Ulta Lab Tests

All Immunity and Titer Tests

All Immunity and Titer Tests brings together the blood tests used to document vaccine immunity, check past infection, and screen immune function. Common reasons to test include school or employment requirements, health-care onboarding, travel, proof of hepatitis B response, TB screening before certain medicines, or evaluation of frequent infections.

A proactive plan starts by matching the exact titers you need (MMR, varicella, hepatitis B, tetanus/diphtheria). For past exposure questions, add COVID-19 antibodies (spike ± nucleocapsid). For tuberculosis screening, choose a TB blood test (IGRA) such as QuantiFERON or T-SPOT. When infections are frequent or severe, add immunoglobulins (IgG/IgA/IgM), IgG subclasses, pneumococcal serotype responses, lymphocyte subsets, and complement. These labs support screening, documentation, and monitoring, but they do not diagnose active illness or replace clinical evaluation.

Signs, Symptoms & Related Situations

  • Documentation & compliance

    • School, healthcare employment, immigration, travel, volunteer clearance

    • Proof of immunity: MMR, varicella, hepatitis B, tetanus/diphtheria (± pertussis per program)

  • Exposure & pre-treatment

    • TB screening for close contacts or before immunosuppressive therapy

    • COVID-19 antibody testing for past infection or vaccine response (not for current illness)

  • Frequent or unusual infections

    • Recurrent sinus/ear/chest infections, pneumonia, poor vaccine responses

  • Family planning

    • Rubella or varicella IgG status before pregnancy (clinician-guided)

  • Urgent care now

    • Trouble breathing, chest pain, confusion, severe dehydration, or rapidly worsening symptoms

Testing choices and symptoms should be reviewed with a qualified clinician.

Why These Tests Matter

What testing can do

  • Provide proof of immunity for schools, employers, and programs

  • Detect TB infection (latent or active) via IGRA screening; unaffected by BCG vaccination

  • Characterize immune status (immunoglobulins, subclasses, functional antibody) and guide next steps

What testing cannot do

  • Diagnose active infection or confirm contagiousness

  • Guarantee lifelong protection—antibodies can wane and cutoffs vary by disease/assay

  • Replace vaccinations/boosters, imaging, or clinician judgment when indicated

What These Tests Measure (at a glance)

  • Vaccine/Exposure Titers (IgG): Measles, Mumps, Rubella; Varicella-Zoster; Hepatitis B surface antibody (anti-HBs); Tetanus/Diphtheria; Hepatitis A IgG; others as requested.

  • COVID-19 Antibodies: Spike (S) IgG for vaccine response/previous exposure; Nucleocapsid (N) IgG for prior infection; some panels include surrogate neutralizing activity.

  • TB Blood Tests (IGRAs): QuantiFERON-TB Gold Plus or T-SPOT.TB—single visit, not affected by BCG; results are positive/negative/indeterminate and require clinical follow-up.

  • Immunoglobulin Profile: IgG/IgA/IgM (± IgE); low levels can signal immune deficits, high levels may reflect inflammation.

  • IgG Subclasses (1–4): supportive when total IgG is normal but infections persist; interpret with functional antibody testing.

  • Functional Antibody Testing: Pneumococcal serotype IgG before/after vaccination to assess antibody production.

  • Lymphocyte Subsets (Flow): CD3/CD4/CD8 T cells, CD19/20 B cells, CD16/56 NK cells—screens cellular immunity.

  • Complement System: C3, C4, CH50 (± AH50) to evaluate classical/alternative pathway activity.

  • Context labs: CBC with differential and CRP/ESR for infection/inflammation clues.

Quick Build Guide

Goal Start with Add if needed
School/health-care onboarding MMR IgG • Varicella IgG • Hep B surface Ab • Tetanus/Diphtheria IgG Pertussis IgG if your program accepts it
Post-vaccine proof (Hep B) Hep B surface Ab (draw ≥3–4 weeks post-series) Repeat after booster if nonreactive (clinician-directed)
TB screening (employment/exposure) QuantiFERON-TB Gold Plus T-SPOT.TB if indeterminate or immunosuppressed
COVID-19 past exposure/response Spike IgG Nucleocapsid IgG ± Neutralizingactivity
Frequent infections—initial screen IgG/IgA/IgM • CBC with differential IgG Subclasses • Pneumococcal serotypes (pre/post)
Suspected complement issue C3 • C4 CH50 (± AH50)
Pregnancy planning Rubella IgG • Varicella IgG Follow timing per clinician

How the Testing Process Works

  1. Match your checklist: pick the exact titers or screens your program or clinician requests.

  2. Time your draw: for post-vaccine checks, test ≥3–4 weeks after the last dose. IGRAs do not require fasting.

  3. Visit a draw site: one blood draw; some tests use additional tubes or same-day processing.

  4. Review results: compare to your report’s reference ranges and program criteria; your clinician may add imaging or confirmatory tests if indicated.

  5. Plan follow-up: vaccination, booster, or repeat testing may be advised for nonreactive or indeterminate results.

Interpreting Results (General Guidance)

  • Titers (IgG): Reactive/positive suggests immunity; nonreactive/negative may reflect no immunity, early testing, or waning antibodies.

  • COVID-19 antibodies: Spike+ / N− aligns with vaccination; Spike+ / N+ suggests prior infection; both negativecan mean no exposure or early/waning response.

  • TB IGRAs: Positive indicates TB infection (latent or active) and needs clinical evaluation, often with chest X-ray; indeterminate often requires repeat or alternate IGRA.

  • Immunoglobulins/subclasses: low levels or poor vaccine responses can suggest immune deficits; high polyclonal levels may reflect inflammation.
    Always interpret results with a qualified healthcare professional; patterns, timing, and context matter more than a single value.

Choosing Panels vs. Individual Tests

  • Program bundle: select a titer package (MMR, varicella, hepatitis B, tetanus/diphtheria) that mirrors your form.

  • Single-question check: order one marker (e.g., anti-HBs after vaccination).

  • Immune-function screen: IgG/IgA/IgM + CBC with differential, and add subclasses, pneumococcal serotypes, lymphocyte subsets, or complement based on findings.

  • TB pathway: choose a single IGRA (QuantiFERON or T-SPOT) rather than TST when possible.

FAQs

Do I need to fast for these tests?
No. Titers, IGRAs, and immunoglobulins do not require fasting.

How soon after a vaccine should I draw a titer?
Wait at least 3–4 weeks after the final dose for the clearest result.

Will BCG affect my TB test?
BCG does not affect IGRA blood tests; it can affect the skin test (TST).

Can titers prove I’m fully protected?
Titers correlate with protection, but no test guarantees immunity for every disease. Follow your program rules and clinician advice.

What if my TB IGRA is positive?
You’ll need a clinician evaluation, usually a chest X-ray, and possibly sputum testing to rule out active disease.

My hepatitis B titer is negative—now what?
Your clinician may recommend a booster or repeat series and a follow-up titer.

Do recurrent infections mean immune deficiency?
Not always. Baseline Ig levels, CBC, and functional antibody tests help clarify next steps.

Related Categories & Key Tests

References

Available Tests & Panels

Your All Immunity and Titer Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to build your package—required titers, COVID-19 antibodies, TB blood tests, and immune-function screens—and schedule your draw. Follow timing guidance (especially ≥3–4 weeks post-vaccination) and review results with your clinician before submitting documentation or planning next steps.

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The Magnesium Serum Test measures magnesium levels in blood to evaluate electrolyte balance, nerve and muscle function, and overall metabolic health. Abnormal levels may indicate kidney disease, malnutrition, gastrointestinal disorders, or uncontrolled diabetes. Low magnesium can cause weakness, cramps, or irregular heartbeat, while high levels may signal kidney dysfunction. Doctors use this test to diagnose deficiencies, monitor therapy, or assess chronic health conditions.

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The Mast Cell & Histamine Response Panel includes Tryptase, immune antibodies, hormones, homocysteine, osmolality, and a CMP to help evaluate lab markers related to mast cell activity, histamine-type symptoms, immune balance, and overall wellness.

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The Measles IgG Antibody Test measures IgG antibodies to determine immunity from past infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility to measles. Doctors use this blood test to confirm immune status, evaluate vaccination records, or meet school, travel, or employment requirements. It provides valuable insight into measles protection and public health safety.

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Also Known As: Rubeola Test, Measles Virus Test, Measles Titer Test
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The Measles IgG IgM Antibodies Test measures immune response to the measles virus by detecting IgM for recent or acute infection and IgG for past exposure or vaccine immunity. This test helps confirm suspected measles cases in patients with fever, rash, cough, or conjunctivitis, and evaluates immunity in those with uncertain vaccination history, supporting diagnosis, outbreak control, and public health monitoring.

Also Known As: Rubeola Test, Measles Virus Test, Measles Titer test, Measles Infection Test
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The Measles IgM Antibody Test detects IgM antibodies specific to the measles virus, providing evidence of recent or acute infection. IgM antibodies typically appear shortly after exposure and indicate an active immune response. This test is used to confirm measles in symptomatic patients, support outbreak investigations, and distinguish between current infection and prior immunity, aiding timely clinical and public health decisions.

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Also Known As: Rubeola Test, Measles Virus Test, Measles Infection Test
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The Measles Titer Test measures IgG antibody levels to determine immunity from prior measles infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility. Doctors order this test to confirm immune status for school, healthcare, travel, or employment requirements. It is also used to verify vaccination response, ensuring individuals are protected against measles and reducing outbreak risk.

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Also Known As: Rubeola Test, Measles Virus Test, Measles IgG Antibody Test
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The Measles, Mumps, Rubella (MMR) Immunity Profile is a quantitative blood test that measures antibody levels to measles, mumps, and rubella. Results confirm prior infection or vaccine response and show if antibody levels are protective. Doctors order this test for school, employment, or travel requirements, to evaluate vaccine effectiveness, and to guide revaccination decisions. It provides reliable assessment of immune protection against all three viral diseases.

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The MMR Titer Test is a quantitative blood test that measures antibody levels to measles, mumps, and rubella. Results provide exact antibody values to confirm prior infection or response to vaccination. Low levels suggest lack of protection, while higher levels indicate adequate response. Doctors order this test for school, employment, or travel requirements and to guide revaccination decisions, ensuring accurate evaluation of immune status against these viral diseases.

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The Natural Killer Cells Test measures absolute counts and percentage of NK cells (CD3-CD16+CD56+) and absolute lymphocytes using flow cytometry. Low NK cell numbers are associated with susceptibility to viral infections such as cytomegalovirus and varicella. This test supports evaluation of immune function, especially in patients with recurrent viral illness or suspected immunodeficiency.

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The Neopterin Serum Test measures levels of neopterin, a marker released by activated macrophages in response to interferon-gamma. Elevated concentrations reflect immune system activation and may indicate viral infections, autoimmune disease, cancer, or transplant rejection risk. This test helps clinicians assess cellular immune response, track inflammatory activity, and evaluate disease progression or treatment monitoring.

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The Poliovirus 1 and 3 Titer Test measures neutralizing antibodies to poliovirus types 1 and 3 to evaluate immunity from vaccination or past infection. Doctors order this test to confirm protective immunity, assess response to polio vaccines, or check susceptibility in healthcare, laboratory, or travel settings. Results help determine if additional vaccination is needed and provide vital information for monitoring polio immunity and global disease prevention.

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Also Known As: Poliovirus 1 and 3 Antibodies Neutralization Test
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The Post COVID-19 Coagulation (Long Covid) Panel is designed to evaluate the coagulation status of individuals who have recovered from COVID-19 but continue to experience long-term effects, commonly referred to as "Long Covid." This condition has been observed to affect multiple systems within the body, including the coagulation system, which is crucial for blood clotting and wound healing processes. By assessing markers such as D-Dimer and Fibrinogen Activity, healthcare professionals can monitor patients' recovery from COVID-19 and manage any ongoing risks related to blood clotting disorders.
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The QuantiFERON-TB Gold Plus Test is a blood test that detects latent or active tuberculosis (TB) infection by measuring the immune response to TB antigens. It offers greater accuracy than the traditional skin test and avoids false positives from prior BCG vaccination. Doctors use it for TB screening, diagnosis, and monitoring in high-risk individuals. The QFT-Plus test is recommended for healthcare workers, travelers, and those exposed to TB.

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The QuestAssureD™ Vitamin D 25-Hydroxy Total Test measures Vitamin D2, Vitamin D3, and total 25-hydroxy vitamin D to assess overall vitamin D status. Adequate vitamin D supports bone strength, calcium absorption, immune health, and muscle function. Low levels may cause osteoporosis, weakness, or increased disease risk, while high levels can indicate toxicity. Doctors use this test to diagnose deficiency, monitor supplementation, and evaluate metabolic and endocrine health.

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The Rabies Vaccine Response End Point Titer Test measures rabies virus–neutralizing antibodies to assess immune response after vaccination. By quantifying antibody levels, this test determines whether protective immunity has been achieved, guides decisions on booster doses, and monitors long-term vaccine effectiveness. It is especially valuable for individuals at occupational risk of rabies exposure.

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The Rheumatoid Factor IgA Antibody Test measures IgA-class rheumatoid factor, an autoantibody linked to rheumatoid arthritis and other autoimmune diseases. Elevated levels may indicate joint inflammation, Sjögren’s syndrome, or chronic infections. Doctors use this blood test alongside other markers to confirm diagnosis, assess disease activity, and guide treatment decisions for patients with suspected autoimmune or inflammatory disorders.

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The Rheumatoid Factor IgA IgG IgM Antibodies Test measures multiple rheumatoid factor classes to aid in diagnosing rheumatoid arthritis and related autoimmune diseases. Elevated levels may suggest joint inflammation, Sjögren’s syndrome, lupus, or chronic infections. Doctors use this comprehensive test to confirm autoimmune involvement, investigate persistent pain or stiffness, and guide treatment planning by assessing disease activity across antibody types.

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