte Subsets (Flow): CD3/CD4/CD8 T cells, CD19/20 B cells, CD16/56 NK cells—screens cellular immunity.

  • Complement System: C3, C4, CH50 (± AH50) to evaluate classical/alternative pathway activity.

  • Context labs: CBC with differential and CRP/ESR for infection/inflammation clues.

Quick Build Guide

Goal Start with Add if needed
School/health-care onboarding MMR IgG • Varicella IgG • Hep B surface Ab • Tetanus/Diphtheria IgG Pertussis IgG if your program accepts it
Post-vaccine proof (Hep B) Hep B surface Ab (draw ≥3–4 weeks post-series) Repeat after booster if nonreactive (clinician-directed)
TB screening (employment/exposure) QuantiFERON-TB Gold Plus T-SPOT.TB if indeterminate or immunosuppressed
COVID-19 past exposure/response Spike IgG Nucleocapsid IgG ± Neutralizingactivity
Frequent infections—initial screen IgG/IgA/IgM • CBC with differential IgG Subclasses • Pneumococcal serotypes (pre/post)
Suspected complement issue C3 • C4 CH50 (± AH50)
Pregnancy planning Rubella IgG • Varicella IgG Follow timing per clinician

How the Testing Process Works

  1. Match your checklist: pick the exact titers or screens your program or clinician requests.

  2. Time your draw: for post-vaccine checks, test ≥3–4 weeks after the last dose. IGRAs do not require fasting.

  3. Visit a draw site: one blood draw; some tests use additional tubes or same-day processing.

  4. Review results: compare to your report’s reference ranges and program criteria; your clinician may add imaging or confirmatory tests if indicated.

  5. Plan follow-up: vaccination, booster, or repeat testing may be advised for nonreactive or indeterminate results.

Interpreting Results (General Guidance)

  • Titers (IgG): Reactive/positive suggests immunity; nonreactive/negative may reflect no immunity, early testing, or waning antibodies.

  • COVID-19 antibodies: Spike+ / N− aligns with vaccination; Spike+ / N+ suggests prior infection; both negativecan mean no exposure or early/waning response.

  • TB IGRAs: Positive indicates TB infection (latent or active) and needs clinical evaluation, often with chest X-ray; indeterminate often requires repeat or alternate IGRA.

  • Immunoglobulins/subclasses: low levels or poor vaccine responses can suggest immune deficits; high polyclonal levels may reflect inflammation.
    Always interpret results with a qualified healthcare professional; patterns, timing, and context matter more than a single value.

Choosing Panels vs. Individual Tests

  • Program bundle: select a titer package (MMR, varicella, hepatitis B, tetanus/diphtheria) that mirrors your form.

  • Single-question check: order one marker (e.g., anti-HBs after vaccination).

  • Immune-function screen: IgG/IgA/IgM + CBC with differential, and add subclasses, pneumococcal serotypes, lymphocyte subsets, or complement based on findings.

  • TB pathway: choose a single IGRA (QuantiFERON or T-SPOT) rather than TST when possible.

FAQs

Do I need to fast for these tests?
No. Titers, IGRAs, and immunoglobulins do not require fasting.

How soon after a vaccine should I draw a titer?
Wait at least 3–4 weeks after the final dose for the clearest result.

Will BCG affect my TB test?
BCG does not affect IGRA blood tests; it can affect the skin test (TST).

Can titers prove I’m fully protected?
Titers correlate with protection, but no test guarantees immunity for every disease. Follow your program rules and clinician advice.

What if my TB IGRA is positive?
You’ll need a clinician evaluation, usually a chest X-ray, and possibly sputum testing to rule out active disease.

My hepatitis B titer is negative—now what?
Your clinician may recommend a booster or repeat series and a follow-up titer.

Do recurrent infections mean immune deficiency?
Not always. Baseline Ig levels, CBC, and functional antibody tests help clarify next steps.

Related Categories & Key Tests

References

Available Tests & Panels

Your All Immunity and Titer Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to build your package—required titers, COVID-19 antibodies, TB blood tests, and immune-function screens—and schedule your draw. Follow timing guidance (especially ≥3–4 weeks post-vaccination) and review results with your clinician before submitting documentation or planning next steps.

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 The Immunity Panel is a set of laboratory tests designed to assess an individual's immunity status against specific infectious diseases. By measuring the presence and levels of specific antibodies in the blood, the panel provides valuable insights into whether an individual has been previously exposed to these pathogens or has been vaccinated against them, thus offering protection.
Blood
Blood Draw, Phlebotomist
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 The Immunity Panel Plus is a comprehensive set of tests designed to evaluate an individual's immunity to certain infectious diseases. This panel includes tests for Hepatitis A Antibody Total, Hepatitis B Surface Antibody, Quantitative, Measles IgG Antibody, Mumps IgG Antibody, Rubella IgG Antibody, and Varicella-Zoster Virus IgG Antibody. It is often used to determine if an individual has immunity, either from previous infections or vaccinations, against these specific diseases.
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The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

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Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test
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The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 
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The Cytomegalovirus (CMV) IgG Antibody Test detects IgG antibodies to CMV, indicating past infection or immunity. This blood test helps determine prior exposure, assess immune status in pregnancy, transplant patients, or immunocompromised individuals, and guide risk evaluation. A positive result shows past CMV infection, while results are used with IgM testing to distinguish recent vs. past infection.

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Also Known As: CMV IgG Antibody Test, Cytomegalovirus IgG Test
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The Cytomegalovirus (CMV) IgM Antibody Test detects IgM antibodies, indicating a recent or active CMV infection. This blood test helps diagnose primary CMV, reactivation, or reinfection, especially important for pregnant women, transplant candidates, and immunocompromised patients. Used with CMV IgG testing, it helps distinguish new infections from past exposure for accurate clinical evaluation.

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Also Known As: CMV IgM Antibody Test, Cytomegalovirus IgM Test
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The Diphtheria and Tetanus Antitoxoids Test measures protective antibody levels to confirm immunity from prior vaccination or exposure. Adequate antibody levels indicate effective protection, while low levels may signal the need for a booster. Doctors use this test to verify immune status for healthcare workers, students, or travelers, and to ensure long-term protection against diphtheria and tetanus infections that can cause serious complications.

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The Diphtheria Titer Test measures antibody levels to evaluate immune protection against Corynebacterium diphtheriae, the bacterium that causes diphtheria. This test helps determine whether immunity is adequate following vaccination or exposure. By assessing diphtheria antibody titers, it provides insight into immune system response, vaccine effectiveness, and long-term protection against this serious infection.

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Blood Draw
Also Known As: Diphtheria Antitoxoid Test
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The Hepatitis A & B Titer Test Panel is a comprehensive diagnostic tool designed to evaluate an individual's immunity status or infection presence for Hepatitis A and Hepatitis B viruses. This panel combines serological assays that measure specific antibodies and antigens associated with Hepatitis A and B, providing crucial insights for clinical diagnosis, vaccination verification, and the assessment of immune response post-vaccination or post-exposure.
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The Hepatitis A Antibody Total Test is a qualitative test that detects antibodies to hepatitis A virus (HAV) and reports results as Reactive or Non-Reactive. It does not distinguish between IgM and IgG antibodies. A reactive result may indicate past infection or immunity from vaccination, while a non-reactive result suggests no prior exposure. Doctors use this test to assess immune status, guide vaccination decisions, and evaluate risk of hepatitis A infection.

Blood
Blood Draw
Also Known As: Hep A Ab Total Test, HAV Ab Total Test, Hep A Test, Hepatitis A Test
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Blood
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The Hepatitis A IgM Antibody Test is a qualitative blood test that detects IgM antibodies to the hepatitis A virus (HAV) and reports results as Reactive or Non-Reactive. A reactive result usually indicates a recent or current hepatitis A infection, while a non-reactive result means no active infection. Doctors use this test to confirm acute hepatitis A in patients with symptoms like jaundice, nausea, fatigue, or abdominal pain and to guide timely treatment and prevention.

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Blood Draw
Also Known As: Hep A IgM test, HAV IgM Ab Test
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The Hepatitis B Core Antibody Total Test is a qualitative blood test that detects antibodies to the hepatitis B core antigen (anti-HBc) and reports results as Reactive or Non-Reactive. A reactive result may indicate past or ongoing infection, while a non-reactive result suggests no exposure. This test does not distinguish between IgM and IgG antibodies. Doctors use it to evaluate hepatitis B exposure, confirm infection history, and assess overall immune response.

Blood
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Also Known As: HBcAb Total Test, HBc Total Test, Hep B Core Ab Total Test
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The Hepatitis B Immunity Panel Test evaluates immune status by measuring Hepatitis B surface antibody levels in the blood. A positive result typically indicates immunity from vaccination or past infection, while a negative result suggests susceptibility. This test is important for verifying protection, monitoring vaccine response, or determining if additional vaccination or further evaluation for Hepatitis B exposure is needed.

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The Hepatitis B Surface Antibody Quantitative Test measures the exact level of anti-HBs antibodies in blood to determine past exposure and whether protective immunity has developed from infection or vaccination. A higher antibody level generally indicates adequate immune response, while a low level suggests limited or no protection. Doctors use this test to confirm vaccine effectiveness, assess immune status, and support hepatitis B screening or preventive care.

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Blood Draw
Also Known As: HBsAb Qn Test, Hepatitis B Titer Test
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The Hepatitis B Surface Antigen (HBsAg) Test with Reflex to Confirmation screens for hepatitis B surface antigen in blood and, if reactive, automatically performs confirmatory testing. A reactive confirmed result indicates an active hepatitis B infection, while a non-reactive result shows no infection. Doctors use this test to diagnose acute or chronic hepatitis B, investigate abnormal liver tests, and guide treatment, monitoring, and infection control decisions.

Blood
Blood Draw
Also Known As: HBsAg Test, Hep B Surface Ag Test, HBs Antigen Test, Hep B Test
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The Hepatitis B Test (Hepatitis B Surface Antigen with Reflex to Confirmation) screens for hepatitis B surface antigen (HBsAg) in the blood to identify active infection. If the result is positive, a confirmation test is automatically performed to verify accuracy and support proper diagnosis.

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 The Hepatitis B Titer Test Panel is a diagnostic panel that comprises three essential tests designed to assess immunity, infection status, and antibody levels for the Hepatitis B virus (HBV). The panel includes the following tests: Hepatitis B Core Antibody Total, Hepatitis B Surface Antibody Quantitative, and Hepatitis B Surface Antigen with Reflex Confirmation.
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The Herpes 1 IgG Antibody Test detects IgG antibodies to HSV-1, the virus that commonly causes oral herpes (cold sores). IgG develops weeks after exposure and remains for life, making this test useful for confirming past infection and exposure history. Doctors order it for patients with oral sores, blisters, or concerns about herpes transmission. Results help confirm HSV-1 infection, guide treatment, and support counseling and prevention strategies.

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Blood Draw
Also Known As: Herpes Simplex Virus 1 IgG Type-Specific Antibody HerpeSelect® Test, Herpes 1 IgG Test, Oral Herpes Test
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The Herpes 1 and 2 Test uses type-specific HSV-1/HSV-2 IgG to assess past infection and differentiate exposure to each virus. It is useful for evaluating recurrent lesions, screening asymptomatic partners, and documenting baseline status for clinical management. Because IgG can take 2–12 weeks to develop, early negatives may need repeat testing; HSV-2 reactive results reflex to an inhibition assay to verify specificity and reduce cross-reactivity.

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The Herpes 2 IgG Antibody Test detects IgG antibodies to HSV-2, the virus that most often causes genital herpes. IgG develops weeks after infection and remains for life, making this test valuable for confirming past exposure or infection history. Doctors order it for patients with genital sores, blisters, or concerns about herpes transmission. Results help confirm HSV-2 infection, guide treatment, and support counseling, prevention, and long-term care.

Blood
Blood Draw
Also Known As: Herpes Simplex Virus 2 IgG HerpeSelect® Test with Reflex to HSV 2 Inhibition, Herpes 2 IgG Test, Genital Herpes Test
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