Interleukin-2 Receptor, EIA

The Interleukin-2 Receptor, EIA test contains 1 test with 2 biomarkers.

Clinical Use
Assess T-cell activation following transplantation
Assess prognosis in patients with lymphoma
Monitor therapeutic response in patients with hairy cell leukemia

Clinical Background
Elevated levels of soluble IL-2 receptor are detected in AIDS, autoimmune diseases, sarcoidosis, and a variety of leukemias and lymphomas. In HIV-positive individuals, the IL-2 receptor level is elevated during the asymptomatic phase, as well as during persistent generalized lymphadenopathy and symptomatic phases. IL-2 receptor detection may be useful in monitoring HIV and in assessing T-cell activation following transplantation. Elevated IL-2 receptor levels may also have clinical and prognostic significance in patients with malignant lymphoma, non-Hodgkin's lymphoma, B-cell, and undifferentiated lymphomas.

Studies have suggested that IL-2 receptor levels in a broad spectrum of conditions associated with T- or B-cell immune activation offer a rapid and reliable measure of disease activity, response to therapy, and, in some cases, prognosis. Measurement of the soluble IL-2 receptor level is also helpful in assessing therapeutic response in patients with hairy cell leukemia.

Method
Enzyme immunoassay (EIA)

Clinical Significance 

Following stimulation by antigen, IL-2R is expressed on all T cells. IL-2R is released by activated cells into the surrounding extracellular fluid. IL2-R is involved in infectious, inflammatory and autoimmune diseases, cancer, and transplantation. IL-2R Antibodies are used therapeutically.

Alternative Name(s) 

IL-2 Receptor,  CYTOKINE