DHEA Sulfate, Immunoassay Most Popular

The DHEA Sulfate, Immunoassay test contains 1 test with 1 biomarker.

Brief Description: The DHEA-S test measures the level of dehydroepiandrosterone sulfate (DHEA-S) in your blood. DHEA-S is a hormone produced mainly by the adrenal glands, which are small glands located above your kidneys. This hormone is important because it serves as a building block for other hormones, including estrogen and testosterone.

Benefits of the DHEA-S Test:

1. Understanding Hormonal Balance: This test is crucial for checking if your adrenal glands are working properly. It can help you understand whether your body has a healthy balance of hormones, which is important for overall health.

2. Identifying Adrenal Issues: High or low levels of DHEA-S can indicate problems with the adrenal glands, such as adrenal insufficiency or hyperfunction. This is especially important for people experiencing symptoms like fatigue, muscle weakness, or changes in mood.

3. Aging and Health Monitoring: DHEA-S levels naturally decline with age. Monitoring these levels can give insights into how your body is aging and help guide decisions about hormone replacement therapy or other treatments to maintain vitality and health as you get older.

4. Evaluating and Managing Other Health Conditions: For women, abnormal DHEA-S levels may be linked to conditions like polycystic ovary syndrome (PCOS) or other hormonal disorders that can affect menstrual cycles and fertility. In men, it might be related to testosterone levels and overall vitality.

The DHEA-S test is simple to order and can be done from home, making it convenient to get important health information without a trip to the doctor's office. Once you have your results, you can discuss them with your healthcare provider to decide if any further testing or treatment is needed to manage your health effectively.

Also Known As: DHEA-SO4 Test, DHEAS Test, DHES1 Test, Dehydroepiandrosterone Sulfate Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

When to Order a DHEA Sulfate Test

You might consider ordering a DHEA-S (Dehydroepiandrosterone Sulfate) test in a few different situations:

1. Checking Adrenal Gland Health: This test is often used to see how well your adrenal glands are working. If you're feeling really tired, noticing changes in your hair growth, or if women are having irregular periods, a DHEA-S test can help find out if your adrenal hormones are out of balance.

2. Looking into Hormone Issues: If you have symptoms like a lot of hair growth where it usually doesn't grow, acne, or signs of masculinization (like a deeper voice or changes in body shape), this test can check your androgen levels. Androgens are a type of hormone that includes testosterone, and they can play a part in these changes.

3. Keeping Track of Hormone Treatment: If you're taking DHEA supplements or other hormone therapies, this test can check if the levels in your body are right. This helps make sure you're getting the correct dose and that the treatment is working properly.

Ordering this test is straightforward and you can do it from home, which is convenient and saves a trip to the doctor. After you get your results, you can talk them over with your healthcare provider to see if you need any treatment or changes in your health plan.

What Does a DHEA Sulfate Blood Test Check For?

The DHEA Sulfate (DHEAS) blood test measures the amount of DHEAS in your blood. DHEAS is a male sex hormone, but it's found in both men and women. Here’s what this test helps check:

1. Development at Puberty: DHEAS helps with the development of male traits during puberty, like a deeper voice and facial hair growth.
2. Conversion to Other Hormones: Your body can change DHEAS into stronger hormones like testosterone and androstenedione, or even into estrogen.
3. Source: DHEAS is mostly made by your adrenal glands, which are located on top of your kidneys. A small amount also comes from a woman’s ovaries and a man’s testicles.

This test is a good way to see if your adrenal glands are working right. If there’s too much DHEAS, it could mean there’s a problem like a tumor on your adrenal glands or, though it's rare, a tumor on the ovaries.

Sample Ulta Lab Tests View of DHEA Sulfate Test Results

Sample Quest Result Report View of DHEA Sulfate Test Results

Reference ranges will vary based on age and gender.

Effects of Too Much DHEAS:

• In adult men: Often, it might not cause noticeable problems.
• In young boys: It can lead to early puberty.
• In women and girls: It can cause irregular periods and male-like physical traits, such as a lot of body and facial hair.
• In newborn girls: It might cause the genitals to look different from typical male or female genitals.

Ordering this test yourself is straightforward and can be done from home. It's helpful if you're seeing symptoms that might be linked to hormone issues, and you can discuss the results with your healthcare provider to figure out what to do next.

Conditions Where a DHEA Sulfate Test is Recommended

A DHEA Sulfate (DHEAS) test is very helpful for checking and managing different health conditions, such as:

Adrenal Dysfunction: If your DHEAS levels are not normal, it could point to issues like not having enough adrenal function or having adrenal tumors. These problems might need more tests and treatment.

Polycystic Ovary Syndrome (PCOS): People with PCOS might have higher DHEAS levels. PCOS is a condition where the ovaries don't work right, often causing problems with insulin and too much of male hormones.

Hirsutism and Virilization: If you're experiencing a lot of hair growth or developing male traits, a DHEAS test can help find out if it's because of too much male hormones from the adrenal glands or ovaries.

How Does My Healthcare Provider Use a DHEA Sulfate Test?

Your healthcare provider uses the DHEAS test to:

Check Adrenal Gland Function: By looking at your DHEAS levels, your doctor can see how well your adrenal glands are working and if there might be any issues with them.

Diagnose and Monitor Hormonal Imbalances: If you have high DHEAS levels, it could be causing symptoms like excessive hair growth or other male traits. Keeping track of your DHEAS levels helps your doctor figure out the best treatment and see how well it's working.

Guide Treatment: The results from your DHEAS test help your doctor decide the best way to treat conditions like adrenal problems, PCOS, or other hormone-related issues. This might include hormone therapy or changing your medication.

What do my DHEA-S test results mean?

A normal DHEAS level, together with other normal male hormone levels, suggests that the adrenal gland is working properly. When an adrenal tumor or cancer is present but not secreting hormones, DHEAS may be normal.

A high DHEAS blood level could indicate that the person's symptoms are caused or exacerbated by excessive DHEAS production. An elevated level of DHEAS, on the other hand, is not used to make a diagnosis of any particular condition; rather, it usually signals that further testing is required to determine the source of the hormone imbalance. An adrenocortical tumor, Cushing illness, adrenal cancer, or adrenal hyperplasia, as well as a DHEAS-producing ovarian tumor, can all cause high DHEAS.

DHEAS levels may be high in polycystic ovary syndrome, but they may also be normal, as PCOS is usually associated with ovarian androgen production.

Adrenal insufficiency, adrenal dysfunction, Addison disease, or hypopituitarism, a disorder characterized by low levels of pituitary hormones that govern the generation and secretion of adrenal hormones, can all produce low DHEAS levels.

Most Common Questions About the DHEA-S test:

Understanding the Test

What is the DHEA-S test?

The DHEA-S test measures the amount of dehydroepiandrosterone sulfate in your blood. DHEA-S is a hormone produced in the adrenal glands and is converted into other hormones like testosterone and estrogen.

Why would someone need a DHEA-S test?

A DHEA-S test is often ordered when an individual has symptoms suggesting an adrenal gland disorder, such as Cushing's syndrome or Addison's disease. It may also be ordered when a woman presents with symptoms of virilization (masculine physical characteristics), as high levels of DHEA-S can be associated with this.

Interpreting the Results

What do the results of the DHEA-S test mean?

Elevated DHEA-S levels may suggest an adrenal gland disorder or a condition causing excess production of androgens, like polycystic ovary syndrome (PCOS). Reduced levels of DHEA-S may suggest adrenal insufficiency or hypopituitarism. However, results should be interpreted in conjunction with other lab findings and clinical symptoms.

How are the results of the DHEA-S test presented?

The results are typically reported in micrograms per deciliter (µg/dL). Normal ranges can vary based on the laboratory, but generally, normal levels differ by age and sex.

About the Test

How is the DHEA-S test different from other hormone tests?

The DHEA-S test specifically measures the level of DHEA-S, an important androgen hormone predominantly produced by the adrenal glands. While other hormone tests may measure estrogen, testosterone, or other adrenal hormones like cortisol, this test focuses on DHEA-S.

What factors can affect the results of the DHEA-S test?

Certain medications, stress, obesity, and underlying health conditions can influence DHEA-S levels. Smoking is also known to increase DHEA-S levels.

Understanding the Implications

What conditions can cause abnormal DHEA-S levels?

Conditions like adrenal carcinoma or adrenal hyperplasia can lead to elevated DHEA-S levels. Additionally, PCOS, a common condition in women of reproductive age, can result in increased levels. Low levels can be seen in adrenal insufficiency and hypopituitarism.

What are the implications of abnormal DHEA-S levels?

Abnormal levels of DHEA-S can affect multiple body functions. High levels can lead to virilization in women, causing unwanted hair growth, acne, and menstrual problems. Lower levels can lead to fatigue, depression, and a lower sex drive.

Risks and Precautions

How do abnormal DHEA-S levels impact health?

Elevated DHEA-S levels can contribute to conditions like heart disease, diabetes, and certain types of cancers. Low levels can be associated with conditions such as chronic fatigue, depression, anxiety, and certain autoimmune diseases.

Dealing with Abnormal Results

What steps should be taken if the DHEA-S test results are abnormal?

Abnormal results should lead to further investigation to identify the underlying cause. This might involve additional lab tests, imaging studies, or consultations with a specialist, such as an endocrinologist.

Interpreting the Test Results

What is the significance of DHEA-S in relation to cortisol in the DHEA-S test?

DHEA-S and cortisol are both produced by the adrenal glands, but they have opposing effects. While cortisol is involved in stress response and suppresses immunity, DHEA-S counteracts some of cortisol's effects and boosts immunity. An imbalance between these two hormones can lead to health problems.

Understanding the Importance of the Test

How does the DHEA-S test relate to infertility issues?

Elevated levels of DHEA-S may be associated with PCOS, a common cause of infertility in women. Additionally, imbalances of DHEA-S and other hormones can affect ovulation and sperm production, potentially impacting fertility.

How does the DHEA-S test assist in evaluating adrenal function?

As DHEA-S is produced by the adrenal glands, abnormal levels can indicate adrenal dysfunction. High levels may suggest adrenal hyperactivity, while low levels could suggest adrenal insufficiency.

Discussion with Healthcare Provider

What questions should I ask my healthcare provider before getting the DHEA-S test?

Consider asking why the test is being ordered, what the results might mean, and how the results might influence your treatment plan.

What questions should I ask my healthcare provider after getting the DHEA-S test?

You may want to ask for a detailed explanation of your results and what they could mean for your health. If your DHEA-S levels are abnormal, you should discuss potential underlying conditions, next steps, and treatment options.

Future Considerations

How often should the DHEA-S test be repeated?

The frequency of the DHEA-S test depends on your health status and the reason for the initial test. If you're being treated for a condition that affects DHEA-S levels, your healthcare provider may recommend regular testing to monitor your condition.

What future medical tests might be needed if the DHEA-S test reveals abnormal results?

Depending on the results and your symptoms, further tests may be required to determine the cause of abnormal DHEA-S levels. This could include other hormone tests, imaging of the adrenal glands, or even genetic testing.

Lab tests often ordered with a DHEA Sulfate test:

When a DHEA-S test is ordered, several other tests may be included to provide a more comprehensive assessment of hormonal health. Here are some tests commonly ordered alongside a DHEA-S test:

1. Testosterone Free and Total:

   • Purpose: To measure the levels of testosterone in the blood, both bound and unbound.
   • Why Is It Ordered: Elevated testosterone levels can cause or contribute to symptoms like hirsutism and acne, often in conjunction with elevated DHEA-S levels.

2. Androstenedione:

   • Purpose: To measure the level of androstenedione, another adrenal androgen.
   • Why Is It Ordered: Like DHEA-S, androstenedione can contribute to androgen excess and is often elevated in adrenal hyperplasia or tumors.

3. 17-Hydroxyprogesterone:

   • Purpose: To measure the level of this hormone, which is a precursor to cortisol and can be elevated in congenital adrenal hyperplasia (CAH).
   • Why Is It Ordered: To screen for or confirm CAH, especially if symptoms of androgen excess are present.

4. Cortisol:

   • Purpose: To assess cortisol levels, which can be affected by adrenal disorders.
   • Why Is It Ordered: To evaluate adrenal function, particularly in cases where an adrenal tumor or dysfunction is suspected.

5. Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH):

   • Purpose: To assess ovarian function, as these hormones regulate the menstrual cycle and ovarian hormone production.
   • Why Is It Ordered: To distinguish between ovarian and adrenal sources of androgen excess in women with symptoms like hirsutism or menstrual irregularities.

6. Prolactin:

   • Purpose: To measure the level of prolactin, which can affect menstrual function and ovulation.
   • Why Is It Ordered: Elevated prolactin can cause symptoms similar to those caused by androgen excess and can affect overall hormonal balance.

7. Sex Hormone Binding Globulin (SHBG):

   • Purpose: To measure the level of SHBG, which binds to sex hormones, including androgens.
   • Why Is It Ordered: SHBG levels can be affected by androgens and can influence the levels of free, biologically active hormones.

8. Complete Blood Count (CBC):

   • Purpose: To provide a general overview of health.
   • Why Is It Ordered: Although not directly related to DHEA-S levels, a CBC can help identify underlying health issues that may contribute to or be affected by hormonal imbalances.

9. Liver Function Tests:

   • Purpose: To assess liver health.
   • Why Is It Ordered: The liver is involved in hormone metabolism, and liver dysfunction can affect hormone levels.

These tests, along with a DHEA-S test, can help diagnose and manage conditions associated with adrenal or ovarian hormone imbalances. They provide insights into the broader hormonal and health status of the individual, which is essential for accurate diagnosis and effective treatment planning. The selection of these tests will depend on the individual's symptoms, clinical history, and the reasons for testing.

General Questions

How does the DHEA-S test assist in diagnosing polycystic ovary syndrome (PCOS)?

In women, elevated levels of DHEA-S, along with other symptoms like irregular periods and cysts in the ovaries, can suggest PCOS. DHEA-S testing can be an important part of the diagnostic process.

How can the DHEA-S test provide insights into aging and longevity?

DHEA-S levels naturally decline with age. Some research suggests that lower DHEA-S levels may be associated with an increased risk of age-related conditions like heart disease and memory loss. However, more research is needed to fully understand these associations.

How does the DHEA-S test relate to the monitoring of adrenal gland tumors?

DHEA-S is produced by the adrenal glands, and elevated levels can indicate the presence of an adrenal gland tumor. Regular monitoring of DHEA-S levels can help in assessing the growth of the tumor and the effectiveness of treatment.

How can the DHEA-S test help in understanding the causes of abnormal hair growth in women?

High DHEA-S levels can lead to an overproduction of androgens, which can cause hirsutism, or abnormal hair growth, in women. A DHEA-S test can be used to identify this hormonal imbalance.

How does the DHEA-S test contribute to the understanding of adrenal insufficiency?

Low levels of DHEA-S can indicate adrenal insufficiency, a condition in which the adrenal glands do not produce enough hormones. The DHEA-S test can be a useful tool in diagnosing this condition.

Can the DHEA-S test be used in the assessment of mood and psychological health?

Yes, some research suggests a connection between low DHEA-S levels and conditions like depression and anxiety. However, the relationship between DHEA-S and mental health is complex and not fully understood.

Can the DHEA-S test be useful in the evaluation of sexual development in teenagers?

Yes, DHEA-S is one of the first hormones to increase at the start of puberty. If a child shows signs of early or delayed puberty, a DHEA-S test can help evaluate whether hormonal imbalances are playing a role.

What role does the DHEA-S test play in the management of chronic fatigue syndrome?

Low levels of DHEA-S have been observed in some people with chronic fatigue syndrome. While more research is needed, some suggest that DHEA-S supplementation could help manage symptoms. The DHEA-S test can be used to monitor levels before and during such treatment.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.