Reproductive Hormone Tests 

Reproductive Hormone Lab Tests and health information

Do you have a reproductive hormone imbalance?

You may have a reproductive hormone imbalance if you experience reduced libido, exhaustion, weight gain, hair loss, infertility, and mood swings that are all symptoms of a hormonal imbalance that affects the reproductive system. 

In both men and women, reproductive hormone imbalances can occur in a variety of ways. Ovarian insufficiency, menopausal symptoms, polycystic ovarian syndrome, and low testosterone in males are the four major types of hormonal disorders. 

Hormone imbalances are frequently misdiagnosed because many people believe that these issues affect only women. This is simply not true; anyone, at any age, can develop a hormonal imbalance as a result of stress, nutrition, or other reasons. If left untreated, hormone imbalances can lead to a variety of medical conditions. 

If you're interested in learning more about reproductive hormone testing, go here.

Make sure this doesn't happen to you! We're here to help you take control of your health starting now by providing information about these conditions and how they affect your body, as well as lab tests that you can order straight from us to detect, diagnose, and monitor any hormone imbalances. 

We can assist you if you believe your reproductive hormones are out of balance. If this is the case for you, our lab tests will reveal it. You have earned the right to feel better about yourself. Measure your reproductive hormones that include Gonadotropin-Releasing Hormone (GnRH), Luteinising Hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin (PRL), Estradiol (E2), Progesterone (P4), and Testosterone (T) with Ulta Lab Tests and get your results in one to two days for most tests confidentially online.

To get your hormone blood tests, choose from the choices below. This is how you can take control of your health! 

 

 


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This panel contains Cortisol, A.M. #4212 which requires the patient to have their specimen collected between 7 a.m. - 9 a.m.


This panel contains Cortisol, A.M. #4212 which requires the patient to have their specimen collected between 7 a.m. - 9 a.m.


This panel contains Cortisol, A.M. #4212 which requires the patient to have their specimen collected between 7 a.m. - 9 a.m.



Description: 17-hydroxyprogesterone is a test that is measuring the levels of 17-OHP in the blood. 17-OHP is used to detect and monitor the treatment processes for congenital adrenal hyperplasia.

Also Known As: 17-OHP Test, 17-OH Progesterone Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When is this test ordered?

The 17-OHP test is regularly ordered as part of a newborn screening and may be repeated if the screening test results are elevated to confirm the initial findings.

When an infant or young kid exhibits signs and symptoms of adrenal insufficiency or CAH, a 17-OHP test may be administered.

When the milder type of CAH is suspected, this test may be ordered in older children or adults. When a girl or woman is having symptoms that could be caused by CAH or another illness, such as PCOS, the 17-OHP test can be used.

Boys and men may be tested if they are experiencing early puberty or infertility.

When a person is diagnosed with 21-hydroxylase deficiency, a 17-OHP test may be ordered on a regular basis to assess treatment effectiveness.

What is being tested?

17-hydroxyprogesterone is a steroid hormone that is created during the cortisol production process. This test detects and/or evaluates congenital adrenal hyperplasia, a hereditary disorder characterized by decreased adrenal cortisol and aldosterone production and increased male sex hormone production.

Cholesterol is the source of 17-OHP. It is a precursor of active steroid hormones, rather than an active steroid hormone.

Cortisol is a hormone produced by the adrenal glands that aids in the breakdown of protein, carbohydrates, and fats, regulates the immune system, and maintains blood pressure. Other steroid hormones produced by the adrenal glands include aldosterone, which helps regulate salt levels and blood pressure, and androgens, which, like testosterone, cause male sexual characteristics and other consequences.

The processes in the synthesis of cortisol necessitate the use of several enzymes. Inadequate levels of cortisol are produced when one or more of these enzymes are insufficient or malfunctioning, as is the case with CAH. CAH is caused by a partial or total loss of the enzyme 21-hydroxylase, which accounts for around 90% of cases.

The adrenal gland grows in size because a low level of cortisol induces an increase in the level of a specific pituitary hormone that drives adrenal growth and hormone production. The increased size and activity, however, are insufficient to overcome the cortisol production bottleneck. Other chemicals that do not require the faulty enzyme, such as 17-hydroxyprogesterone and androgens, are created in excess. This is why 17-OHP testing can aid in the detection of CAH.

CAH is a set of hereditary illnesses characterized by cortisol-related enzyme deficits and caused by particular gene mutations. A mutation in the 21-hydroxylase gene causes around 90% of CAH cases, which can be diagnosed by an increase in 17-OHP in the blood. When both genes, one from each parent, contain mutations that reduce or cease the activity of the enzyme for which the gene codes, the disease is caused. Parents could be carriers, and carriers could not show any symptoms.

CAH with 21-hydroxylase deficiency can be inherited in two forms: severe and mild.

Severe forms can result in kids being born with severe aldosterone and cortisol deficits, necessitating medical treatment. This severe variant is most commonly found in infancy or early childhood through regular newborn screening. It may manifest in early childhood with signs and symptoms such as vomiting, listlessness, lack of energy, not eating properly, failure to thrive, dehydration, and low blood pressure if it is not found through screening, especially with severe sickness.

Excess male sex hormones can cause the development of male characteristics in females. Female babies' sex organs may not be obviously male or female, making it difficult to tell their gender at first. During childhood and adolescence, females may have excessive hair development on the face and body, as well as other male secondary sexual traits such as irregular menstruation. Men with this disorder may not appear different at birth, but they might develop sexual traits early in life, putting them at risk for fertility problems later in life.

Only partial lack of the enzyme may be present in the milder, though more prevalent type of CAH caused by 21-hydroxylase deficiency. This kind of CAH, also known as late-onset or non-classical CAH, can manifest symptoms at any age during childhood, adolescence, or adulthood. Symptoms might be nonspecific, develop slowly over time, and differ from one person to the next. Though this type of CAH is rarely life-threatening, it can cause growth, development, and puberty issues in children, as well as infertility in adults.

Related Tests and Panels:

  • Cortisol
  • ACTH
  • Testosterone
  • Androstenedione
  • Pregnenolone

Related Conditions:

  • Congenital Adrenal Hyperplasia
  • Polycystic Ovary Syndrome
  • Adrenal Insufficiency
  • Addison Disease
  • Endocrine Syndromes
  • Infertility

How is this test used by my health care provider?

The 17-hydroxyprogesterone test is used to detect congenital adrenal hyperplasia and can be used in the conjunction with other tests to diagnose and track CAH.

In the United States, the 17-OHP test is frequently ordered as part of newborn screening to detect CAH caused by a lack of 21-hydroxylase.

The 17-OHP test can be used to screen for CAH in older children and adults before symptoms develop, or to confirm a CAH diagnosis in persons who are already experiencing symptoms.

Diagnosis

The presence of 17-OHP in the blood can help doctors diagnose CAH in older children and people who have a milder, "late-onset" variant of the disease.

A 17-OHP test, along with plasma renin activity, androstenedione, and testosterone assays, may be used to evaluate the success of treatment if someone is diagnosed with 21-hydroxylase insufficiency.

In women with symptoms such as abundant face and body hair and irregular periods, a 17-OHP test, along with other hormone testing, may be done to help rule out CAH. Women with probable polycystic ovarian syndrome and infertility, as well as those with suspected adrenal or ovarian malignancies, fall under this category.

False-positive results have been reported with 17-OHP testing, particularly the newborn screening test. Other tests may be performed if the level is higher but not to the point where it is indicative of CAH.

As a follow-up test, an ACTH test may be ordered. ACTH stimulation causes a significant increase in 17-OHP levels in CAH.

CYP21A2 gene mutations that cause the disorder may be detected by genetic testing.

A karyotype test may be ordered as a follow-up test to discover chromosome problems and to assist in determining the gender of a newborn.

Electrolytes may be ordered to determine the sodium and potassium levels of a person.

What do my 17 Hydroxyprogesterone test results mean?

If a newborn or infant has highly elevated 17-OHP levels, he or she is most likely suffering from CAH. If a person's levels are somewhat elevated, he or she may have a milder case of CAH or an 11-beta-hydroxylase deficiency.

The absence of CAH due to a 21-hydroxylase deficit is most often shown by normal 17-OHP findings.

In a person with CAH, low or declining amounts suggest a positive response to treatment. High or rising levels may suggest that treatment has to be changed.

We advise having your results reviewed by a licensed medical physician for proper interpretation of your results.


Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's disease, Cushing's syndrome, adrenal carcinoma, ectopic ACTH syndrome, and adrenal nodular hyperplasia.

Determination of aldosterone is useful in the diagnosis and evaluation of primary aldosteronism, selective hypoaldosteronism, edematous states, and other conditions of electrolyte imbalance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentration for aldosterone.

The Aldosterone-renin ratio is used to screen for primary aldosteronism

Androstenedione is useful when evaluating patients with androgen excess and managing patients with Congenital Adrenal Hyperplasia (CAH).


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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 7 a.m.-9 a.m.


Deoxycorticosterone (DOC) is a weak mineralocorticoid derived from 21-hydroxylation of progesterone in the adrenal cortex.

DHEA is a weakly androgenic steroid that is useful when congenital adrenal hyperplasia is suspected. It is also useful in determining the source of androgens in hyperandrogenic conditions, such as polycystic ovarian syndrome and adrenal tumors.

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with polycystic ovarian syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with Polycystic Ovarian Syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.


DHT is a potent androgen derived from testosterone via 5-alpha-reductase activity. 5-alpha-reductase deficiency results in incompletely virilized males (phenotypic females). This diagnosis is supported by an elevated ratio of testosterone to DHT.


Elevated levels of serum erythropoietin (EPO) occur in patients with anemias due to increased red cell destruction in hemolytic anemia and also in secondary polycythemias associated with impaired oxygen delivery to the tissues, impaired pulmonary oxygen exchange, abnormal hemoglobins with increased oxygen affinity, constriction of the renal vasculature, and inappropriate EPO secretion caused by certain renal and extrarenal tumors. Normal or depressed levels may occur in anemias due to increased oxygen delivery to tissues, in hypophosphatemia, and in polycythemia vera.

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Description: Estradiol is a blood test that is used to measure the levels of Estradiol in the blood's serum. Estradiol is one of the Estrogen hormones in the body.  Estradiol, Ultrasensitive LC/MS/MS #30289 is a more appropriate test for children that have not yet started a menstrual cycle.

Also Known As: E2 Test, Estrogen 2 Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When is this test ordered?

Tests for estradiol for women and young girls may be ordered if:

  • The development of a girl's sex organs might occur sooner or later than predicted.
  • After menopause, a woman may experience symptoms such as abnormal vaginal bleeding or irregular or absent menstrual cycles.
  • When a woman is unable to conceive, a series of estradiol readings taken over the course of her menstrual cycle may be used to track follicle development before using in vitro fertilization procedures
  • A woman is experiencing menopause symptoms such as hot flashes, night sweats, sleeplessness, and/or irregular or absent menstrual cycles.
  • If a menopausal woman is on hormone replacement therapy, her doctor may order estrone levels on a regular basis to check her progress.

Men and young boys may be subjected to estradiol testing if:

  • A boy's puberty is delayed, as evidenced by slow or delayed growth of testicles and penis, as well as a lack of deepening of voice or growth of body hair.
  • Signs of feminization, such as larger breasts, can be seen in a guy.

What is being tested?
Estradiol, or E2, is a component of Estrogen that is present in the blood. For women, Estradiol is something that should be produced naturally, and the body produces larger amounts of Estradiol during puberty and it fluctuates throughout the menstrual cycle. Estradiol is most prominent in women of reproductive age. Low levels are common in girls who have not yet had their first menstrual cycle and in women after their reproductive age.

Related Tests and Panels:

  • Estrogen
  • Estriol
  • Estrone
  • Estradiol, Ultrasensitive
  • Testosterone Free and Total
  • Sex Hormone Binding Globulin
  • FSH
  • LH
  • Progesterone

Related Conditions:

  • Infertility
  • Menopause
  • Polycystic Ovarian Syndrome
  • Hormone Imbalance
  • Premature, delayed, or abnormal development of sex organs

Commonly Asked Questions:

How is the Estradiol test used by my health care provider?

Estrogen tests are used to detect a deficit or excess of estrogen in a woman, as well as to aid in the diagnosis of a range of illnesses linked to this imbalance. They may also be ordered to monitor the health of the growing fetus and placenta during pregnancy, as well as to help predict the timing of a woman's ovulation. Estrogen testing can be used to detect a hormone excess and its origin in men.

In the case of girls and women

Estradiol testing may be requested for the following reasons:

  • Diagnose early-onset puberty, which occurs when a girl develops secondary sex traits much earlier than anticipated, or late puberty, which occurs when a female develops secondary sex characteristics or begins menstruation later than predicted.
  • Examine menstrual irregularities such as the absence of menstrual periods, infertility, and unusual vaginal bleeding.
  • Evaluate ovary function and look for signs of ovarian failure.
  • Serial measurements of estradiol can be used to track follicle development in the ovary in the days leading up to in vitro fertilization.
  • Keep track of any hormone replacement therapy you're getting to help with your fertility.
  • Keep track of menopausal hormone replacement medication, which is used to treat symptoms caused by estrogen insufficiency.
  • Identify cancers that produce estrogen.
  • As with breast cancer, keep an eye on anti-estrogen therapy.

Boys and men may be subjected to estradiol testing in order to:

  • Assist in the diagnosis of delayed puberty
  • Assist in determining the cause of larger breasts or other feminization indications.
  • Detect an excess of relative estrogen due to a testosterone or androgen deficit.
  • Identify cancers that produce estrogen.

What do my Estradiol test results mean?

Estradiol is one of the three Estrogens that have a large impact on the women's body throughout the menstrual cycle. When these hormones are too high or too low, it could cause irregular bleeding, infertility, complications with menopause, and delayed or premature puberty. Out of range levels can also be indicative of an ovarian condition such as PCOS. It is important to note that these values will fluctuate throughout a woman's cycle. The Estrogen hormones work together and if one is out of range, the others may also be out of range. It is recommended to follow up with a licensed healthcare professional to determine the best treatment if need.

We advise having your results reviewed by a licensed medical physician for proper interpretation of your results.

IMPORTANT - Note this Estradiol test is not for children that have yet to start their menstrual cycle.  If this test is ordered for a child that has yet to begin their menstrual cycle Quest Diagnostics labs will substitute in Estradiol, Ultrasensitive LC/MS/MS - #30289 at an additional charge of $34


Estradiol and Testosterone Total contains the following tests.

  • Estradiol
  • Testosterone, Total, LC/MS/MS

IMPORTANT - Note the Estradiol test included in this panel is not for children that have yet to start their menstrual cycle.  If this test is ordered for a child that has yet to begin their menstrual cycle Quest Diagnostics labs will substitute Estradiol, Free, LC/MS/MS at an additional fee of $290.00



Did you know that your reproductive hormones affect more than your fertility? Did you know that they can cause balding, abnormal hair growth, mood swings, and more?

If you're experiencing odd symptoms like these, you may need to get a reproductive hormone lab test to test the levels of your reproductive hormones. Getting tests for reproductive hormones can help you determine if you need to go on hormone replacement. Even if you aren't looking to conceive anytime soon, it's important to make sure that you have the right balance of hormones in your body.

To learn more about reproductive hormones and how they affect your body, keep reading. It may be time for you to get a reproductive hormone test.

What Is a Reproductive Hormone Imbalance?

Reproductive hormone imbalance sounds exactly what it's like. It's an imbalance of the reproductive hormones in your body. These include estrogen, testosterone, luteinizing hormone, follicle-stimulating hormone, and more.

There are many different kinds of reproductive hormone imbalances, and each condition causes different symptoms with different outcomes. However, there are four main kinds of reproductive hormone imbalances that we'll focus on for now:

  1. Ovarian insufficiency
  2. Menopausal symptoms
  3. Polycystic Ovarian Syndrome
  4. Low testosterone in men

Hormone imbalances can happen in men and women.

What Are the Risk Factors for a Reproductive Hormone Imbalance?

Since physicians don't know much about the causes of hormone imbalances, it's hard to say what kind of things put people at a greater risk for developing them. However, researchers have noticed a few trends in the population of those with hormone imbalances.

Here are some of the commonalities researchers and physicians found in those with hormone imbalances:

  • Older ages
  • Higher weights
  • Poor diets
  • Little to no exercise
  • High stress
  • Presence of toxins in their diets

We should note that these risk factors do not determine whether someone has a hormone imbalance. These are simply trends in the patient population. So, if you believe that you may have a hormone imbalance, you should talk to your doctor even if these qualities don't describe you.

What Causes a Reproductive Hormone Imbalance?

Since there are different kinds of reproductive hormone imbalances, each kind of imbalance comes about differently. Although, every imbalance starts with the endocrine system. And most causes are unknown.

Some researchers believe that hormone imbalances are autoimmune in nature, while others think that diet and environment affect hormones.

With the current research on the subject, it's hard to pinpoint a specific cause.

What Are the Signs and Symptoms of a Reproductive Hormone Imbalance?

There is a multitude of symptoms that can come from a hormone imbalance. Because the imbalance could lead to too much or too little of a hormone, patients are sitting at both ends of the spectrum when it comes to symptoms.

This means that some patients may have chills while others have hot flashes. Some could be hungry all the time, while others are never hungry. It depends on the condition that they have.

Ovarian insufficiency happens when the ovaries don't develop properly. This could be because of an autoimmune problem or a lack of proper endocrine signaling. Because of the fertility problems that come with this, this condition is also known as premature menopause.

The ovaries can also become damaged due to chemotherapy or radiation. This is why many women who go through this kind of cancer cannot have children after they receive treatments.

The damaged ovaries can cause an imbalance of progesterone and estrogen in the system. This leads to a myriad of symptoms like night sweats, vaginal dryness, and hot flashes.

Menopause is another kind of hormonal imbalance, although it's completely normal to go through this kind of hormonal imbalance. During this time, the levels of estrogen and progesterone in the body are low.

However, hormone replacement therapy may help some women avoid the symptoms that come with menopause.

Polycystic ovarian syndrome (PCOS) is a hormonal imbalance that refers to high testosterone production in the female body. The introduction of too many male hormones can cause irregular periods, fatigue, mood swings, abnormal hair growth, and more.

Furthermore, the condition can lead to insulin resistance, diabetes, and cardiovascular disease.

Some people believe that PCOS is an autoimmune condition of the endocrine system. However, this has not been proven.

Lastly, low testosterone in men may affect fertility, strength, energy, and metabolism. Over time, the imbalance can lead to low bone density then osteoporosis.

Like hormone imbalances in women, hormone imbalances in men should be caught and treated as soon as possible. 

What Are the Lab Tests to Diagnose a Reproductive Hormone Imbalance?

To determine whether or not you have a hormone imbalance, you have to do some lab work. Luckily, our team here at Ulta Lab Tests offers a wide variety of lab tests to determine whether or not you have enough of each reproductive hormone.

Our reproductive hormone tests look at estrogen, testosterone, progesterone, and more. By measuring the levels of each, we can help you determine whether or not you have a hormone imbalance.

If you determine that you do have a hormone imbalance, you can start talking to your doctor about a treatment plan that's right for you. If your lab tests come back normal, you may need to discuss your symptoms with your physician to see if something else is going on.

Testing Your Reproductive Hormones

What are you waiting for? If you're showing signs of unbalanced reproductive hormones, you need to act fast. If left untreated, your hormone levels will only get worse.

Ulta Lab Tests offers tests that are highly accurate and reliable so you can make informed decisions about your health. Here are a few great things to love about Ulta Lab Tests:

  • You'll get secure and confidential results
  • You don't need health insurance
  • You don't need a physician's referral
  • You'll get affordable pricing
  • We offer a 100% satisfaction guarantee 

Order your hormone lab tests today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control with Ulta Lab Tests today!