Poliovirus (Types 1, 3) Antibodies, Neutralization

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Polio 1 Titer

Polio 3 Titer

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The Poliovirus (Types 1, 3) Antibodies, Neutralization test contains 1 test with 2 biomarkers.

Brief Description: The Poliovirus (Types 1, 3) Antibodies, Neutralization test is a specialized immunological assay designed to detect and quantify the presence of neutralizing antibodies against poliovirus types 1 and 3 in the blood. These antibodies are part of the body's immune response to either past exposure to the poliovirus, through infection or vaccination. The test specifically measures the ability of these antibodies to neutralize or inhibit the infectivity of the virus, which is a crucial aspect of immunity.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the Test May Be Ordered

The Poliovirus (Types 1, 3) Antibodies, Neutralization test may be ordered in several contexts. It is commonly used in public health settings to assess population immunity levels and the effectiveness of polio vaccination programs. In individual cases, it may be ordered for patients who have a history of polio vaccination but are at increased risk of exposure due to travel to areas where polio is endemic or for those who have been in contact with the virus. Additionally, it may be used in the evaluation of individuals with unexplained neurological symptoms where poliovirus infection is a consideration, or to assess the immune status of immunocompromised patients.

Test Details: Polio 1 Titer and Polio 3 Titer

The test markers within the Poliovirus (Types 1, 3) Antibodies, Neutralization test are the Polio 1 Titer and Polio 3 Titer. These titers reflect the concentration of antibodies in the blood capable of neutralizing poliovirus types 1 and 3, respectively. The test is conducted by mixing the patient's serum with known concentrations of the virus and allowing any antibodies present to bind and neutralize the virus. The mixture is then inoculated onto cell cultures, and the ability of the serum to prevent viral replication is assessed. A higher titer indicates a greater level of immunity against the poliovirus.

Interpreting the Results

Healthcare professionals use the results of the Poliovirus (Types 1, 3) Antibodies, Neutralization test to make informed decisions about patient care. A positive result, indicating the presence of neutralizing antibodies, suggests immunity to the corresponding poliovirus types, either from vaccination or past infection. In contrast, a low or absent titer may indicate a lack of immunity, necessitating vaccination or revaccination. The specific titer levels can guide healthcare professionals in assessing the strength of an individual's immune response to the poliovirus.

The Poliovirus (Types 1, 3) Antibodies, Neutralization test is a critical tool in both public health and individual patient care contexts for assessing immunity to two types of poliovirus. By quantifying neutralizing antibodies, it offers insights into an individual's immune status and helps guide vaccination and healthcare decisions. When used in conjunction with other diagnostic tests, it enables a comprehensive evaluation of a patient's health status and aids in the investigation of unexplained neurological symptoms, contributing to informed and effective healthcare management.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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