Immunity

Immunity tests evaluate how well your immune system responds to infections and vaccines. They include antibody titers (evidence of past vaccination or exposure) and immune-function screens (immunoglobulins, lymphocyte subsets, and complement). People use these labs to document immunity for school or work, to check vaccine response, or to investigate frequent infections.

A proactive approach starts with what you need to answer: Do I have protective antibodies? (vaccine titers), Is my immune system balanced? (IgG/IgA/IgM, IgG subclasses), and Are there clues to a deficiency? (CBC with differential, lymphocyte subsets, complement). Labs support screeningdiagnostic triage, and monitoring, but they do not replace a clinician’s evaluation, vaccines/boosters when recommended, or urgent care for severe illness.

Signs, Symptoms & Related Situations

  • Documentation & prevention

    • School, employment, or travel forms needing MMRvaricellahepatitis B, or tetanus/diphtheria immunity

    • Checking post-vaccination response (e.g., after hepatitis B series)

  • Frequent or unusual infections

    • ≥4 ear infections/year, recurrent sinus or lung infections, pneumonias, severe skin infections, or infections that don’t respond as expected

    • Unusual bacteria/fungi, need for IV antibiotics, or poor wound healing (clinician review needed)

  • Autoimmune/inflammatory context

    • Persistent fevers, joint pains, rashes, or swollen lymph nodes (clinician-directed evaluation)

  • When to seek urgent care

    • Trouble breathing, high fever with confusion, severe dehydration, chest pain, or rapidly worsening symptoms

Symptoms and testing decisions should be reviewed with a qualified clinician.

Why These Tests Matter

What testing can do

  • Verify immunity to vaccine-preventable diseases with antibody titers

  • Screen immune function using immunoglobulinsIgG subclassesCBC with differentiallymphocyte subsets, and complement

  • Guide next steps (e.g., repeat vaccination, further evaluation) with your clinician

What testing cannot do

  • Diagnose a specific immune disorder from one result

  • Guarantee protection—protective thresholds vary by disease and assay

  • Replace recommended vaccinations/boosters or clinical judgment

What These Tests Measure (at a glance)

  • Vaccine/Exposure Antibody Titers (IgG):

    • Measles, Mumps, Rubella (MMR)Varicella-ZosterHepatitis B surface antibody (anti-HBs)Tetanus/Diphtheria IgG

    • Most useful ≥3–4 weeks after vaccination; some reports include disease-specific cutoffs when established.

  • Total Immunoglobulins: IgGIgAIgM—low levels can signal immunodeficiency; IgE relates to allergy patterns.

  • IgG Subclasses (1–4): supportive when total IgG is normal but infections persist. Interpret with vaccine response tests.

  • Specific Antibody Response Panels: Pneumococcal serotype IgG (pre- and post-vaccination) to assess functional antibody production.

  • CBC with Differential: white-blood-cell counts (neutrophils, lymphocytes, eosinophils) for infection and allergy clues.

  • Lymphocyte Subsets (Flow Cytometry): CD3/CD4/CD8 T cellsCD19/20 B cellsCD16/56 NK cells—screen cellular immunity.

  • Complement Testing: C3C4CH50 (classical pathway), AH50 (alternative pathway) to evaluate complement deficiencies.

  • Inflammation Context (as directed): ESR/CRP for systemic inflammation; total protein/albumin for general health context.

Quick Build Guide

Goal Start with Add if needed
Proof of immunity for school/work MMR IgG • Varicella IgG • Hepatitis B surface antibody (anti-HBs) • Tetanus/Diphtheria IgG Hepatitis A IgG or others per requirement
Check vaccine response Target-specific IgG (e.g., anti-HBs ≥3–4 wks post-series) Pneumococcal serotype IgGpre/post vaccination
Frequent infections—basic screen IgG/IgA/IgM • CBC with differential IgG subclasses • Pneumococcal IgG
Suspected cellular issues CBC with diff Lymphocyte subsets (CD4/CD8/CD19/NK)
Complement deficiency clues C3 • C4 CH50 ± AH50
Autoimmune/inflammatory clues ESR/CRP Clinician-directed autoantibody panels

How the Testing Process Works

  1. Choose the right tests: documentation (titers), response checks (post-vaccine), or immune-function screen (immunoglobulins, subsets, complement).

  2. Time it well: draw ≥3–4 weeks after vaccination for the clearest antibody results.

  3. Get your blood draw: visit a nearby patient service center; your results post securely, usually within a few days.

  4. Review in context: compare titers to lab reference ranges and program requirements; discuss next steps with your clinician.

  5. Plan follow-up: repeat testing only when requested (e.g., after completing a vaccine series or if infections continue).

Interpreting Results (General Guidance)

  • Positive/Reactive titer: suggests immunity or prior exposure; some diseases have established protective thresholds (your report will note these when available).

  • Negative/Non-reactive titer: may mean no prior immunityearly testing, or waning antibodies—your clinician may recommend vaccination or re-testing.

  • Low immunoglobulins or abnormal subsets/complement: may indicate an immune deficit and often needs confirmatory testing and specialist input.
    Always interpret labs with a qualified healthcare professional; decisions depend on patterns, timing, and clinical history.

Choosing Panels vs. Individual Tests

  • Documentation bundle: pick the exact titers your school/employer requests (MMR, varicella, anti-HBs, tetanus/diphtheria).

  • Immune screen: IgG/IgA/IgM + CBC with differential, then add IgG subclassespneumococcal serotypeslymphocyte subsets, or complement based on findings.

  • Post-vaccine checks: order the specific IgG for that vaccine and schedule the draw ≥3–4 weeks after dose/series completion.

FAQs

Do antibody titers prove I’m protected?
They often correlate with protection, but standards differ by disease and test method. Follow your clinician’s advice and program requirements.

How soon after a vaccine should I test?
Wait at least 3–4 weeks to allow antibodies to rise.

If my hepatitis B surface antibody is negative, what next?
Your clinician may suggest revaccination or repeat testing; follow their plan.

What are IgG subclasses and why check them?
They are subtypes of IgG. Abnormal patterns can help explain recurrent sinus/lung infections, especially with poor vaccine responses.

Do I need to fast?
No fasting is needed for antibody titers or immunoglobulins.

Can medications affect results?
Certain medicines (e.g., immunosuppressants) can blunt antibody responses. List all meds and vaccines on your order.

What’s a pneumococcal serotype panel?
It measures antibodies to multiple Streptococcus pneumoniae types—often before and after vaccination—to test functional antibody production.

Related Categories & Key Tests

  • Immunity & Titer Tests Hub

  • COVID-19 Antibody Tests • Vaccine Titers • Infection Screening (Hepatitis, HIV) • Inflammation (CRP/ESR) • Autoimmune & Rheumatologic Tests

  • Key Tests: MMR IgG • Varicella IgG • Hepatitis B surface antibody (anti-HBs) • Tetanus & Diphtheria IgG • Hepatitis A IgG • Total Immunoglobulins (IgG/IgA/IgM) • IgG Subclasses (1–4) • Pneumococcal Serotype IgG (pre/post) • CBC with Differential • Lymphocyte Subsets (CD3/CD4/CD8/CD19/NK) • C3/C4/CH50/AH50 • ESR/CRP

  • Our Immune Panel has been designed to help you understand your immune system. Most nutrients in your diet play a critical role in helping to maintain your "optimal" immune response. Both excessive and insufficient intakes can negatively impact susceptibility to various infections and your immune status. You can take control of your health by getting tested for these key areas, so you know what's wrong before it gets serious. 

  • Our Immune Health Panel includes 10 key lab tests that will help you understand the state of your immune system. Our panel comprises of 9 tests and 73 biomarkers with a comprehensive assessment of nutrient intake, which can be used as an indicator for optimal immune response. This test can also provide insight into susceptibility to various infections and your immune status.

References

  • Centers for Disease Control and Prevention — Adult Immunization Schedule and serologic evidence of immunity.
  • Infectious Diseases Society of America — Clinical use of immunoglobulins and evaluation of antibody responses.
  • American Academy of Allergy, Asthma & Immunology — Practice parameters for primary immunodeficiency evaluation.
  • World Health Organization — Serologic testing considerations for vaccine-preventable diseases.
  • National Institutes of Health — Primary immune deficiency overviews and testing pathways.
  • CLSI — Serology and immunology testing best-practice guidelines.

Available Tests & Panels

Your Immunity Tests menu is pre-populated in the Ulta Lab Tests system. Select the specific titers required for documentation, add post-vaccine checks when needed, or build an immune-function screen with immunoglobulins, IgG subclasses, CBC with differential, lymphocyte subsets, and complement. Follow timing guidance and review results with your clinician to plan next steps.

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Blood Draw, Phlebotomist

Most Popular
 The Immunity Panel is a set of laboratory tests designed to assess an individual's immunity status against specific infectious diseases. By measuring the presence and levels of specific antibodies in the blood, the panel provides valuable insights into whether an individual has been previously exposed to these pathogens or has been vaccinated against them, thus offering protection.
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Blood Draw, Phlebotomist

 The Immunity Panel Plus is a comprehensive set of tests designed to evaluate an individual's immunity to certain infectious diseases. This panel includes tests for Hepatitis A Antibody Total, Hepatitis B Surface Antibody, Quantitative, Measles IgG Antibody, Mumps IgG Antibody, Rubella IgG Antibody, and Varicella-Zoster Virus IgG Antibody. It is often used to determine if an individual has immunity, either from previous infections or vaccinations, against these specific diseases.
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Blood Draw, Phlebotomist

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

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Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Cytomegalovirus (CMV) IgG Antibody Test detects IgG antibodies to CMV, indicating past infection or immunity. This blood test helps determine prior exposure, assess immune status in pregnancy, transplant patients, or immunocompromised individuals, and guide risk evaluation. A positive result shows past CMV infection, while results are used with IgM testing to distinguish recent vs. past infection.

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Blood Draw
Also Known As: CMV IgG Antibody Test, Cytomegalovirus IgG Test

The Cytomegalovirus (CMV) IgM Antibody Test detects IgM antibodies, indicating a recent or active CMV infection. This blood test helps diagnose primary CMV, reactivation, or reinfection, especially important for pregnant women, transplant candidates, and immunocompromised patients. Used with CMV IgG testing, it helps distinguish new infections from past exposure for accurate clinical evaluation.

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Blood Draw
Also Known As: CMV IgM Antibody Test, Cytomegalovirus IgM Test

The Diphtheria Titer Test measures antibody levels to evaluate immune protection against Corynebacterium diphtheriae, the bacterium that causes diphtheria. This test helps determine whether immunity is adequate following vaccination or exposure. By assessing diphtheria antibody titers, it provides insight into immune system response, vaccine effectiveness, and long-term protection against this serious infection.

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Blood Draw
Also Known As: Diphtheria Antitoxoid Test

The Hepatitis A IgM Antibody Test is a qualitative blood test that detects IgM antibodies to the hepatitis A virus (HAV) and reports results as Reactive or Non-Reactive. A reactive result usually indicates a recent or current hepatitis A infection, while a non-reactive result means no active infection. Doctors use this test to confirm acute hepatitis A in patients with symptoms like jaundice, nausea, fatigue, or abdominal pain and to guide timely treatment and prevention.

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Blood Draw
Also Known As: Hep A IgM test, HAV IgM Ab Test

The Hepatitis B Core Antibody Total Test is a qualitative blood test that detects antibodies to the hepatitis B core antigen (anti-HBc) and reports results as Reactive or Non-Reactive. A reactive result may indicate past or ongoing infection, while a non-reactive result suggests no exposure. This test does not distinguish between IgM and IgG antibodies. Doctors use it to evaluate hepatitis B exposure, confirm infection history, and assess overall immune response.

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Blood Draw
Also Known As: HBcAb Total Test, HBc Total Test, Hep B Core Ab Total Test

The Hepatitis B Immunity Panel Test evaluates immune status by measuring Hepatitis B surface antibody levels in the blood. A positive result typically indicates immunity from vaccination or past infection, while a negative result suggests susceptibility. This test is important for verifying protection, monitoring vaccine response, or determining if additional vaccination or further evaluation for Hepatitis B exposure is needed.


The Hepatitis B Surface Antibody Quantitative Test measures the exact level of anti-HBs antibodies in blood to determine past exposure and whether protective immunity has developed from infection or vaccination. A higher antibody level generally indicates adequate immune response, while a low level suggests limited or no protection. Doctors use this test to confirm vaccine effectiveness, assess immune status, and support hepatitis B screening or preventive care.

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Blood Draw
Also Known As: HBsAb Qn Test, Hepatitis B Titer Test

The Hepatitis B Surface Antigen (HBsAg) Test with Reflex to Confirmation screens for hepatitis B surface antigen in blood and, if reactive, automatically performs confirmatory testing. A reactive confirmed result indicates an active hepatitis B infection, while a non-reactive result shows no infection. Doctors use this test to diagnose acute or chronic hepatitis B, investigate abnormal liver tests, and guide treatment, monitoring, and infection control decisions.

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Blood Draw
Also Known As: HBsAg Test, Hep B Surface Ag Test, HBs Antigen Test, Hep B Test

The Hepatitis B Test (Hepatitis B Surface Antigen with Reflex to Confirmation) screens for hepatitis B surface antigen (HBsAg) in the blood to identify active infection. If the result is positive, a confirmation test is automatically performed to verify accuracy and support proper diagnosis.

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Blood Draw

The Herpes 1 IgG Antibody Test detects IgG antibodies to HSV-1, the virus that commonly causes oral herpes (cold sores). IgG develops weeks after exposure and remains for life, making this test useful for confirming past infection and exposure history. Doctors order it for patients with oral sores, blisters, or concerns about herpes transmission. Results help confirm HSV-1 infection, guide treatment, and support counseling and prevention strategies.

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Blood Draw
Also Known As: Herpes Simplex Virus 1 IgG Type-Specific Antibody HerpeSelect® Test, Herpes 1 IgG Test, Oral Herpes Test

The Herpes 1 and 2 Test uses type-specific HSV-1/HSV-2 IgG to assess past infection and differentiate exposure to each virus. It is useful for evaluating recurrent lesions, screening asymptomatic partners, and documenting baseline status for clinical management. Because IgG can take 2–12 weeks to develop, early negatives may need repeat testing; HSV-2 reactive results reflex to an inhibition assay to verify specificity and reduce cross-reactivity.

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Blood Draw

The Herpes 2 IgG Antibody Test detects IgG antibodies to HSV-2, the virus that most often causes genital herpes. IgG develops weeks after infection and remains for life, making this test valuable for confirming past exposure or infection history. Doctors order it for patients with genital sores, blisters, or concerns about herpes transmission. Results help confirm HSV-2 infection, guide treatment, and support counseling, prevention, and long-term care.

Blood
Blood Draw
Also Known As: Herpes Simplex Virus 2 IgG HerpeSelect® Test with Reflex to HSV 2 Inhibition, Herpes 2 IgG Test, Genital Herpes Test

The Herpes Simplex Virus 1 and 2 IgG Type-Specific Antibody HerpeSelect® Test detects IgG antibodies to HSV-1 and HSV-2, distinguishing between the two types. A positive result indicates past exposure, as IgG develops weeks after infection and remains long-term. Doctors use this test to confirm herpes diagnosis, guide treatment, or support sexual health decisions. Results provide vital insight into HSV status, infection history, and long-term immune response.

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Blood Draw
Also Known As: Herpes 1 and 2 Test, Herpes IgG Test

The Interleukin 2 Receptor (IL-2R) Test evaluates soluble receptor levels in blood, reflecting immune system activation and regulation. Increased IL-2R may be seen in lymphoma, sarcoidosis, autoimmune conditions, and chronic inflammatory disease. This test provides insights into T-cell activation, immune dysregulation, and disease monitoring, helping guide evaluation of systemic immune health.
 

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Blood Draw

The Iron Total and Total Iron Binding Capacity (TIBC) Test measures iron levels in blood along with the blood’s ability to transport iron. It helps diagnose iron deficiency anemia, iron overload (hemochromatosis), and monitor nutritional or chronic health conditions. Low iron or high TIBC may indicate anemia, while high iron or low TIBC can suggest overload. Doctors use this test to evaluate fatigue, weakness, or other symptoms linked to iron and metabolic health.

Blood
Blood Draw
Also Known As: Serum Iron Test, Total Iron Binding Capacity Test, TIBC Test, UIBC Test

Most Popular

The Magnesium Serum Test measures magnesium levels in blood to evaluate electrolyte balance, nerve and muscle function, and overall metabolic health. Abnormal levels may indicate kidney disease, malnutrition, gastrointestinal disorders, or uncontrolled diabetes. Low magnesium can cause weakness, cramps, or irregular heartbeat, while high levels may signal kidney dysfunction. Doctors use this test to diagnose deficiencies, monitor therapy, or assess chronic health conditions.

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Blood Draw
Also Known As: Mg Test, Mag Test

The Measles IgG IgM Antibodies Test measures immune response to the measles virus by detecting IgM for recent or acute infection and IgG for past exposure or vaccine immunity. This test helps confirm suspected measles cases in patients with fever, rash, cough, or conjunctivitis, and evaluates immunity in those with uncertain vaccination history, supporting diagnosis, outbreak control, and public health monitoring.

Also Known As: Rubeola Test, Measles Virus Test, Measles Titer test, Measles Infection Test

The Measles IgG Antibody Test measures IgG antibodies to determine immunity from past infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility to measles. Doctors use this blood test to confirm immune status, evaluate vaccination records, or meet school, travel, or employment requirements. It provides valuable insight into measles protection and public health safety.

Blood
Blood Draw
Also Known As: Rubeola Test, Measles Virus Test, Measles Titer Test

The Measles Titer Test measures IgG antibody levels to determine immunity from prior measles infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility. Doctors order this test to confirm immune status for school, healthcare, travel, or employment requirements. It is also used to verify vaccination response, ensuring individuals are protected against measles and reducing outbreak risk.

Blood
Blood Draw
Also Known As: Rubeola Test, Measles Virus Test, Measles IgG Antibody Test

The Measles, Mumps, Rubella (MMR) Immunity Profile is a quantitative blood test that measures antibody levels to measles, mumps, and rubella. Results confirm prior infection or vaccine response and show if antibody levels are protective. Doctors order this test for school, employment, or travel requirements, to evaluate vaccine effectiveness, and to guide revaccination decisions. It provides reliable assessment of immune protection against all three viral diseases.

Also Known As: MMR Titer Test

Did you know over 200 forms of primary immune deficiency diseases affect almost 500,000 people in the United States? 

Primary immune deficiency diseases (PIDDs) are rare, costly, and can lead to disability and huge changes in your life. Immunity blood tests are critical in the diagnosis and treatment of these disorders.

If you lack immunity to common diseases and wonder about a blood test to check your immune system, you're in the right place.

Keep reading this guide to learn everything you need to know about immunity deficiencies and immunity blood tests.

What is Immune Deficiency

Immunity deficiency is categorized by a group of disorders called primary immune deficiency diseases (PIDDs). These disorders are rare, genetic, and impair your immune system. If your immune system doesn't function properly, you're subject to debilitating and chronic infections.

Over 200 forms of PIDDs can be diagnosed in infancy, childhood, or when you're an adult depending on the severity. Certain PIDDs are fatal.

When you have PIDD, you're born missing some of the body's natural immune defenses, or your immune system doesn't work normally. This defect leaves you more susceptible to germs that cause infections.

Certain forms of PIDD are very mild and aren't detected until adulthood. Other forms are so severe they're discovered immediately after a baby is born. 

Nowadays, treatments can boost the immune system in many types of PIDD and lead to improved outcomes and quality of life for people with this condition.

Risk factors for Immune Deficiency

The one known risk factor for primary immune deficiency disorder is your family history. If you have a type of PIDD or are concerned, you might due to your family history, talk to your doctor. You also may want to seek genetic counseling before starting a family.

Causes of Immune Deficiency

Many causes of immunodeficiency disorders are inherited, meaning they're passed down from one or both parents. Problems with the genetic code that produces cells in the immune system cause this disorder. PIDD is classified into six groups based on the part of the immune system affected. These groups include:

  • B cell antibody deficiencies
  • T cell deficiencies
  • A combination of B and T cell deficiencies
  • Defective phagocytes
  • Complement deficiency
  • Unknown or idiopathic

Signs and Symptoms of Immune Deficiency

The most common sign of PIDD is frequent infections that last longer and are harder to treat. You'll also likely get infections that people with normal immune systems don't get. Signs and symptoms depend on the type of PIDD you have, but usually include:

  • Frequent pneumonia, bronchitis, sinus infections, skin infections, or ear infections
  • Infection and inflammation of your internal organs
  • Blood disorders like anemia
  • Problems with digestion like loss of appetite, nausea, and diarrhea
  • Autoimmune disorders like lupus
  • Delayed growth in children

Complications from primary immunodeficiency disorder vary, depending on the type you have. Though there is still a risk of serious complications like:

  • Autoimmune disorders
  • Recurrent infections
  • Damage to your heart, lungs, nervous system, and intestines
  • Increased risk of developing cancer
  • Death from serious infections 

How is Immune Deficiency Diagnosed

Your doctor will ask you about your personal history of illness and infections. They will also ask you about any close relatives being diagnosed with an immune disorder. Your doctor will also check your symptoms and do a physical examination.

Tests to diagnose immune disorders include tests to level the levels of your infection-fighting proteins (immunoglobulins) in your blood. You'll also have blood tests to measure the number of immune system cells, like white blood cells.

If you're a woman with PIDD, it's a good idea to have genetic testing so you can prepare for future pregnancies. If you're already pregnant, you can have samples of amniotic tested for abnormalities.

Lab Tests for Immune Deficiency

When you need to check your immune system, a blood test is an easiest and cheapest way to detect if you have problems.

Lab tests for PIDD include an immune system blood test called an immunity panel. This panel tests hepatitis B, measles, mumps, rubella (MMR), and chickenpox immunity. 

An immunoglobulins panel checks for elevations in IgG, IgA, and IgM. Decreased levels of these are found in people with immune deficiency.

c-reactive protein is useful for measuring inflammation in your body, indicating how your immune system works.

complete blood count (CBC) measures not only your red blood cells but key components of your immune system, such as white blood cells, neutrophils, and monocytes.

FAQS About Immune Deficiency

Is there a cure for PIDD? Yes, a stem cell transplantation from a close relative can build a normally functioning immune system. The donor must have similar antigens, so the recipient accepts the donor's stem cells. But only the most serious of PIDD get this treatment. Most people with PIDD do not require this.

What treatments are there for PIDD? Many people with PIDD are treated with IgG replacement therapy. This therapy provides the antibodies that the body needs to have a functioning immune system. Many people take antibiotics and other medications to prevent infections.

How do I know if my child has PIDD? If your child has poor growth, weight loss, unusual or difficult to treat infections, or a family history of PIDD, you should talk to your pediatrician.

Where can I go for more information about PIDD? The Immune Deficiency Foundation aims to improve treatments and the quality of life of people affected by PIDD. You can find education, tools, events, news, and research updates.

Immunity Blood Tests With Ulta Lab Tests

Ulta Lab Tests offers highly accurate tests, allowing you to make the best decisions about your health. Here are some things you can love about Ulta Lab Tests:

  • Secure and confidential results
  • No need for health insurance
  • No need for a physician's referral
  • Always affordable pricing
  • A 100% satisfaction guarantee

Order your immunity blood lab tests today, and your results will be provided to you securely and confidentially online in 24 to 48 hours in most cases.

Go to the best blood test lab and take charge of your health. Shop with Ulta Lab Tests today!