Endocrine Tests

The endocrine tests can give you an accurate reading of your hormonal levels to help diagnose a wide range of endocrine disorders, with results sent confidentially online in 24 to 48 hrs for most tests. Order directly from Ulta Lab Tests today!


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The major sources of amylase are the pancreas and the salivary glands. The most common cause of elevation of serum amylase is inflammation of the pancreas (pancreatitis). In acute pancreatitis, serum amylase begins to rise within 6-24 hours, remains elevated for a few days and returns to normal in 3-7 days. Other causes of elevated serum amylase are inflammation of salivary glands (mumps), biliary tract disease and bowel obstruction. Elevated serum amylase can also be seen with drugs (e.g., morphine) which constrict the pancreatic duct sphincter preventing excretion of amylase into the intestine.

In pancreatitis, urine levels of amylase reflect serum changes by a time lag of 6-10 hours.


Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than Cardiolipin Antibody that may express reactivity in patients with syphilis and other infectious diseases

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Serum Triglyceride analysis has proven useful in the diagnosis and treatment of patients with diabetes mellitus, nephrosis, liver obstruction, other diseases involving lipid metabolism, and various endocrine disorders. In conjunction with high density lipoprotein and total serum cholesterol, a triglyceride determination provides valuable information for the assessment of coronary heart disease risk.

Includes Albumin, Albumin/Globulin Ratio (calculated), Alkaline Phosphatase, ALT, AST, BUN/Creatinine Ratio (calculated), Calcium, Carbon Dioxide, Chloride, Creatinine with GFR Estimated, Globulin (calculated), Glucose, Potassium, Sodium, Total Bilirubin, Total Protein, Urea Nitrogen


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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 7 a.m.-9 a.m.


DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with Polycystic Ovarian Syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.



Glutamic Acid Decarboxylase (GAD-65) Antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess risk for development of IDDM, to predict onset of IDDM, and risk of development of related endocrine disorders, e.g., thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells, and by circulating autoantibodies against a variety of islet cell antigens, including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin autoantibody (IAA).

Usual method for determining anemia. Used to calculate indices.

The concentration of IGFBP-1 is correlated with glycemic conditions. IGFBP-1 may be used for monitoring insulin responsiveness, as a marker for insulin-producing tumors, monitoring acute fluctuations in insulin action, and determining if poor glycemic control is due to inadequate insulin treatment or poor control of dietary intake.

Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the six distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II. IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in cromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Thus, both assays and the ratios of IGF-I/IGFBP-2 and IGFBP-2/IGFBP-3 are useful as markers of GH action and for discriminating between growth hormone deficiency and short stature due to other etiologies in children. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction

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Insulin-like growth factor I (IGF-I, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations. Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.

Inhibin-B is the major circulating inhibin in males and can be used as endocrine marker of spermatogenesis in subfertile men. In the female, since Inhibin-B decreases to undetectable levels after normal menopause, certain ovarian cancers (mucinous carcinomas, granulosa cell tumors) continue to produce inhibin after menopause, Inhibin-B can serve as a regular screening test in the female, especially in post-menopausal women.

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Leptin is an adipocyte-derived hormone that is essential for normal body weight regulation. Leptin production is under neuroendocrine control so that serum concentrations vary directly with the amount of triglycerides stored in adipose tissue depots.


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Confirmatory evidence for diagnosis of pancreatitis

Plasma norepinephrine is an independent risk factor in patients with chronic congestive heart failure that relates to subsequent mortality. Norepinephrine is useful in evaluating patients with hypertension


This test is intended for the diagnosis and monitoring of inherited disorders affecting multiple metabolic pathways. 

Organic acidurias are inherited disorders resulting from a deficient enzyme or transport protein. Although most are autosomal recessive disorders, several are X-linked. The more than 60 described organic acidurias affect many metabolic pathways including amino acid metabolism, lipid metabolism, purine and pyrimidine metabolism, the urea cycle, the Krebs cycle and fatty acid oxidation. These disorders are characterized by a wide variety of symptoms such as lethargy, coma, hypotonia, seizures, ataxia, vomiting, failure to thrive, developmental delay, liver disease, neutropenia, thrombocytopenia, osteomalacia and osteoporosis. Severity of presentation is highly variable as is age of onset, and patients may not present with the most characteristic features. Laboratory results commonly indicate metabolic acidosis, increased anion gap, hyperammonemia, hypoglycemia, lactic acidemia, ketosis, or abnormal lipid patterns. Treatment may be based on dietary restrictions and/or supplementation with cofactors (e.g., riboflavin or cobalamin) or conjugating agents (e.g., carnitine or sodium benzoate); however, there is no effective therapy for some of the disorders. 

Elevation of one or more organic acids is diagnostic for an organic aciduria; however, elevations should be interpreted in context with clinical findings and/or additional test results. See additional information for a table of selected organic acidurias and associated organic acid elevations. Since many organic acidurias are episodic, the diagnostic efficacy is maximized when the patient is expressing symptoms at the time of specimen collection. 

The test will be capable of diagnosing over 30 inherited metabolic defects, and will also allow physicians to determine dietary compliance or the effectiveness of dietary/cofactor therapy for their patients. It can also be used, alone or in conjunction with other tests, to confirm the findings of a positive expanded newborn screen.


Serum pancreastatin is a sensitive and specific diagnostic biomarker in neuroendocrine tumors (NETs)

Patient Preparation: Patient must be fasting 10-12 hours prior to collection of specimen. Patient should not be on any medications that may influence insulin levels, if possible, for at least 48 hours prior to collection.

Collection Instructions: Collect blood and separate plasma as soon as possible. Freeze plasma immediately after separation and transfer to new tube.
Specimen must be shipped frozen on dry ice. Specimens are not to be refrigerated or at room temperature.

Performing Laboratory 

Cambridge Biomedical, Inc , 1320 Soldiers Field Road, Boston, MA 02135-1020

Setup Schedule Set up: Mon every two weeks; Report available: 5-19 days


Pancreatic polypeptide tests are used in the assessment of pancreatic tumor burden and to assist in the early diagnosis of pancreatic tumors. The measurement of its concentrations is also used to monitor pancreatic carcinoma therapy and to predict the recurrence of pancreatic tumors


Renin plays a central role in maintaining blood pressure by enzymatically converting angiotensinogen to angiotensin I, which is then cleaved by angiotensin converting enzyme to form angiotensin II. Angiotensin II increases blood pressure directly through vasoconstriction and indirectly by stimulating secretion of aldosterone, a hormone that promotes sodium retention and potassium loss. Renin secretion is inhibited by high blood pressure and stimulated by factors that lower blood pressure, such as upright posture and sodium deprivation. A variety of drug classes also physiologically affect plasma renin activity (PRA) levels (Table). PRA is typically used in conjunction with the measurement of aldosterone, sodium, and potassium levels in plasma and/or urine.


Have you been experiencing fluctuations in weight, mood swings, hair loss, or insomnia? If so, it may be a hormone imbalance. 

Your endocrine system is responsible for producing hormones in your body. If your hormones are unbalanced, they can throw your whole body off. 

Metabolism, sexual function, reproduction, sleep, weight, and mood are all regulated by hormones. Keeping your endocrine system running well is essential. 

If you're feeling like there is something disrupting your hormones, it is important that you look into endocrine tests to find out what is actually going on. 

Let's look into this deeper.

What Are Endocrine Disorders?

Your endocrine system is one of the most important parts of your body. In simple terms, an endocrine disorder is when your endocrine systemis malfunctioning, and a gland in the body isn't doing its job correctly. 

Diabetes is one of the most commonly known endocrine disorders. Thyroid diseases such as Hypothyroidism, Hyperthyroidism, Hashimoto's, Graves Disease, and Addison's Disease are more common than you might think. And then there are some diseases like Cushing's Syndrome, Prolactinoma, adrenal dysfunction, and Polycystic Ovary Syndrome that are much less talked about.

Your endocrine system needs to be running efficiently in order for all of your organs to work properly. With too much cortisol, you may find yourself in a constant state of "fight or flight." Too much testosterone can cause excessive hair growth, hair loss, and acne. The imbalance of your thyroid hormones can cause rapid weight gain with the inability to lose weight. 

Risk Factors & Causes

There are many internal and external factors that can increase your risk for endocrine system disorders. 

Externally, lack of nutrition, a poor diet, injury, sedentary lifestyle, and lack of exercise can have significant adverse effects on your endocrine system. 

Internally, infection, elevated cholesterol levels, tumors, and genetic disorders are common causes and risk factors. Personal history of autoimmune disease can also be a large risk factor for endocrine diseases and disorders. 

Women are far more likely to have an endocrine disorder than men, and menstruation and pregnancy are likely part of the reason. Pregnancy is known for throwing your hormones out of sync. 

Signs & Symptoms

Medical professionals often misread symptoms of endocrine disorders. Anxiety and depression are two of the main symptoms. If your doctor is only treating the symptom, the disorder itself could only get worse. 

Other signs and symptoms of endocrine disorders can also be commonly misdiagnosed. Unexplained weight changes, fatigue, insomnia, hair loss, constipation, excessive thirst, and heat or cold intolerance are all symptoms. 

If your doctor isn't taking your symptoms and concerns seriously, it is important to be your own advocate. Ulta Lab Tests makes this easy with the ability to order your own tests. 

Rare endocrine disorders can produce symptoms such as confusion, memory loss, low heart rate or blood pressure, and eye and vision problems. If you are experiencing any of these and it seems life-threatening, you should seek medical attention immediately. 

Endocrine Tests

When diagnosing, Endocrine Disorders tests are always needed. Endocrine Disorders tests will all look into the hormones in your body and making sure they are in the normal range.  

The Endocrine Advanced Panel includes the tests ordered most often to identify endocrine disorders. This Endocrine lab test panel contains 20 tests with 83 biomarkers used to identify a malfunctioning endocrine gland.

  • C-Reactive Protein (CRP)
  • CBC (includes Differential and Platelets)
  • Comprehensive Metabolic Panel (CMP)
  • Cortisol, A.M.
  • DHEA Sulfate, Immunoassay
  • Estradiol
  • FSH and LH
  • Hemoglobin A1c (HgbA1C)
  • IGF-I, LC/MS
  • Lipid Panel
  • Progesterone, Immunoassay
  • Prolactin
  • T3 Total
  • T3, Free
  • T4 (Thyroxine), Total
  • T4, Free
  • Testosterone, Free (Dialysis) and Total MS
  • TSH
  • Vitamin D, 25-Hydroxy, Total, Immunoassay
  • Vitamin B12 (Cobalamin) and Folate Panel, Serum

Once your doctor reviews your labs and can see which hormones are out of balance and which biomarkers are out of functional reference ranges, she can work towards a specific direction she thinks your diagnoses could go in and order more specific tests.

It is possible that your doctor will want to do ultrasounds on the gland they think is malfunctioning. Computerized tomography (CT) scans and Magnetic resonance imaging (MRI) will provide highly detailed scans for your doctor to help diagnose and treat your endocrine disorder. 

There are many tests for endocrine disorders, but the first step is to get initial blood tests done.  

FAQ About Endocrine Disorders & Tests

You may have a lot of questions concerning endocrine disorders and endocrine disorders tests. Here are some common questions. If you have any further questions, make an appointment to see a doctor. 

When Should I See My Doctor?

Any time you think your body isn't functioning correctly, you should see your doctor; however, if your doctor isn't as attentive or proactive as you would like, order tests from Ulta Lab Tests and be your own advocate. 

Is My Weight Gain Because of an Endocrine Disorder?

It is definitely possible that your weight is fluctuating because of an Endocrine Disorder. Make sure to mention this symptom to your doctor. 

What Tests Should I Order?

Start with Ulta Lab Tests Endocrine Advanced Panel This will cover most of the bases for any severe endocrine disorders. These 20 tests will give you 83 biomarkers, and the most common types of endocrine disorders will be able to be identified with these tests

Is My Endocrine Disorder Curable?

Technically, no, but they can be managed. Most Endocrine Disorders are something you will have to monitor for the rest of your life. If your hormones are unbalanced because of a cyst, tumor, or trauma, then it is possible that the disorder can be corrected. 

Lab Testing With Ulta Lab Tests

Ulta Lab Tests offers tests that are highly accurate and reliable, so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

Order your endocrine lab tests today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control of your health today with Ulta Lab Tests.

 The endocrine system is a network that is made up of different glands throughout the human body. The endocrine system and the nervous system work together to regulate and control many of the internal functions of the body. The nervous system makes use of nerve impulses as its means for control; the endocrine system utilizes hormones, which are chemical messenger molecules. These hormones are created, stored, as well as secreted by an integrated network of different glands. When endocrine glands release different hormones into the blood, they will target specific organs, tissues, or cells. Every target will have dedicated receptors for that specific hormone, which can be explained as a key that fits into a lock.  

This network is made up of several parts. One of these is the hypothalamus, which is the endocrine gland situated in the brain. Another includes the pituitary gland, located in its own dedicated place inside of the sella turcica, just under the hypothalamus. The signals sent by the brain instruct the hypothalamus to create many types of hormones that either inhibit or stimulate the pituitary. These are the signals that make the pituitary either decrease or increase the hormones that it produces, followed by releasing them into the blood. Hormones that the pituitary releases in different amounts will travel through the blood to the endocrine glands. Some of these glands include the ovaries and testicles, adrenal, and thyroid glands. Many other tissues and organs in the body are also classified as hormone targets.  

Many of the endocrine glands are governed by specific feedback systems to prevent hormone imbalance. An example of this includes the hypothalamus that first stimulates the pituitary gland, followed by the adrenal gland to regulate the way it functions. The hypothalamus will first release CRH (corticotropin-releasing hormone), which stimulates the pituitary gland into releasing corticotropin (commonly known as an adrenocorticotrophic hormone or ACTH). ACTH then stimulates the adrenal gland into producing cortisol. When cortisol levels reach a specific threshold, the pituitary and the hypothalamus glands start to lower ACTH and CRH production, which creates a feedback loop that is negative.  

Certain hormones, like cortisol, have a monthly or a daily pattern or sequence of release. Levels of cortisol are usually higher in the mornings and lower in the evenings. The pituitary hormone levels of FSH (follicle-stimulating hormone) and LH (luteinizing hormone) decrease and increase in a regular pattern, which regulates the monthly menstrual cycles in women. Other types of hormones in the blood are typically present in far smaller quantities, will release in specific types of situations. An example of this is when adrenaline (epinephrine) is released from the adrenal glands as a direct response to a stressful situation.  

This gland network and the endocrine system are, in most cases, interdependent, which means any type of disorder which affects one of these glands can cause diseases that are linked to the other glands present in this system. For example, disorders that affect the hypothalamus might also impact on the pituitary gland along with the “downstream” targeted organs. The endocrine syndromes are often categorized by the affected gland.  

Primary disorders will affect one of the target organs, such as the adrenal or thyroid glands.  

Secondary disorders directly affect glands that perform the function of regulating the target organs. This is most commonly the pituitary gland.  

Tertiary disorders are linked to the hypothalamus.  

The Common Causes of Endocrine Syndromes 

Hormones influence multiple systems in the body, which includes the development of female and male characteristics, growth, fertility, digestion, stress response, glucose utilization, energy consumption, water/fluid balance, maintaining the correct blood pressure, and bone metabolism. When the glands are producing too little or too much of a hormone, it can affect these natural processes. This is a condition that is more commonly known as hormonal imbalances. These conditions also go by certain names, like Cushing syndrome (linked with excess cortisol), as they are associated with typical sets of complications and symptoms.  

Endocrine gland dysfunction might occur when the actual gland has a problem, an issue with the feedback-system, or/and when the target tissues are failing to respond to the hormone. When hormone production decreases, it can relate to infections when the immune system is damaged, trauma, crowding of hormone-producing cells caused by the presence of a tumor. Other causes also arise from a gene mutation (inherited) that affects the quality, quantity, or the overall structure of the hormone. When these glands are failing to release or produce enough hormone amounts to stimulate a targeted gland into releasing and producing its hormone, it might also lower production.  

An increase in the production of a hormone can be associated with an imbalance with the feedback system. An example of this is when the pituitary produces an excess amount of ACTH, which will disrupt and interfere with the feedback-system. An increase in production can also be linked to enlarged glands (hyperplasia) or tumors of the cells that produce these hormones. It can also occur when the tissue response is lacking, the use of certain types of medications, or inherited conditions.  

The endocrine tumors which are responsible for producing too many hormones are typically benign and small. Many of these are situated inside the gland that is affected, and that gland only produces one specific hormone type. These tumors rarely become cancerous. It is also very rare that an endocrine-disrupting tumor will be situated anywhere else inside the body. The tumor itself may be responsible for causing symptoms due to the hormone levels that it produces, as its growth will eventually crowd out and lower the production of any other hormone in the affected gland. This is also caused by the size of the tumor that puts pressure on the surrounding structures and nerves.  

Many of the endocrine conditions that are inherited are typically rare and are typically linked to dysfunctional or deficient production associated with one hormone. Or with the hormone production of glands, such as congenital hypothyroidism. There are, however, a few genetic syndromes or conditions that will affect several glands. The two that are identified to affect many of the endocrine glands include MEN-1 and MEN-2. This stands for Multiple Endocrine Neoplasia, Type 1 and Type 2.  

These are the conditions that relate to an alteration in genes. They also increase the likelihood that the affected person will develop a tumor or tumors in one or many of the endocrine glands in their body.  

Endocrine Disorders and Syndromes 

The common tests used to detect endocrine syndromes and disorders include: 

hCG Tumor Marker 

Catecholamines 

Antidiuretic Hormone (ADH) 

Plasma Free Metanephrines 

Urine Metanephrines