Ulta Lab Tests

All Immunity and Titer Tests

All Immunity and Titer Tests brings together the blood tests used to document vaccine immunity, check past infection, and screen immune function. Common reasons to test include school or employment requirements, health-care onboarding, travel, proof of hepatitis B response, TB screening before certain medicines, or evaluation of frequent infections.

A proactive plan starts by matching the exact titers you need (MMR, varicella, hepatitis B, tetanus/diphtheria). For past exposure questions, add COVID-19 antibodies (spike ± nucleocapsid). For tuberculosis screening, choose a TB blood test (IGRA) such as QuantiFERON or T-SPOT. When infections are frequent or severe, add immunoglobulins (IgG/IgA/IgM), IgG subclasses, pneumococcal serotype responses, lymphocyte subsets, and complement. These labs support screening, documentation, and monitoring, but they do not diagnose active illness or replace clinical evaluation.

Signs, Symptoms & Related Situations

  • Documentation & compliance

    • School, healthcare employment, immigration, travel, volunteer clearance

    • Proof of immunity: MMR, varicella, hepatitis B, tetanus/diphtheria (± pertussis per program)

  • Exposure & pre-treatment

    • TB screening for close contacts or before immunosuppressive therapy

    • COVID-19 antibody testing for past infection or vaccine response (not for current illness)

  • Frequent or unusual infections

    • Recurrent sinus/ear/chest infections, pneumonia, poor vaccine responses

  • Family planning

    • Rubella or varicella IgG status before pregnancy (clinician-guided)

  • Urgent care now

    • Trouble breathing, chest pain, confusion, severe dehydration, or rapidly worsening symptoms

Testing choices and symptoms should be reviewed with a qualified clinician.

Why These Tests Matter

What testing can do

  • Provide proof of immunity for schools, employers, and programs

  • Detect TB infection (latent or active) via IGRA screening; unaffected by BCG vaccination

  • Characterize immune status (immunoglobulins, subclasses, functional antibody) and guide next steps

What testing cannot do

  • Diagnose active infection or confirm contagiousness

  • Guarantee lifelong protection—antibodies can wane and cutoffs vary by disease/assay

  • Replace vaccinations/boosters, imaging, or clinician judgment when indicated

What These Tests Measure (at a glance)

  • Vaccine/Exposure Titers (IgG): Measles, Mumps, Rubella; Varicella-Zoster; Hepatitis B surface antibody (anti-HBs); Tetanus/Diphtheria; Hepatitis A IgG; others as requested.

  • COVID-19 Antibodies: Spike (S) IgG for vaccine response/previous exposure; Nucleocapsid (N) IgG for prior infection; some panels include surrogate neutralizing activity.

  • TB Blood Tests (IGRAs): QuantiFERON-TB Gold Plus or T-SPOT.TB—single visit, not affected by BCG; results are positive/negative/indeterminate and require clinical follow-up.

  • Immunoglobulin Profile: IgG/IgA/IgM (± IgE); low levels can signal immune deficits, high levels may reflect inflammation.

  • IgG Subclasses (1–4): supportive when total IgG is normal but infections persist; interpret with functional antibody testing.

  • Functional Antibody Testing: Pneumococcal serotype IgG before/after vaccination to assess antibody production.

  • Lymphocyte Subsets (Flow): CD3/CD4/CD8 T cells, CD19/20 B cells, CD16/56 NK cells—screens cellular immunity.

  • Complement System: C3, C4, CH50 (± AH50) to evaluate classical/alternative pathway activity.

  • Context labs: CBC with differential and CRP/ESR for infection/inflammation clues.

Quick Build Guide

Goal Start with Add if needed
School/health-care onboarding MMR IgG • Varicella IgG • Hep B surface Ab • Tetanus/Diphtheria IgG Pertussis IgG if your program accepts it
Post-vaccine proof (Hep B) Hep B surface Ab (draw ≥3–4 weeks post-series) Repeat after booster if nonreactive (clinician-directed)
TB screening (employment/exposure) QuantiFERON-TB Gold Plus T-SPOT.TB if indeterminate or immunosuppressed
COVID-19 past exposure/response Spike IgG Nucleocapsid IgG ± Neutralizingactivity
Frequent infections—initial screen IgG/IgA/IgM • CBC with differential IgG Subclasses • Pneumococcal serotypes (pre/post)
Suspected complement issue C3 • C4 CH50 (± AH50)
Pregnancy planning Rubella IgG • Varicella IgG Follow timing per clinician

How the Testing Process Works

  1. Match your checklist: pick the exact titers or screens your program or clinician requests.

  2. Time your draw: for post-vaccine checks, test ≥3–4 weeks after the last dose. IGRAs do not require fasting.

  3. Visit a draw site: one blood draw; some tests use additional tubes or same-day processing.

  4. Review results: compare to your report’s reference ranges and program criteria; your clinician may add imaging or confirmatory tests if indicated.

  5. Plan follow-up: vaccination, booster, or repeat testing may be advised for nonreactive or indeterminate results.

Interpreting Results (General Guidance)

  • Titers (IgG): Reactive/positive suggests immunity; nonreactive/negative may reflect no immunity, early testing, or waning antibodies.

  • COVID-19 antibodies: Spike+ / N− aligns with vaccination; Spike+ / N+ suggests prior infection; both negativecan mean no exposure or early/waning response.

  • TB IGRAs: Positive indicates TB infection (latent or active) and needs clinical evaluation, often with chest X-ray; indeterminate often requires repeat or alternate IGRA.

  • Immunoglobulins/subclasses: low levels or poor vaccine responses can suggest immune deficits; high polyclonal levels may reflect inflammation.
    Always interpret results with a qualified healthcare professional; patterns, timing, and context matter more than a single value.

Choosing Panels vs. Individual Tests

  • Program bundle: select a titer package (MMR, varicella, hepatitis B, tetanus/diphtheria) that mirrors your form.

  • Single-question check: order one marker (e.g., anti-HBs after vaccination).

  • Immune-function screen: IgG/IgA/IgM + CBC with differential, and add subclasses, pneumococcal serotypes, lymphocyte subsets, or complement based on findings.

  • TB pathway: choose a single IGRA (QuantiFERON or T-SPOT) rather than TST when possible.

FAQs

Do I need to fast for these tests?
No. Titers, IGRAs, and immunoglobulins do not require fasting.

How soon after a vaccine should I draw a titer?
Wait at least 3–4 weeks after the final dose for the clearest result.

Will BCG affect my TB test?
BCG does not affect IGRA blood tests; it can affect the skin test (TST).

Can titers prove I’m fully protected?
Titers correlate with protection, but no test guarantees immunity for every disease. Follow your program rules and clinician advice.

What if my TB IGRA is positive?
You’ll need a clinician evaluation, usually a chest X-ray, and possibly sputum testing to rule out active disease.

My hepatitis B titer is negative—now what?
Your clinician may recommend a booster or repeat series and a follow-up titer.

Do recurrent infections mean immune deficiency?
Not always. Baseline Ig levels, CBC, and functional antibody tests help clarify next steps.

Related Categories & Key Tests

References

Available Tests & Panels

Your All Immunity and Titer Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to build your package—required titers, COVID-19 antibodies, TB blood tests, and immune-function screens—and schedule your draw. Follow timing guidance (especially ≥3–4 weeks post-vaccination) and review results with your clinician before submitting documentation or planning next steps.

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The Rheumatoid Factor IgG Antibody Test measures IgG-class rheumatoid factor, an autoantibody often linked to rheumatoid arthritis and autoimmune diseases. Elevated levels may indicate joint inflammation, Sjögren’s syndrome, or chronic infection. Doctors use this test with other markers to confirm diagnosis, assess autoimmune activity, and guide treatment for patients with persistent joint pain, swelling, or suspected inflammatory disorders.

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Also Known As: RF IgG Test, Rheumatoid Arthritis Factor IgG Antibody Test
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The Rheumatoid Factor (RF) Test measures RF antibodies in blood to help diagnose rheumatoid arthritis and other autoimmune conditions. High RF levels may indicate rheumatoid arthritis, Sjögren’s syndrome, or other connective tissue diseases, though they can also appear in some infections. Doctors order this test to investigate joint pain, stiffness, or swelling. Results provide important insight into autoimmune activity, joint health, and inflammatory disease management.

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Also Known As: RF Test, Rheumatoid Arthritis Factor Test
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The RPR (Monitor) with Reflex to Titer Test screens for syphilis by detecting antibodies to Treponema pallidum. If positive, a reflex titer determines antibody concentration to assess disease activity and treatment response. Doctors order this test to diagnose syphilis, monitor therapy, or check reinfection. Results provide essential information for managing active infection, confirming treatment success, and guiding follow-up care.

Also Known As: Syphilis RPR Test, Rapid Plasma Reagin Test
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The Rubella IgG IgM Antibodies Test measures antibodies to the rubella virus, helping evaluate immunity or recent infection. IgM indicates an active or recent infection, while IgG confirms past infection or vaccination. Doctors use this test to assess immune status in women of childbearing age, screen during pregnancy, or confirm suspected rubella exposure, as infection can cause serious complications for unborn babies.

Also Known As: Rubella Titer, Rubella Antibodies Test, German Measles Test
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The Rubella IgM Antibody Test measures immune response to the rubella virus by identifying IgM antibodies produced soon after exposure. Detection of rubella IgM helps diagnose recent infection, assess rash-related illness, and monitor risk in pregnancy where congenital rubella syndrome may occur. This test provides valuable insight into acute infection, immunity status, and systemic health.

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Also Known As: German Measles test, 3 Day Measles Test, Three Day Measles Test, Rubella Infection Test
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The Rubella Titer Test measures IgG antibodies to determine immunity to rubella (German measles). A positive result indicates protection from prior infection or vaccination, while a negative result suggests susceptibility. Doctors order this test for women planning pregnancy, healthcare workers, students, or travelers. It helps confirm immune status, guide vaccination needs, and protect against congenital rubella syndrome and outbreak risks.

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Also Known As: Rubella IgG Antibody Test, Rubella Immune Status Test, German Measles Test, 3 Day Measles Test, Three Day Measles Test
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The Selenium Micronutrient Blood Test measures selenium levels in the blood to assess nutritional status and detect deficiencies or excess. Selenium is a powerful antioxidant that supports thyroid function, immune defense, and protection against oxidative stress. This test helps identify dietary insufficiency, malabsorption, or toxicity, supporting diagnosis and management of overall health and wellness.

Patient must be 18 years of age or older.
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The Selenium Test measures selenium levels in blood to evaluate nutritional status and overall health. Selenium is essential for thyroid function, antioxidant defense, and immune support. Low levels may cause fatigue, muscle weakness, thyroid problems, or impaired immunity, while high levels may indicate toxicity. Doctors use this test to monitor nutrition, supplementation, or suspected deficiency. Results provide key insight into metabolic health and antioxidant balance.

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The Student Titers Panel evaluates immunity to key infections often required for school or healthcare enrollment. It includes Hepatitis B Surface Antibody, Measles IgG, Mumps IgG, Rubella IgG, Varicella-Zoster Virus IgG, and QuantiFERON-TB Gold Plus for tuberculosis. Results confirm vaccination response or past exposure, helping students meet program requirements and ensure protection against preventable diseases.

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The Syphilis FTA-ABS Test (Fluorescent Treponemal Antibody Absorption) detects antibodies specific to Treponema pallidum, the bacteria that cause syphilis. Doctors use this confirmatory test after a positive screening to verify infection, even in late or latent stages. Results help distinguish syphilis from false positives, guiding diagnosis, treatment, and follow-up. This test is essential for accurate detection and long-term monitoring of syphilis.

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Also Known As: Fluorescent Treponemal Antibody Absorption Antibodies Test
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The Syphilis (RPR + FTA-ABS) panel is a diagnostic tool used to detect and confirm the presence of syphilis, a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. This panel combines two tests: the RPR (Rapid Plasma Reagin) Screen with Reflex to Titer, and the FTA-ABS (Fluorescent Treponemal Antibody Absorption) test, offering both initial screening and confirmatory diagnosis capabilities.
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The Syphilis RPR Test screens for syphilis by detecting nonspecific antibodies produced in response to Treponema pallidum. If positive, a reflex titer is performed to measure antibody levels and monitor disease activity. Doctors use this blood test to confirm infection, determine stage, and track treatment response. It is widely used for STD screening, prenatal care, and early detection to prevent complications and transmission.

Also Known As: RPR (Monitor) Test with Reflex to Titer, Rapid Plasma Reagin Test
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The QuantiFERON®-TB Gold Plus (QFT-Plus) Test is a modern blood test that detects tuberculosis infection, including latent and active TB. Unlike the traditional skin test, it does not require a return visit and provides highly specific results by measuring interferon-gamma release in response to TB antigens. Physicians use this test to screen high-risk individuals, confirm TB exposure, and guide timely treatment decisions for better patient outcomes.

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The Tetanus and Diphtheria Titer Test measures antibody levels to determine immunity from prior vaccination or exposure. Adequate titers indicate protective immunity, while low levels may suggest the need for a booster. Doctors order this test for healthcare workers, students, travelers, or those with uncertain vaccination history. It provides essential information for maintaining protection against these serious bacterial infections.

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The Tetanus Antitoxoid Test evaluates antibody levels to tetanus toxin, offering information about immune defense and vaccination status. Adequate levels indicate protection, while low results may suggest reduced immunity. This test aids in assessing immune response, monitoring vaccine effectiveness, and identifying systemic conditions that influence antibody production and immune balance.

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Also Known As: Tetanus Antitoxoid Test
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The Trimethylamine N-Oxide (TMAO) Test measures TMAO levels in blood to assess cardiovascular and metabolic risk. TMAO is produced when gut bacteria metabolize nutrients like choline, carnitine, and betaine from foods such as red meat and eggs. Elevated levels are linked to heart disease, stroke, kidney dysfunction, and metabolic disorders. Doctors order this test to evaluate cardiovascular risk and guide lifestyle, diet, or treatment strategies.

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Also Known As: Trimethylamine N-Oxide Test
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The Total Immunoglobulins Panel measures IgA, IgG, and IgM levels to evaluate immune system function. Abnormal results may indicate immune deficiency, chronic infections, autoimmune disorders, or certain blood cancers. IgA helps protect mucous membranes, IgG provides long-term defense, and IgM is the body’s first response to infection. Doctors use this blood test to diagnose, monitor, and manage immune-related conditions and overall immune health.

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The Toxoplasma IgG Antibody Test detects IgG antibodies to Toxoplasma gondii, the parasite that causes toxoplasmosis. A positive result indicates past infection or immunity, while rising levels may suggest recent exposure. Doctors use this blood test to evaluate immune status in pregnant women, immunocompromised patients, or those at risk for complications. Results help guide diagnosis, monitor infection history, and inform patient care planning.

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Also Known As: Toxoplasma gondii IgG Antibody Test
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