Endocrine Tests

Your endocrine system is a network of glands that release hormones to control energy, growth, mood, reproduction, and fluid balance. When hormones are too high or too low, you may notice fatigue, weight changes, irregular periods, hair/skin changes, or blood-pressure and glucose shifts.

Endocrine testing uses targeted blood and urine tests to evaluate these glands—thyroid, adrenals, pituitary, ovaries/testes, and parathyroids—and related systems. A proactive plan often begins with TSH and thyroid hormonesglucose/A1c, and electrolytes, then adds adrenal, pituitary, and reproductive markers based on symptoms. Some conditions need dynamic (stimulation/suppression) tests arranged by a clinician. Results guide screeningdiagnosis, and monitoring, but they do not replace an exam, imaging, or urgent care for severe symptoms.

Signs, Symptoms & Related Situations

  • Energy & metabolism: fatigue, weight gain or loss, cold/heat intolerance, hair thinning, dry skin

  • Blood pressure & fluids: dizziness on standing, salt craving, swelling, high or low BP

  • Glucose & lipids: thirst, frequent urination, cravings, high triglycerides

  • Reproductive & sexual health: irregular or heavy periods, fertility concerns, hot flashes, low libido, erectile issues

  • Mood & sleep: anxiety, depression, poor sleep, brain fog

  • Bone & muscle: cramps, weakness, fractures, height loss

  • When to seek urgent care: severe vomiting/diarrhea with low BP (possible adrenal crisis), chest pain, confusion, fainting, or stroke-like symptoms

Why These Tests Matter

What testing can do

  • Identify hormone excess or deficiency (thyroid, adrenal, reproductive, pituitary, parathyroid)

  • Triage causes of common symptoms like fatigue, weight change, and cycle irregularity

  • Provide baselines and trends to monitor treatment safety and progress

What testing cannot do

  • Prove a diagnosis from one result without clinical context

  • Replace imaging (e.g., ultrasound, MRI, DXA) or specialist procedures when indicated

  • Provide treatment or dosing advice—work with your clinician on next steps

What These Tests Measure (at a glance)

  • Thyroid: TSHFree T4Free T3; antibodies (TPOTgTRAb) for autoimmune patterns. High-dose biotin can interfere—follow hold instructions.

  • Adrenal (insufficiency/Cushing): 8 a.m. cortisolACTHcosyntropin (ACTH) stimulation for low/borderline cortisol; late-night salivary cortisol1-mg dexamethasone test, or 24-hr urinary free cortisol for suspected Cushing syndrome.

  • Mineralocorticoids & BP: Renin and Aldosterone for primary aldosteronismelectrolytes (Na/K/CO2) for safety and clues.

  • Catecholamines (select cases): Plasma or urine fractionated metanephrines for pheochromocytoma/paraganglioma when symptoms suggest.

  • Reproductive hormones (men): Total & Free TestosteroneSHBGLH/FSHprolactin.

  • Reproductive hormones (women): EstradiolProgesterone (cycle-timed), LH/FSHprolactinandrogens(total/free testosterone, DHEA-S)—useful for cycle issues or PCOS-type patterns.

  • Pituitary markers: ProlactinIGF-1 (growth-hormone axis) ± dynamic tests per clinician.

  • Calcium-bone axis: CalciumPTHVitamin D (25-OH)phosphatemagnesium.

  • Metabolic context: A1c/fasting glucose (± insulin/C-peptide), lipid panelCMP for liver/kidney function.

Quick Build Guide

Goal Start with Add if needed
General endocrine screen TSHA1c/GlucoseCMP/ElectrolytesVitamin D Lipids • CBC
Thyroid symptoms TSH + Free T4 Free T3 • TPO/Tg Ab • TRAb (hyperthyroid pattern)
Adrenal symptoms (fatigue/low BP) 8 a.m. Cortisol + ACTH + Electrolytes Cosyntropin test • Renin/Aldosterone (low K?/resistant HTN)
Possible Cushing syndrome Choose one: Late-night saliva cortisol (x2) • 1-mg DST • 24-hr UFC (x2) Morning ACTH to classify if confirmed
Women: cycle/PCOS/fertility TSHEstradiol/Progesterone (timed), LH/FSHProlactin Total/Free Testosterone, DHEA-S, 17-OH-Progesterone (per clinician)
Men: low libido/energy AM Total Testosterone Free T/SHBGLH/FSHProlactinTSH
Calcium/bone concerns Calcium + Vitamin D PTH, phosphate, magnesium
BP hard to control Electrolytes, Creatinine/eGFR Renin + Aldosterone (ARR) • Metanephrines (spells)

How the Testing Process Works

  1. Pick your starting panel based on symptoms (see Quick Build).

  2. Prepare for accuracy: follow fasting or timing notes; some tests require morning draws or cycle-timed collection. List medications (steroids, oral estrogen, thyroid pills) and biotin supplements.

  3. Get your draw/collection: visit a nearby patient service center; some tests use saliva or 24-hour urine.

  4. Review results securely: discuss with your clinician; add confirmatory dynamic tests only when needed.

  5. Set a follow-up cadence: recheck on a schedule that matches your goals and care plan.

Interpreting Results (General Guidance)

  • Use trends, not single values; compare to your baseline and symptoms.

  • Some results vary with time of day, cycle phase, meds, and illness (e.g., cortisol peaks in the morning; estradiol/progesterone are cycle-dependent).

  • Borderline results often need repeat or dynamic testing.
    Always interpret labs with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Broad checkup: a mini endocrine bundle—TSH, A1c/glucose, CMP/electrolytes, Vitamin D—then add by symptom.

  • Targeted follow-up: choose one or two high-yield markers (e.g., Free T4 with abnormal TSH; AM total testosterone with symptoms).

  • Complex questions: combine core labs with a clinician-ordered stimulation/suppression test (cosyntropin, dexamethasone, OGTT-based GH testing).

FAQs

Do I need to fast?
Fasting is usually needed for glucose/insulin and sometimes for lipids. Most hormone tests don’t require fasting—follow your order.

When should I test testosterone or cortisol?
Test testosterone in the morning. Screen cortisol around 8 a.m. unless using late-night saliva for Cushing screening.

Can biotin or estrogen affect results?
Yes. Biotin can distort some immunoassays; oral estrogen raises cortisol-binding proteins. Follow any hold instructions and list your meds.

How are women’s hormone tests timed?
Estradiol/progesterone are cycle-dependent. Your clinician may request specific cycle days.

What if my results are borderline?
Repeat testing or a dynamic test may be needed. One value rarely tells the whole story.

Can I order dynamic tests myself?
Stimulation/suppression tests usually require clinician oversight for safety and accurate interpretation.

Related Categories & Key Tests

  • Upward: Hormone Tests Hub

  • Sideways: Thyroid Testing • Adrenal Insufficiency & Addison Disease • Cushing Syndrome • Men’s Hormones • Women’s Hormones & PCOS • Diabetes & Insulin Resistance • Calcium & Bone Health

  • Key Tests (downward): TSH • Free T4/Free T3 • TPO/Tg/TRAb Antibodies • AM Cortisol • ACTH • Cosyntropin Test • Late-Night Saliva Cortisol • 1-mg DST • 24-hr Urinary Free Cortisol • Renin & Aldosterone • Plasma/Urine Metanephrines • Total/Free Testosterone & SHBG • Estradiol • Progesterone • LH/FSH • Prolactin • IGF-1 • PTH • Calcium • Vitamin D • A1c/Glucose • CMP/Electrolytes

References

  • Endocrine Society — Clinical practice guidelines on thyroid disease, adrenal insufficiency, Cushing syndrome, and hypogonadism.
  • American Thyroid Association — Thyroid testing and antibody guidance.
  • American Association of Clinical Endocrinology — Endocrine testing best practices.
  • Pituitary Society — Evaluation of pituitary disorders and prolactinomas.
  • American Diabetes Association — Standards of Care in Diabetes (A1c/glucose testing).
  • National Osteoporosis Foundation — Calcium, vitamin D, and bone-health guidance.
  • Endocrine Disorders and Lab Testing - What You Need to Know

Available Tests & Panels

Your Endocrine Tests menu is pre-populated in the Ulta Lab Tests system. Start with a core set (TSH, A1c/glucose, CMP/electrolytes, Vitamin D), then add adrenal, pituitary, reproductive, or calcium-bone markers to match your symptoms. Follow any timing/fasting instructions and review results with your clinician to decide on confirmatory testing and follow-up.

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The Aldosterone Test measures levels of aldosterone, a hormone produced by the adrenal glands that helps regulate blood pressure, sodium, and potassium balance. Abnormal levels may indicate primary aldosteronism, adrenal tumors, kidney disease, or secondary hypertension. Doctors use this blood test to investigate high blood pressure, electrolyte imbalances, or suspected adrenal disorders, helping guide diagnosis, treatment, and long-term patient management.

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Also Known As: Aldosterone Plasma Test

The Plasma Renin Activity Test evaluates how much renin the kidneys release, providing insight into blood pressure control and fluid regulation. Abnormal activity may suggest hypertension, adrenal gland dysfunction, or kidney disease. This test supports assessment of aldosterone-renin ratio, secondary hypertension, and systemic conditions that impact cardiovascular and renal health.

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The Growth Hormone Test measures GH levels in blood to evaluate pituitary gland function, growth disorders, and metabolic health. Abnormal levels may indicate acromegaly, gigantism, or growth hormone deficiency. Doctors use this test to assess children with short stature, adults with suspected hormone imbalance, or patients with pituitary tumors. Results provide critical insight into endocrine function, metabolism, and overall growth regulation.

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Also Known As: GH Test, HGH Test, Human Growth Hormone Test, Somatotropin Test

The Estrogen Total Test measures all forms of estrogen in blood, including estradiol, estrone, and estriol, to assess reproductive and hormonal health. Abnormal levels may indicate menstrual irregularities, menopause status, infertility, or hormone-related disorders. Doctors order this test to evaluate fertility, monitor hormone therapy, and investigate symptoms such as hot flashes, irregular cycles, or abnormal bleeding. It provides key insight into endocrine and reproductive function.

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Also Known As: Total Estrogen Test, Estrogen Serum Test

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The FSH and LH Test measures follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to evaluate reproductive and endocrine health in both men and women. In women, it helps assess menstrual irregularities, infertility, menopause, or polycystic ovary syndrome (PCOS). In men, it aids in diagnosing low testosterone, infertility, or testicular dysfunction. Doctors also use this test to investigate puberty disorders, hormone imbalance, and pituitary function.

Also Known As: Follitropin Test, Lutropin Test, Interstitial Cell Stimulating Hormone Test, ICSH Test

The Sex Hormone Binding Globulin (SHBG) Test measures SHBG, a protein that binds testosterone and estrogen, to assess how much active hormone is available in the body. Abnormal levels may indicate PCOS, infertility, low testosterone, liver disease, or thyroid disorders. Doctors order this test to investigate symptoms like low libido, irregular periods, acne, or hair loss and to evaluate hormone balance, endocrine function, and metabolic health in men and women.

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Also Known As: SHBG Test, TeBG Test, Testosterone-Estrogen Binding Globulin Test

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The LH Test measures luteinizing hormone levels in blood to assess fertility, reproductive health, and endocrine function. Abnormal LH may indicate infertility, menstrual irregularities, menopause, or pituitary disorders in women, and low testosterone or testicular dysfunction in men. Doctors use this test to evaluate ovulation, investigate infertility, monitor puberty disorders, or guide hormone therapy. It provides key insight into reproductive and hormonal balance.

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Also Known As: Luteinizing Hormone Test, Lutropin Test, Interstitial Cell Stimulating Hormone Test, ICSH Test

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The Progesterone Test measures progesterone levels in blood to evaluate ovulation, fertility, and menstrual health. It helps confirm whether ovulation has occurred, assess causes of infertility, and monitor hormone therapy or high-risk pregnancies. Doctors also use it to investigate abnormal bleeding, detect ovarian or adrenal disorders, and evaluate miscarriage risk. This test provides key insight into reproductive, hormonal, and overall endocrine health.

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Also Known As: PGSN Test

The Progesterone Ultrasensitive Test measures very low progesterone levels in blood with high accuracy to evaluate reproductive and endocrine health. Doctors use it to assess menstrual cycle function, confirm ovulation, investigate infertility, and monitor hormone therapy. It is also useful in pregnancy evaluation and detecting hormonal disorders. Results provide precise insight into progesterone balance, fertility, and overall reproductive health.

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Also Known As: Ultrasensitive PGSN, Progesterone LCMS Test

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The IGF-1 Test measures insulin-like growth factor 1, a hormone regulated by growth hormone (GH), to assess growth and endocrine function. Abnormal levels may indicate growth disorders, acromegaly, gigantism, or GH deficiency. Doctors order this test to evaluate delayed growth, short stature, excessive growth, or pituitary disease and to monitor GH therapy. Results provide valuable insight into hormone balance, metabolism, and overall endocrine health.

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Also Known As: Insulin-like Growth Factor 1 Test, Somatomedin-C Test, IGF-I Test

The IGF Binding Protein 1 (IGFBP-1) Test measures IGFBP-1, a protein that regulates insulin-like growth factor (IGF) activity and reflects insulin sensitivity. Abnormal levels may indicate insulin resistance, type 2 diabetes risk, or metabolic syndrome. Doctors use this test to evaluate glucose regulation, investigate metabolic disorders, and support early detection of endocrine imbalances that affect growth, energy balance, and long-term health.

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Also Known As: IGFBP-1 Test

The IGF Binding Protein 3 (IGFBP-3) Test measures IGFBP-3, the primary carrier of insulin-like growth factor 1 (IGF-1), to evaluate growth hormone activity. Abnormal levels may indicate growth disorders, pituitary dysfunction, or nutritional problems. Doctors use this test with IGF-1 to assess short stature, delayed or rapid growth, and monitor therapy for growth hormone deficiency or excess, supporting accurate diagnosis and treatment.

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Also Known As: IGFBP-3 Test

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The PTH Intact Test measures intact parathyroid hormone (PTH) levels in blood to evaluate parathyroid gland function and calcium balance. Abnormal PTH may indicate hyperparathyroidism, hypoparathyroidism, kidney disease, or vitamin D imbalance. Doctors use this test to investigate osteoporosis, kidney stones, or unexplained calcium abnormalities. Results provide vital insight into endocrine function, bone metabolism, and overall calcium regulation.

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Also Known As: Parathyroid Hormone Intact test, Intact PTH test, Parathormone Test

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The Amylase Test measures amylase enzyme levels in blood to evaluate pancreatic and digestive health. Elevated amylase may indicate pancreatitis, gallbladder disease, intestinal blockage, or salivary gland disorders, while low levels may suggest chronic pancreatitis or liver damage. Doctors order this test to investigate abdominal pain, nausea, or fever. Results provide vital insight into pancreatic function, digestive disorders, and overall metabolic health.

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Also Known As: Amy Test

The Beta-2-Glycoprotein I IgG IgA IgM Antibodies Test detects autoantibodies linked to antiphospholipid syndrome (APS), a disorder that increases risk of abnormal blood clotting. Measuring all three antibody classes provides a thorough evaluation of immune activity. Elevated results may be associated with recurrent miscarriages, venous or arterial thrombosis, and autoimmune conditions, supporting diagnosis and monitoring of clotting-related disorders.


The Beta-2-Glycoprotein I IgA Antibody Test detects IgA antibodies targeting beta-2 glycoprotein I, helping identify autoimmune conditions and clotting disorders. Positive results may indicate antiphospholipid syndrome, thrombotic risk, or pregnancy complications. This test provides insight into immune activity, vascular health, and systemic conditions linked to abnormal coagulation and inflammation.

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The Beta-2-Glycoprotein I IgG Antibody Test detects IgG antibodies targeting beta-2 glycoprotein I, helping assess autoimmune disorders and clotting risk. Positive results may indicate antiphospholipid syndrome, pregnancy complications, or thrombotic conditions. This test provides insight into vascular health, immune response, and systemic disorders related to antibody activity and coagulation balance.

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The Beta-2-Glycoprotein I IgM Antibody Test detects IgM antibodies targeting beta-2 glycoprotein I to help assess autoimmune activity and clotting disorders. Positive findings may suggest antiphospholipid syndrome, thrombotic risk, or recurrent miscarriage. This test provides insight into vascular health, immune regulation, and systemic disorders tied to antibody activity and coagulation balance.

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The Cardio IQ™ Triglycerides Test measures triglyceride levels in the blood, an important marker of lipid metabolism and cardiovascular health. Elevated triglycerides are linked to increased risk of heart disease, pancreatitis, and metabolic syndrome. Physicians use this test to assess risk factors, monitor therapy response, and guide lifestyle or treatment decisions, often as part of a broader lipid or heart health evaluation.

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The Catecholamines Fractionated 24-Hour Urine Test with Creatinine measures epinephrine, norepinephrine, and dopamine excretion, normalized to creatinine, to assess adrenal gland and sympathetic nervous system function. Elevated levels may indicate pheochromocytoma, paraganglioma, or other neuroendocrine tumors. This test supports evaluation of unexplained hypertension, palpitations, and symptoms linked to catecholamine excess.

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Urine Collection

The Catecholamines Fractionated Random Urine Test analyzes urinary dopamine, norepinephrine, and epinephrine to assess adrenal medulla activity and sympathetic function. Elevated catecholamines may suggest adrenal tumors such as pheochromocytoma or paraganglioma, while abnormalities can reflect neuroblastoma or stress-related disorders. This test provides insight into hormone regulation and systemic health.

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Urine Collection

The Electrolyte Panel Test measures sodium, potassium, chloride, and carbon dioxide in blood to evaluate fluid balance, kidney function, and acid-base status. Abnormal results may indicate dehydration, kidney disease, adrenal disorders, or respiratory issues. Doctors use this test to investigate symptoms such as weakness, confusion, or irregular heartbeat. Results provide essential insight into electrolyte balance, hydration, and overall metabolic and organ health.

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Also Known As: Lytes Panel, Anion Gap Panel, Electrolyte Test, Lytes Test, Anion Gap Test

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The Estradiol (E2) Test measures levels of estradiol, the primary form of estrogen, to evaluate reproductive and hormonal health. It helps assess menstrual irregularities, fertility issues, menopause status, and estrogen-producing disorders. In men, it aids in diagnosing hormonal imbalances. Doctors use the estradiol test to monitor hormone therapy, ovarian function, and conditions affecting puberty, bone health, and overall endocrine balance.

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Also Known As: E2 Test, Estrogen 2 Test

The Estradiol and Estrone Test measures two primary forms of estrogen to assess hormonal balance, ovarian function, and endocrine health. Estradiol, the most active estrogen, and estrone, the predominant form after menopause, provide insight into reproductive health, fertility, and menopausal transition. This test aids in evaluating estrogen-related disorders, hormone therapy monitoring, and overall endocrine function.


Have you been experiencing fluctuations in weight, mood swings, hair loss, or insomnia? If so, it may be a hormone imbalance. 

Your endocrine system is responsible for producing hormones in your body. If your hormones are unbalanced, they can throw your whole body off. 

Metabolism, sexual function, reproduction, sleep, weight, and mood are all regulated by hormones. Keeping your endocrine system running well is essential. 

If you're feeling like there is something disrupting your hormones, it is important that you look into endocrine tests to find out what is actually going on. 

Let's look into this deeper.

What Are Endocrine Disorders?

Your endocrine system is one of the most important parts of your body. In simple terms, an endocrine disorder is when your endocrine system is malfunctioning, and a gland in the body isn't doing its job correctly. 

Diabetes is one of the most commonly known endocrine disorders. Thyroid diseases such as Hypothyroidism, Hyperthyroidism, Hashimoto's, Graves Disease, and Addison's Disease are more common than you might think. And then there are some diseases like Cushing's Syndrome, Prolactinoma, adrenal dysfunction, and Polycystic Ovary Syndrome that are much less talked about.

Your endocrine system needs to be running efficiently in order for all of your organs to work properly. With too much cortisol, you may find yourself in a constant state of "fight or flight." Too much testosterone can cause excessive hair growth, hair loss, and acne. The imbalance of your thyroid hormones can cause rapid weight gain with the inability to lose weight. 

Risk Factors & Causes

There are many internal and external factors that can increase your risk for endocrine system disorders. 

Externally, lack of nutrition, a poor diet, injury, sedentary lifestyle, and lack of exercise can have significant adverse effects on your endocrine system. 

Internally, infection, elevated cholesterol levels, tumors, and genetic disorders are common causes and risk factors. Personal history of autoimmune disease can also be a large risk factor for endocrine diseases and disorders. 

Women are far more likely to have an endocrine disorder than men, and menstruation and pregnancy are likely part of the reason. Pregnancy is known for throwing your hormones out of sync. 

Signs & Symptoms

Medical professionals often misread symptoms of endocrine disorders. Anxiety and depression are two of the main symptoms. If your doctor is only treating the symptom, the disorder itself could only get worse. 

Other signs and symptoms of endocrine disorders can also be commonly misdiagnosed. Unexplained weight changes, fatigue, insomnia, hair loss, constipation, excessive thirst, and heat or cold intolerance are all symptoms. 

If your doctor isn't taking your symptoms and concerns seriously, it is important to be your own advocate. Ulta Lab Tests makes this easy with the ability to order your own tests. 

Rare endocrine disorders can produce symptoms such as confusion, memory loss, low heart rate or blood pressure, and eye and vision problems. If you are experiencing any of these and it seems life-threatening, you should seek medical attention immediately. 

Endocrine Tests

When diagnosing, Endocrine Disorders tests are always needed. Endocrine Disorders tests will all look into the hormones in your body and making sure they are in the normal range.  

The Endocrine Advanced Panel includes the tests ordered most often to identify endocrine disorders. This Endocrine lab test panel contains 20 tests with 83 biomarkers used to identify a malfunctioning endocrine gland.

  • C-Reactive Protein (CRP)
  • CBC (includes Differential and Platelets)
  • Comprehensive Metabolic Panel (CMP)
  • Cortisol, A.M.
  • DHEA Sulfate, Immunoassay
  • Estradiol
  • FSH and LH
  • Hemoglobin A1c (HgbA1C)
  • IGF-I, LC/MS
  • Lipid Panel
  • Progesterone, Immunoassay
  • Prolactin
  • T3 Total
  • T3, Free
  • T4 (Thyroxine), Total
  • T4, Free
  • Testosterone, Free (Dialysis) and Total MS
  • TSH
  • Vitamin D, 25-Hydroxy, Total, Immunoassay
  • Vitamin B12 (Cobalamin) and Folate Panel, Serum

Once your doctor reviews your labs and can see which hormones are out of balance and which biomarkers are out of functional reference ranges, she can work towards a specific direction she thinks your diagnoses could go in and order more specific tests.

It is possible that your doctor will want to do ultrasounds on the gland they think is malfunctioning. Computerized tomography (CT) scans and Magnetic resonance imaging (MRI) will provide highly detailed scans for your doctor to help diagnose and treat your endocrine disorder. 

There are many tests for endocrine disorders, but the first step is to get initial blood tests done.  

FAQ About Endocrine Disorders & Tests

You may have a lot of questions concerning endocrine disorders and endocrine disorders tests. Here are some common questions. If you have any further questions, make an appointment to see a doctor. 

When Should I See My Doctor?

Any time you think your body isn't functioning correctly, you should see your doctor; however, if your doctor isn't as attentive or proactive as you would like, order tests from Ulta Lab Tests and be your own advocate. 

Is My Weight Gain Because of an Endocrine Disorder?

It is definitely possible that your weight is fluctuating because of an Endocrine Disorder. Make sure to mention this symptom to your doctor. 

What Tests Should I Order?

Start with Ulta Lab Tests Endocrine Advanced Panel This will cover most of the bases for any severe endocrine disorders. These 20 tests will give you 83 biomarkers, and the most common types of endocrine disorders will be able to be identified with these tests

Is My Endocrine Disorder Curable?

Technically, no, but they can be managed. Most Endocrine Disorders are something you will have to monitor for the rest of your life. If your hormones are unbalanced because of a cyst, tumor, or trauma, then it is possible that the disorder can be corrected. 

Lab Testing With Ulta Lab Tests

Ulta Lab Tests offers tests that are highly accurate and reliable, so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

Order your endocrine lab tests today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control of your health today with Ulta Lab Tests.

 The endocrine system is a network that is made up of different glands throughout the human body. The endocrine system and the nervous system work together to regulate and control many of the internal functions of the body. The nervous system makes use of nerve impulses as its means for control; the endocrine system utilizes hormones, which are chemical messenger molecules. These hormones are created, stored, as well as secreted by an integrated network of different glands. When endocrine glands release different hormones into the blood, they will target specific organs, tissues, or cells. Every target will have dedicated receptors for that specific hormone, which can be explained as a key that fits into a lock.  

This network is made up of several parts. One of these is the hypothalamus, which is the endocrine gland situated in the brain. Another includes the pituitary gland, located in its own dedicated place inside of the sella turcica, just under the hypothalamus. The signals sent by the brain instruct the hypothalamus to create many types of hormones that either inhibit or stimulate the pituitary. These are the signals that make the pituitary either decrease or increase the hormones that it produces, followed by releasing them into the blood. Hormones that the pituitary releases in different amounts will travel through the blood to the endocrine glands. Some of these glands include the ovaries and testicles, adrenal, and thyroid glands. Many other tissues and organs in the body are also classified as hormone targets.  

Many of the endocrine glands are governed by specific feedback systems to prevent hormone imbalance. An example of this includes the hypothalamus that first stimulates the pituitary gland, followed by the adrenal gland to regulate the way it functions. The hypothalamus will first release CRH (corticotropin-releasing hormone), which stimulates the pituitary gland into releasing corticotropin (commonly known as an adrenocorticotrophic hormone or ACTH). ACTH then stimulates the adrenal gland into producing cortisol. When cortisol levels reach a specific threshold, the pituitary and the hypothalamus glands start to lower ACTH and CRH production, which creates a feedback loop that is negative.  

Certain hormones, like cortisol, have a monthly or a daily pattern or sequence of release. Levels of cortisol are usually higher in the mornings and lower in the evenings. The pituitary hormone levels of FSH (follicle-stimulating hormone) and LH (luteinizing hormone) decrease and increase in a regular pattern, which regulates the monthly menstrual cycles in women. Other types of hormones in the blood are typically present in far smaller quantities, will release in specific types of situations. An example of this is when adrenaline (epinephrine) is released from the adrenal glands as a direct response to a stressful situation.  

This gland network and the endocrine system are, in most cases, interdependent, which means any type of disorder which affects one of these glands can cause diseases that are linked to the other glands present in this system. For example, disorders that affect the hypothalamus might also impact on the pituitary gland along with the “downstream” targeted organs. The endocrine syndromes are often categorized by the affected gland.  

Primary disorders will affect one of the target organs, such as the adrenal or thyroid glands.  

Secondary disorders directly affect glands that perform the function of regulating the target organs. This is most commonly the pituitary gland.  

Tertiary disorders are linked to the hypothalamus.  

The Common Causes of Endocrine Syndromes 

Hormones influence multiple systems in the body, which includes the development of female and male characteristics, growth, fertility, digestion, stress response, glucose utilization, energy consumption, water/fluid balance, maintaining the correct blood pressure, and bone metabolism. When the glands are producing too little or too much of a hormone, it can affect these natural processes. This is a condition that is more commonly known as hormonal imbalances. These conditions also go by certain names, like Cushing syndrome (linked with excess cortisol), as they are associated with typical sets of complications and symptoms.  

Endocrine gland dysfunction might occur when the actual gland has a problem, an issue with the feedback-system, or/and when the target tissues are failing to respond to the hormone. When hormone production decreases, it can relate to infections when the immune system is damaged, trauma, crowding of hormone-producing cells caused by the presence of a tumor. Other causes also arise from a gene mutation (inherited) that affects the quality, quantity, or the overall structure of the hormone. When these glands are failing to release or produce enough hormone amounts to stimulate a targeted gland into releasing and producing its hormone, it might also lower production.  

An increase in the production of a hormone can be associated with an imbalance with the feedback system. An example of this is when the pituitary produces an excess amount of ACTH, which will disrupt and interfere with the feedback-system. An increase in production can also be linked to enlarged glands (hyperplasia) or tumors of the cells that produce these hormones. It can also occur when the tissue response is lacking, the use of certain types of medications, or inherited conditions.  

The endocrine tumors which are responsible for producing too many hormones are typically benign and small. Many of these are situated inside the gland that is affected, and that gland only produces one specific hormone type. These tumors rarely become cancerous. It is also very rare that an endocrine-disrupting tumor will be situated anywhere else inside the body. The tumor itself may be responsible for causing symptoms due to the hormone levels that it produces, as its growth will eventually crowd out and lower the production of any other hormone in the affected gland. This is also caused by the size of the tumor that puts pressure on the surrounding structures and nerves.  

Many of the endocrine conditions that are inherited are typically rare and are typically linked to dysfunctional or deficient production associated with one hormone. Or with the hormone production of glands, such as congenital hypothyroidism. There are, however, a few genetic syndromes or conditions that will affect several glands. The two that are identified to affect many of the endocrine glands include MEN-1 and MEN-2. This stands for Multiple Endocrine Neoplasia, Type 1 and Type 2.  

These are the conditions that relate to an alteration in genes. They also increase the likelihood that the affected person will develop a tumor or tumors in one or many of the endocrine glands in their body.  

The common tests used to detect endocrine syndromes and disorders include: 

hCG Tumor Marker 

Catecholamines 

Antidiuretic Hormone (ADH) 

Plasma Free Metanephrines 

Urine Metanephrines