Thyroid Complete Profile

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Reverse T3, Reverse Triiodothyronine, RT3, T3 Reverse RT3 LCMSMS, Triiodothyronine Reverse

T3 Reverse, LC/MS/MS

Reverse T3 produced in the thyroid comes from the conversion of the storage hormone T4. Your body, especially the liver, can constantly be converting T4 to RT3 as a way to get rid of any unneeded T4. In any given day approx. 40% of T4 goes to T3 and 20% of T4 goes to Reverse T3. However in any situation where your body needs to conserve energy and focus on something else, it will change the above percentages, changing the conversion of RT3 to 50% or more, and the T3 goes down, down. Examples are emotional, physical, or biological stress, such as being chronically or acutely sick (the flu, pneumonia, etc), after surgery, after a car accident or any acute injury, chronic stress causing high cortisol, being exposed to an extremely cold environment, diabetes, aging, or even being on drugs like beta blockers and amiodarone.

Also known as: Triiodothyronine

T3, Total

Triiodothyronine (T3) is a thyroid hormone. It plays an important role in the body's control of metabolism.

T3 Uptake

T3 uptake is also known as T3 Resin Uptake (T3RU) or Thyroid Uptake. It estimates how much thyroid hormone-binding proteins are available in the blood through a calculation based on levels of T3 or T4 added to a person's blood specimen.

Also known as: Free T3, FT3, T3 Free

T3, Free

This test measures the amount of triiodothyronine, or T3, in the blood.

Also known as: T4 Thyroxine Total

Free T4 Index (T7)

FTI stands for the Free Thyroxine Index and is also sometimes referred to as T7. It is a calculated value determined from the T3 uptake test and total T4 test and provides an estimate of the level of free T4 in the blood.

T4 (Thyroxine), Total

This test measures the amount of thyroxine, or T4, in the blood. T4 is one of two major hormones produced by the thyroid gland. The total T4 test is used to help diagnose hyperthyroidism and hypothyroidism. It is a useful test but can be affected by the amount of protein available in the blood to bind to the hormone.

Also known as: Free T4, FT4, T4 Free

T4, Free

The free T4 test is not affected by protein levels. Since free T4 is the active form of thyroxine, the free T4 test is may be a more accurate reflection of thyroid hormone function.

Also known as: TBG Thyroxine Binding Globulin, Thyroxine Binding Globulin, Thyroxine-binding globulin (TBG)


Thyroglobulin Antibodies

Measurement of thyroglobulin antibodies is useful in the diagnosis and management of a variety of thyroid disorders including Hashimoto's thyroiditis, Graves Disease and certain types of goiter.

Thyroid Peroxidase

Also known as: Thyroid Stimulating Hormone, Thyroid Stimulating Hormone (TSH), Thyrotropin


A TSH test is a lab test that measures the amount of thyroid stimulating hormone (TSH) in your blood. TSH is produced by the pituitary gland. It tells the thyroid gland to make and release thyroid hormones into the blood.


Also known as: Thyroid Receptor Antibody, Thyroid Stimulating Immunoglobulin, TSI Thyroid Stimulating Immunoglobulin


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The Thyroid Complete Profile panel contains 10 tests with 13 biomarkers.

Brief Description: The Thyroid Complete Profile is a comprehensive panel designed to provide an in-depth assessment of thyroid function. This profile evaluates various hormones, antibodies, and proteins that are critical to the thyroid's health and its regulatory mechanisms. By measuring these components, healthcare providers can gain a detailed understanding of thyroid activity, identify potential disorders, and monitor treatment efficacy. This panel is essential for diagnosing a wide range of thyroid conditions, including hyperthyroidism, hypothyroidism, and autoimmune thyroid diseases.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: Specific to TSH: Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks.

According to the assay manufacturer Siemens: "Samples containing fluorescein can produce falsely depressed values when tested with the Advia Centaur TSH3 Ultra assay."

When and Why the Thyroid Complete Profile May Be Ordered

The Thyroid Complete Profile may be ordered when a patient presents symptoms indicative of thyroid dysfunction, such as unexplained weight changes, fatigue, temperature sensitivity, hair loss, or changes in heart rate. It is also utilized in patients with a family history of thyroid disorders or those who have been previously diagnosed with thyroid conditions and require ongoing monitoring. Additionally, it may be recommended as part of a routine health check-up in individuals at risk of thyroid diseases.

What the Thyroid Complete Profile Checks For

The Thyroid Complete Profile includes a series of tests that evaluate various aspects of thyroid function and health:

T3 Reverse

This test measures reverse triiodothyronine (rT3), an inactive form of T3 that can block the activity of active T3. Elevated levels of rT3 can indicate a condition where the body is converting too much T4 into rT3 rather than the active T3, often due to stress or illness.

T3 Total

Measures the total amount of triiodothyronine (T3) in the blood, including both the bound and unbound forms. T3 is crucial for regulating metabolism, and abnormal levels can indicate thyroid dysfunction.

T3 Uptake

Evaluates the number of binding sites on thyroid hormone-binding proteins in the blood. This test helps in interpreting total T4 and T3 levels and in diagnosing hyperthyroidism or hypothyroidism.

T3 Free

Measures the unbound fraction of T3 that is available to the tissues. Free T3 is a more accurate reflection of thyroid hormone activity and is critical for assessing thyroid function.

T4 Total

Determines the total amount of thyroxine (T4) in the blood, including both bound and free forms. T4 is the primary hormone produced by the thyroid gland and is converted to the more active T3 in the body.

T4 Free

Measures the unbound fraction of T4 that is available to the tissues. Free T4 levels provide a clearer picture of thyroid hormone production and availability.

Thyroxine Binding Globulin (TBG)

TBG is a protein that binds thyroid hormones in the bloodstream. This test measures the amount of TBG, which can affect the levels of total T4 and T3.

Thyroid Peroxidase Antibodies (TPO)

Detects antibodies against thyroid peroxidase, an enzyme critical for thyroid hormone production. The presence of TPO antibodies is often associated with autoimmune thyroid diseases like Hashimoto's thyroiditis and Graves' disease.

Thyroglobulin Antibodies (TgAb)

Measures antibodies against thyroglobulin, a protein involved in thyroid hormone production. Elevated levels can indicate autoimmune thyroid conditions.

Thyroid Stimulating Hormone (TSH)

Produced by the pituitary gland, TSH regulates the production of thyroid hormones. Abnormal levels can indicate primary thyroid dysfunction or pituitary gland issues.

Thyroid Stimulating Immunoglobulin (TSI)

Measures the level of thyroid-stimulating immunoglobulins, which can cause hyperthyroidism by stimulating the thyroid to produce excess hormones. This test is particularly useful for diagnosing Graves' disease.

Conditions or Diseases the Thyroid Complete Profile Can Detect

The Thyroid Complete Profile is vital in diagnosing a variety of thyroid-related conditions:


Hypothyroidism is characterized by an underactive thyroid gland, leading to low levels of thyroid hormones. Symptoms include fatigue, weight gain, and cold intolerance. High TSH and low free T4 or T3 levels typically indicate this condition.


Hyperthyroidism involves an overactive thyroid gland, producing excessive thyroid hormones. Symptoms include weight loss, increased heart rate, and anxiety. Low TSH and high free T4 or T3 levels are indicative of hyperthyroidism.

Hashimoto's Thyroiditis

Hashimoto's thyroiditis is an autoimmune disorder where the immune system attacks the thyroid gland, leading to hypothyroidism. The presence of TPO and TgAb antibodies, along with abnormal TSH and thyroid hormone levels, can diagnose this condition.

Graves' Disease

Graves' disease is another autoimmune disorder causing hyperthyroidism. It is characterized by the presence of TSI, which stimulates the thyroid to produce too much hormone. High levels of free T4 or T3, low TSH, and positive TSI confirm the diagnosis.

How a Healthcare Professional Uses the Results


For hypothyroidism, healthcare providers typically prescribe thyroid hormone replacement therapy. Regular monitoring of TSH and free T4 levels ensures the effectiveness of the treatment and allows for dosage adjustments as necessary.


Treatment options for hyperthyroidism include antithyroid medications, radioactive iodine, or surgery. Monitoring TSH, free T4, and free T3 levels helps assess the response to treatment and adjust the therapeutic approach.

Hashimoto's Thyroiditis

Management focuses on symptom relief and normalizing hormone levels through hormone replacement therapy. Regular checks of TSH, TPO, and TgAb levels help track the progression of the disease and treatment efficacy.

Graves' Disease

Treatment for Graves' disease may involve antithyroid medications, radioactive iodine therapy, or surgery. Monitoring TSI, free T4, and TSH levels is crucial for evaluating treatment success and making necessary adjustments.

The Thyroid Complete Profile provides a comprehensive evaluation of thyroid function and health, offering critical insights for diagnosing and managing various thyroid conditions. By assessing a wide range of thyroid-related markers, this panel enables healthcare providers to develop tailored treatment strategies, monitor disease progression, and ensure effective management of thyroid disorders. This thorough approach to thyroid testing is essential for achieving optimal patient outcomes and maintaining thyroid health.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results

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