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The Thyroid Peroxidase Antibodies (TPOAb) Test detects antibodies that target thyroid peroxidase, an enzyme vital for thyroid hormone production. High levels often indicate autoimmune thyroid disorders such as Hashimoto’s thyroiditis or Graves’ disease. Doctors order this test to evaluate symptoms like fatigue, weight changes, hair loss, or irregular heartbeat and to confirm thyroid disease. It provides key insight into autoimmune activity and overall thyroid health.