Drug Monitoring, Methadone Metabolite, with Confirmation, Urine

The Drug Monitoring, Methadone Metabolite, with Confirmation, Urine test contains 1 test with 4 biomarkers.

Drug Monitoring, Methadone Metabolite, with Confirmation, Urine

Clinical Significance
Drug Monitoring, Methadone Metabolite, with Confirmation, Urine - Methadone is prescribed to patients for the alleviation of opioid addiction withdrawal symptoms and analgesic purposes. The test is a screening assay using a homogeneous enzyme immunoassay method of analysis. Presumptive positive screening tests are reflexed to a more specific and sensitive liquid chromatography mass spectroscopy (LC/MS/MS) confirmation test. Therapeutic urine drug monitoring of methadone and its metabolite EDDP is important for ensuring compliance to treatment strategies, as well as ensuring non-diversion for illicit purposes strategies. Urine or oral fluid are the specimens of choice for routine monitoring of patients taking prescription drugs. Use of serum/plasma should be limited to anuretic patients, or where a patient's clinical appearance does not coincide with their prescribed medications. No single monitoring approach provides adequate information about the pattern or dose of patient drug use. Safest prescribing habits should include a combination of tools and laboratory test results to correctly detect drug use patterns. Quantitative values cannot be used to assess the drug dose, because the drug is extensively metabolized and excreted in the urine.

If you require medMATCH for this order code, you must also order code 39158 - Prescribed Drugs, medMATCH®. If 39158 is ordered, all Drug Monitoring order codes will be treated as medMATCH.
If this test code is not ordered with 39158, all medMATCH result codes will be DNR’d.
Initial screen of the Methadone Metabolite drug class. If screen is positive, a confirmation will be performed at an additional charge (CPT code(s): 80358; HCPCS: G0480).
Confirmation includes the following analytes: EDDP, Methadone

Reference Range(s)
Methadone Metabolite    <100 ng/mL
  EDDP    <100 ng/mL
  Methadone    <100 ng/mL

Alternative Name(s)
Prescription Drug Monitoring,Pain Management

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.


Medmatch Methadone



*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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