Drug & Alcohol Tests

This hub is for employers and safety-sensitive programsclinicians/pain-management teamslegal/court-ordered testing, and individuals seeking documented screening or monitoring. Core options include urine immunoassay screening with GC/MS or LC-MS/MS confirmationoral fluid (saliva)hairblood/serumbreath alcoholEtG/EtS (urine) for recent alcohol, and PEth (blood) for patterned drinking. Results inform employment compliancereturn-to-dutyclinical monitoring, and personal documentation.


What It Tests

“Drug & alcohol testing” spans multiple specimen types and use cases:

  • Screening vs confirmation: Immunoassays screen quickly; positives are presumptive and require GC/MS or LC-MS/MS confirmation.

  • Specimen choices:

    • Urine — broad coverage; recent to sub-acute use.

    • Oral fluid — observed collection; captures very recent use.

    • Blood/serum — short window; used for ethanol, some confirmations, or clinical contexts.

    • Breath — immediate BrAC (alcohol impairment screening).

    • EtG/EtS (urine) — recent alcohol exposure (short window).

    • PEth (blood) — patterned drinking over weeks (longer window).

  • Contexts: Workplace/DOT complianceclinical SUD or pain-management monitoringlegal/court-ordered, and personal documentation.


Key Tests

Test Also Called (Synonyms) What It Measures Typical Prep Specimen Related Panels Use Type Typical Detection Window
Urine 5-Panel (SAMHSA) “SAMHSA 5” Amphetamines, Cocaine (BE), Marijuana (THC-COOH), Opiates, PCP Normal hydration; bring ID; COC if compliance Urine Workplace Screen Compliance / Screening ~1–3 d (class-dependent; THC longer in chronic use)
Urine 10-Panel (Expanded) Benzos, Barbs, Methadone, etc. Broader drug classes incl. sedatives As above Urine Expanded Screen Compliance / Screening ~1–7 d (class-dependent; some benzos/barbs longer)
Expanded Opioids Fentanyl Oxy/Hydro-codone & -morphone, Fentanyl/Norfentanyl Semi-synthetic & synthetic opioids As above Urine Opioid Compliance Screening / Monitoring ~1–3 d (fentanyl up to several days in some users)
Buprenorphine / Norbuprenorphine BUP/NBUP MOUD adherence As above Urine MAT Monitoring Monitoring / Clinical ~1–3 d
Methadone / EDDP Methadone therapy/metabolite As above Urine Pain/MAT Monitoring / Clinical ~1–7 d
Benzodiazepines (class) incl. metabolites Sedative class screen As above Urine 10-Panel Screening / Monitoring ~2–7 d (long-acting may be longer)
Barbiturates (class) Sedative class screen As above Urine 10-Panel Screening / Monitoring ~2–7 d (phenobarbital can be longer)
Cocaine metabolite Benzoylecgonine Cocaine exposure As above Urine 5/10-Panel Screening / Monitoring ~1–3 d
Amphetamines / Methamphetamine / MDMA Stimulant class screen As above Urine 5/10-Panel Screening / Monitoring ~1–3 d
Cannabinoids THC-COOH Marijuana exposure As above Urine 5/10-Panel Screening / Monitoring Intermittent: ~1–3 d; Chronic: up to weeks
PCP Phencyclidine Dissociative agent As above Urine 5-Panel Screening / Monitoring ~3–7 d
Serum/Whole-Blood Ethanol Blood alcohol None unless specified Blood Alcohol Panel Clinical / Confirmation Hours (short window)
Urine EtG/EtS Ethyl glucuronide/sulfate Recent alcohol exposure Normal hydration; ID Urine Alcohol Monitoring Monitoring / Clinical ~24–72 h (varies with intake)
PEth (Blood) Phosphatidylethanol Patterned alcohol use over weeks None unless specified Blood (DBS/venous) Alcohol Monitoring Monitoring / Clinical ~2–4 weeks (intake-dependent)
GC/MS or LC-MS/MS Confirmation Confirmatory testing Specific analyte confirmation & cutoffs Follows screen Urine/other Add-on Confirmation N/A

COC = Chain-of-Custody; MAT = Medication-Assisted Treatment; BE = Benzoylecgonine.


When to Test

  • Pre-employment / hiring (baseline screen).

  • Random program testing (safety-sensitive roles).

  • Reasonable suspicion and post-accident testing.

  • Return-to-duty & follow-up (programmed schedules).

  • Clinical monitoring (SUD treatment, MOUD adherence, pain-management compliance).

  • Legal/court-ordered, custody, probation (per order).

  • Personal documentation (e.g., abstinence or recovery monitoring).

  • Policy change or incident response (program updates).


How to Prepare

  • Bring ID and required paperwork. For compliance testing, follow chain-of-custody directions exactly.

  • Medication disclosure: List prescriptions, OTCs, and supplements; an MRO may contact you to verify legitimate use.

  • Hydration: Drink normally. Over-hydration may create a dilute urine specimen requiring recollection.

  • Oral fluid: Avoid food, drink, smoking/vaping, and alcohol-containing mouthwash for the kit-specified interval.

  • Hair testing: Routine shampooing is fine; avoid harsh cosmetic treatments right before collection. Shaving to avoid testing is not permitted (alternative sites can be used).

  • Alcohol biomarkers: EtG/EtS and PEth can reflect non-beverage alcohol exposures (e.g., sanitizers, mouthwash); follow lab guidance.

  • No tampering: Adulterants, substitution, or dilution violate policy; labs check creatinine, specific gravity, pH, and oxidants.


Interpreting Results

  • Screen vs confirm: Immunoassay screen positives are presumptive; labs reflex to GC/MS or LC-MS/MS with specific cutoffs for confirmation.

  • Cutoffs ≠ impairment: A positive indicates presence above a thresholdnot legal impairment at the time of collection.

  • Detection windows vary: by substance, dose/frequencymetabolismspecimen typehair length, and cutoffs. Hair ≈ history; oral fluid ≈ very recent; urine ≈ recent/sub-acute; PEth ≈ weeks; EtG/EtS ≈ hours–days.

  • Prescriptions & false positives: Some meds can trigger presumptive positives; MRO review assesses medical legitimacy for compliance programs.

  • Clinical vs compliance: Clinical monitoring is for care; compliance testing follows policy/regulation (e.g., DOT 49 CFR Part 40).

  • Specimen validity: “Dilute,” “invalid,” or “adulterated” reports may require recollection under program rules.


Related Conditions / Use Cases 

  • Substance Use Disorder (SUD) monitoring

  • Alcohol Use Disorder (AUD) monitoring

  • Pain-management compliance

  • Workplace safety / DOT compliance

  • Legal/court-ordered testing

  • Post-accident & reasonable-suspicion protocols


Bundles & Panels


FAQs

How long do drugs or alcohol stay detectable?
It depends on substance, dose/frequency, metabolism, specimen type, and cutoffs. Hair ≈ months; urine/oral fluid ≈ hours–days; EtG/EtS ≈ hours–days; PEth ≈ weeks.

What’s the difference between screening and confirmation?
Screening uses immunoassays; non-negatives must be confirmed by GC/MS or LC-MS/MS before final reporting.

What is a chain-of-custody test and MRO review?
Chain-of-custody tracks the specimen for compliance programs. An MRO (physician) reviews results and medications to finalize reports.

Will my prescriptions cause a positive?
Some can cause presumptive positives. Provide medication proof; an MRO may verify legitimate use for compliance testing.

EtG/EtS vs PEth—what’s the difference?
EtG/EtS detect recent alcohol exposure (short window). PEth reflects repeated/moderate-to-heavy drinking over weeks.

Do I need to fast?
Usually no. Follow the kit’s instructions (avoid eating/drinking before oral fluid collection).

Can passive cannabis exposure cause a positive?
Program cutoffs aim to reduce passive positives. Policies vary; discuss specifics with your program/clinician.

Does hair dye/bleach affect hair testing?
Heavy cosmetic treatment can affect analyte levels; labs use collection/site alternatives and validity checks.

What if my result is dilute, invalid, or adulterated?
Programs typically require recollection—sometimes under direct observation—per policy.

Can a positive test prove impairment?
No. It indicates presence above a cutoff, not legal impairment.


References

  • SAMHSA — Model Guidelines for Workplace Drug Testing (screening/confirmation standards)

  • U.S. DOT (49 CFR Part 40) — Procedures for Transportation Workplace Drug and Alcohol Testing Programs

  • NIAAA — Alcohol biomarkers, PEth and EtG/EtS overviews

  • ASAM — Consensus on appropriate use of drug testing in clinical addiction medicine

  • ARUP Consult / Mayo Clinic Labs — Test overviews and specimen/detection considerations

Last reviewed: September 2025 by Ulta Lab Tests Medical Review

There is a range of drug tests. Drug screens vary from one another in the kind of drug they spot, the sort of sample required for testing, and if they check for the existence of drug metabolites or the drug itself. A drug metabolite refers to a substance that stays in the system after the drug has already been metabolized.  

Even though urine is the frequently used test sample for drug testing, other test samples may include saliva, breath, sweat, feces, hair, and blood. Urine testing is frequently used because the test is affordable, non-intrusive, and spots a broad range of drugs. Hair follicle testing may be done to test for long-term or chronic drug usage. 

Evidence of drug usage is detectable within a certain timespan, referred to as a detection window. Detection windows depend on various factors, including the amount of use and length and the frequency at which the drug is broken down and eliminated from the system. Here are some of the drugs that may be included in drug tests:  

  • · Amphetamines testing identifies the drug itself using a urine or blood sample
  • · Alcohol (ethanol) testing identifies the drug or its metabolites using a blood sample. 
  • · Benzodiazepines testing identifies the drug or its metabolites using a urine or blood sample. 
  • · Barbiturates testing identifies the drug or its metabolites using a urine or blood sample. 
  • · Marijuana (THC) testing identifies the drug metabolites using blood
  • · Cocaine testing identifies the drug metabolites using urineblood
  • · Opioid testing identifies the drug or its metabolites using a bloodurine, or saliva sample. 
  • · Nicotine and cotinine testing identify the drug or its metabolites using a  blood sample. 
  • · Phencyclidine (PCP) testing identifies the drug itself using a  blood sample. 

Although drug screening may be aimed at detecting one drug, it usually tests for a range of drugs simultaneously by using test panels. The most frequently used panel for testing patients suspected of illegal drug usage detects five substances: PCP, opioids, marijuana, cocaine, and amphetamines.  

Buy your drug lab tests here to keep an eye on your health and use the results to make smart health decisions. Click on the link below to learn more about the drug tests that can help you understand and keep track of your health.

  • Pharmacogenetic Lab Tests

Visit the link below to learn more about drug and alcohol lab testing.

  • Pharmacogenetics & Pharmacogenetic Tests
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What Are Drugs?  

Drugs are plant constituents or chemicals that influence the body and mind. The definition of drugs incorporates legal substances like tobacco and illegal substances, prescription medicines, and over-the-counter medication. 

When appropriately utilized, over-the-counter medications and prescription medicines can treat medical conditions and help recuperate one's health. Nevertheless, continual usage of drugs can result in health risks addiction. Substance usage can be split into two broad classifications depending on the manner the drug is acquired: 

· Drug use: Drug usage alludes to making use of any prohibited substances. Individuals who fall under this category use these drugs by inhaling, ingesting, smoking, or injecting them inside their bodies. Illicit drugs are frequently used for their mind-altering properties but may be consumed for other reasons like boosting athletic performance or losing weight. 

· Drug misuse: Drug misuse alludes to making use of legally acquired substances in a manner that's unhealthy or varies from the recommended guidelines of a physician. Drug misuse refers to excessive alcohol consumption, over-the-counter medication, and tobacco, along with prescription drug misuse. 

Drug use and misuse can result in you developing an addiction. Addiction, also referred to as a substance use disorder is a lasting disease in which recurrent drug usage alters in the brain. Addiction is very complicated and involves genetics, the brain, and life experiences, and the environment. An individual is classified as an addict when using drugs impulsively, despite past negative and experiences.    

Patients dealing with drug addiction, misuse, and substance usage should consult their medical healthcare service provider or physician. There are various effective treatment alternatives for addiction and substance usage disorders. 

The Role of Drug Tests 

The purpose of drug tests is to identify if a particular individual has misused or used drugs. An office setting makes use of drug tests often. Before an applicant is enlisted, an employer may mandate a drug screening. Periodic or random drug tests after employment may also be a caveat an employer demands. 

An employer may demand drug screening when drug usage is assumed and is centered on symptoms noticed at work. A worker may also be subject to a drug test after getting involved in an accident or mishap in the workplace. An individual may be subjected to return-to-duty drug testing upon return after a prolonged period away from work. 

Drug screening may also be applied in various other settings, including:   

· Legal or forensic testing: Drug screening may be required as part of a court case or investigation to act as proof of an offense or in cases involving child endangerment or abuse. What's more, screening may be used to establish whether an individual is publicly intoxicated or driving under the influence. 

· Medical testing: A person may be screened for drug misuse or usage as part of a medical evaluation. For instance, patients on the waitlist for an organ transplant may be subject to a drug test and disqualified if the result comes back positive. A healthcare provider may also require a drug test to be done in the case of a critically ill patient with symptoms of a potential overdose.  

· Treatment adherence: Drug testing may be mandated to check whether the said individual has adhered to court-mandated treatment programs, as probation terms, while undergoing a substance abuse treatment or as part of a continuing parental rights case or custody. 

· Checking for prescription drug misuse: A physician may mandate drug screening to examine patients who are likely to misuse certain prescription drugs, including opioids used for relieving pain. Random or periodic drug screening assists in making sure that patients are ingesting the prescribed medication properly.  

· Athletic testing: Professionals in the athletic field are usually subjected to random drug tests to check for drugs that may be deemed performance-enhancing. 

· Military testing: Random or periodic drug screens may be a requirement for military members. 

Who should get testing? 

There are various settings in which a drug test may be obligatory, including: 

  • · Medication management 
  • · Organized sports 
  • · Employment 
  • · Court cases 
  • · Police investigations 

Medical practitioners may also order a drug screen if a patient is getting treatment related to substance use. 

When it comes to subjecting a person to drug tests, ethical and legal factors need to be considered. Given how sensitive drug screening can be and the likely implications that may arise; as a result, patients being subjected to drug tests should be given a chance to agree to drug screening whenever possible. Complicated ethical and legal questions may crop up in certain scenarios like: 

· Drug testing minors: While it's permissible in some areas for a parent to authorize their child to get screened for drug usage without their approval, the American Academy of Pediatrics advocates that medical personnel shouldn't screen children for drugs without the said child being aware or giving the go-ahead unless it's a medical emergency. 

· Drug testing during pregnancy: When it comes to drug screening during pregnancy, pregnant mothers and their physicians should discuss state and federal patient confidentiality regulations and potential implications if drug use is discovered. The American Society of Addiction Medicine advises physicians to get approval from pregnant mothers before testing unless it's an emergency. 

Getting test results 

Drug tests usually come back as either negative or positive. Positive results show definitive proof of the presence of a drug, or a drug's presence is above the threshold range for the test. A negative result shows proof that there was no presence of a drug or the readings acquired were below the reference range to attain a positive result. There are various factors to consider when translating drug test results:    

· Confirmatory testing may be required: A preliminary drug test's positive results often need to be corroborated with further testing. This test utilizes a different kind of drug screening and increases the accuracy of the overall drug test by minimizing the risk of false-positive results, where the test results of an individual come back positive despite not using any drugs. 

· Drug tests may not account for intoxication: Positive results don't necessarily suggest that an individual is presently intoxicated. Drug screens may detect drugs at a lower concentration than what would be needed to induce physical effects. In addition, some tests can reveal drug usage days to weeks after usage, at which juncture the drug's intoxicating effects have waned. 

· Risk of false-positive results: There are incidences of certain foods and medications giving off false-positive results. Examples include OTC cold medication that can test positive for PCP and consuming poppy seeds, which may test positive for opioids 

· Risk of false-negative results: False-negative arises when an individual's test results come back negative despite drug misuse or usage. These results can happen for an array of reasons like improper testing or sample collection, a patient falsifies or subverts a drug test, or using a drug not spotted in a particular test. For instance, amphetamine testing doesn't scan all types of amphetamines. Frequently used amphetamines like methamphetamine and MDMA may not be detectable on all amphetamine tests.    

Types of Drug Tests 

There is a range of drug tests. Drug screens vary from one another in the kind of drug they spot, the sort of sample required for testing, and if they check for the existence of drug metabolites or the drug itself. A drug metabolite refers to a substance that stays in the system after the drug has already been metabolized.  

Even though urine is the frequently used test sample for drug testing, other test samples may include saliva, breath, sweat, feces, hair, and blood. Urine testing is frequently used because the test is affordable, non-intrusive, and spots a broad range of drugs. Hair follicle testing may be done to test for long-term or chronic drug usage. 

Evidence of drug usage is detectable within a certain timespan, referred to as a detection window. Detection windows depend on various factors, including the amount of use and length and the frequency at which the drug is broken down and eliminated from the system. Here are some of the drugs that may be included in drug tests:  

  • · Amphetamines testing identifies the drug itself using a urine or blood sample
  • · Alcohol (ethanol) testing identifies the drug or its metabolites using a blood sample. 
  • · Benzodiazepines testing identifies the drug or its metabolites using a urine or blood sample. 
  • · Barbiturates testing identifies the drug or its metabolites using a urine or blood sample. 
  • · Marijuana (THC) testing identifies the drug metabolites using blood
  • · Cocaine testing identifies the drug metabolites using urineblood
  • · Opioid testing identifies the drug or its metabolites using a bloodurine, or saliva sample. 
  • · Nicotine and cotinine testing identify the drug or its metabolites using a  blood sample. 
  • · Phencyclidine (PCP) testing identifies the drug itself using a  blood sample. 

Although drug screening may be aimed at detecting one drug, it usually tests for a range of drugs simultaneously by using test panels. The most frequently used panel for testing patients suspected of illegal drug usage detects five substances: PCP, opioids, marijuana, cocaine, and amphetamines.  

Order a drug screen or test with Ulta Lab Tests. 

Ulta Lab Tests offers highly accurate and reliable tests so that you can make informed decisions about your health. Here are a few great things to love about Ulta Lab Tests for your digestive lab tests:  

  • You'll get secure and confidential results  
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  • You don't need a physician's referral  
  • You'll get affordable pricing  
  • We offer a 100% satisfaction guarantee  

Order your drug screen tests today, and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.  

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