The Aldosterone, LC/MS/MS test contains 1 test with 1 biomarker.
Description: Aldosterone is a blood test often ordered to test patients with low potassium or high blood pressure.
Also Known As: Aldosterone Plasma Test
Collection Method: Blood Draw
Specimen Type: Plasma
Test Preparation: No preparation required
When is an Aldosterone test ordered?
When someone has high blood pressure, a blood aldosterone test is generally requested, especially if the person also has low potassium. Even if potassium levels are within normal limits, testing may be necessary if hypertension develops at a young age or if standard drugs fail to control high blood pressure. Because primary aldosteronism is a potentially curable form of hypertension, it’s critical to catch it early and effectively treat it.
When a healthcare practitioner suspects adrenal insufficiency or Addison disease, aldosterone levels, along with additional testing, are occasionally recommended.
What does an Aldosterone blood test check for?
Aldosterone is a hormone that helps to maintain proper sodium and potassium levels in the circulation as well as regulate blood volume and blood pressure.
The adrenal glands, which are positioned on the top and outside portions of each kidney, create aldosterone. Aldosterone increases sodium retention and potassium elimination via the kidneys.
Aldosterone overproduction or underproduction can be caused by a number of factors. Because renin and aldosterone are so closely associated, they’re frequently examined jointly to figure out what’s causing an aberrant aldosterone level.
Lab tests often ordered with an Aldosterone test:
- Plasma Renin Activity
Conditions where an Aldosterone test is recommended:
- Adrenal Insufficiency
- Addison Disease
- Endocrine Syndromes
- Conn Syndrome
How does my health care provider use an Aldosterone test?
Aldosterone and renin tests are performed to determine whether the adrenal glands are producing enough aldosterone and to differentiate between potential causes of excess or insufficiency. Aldosterone can be detected in the blood or in a 24-hour urine sample, which determines how much aldosterone is excreted in the urine over the course of a day.
Primary aldosteronism, commonly known as Conn syndrome, is a condition that produces high blood pressure and can be detected with these tests. If the test is positive, stimulation and suppression testing can be used to further examine aldosterone production.
The highest levels of aldosterone are in the morning, and they fluctuate throughout the day. The position of the body, stress, and a number of prescribed medications all have an impact on them.
What do my aldosterone test results mean?
Conn syndrome is characterized by the adrenal glands overproducing aldosterone, which is usually caused by a benign tumor in one of the glands. A high aldosterone level causes increased salt reabsorption and potassium loss by the kidneys, resulting in an electrolyte imbalance. High blood pressure, headaches, and muscle weakness are signs and symptoms, especially if potassium levels are very low.
When someone has hypertension and their blood potassium is lower than usual, it's time to look for aldosteronism. Blood is drawn from both of the adrenal veins and tested to see whether there is a difference in the amount of aldosterone produced by both of the adrenal glands to establish whether only one or both are impacted.
Secondary aldosteronism, which is more prevalent than primary aldosteronism, is caused by anything other than an adrenal gland condition that causes excess aldosterone. Any disorder that restricts blood flow to the kidneys, lowers blood pressure, or lowers sodium levels could cause aldosteronism. Congestive heart failure, liver cirrhosis, kidney illness, and pregnancy toxemia can all cause secondary aldosteronism. It's also typical when you're dehydrated. The cause of aldosteronism is usually clear in these circumstances.
The most common cause of secondary aldosteronism is renal artery stenosis, which is a constriction of the blood arteries that supply the kidney. High aldosterone levels produce high blood pressure, which can be treated with surgery or angioplasty. A catheter is introduced via the groin and blood is collected straight from the veins draining the kidney to see if only one kidney is damaged. If one side's result is much higher than the other, this suggests that the artery is narrowed.
Adrenal insufficiency is the most common cause of low aldosterone. Dehydration, low blood pressure, a low salt level in the blood, and a high potassium level are all symptoms. Congenital adrenal hyperplasia, a disorder in which babies lack an enzyme needed to create cortisol, can reduce aldosterone production in some circumstances.
We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.