Thyroid Health - Comprehensive Lab Panel

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Reverse T3, Reverse Triiodothyronine, RT3, T3 Reverse RT3 LCMSMS, Triiodothyronine Reverse

T3 Reverse, LC/MS/MS

Reverse T3 produced in the thyroid comes from the conversion of the storage hormone T4. Your body, especially the liver, can constantly be converting T4 to RT3 as a way to get rid of any unneeded T4. In any given day approx. 40% of T4 goes to T3 and 20% of T4 goes to Reverse T3. However in any situation where your body needs to conserve energy and focus on something else, it will change the above percentages, changing the conversion of RT3 to 50% or more, and the T3 goes down, down. Examples are emotional, physical, or biological stress, such as being chronically or acutely sick (the flu, pneumonia, etc), after surgery, after a car accident or any acute injury, chronic stress causing high cortisol, being exposed to an extremely cold environment, diabetes, aging, or even being on drugs like beta blockers and amiodarone.

Also known as: Triiodothyronine

T3, Total

Triiodothyronine (T3) is a thyroid hormone. It plays an important role in the body's control of metabolism.

T3 Uptake

T3 uptake is also known as T3 Resin Uptake (T3RU) or Thyroid Uptake. It estimates how much thyroid hormone-binding proteins are available in the blood through a calculation based on levels of T3 or T4 added to a person's blood specimen.

Also known as: Free T3, FT3, T3 Free

T3, Free

This test measures the amount of triiodothyronine, or T3, in the blood.

Also known as: T4 Thyroxine Total

Free T4 Index (T7)

FTI stands for the Free Thyroxine Index and is also sometimes referred to as T7. It is a calculated value determined from the T3 uptake test and total T4 test and provides an estimate of the level of free T4 in the blood.

T4 (Thyroxine), Total

This test measures the amount of thyroxine, or T4, in the blood. T4 is one of two major hormones produced by the thyroid gland. The total T4 test is used to help diagnose hyperthyroidism and hypothyroidism. It is a useful test but can be affected by the amount of protein available in the blood to bind to the hormone.

Also known as: Free T4, FT4, T4 Free

T4, Free

The free T4 test is not affected by protein levels. Since free T4 is the active form of thyroxine, the free T4 test is may be a more accurate reflection of thyroid hormone function.

Also known as: TBG Thyroxine Binding Globulin, Thyroxine Binding Globulin, Thyroxine-binding globulin (TBG)


Thyroglobulin Antibodies

Measurement of thyroglobulin antibodies is useful in the diagnosis and management of a variety of thyroid disorders including Hashimoto's thyroiditis, Graves Disease and certain types of goiter.

Thyroid Peroxidase

Also known as: Thyroid Stimulating Hormone, Thyroid Stimulating Hormone (TSH), Thyrotropin


A TSH test is a lab test that measures the amount of thyroid stimulating hormone (TSH) in your blood. TSH is produced by the pituitary gland. It tells the thyroid gland to make and release thyroid hormones into the blood.


Also known as: Thyroid Receptor Antibody, Thyroid Stimulating Immunoglobulin, TSI Thyroid Stimulating Immunoglobulin


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The Thyroid Health - Comprehensive Lab Panel panel contains 10 tests with 13 biomarkers.

Brief Description: The Thyroid Health - Comprehensive Lab panel represents the most extensive and thorough diagnostic panel for assessing thyroid function and related autoimmune conditions. This comprehensive panel includes ten essential tests: T3 Reverse, T3 Total, T3 Uptake, T3 Free, T4 Total, T4 Free, Thyroxine Binding Globulin, Thyroid Peroxidase Antibodies, Thyroglobulin Antibodies, Thyroid Stimulating Hormone (TSH), and Thyroid Stimulating Immunoglobulin. It provides a comprehensive evaluation of thyroid hormone levels, autoimmunity, and binding proteins, offering a comprehensive overview of thyroid health.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: Specifc to TSH: Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks.

According to the assay manufacturer Siemens: "Samples containing fluorescein can produce falsely depressed values when tested with the Advia Centaur TSH3 Ultra assay."

When and Why the Thyroid Health - Comprehensive Lab Panel May Be Ordered

The Thyroid Health - Comprehensive Lab panel is ordered when healthcare providers suspect complex thyroid disorders, autoimmune thyroid diseases, or when more detailed thyroid assessment is required due to inconclusive results from previous testing. It is particularly valuable for individuals presenting with multiple symptoms, a family history of thyroid disorders, or signs of autoimmune thyroid conditions like Hashimoto's thyroiditis or Graves' disease. This panel aids in the precise diagnosis and management of complex thyroid disorders.

What the Thyroid Health - Comprehensive Lab Panel Checks For

  1. T3 Reverse: Measures reverse T3 levels, which can indicate thyroid dysfunction and potential metabolic issues.

  2. T3 Total: Measures the total amount of triiodothyronine (T3) hormone in the blood, including both bound and free forms. T3 is essential for regulating metabolism and energy production.

  3. T3 Uptake: Assesses the availability of binding proteins for T3, providing information on the capacity to transport T3 in the bloodstream.

  4. T3 Free: Specifically measures the free, unbound T3 hormone, which is biologically active and available for use by the body's cells.

  5. T4 Total: Measures the total amount of thyroxine (T4) hormone in the blood, including both bound and free T4. T4 is a key thyroid hormone involved in regulating metabolism.

  6. T4 Free: Specifically measures the free, unbound T4 hormone, which is the biologically active form available for cellular uptake.

  7. Thyroxine Binding Globulin: Evaluates the levels of thyroxine binding globulin, a protein that transports thyroid hormones in the blood. Abnormal levels can affect thyroid hormone availability.

  8. Thyroid Peroxidase Antibodies: Detects antibodies against thyroid peroxidase, an enzyme involved in thyroid hormone production. Elevated levels may indicate autoimmune thyroid diseases like Hashimoto's thyroiditis.

  9. Thyroglobulin Antibodies: Measures antibodies against thyroglobulin, a protein found in the thyroid gland. Elevated levels may suggest autoimmune thyroid conditions.

  10. Thyroid Stimulating Hormone (TSH): Produced by the pituitary gland, TSH regulates the thyroid's production of T3 and T4. Elevated TSH levels may indicate an underactive thyroid, while low TSH levels may suggest an overactive thyroid.

  11. Thyroid Stimulating Immunoglobulin: Assesses the presence of antibodies that can stimulate the thyroid gland, often elevated in Graves' disease.

Conditions Detected by the Thyroid Health - Comprehensive Lab Panel

The Comprehensive Lab panel can detect a wide range of thyroid disorders, including autoimmune thyroid diseases (Hashimoto's thyroiditis, Graves' disease), thyroid hormone imbalances, reverse T3-related issues, and conditions associated with binding protein abnormalities. It is particularly useful for diagnosing complex cases where multiple thyroid-related aspects need evaluation.

Utilization of Thyroid Health - Comprehensive Lab Panel Results by Healthcare Professionals

Healthcare professionals use the results of the Comprehensive Lab panel to diagnose, monitor, and manage complex thyroid disorders. Abnormal findings can lead to personalized treatment plans, including medication adjustments, referrals to specialists, or additional imaging studies. This panel provides valuable insights into thyroid autoimmunity, hormone levels, and binding proteins, allowing for more precise and tailored approaches to thyroid disorder management.

The Thyroid Health - Comprehensive Lab panel serves as a crucial diagnostic tool in uncovering the intricacies of thyroid health and autoimmune conditions, empowering healthcare providers to make informed decisions and improve the overall well-being of patients with complex thyroid issues.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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