Endocrine Tests

Your endocrine system is a network of glands that release hormones to control energy, growth, mood, reproduction, and fluid balance. When hormones are too high or too low, you may notice fatigue, weight changes, irregular periods, hair/skin changes, or blood-pressure and glucose shifts.

Endocrine testing uses targeted blood and urine tests to evaluate these glands—thyroid, adrenals, pituitary, ovaries/testes, and parathyroids—and related systems. A proactive plan often begins with TSH and thyroid hormonesglucose/A1c, and electrolytes, then adds adrenal, pituitary, and reproductive markers based on symptoms. Some conditions need dynamic (stimulation/suppression) tests arranged by a clinician. Results guide screeningdiagnosis, and monitoring, but they do not replace an exam, imaging, or urgent care for severe symptoms.

Signs, Symptoms & Related Situations

  • Energy & metabolism: fatigue, weight gain or loss, cold/heat intolerance, hair thinning, dry skin

  • Blood pressure & fluids: dizziness on standing, salt craving, swelling, high or low BP

  • Glucose & lipids: thirst, frequent urination, cravings, high triglycerides

  • Reproductive & sexual health: irregular or heavy periods, fertility concerns, hot flashes, low libido, erectile issues

  • Mood & sleep: anxiety, depression, poor sleep, brain fog

  • Bone & muscle: cramps, weakness, fractures, height loss

  • When to seek urgent care: severe vomiting/diarrhea with low BP (possible adrenal crisis), chest pain, confusion, fainting, or stroke-like symptoms

Why These Tests Matter

What testing can do

  • Identify hormone excess or deficiency (thyroid, adrenal, reproductive, pituitary, parathyroid)

  • Triage causes of common symptoms like fatigue, weight change, and cycle irregularity

  • Provide baselines and trends to monitor treatment safety and progress

What testing cannot do

  • Prove a diagnosis from one result without clinical context

  • Replace imaging (e.g., ultrasound, MRI, DXA) or specialist procedures when indicated

  • Provide treatment or dosing advice—work with your clinician on next steps

What These Tests Measure (at a glance)

  • Thyroid: TSHFree T4Free T3; antibodies (TPOTgTRAb) for autoimmune patterns. High-dose biotin can interfere—follow hold instructions.

  • Adrenal (insufficiency/Cushing): 8 a.m. cortisolACTHcosyntropin (ACTH) stimulation for low/borderline cortisol; late-night salivary cortisol1-mg dexamethasone test, or 24-hr urinary free cortisol for suspected Cushing syndrome.

  • Mineralocorticoids & BP: Renin and Aldosterone for primary aldosteronismelectrolytes (Na/K/CO2) for safety and clues.

  • Catecholamines (select cases): Plasma or urine fractionated metanephrines for pheochromocytoma/paraganglioma when symptoms suggest.

  • Reproductive hormones (men): Total & Free TestosteroneSHBGLH/FSHprolactin.

  • Reproductive hormones (women): EstradiolProgesterone (cycle-timed), LH/FSHprolactinandrogens(total/free testosterone, DHEA-S)—useful for cycle issues or PCOS-type patterns.

  • Pituitary markers: ProlactinIGF-1 (growth-hormone axis) ± dynamic tests per clinician.

  • Calcium-bone axis: CalciumPTHVitamin D (25-OH)phosphatemagnesium.

  • Metabolic context: A1c/fasting glucose (± insulin/C-peptide), lipid panelCMP for liver/kidney function.

Quick Build Guide

Goal Start with Add if needed
General endocrine screen TSHA1c/GlucoseCMP/ElectrolytesVitamin D Lipids • CBC
Thyroid symptoms TSH + Free T4 Free T3 • TPO/Tg Ab • TRAb (hyperthyroid pattern)
Adrenal symptoms (fatigue/low BP) 8 a.m. Cortisol + ACTH + Electrolytes Cosyntropin test • Renin/Aldosterone (low K?/resistant HTN)
Possible Cushing syndrome Choose one: Late-night saliva cortisol (x2) • 1-mg DST • 24-hr UFC (x2) Morning ACTH to classify if confirmed
Women: cycle/PCOS/fertility TSHEstradiol/Progesterone (timed), LH/FSHProlactin Total/Free Testosterone, DHEA-S, 17-OH-Progesterone (per clinician)
Men: low libido/energy AM Total Testosterone Free T/SHBGLH/FSHProlactinTSH
Calcium/bone concerns Calcium + Vitamin D PTH, phosphate, magnesium
BP hard to control Electrolytes, Creatinine/eGFR Renin + Aldosterone (ARR) • Metanephrines (spells)

How the Testing Process Works

  1. Pick your starting panel based on symptoms (see Quick Build).

  2. Prepare for accuracy: follow fasting or timing notes; some tests require morning draws or cycle-timed collection. List medications (steroids, oral estrogen, thyroid pills) and biotin supplements.

  3. Get your draw/collection: visit a nearby patient service center; some tests use saliva or 24-hour urine.

  4. Review results securely: discuss with your clinician; add confirmatory dynamic tests only when needed.

  5. Set a follow-up cadence: recheck on a schedule that matches your goals and care plan.

Interpreting Results (General Guidance)

  • Use trends, not single values; compare to your baseline and symptoms.

  • Some results vary with time of day, cycle phase, meds, and illness (e.g., cortisol peaks in the morning; estradiol/progesterone are cycle-dependent).

  • Borderline results often need repeat or dynamic testing.
    Always interpret labs with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Broad checkup: a mini endocrine bundle—TSH, A1c/glucose, CMP/electrolytes, Vitamin D—then add by symptom.

  • Targeted follow-up: choose one or two high-yield markers (e.g., Free T4 with abnormal TSH; AM total testosterone with symptoms).

  • Complex questions: combine core labs with a clinician-ordered stimulation/suppression test (cosyntropin, dexamethasone, OGTT-based GH testing).

FAQs

Do I need to fast?
Fasting is usually needed for glucose/insulin and sometimes for lipids. Most hormone tests don’t require fasting—follow your order.

When should I test testosterone or cortisol?
Test testosterone in the morning. Screen cortisol around 8 a.m. unless using late-night saliva for Cushing screening.

Can biotin or estrogen affect results?
Yes. Biotin can distort some immunoassays; oral estrogen raises cortisol-binding proteins. Follow any hold instructions and list your meds.

How are women’s hormone tests timed?
Estradiol/progesterone are cycle-dependent. Your clinician may request specific cycle days.

What if my results are borderline?
Repeat testing or a dynamic test may be needed. One value rarely tells the whole story.

Can I order dynamic tests myself?
Stimulation/suppression tests usually require clinician oversight for safety and accurate interpretation.

Related Categories & Key Tests

  • Upward: Hormone Tests Hub

  • Sideways: Thyroid Testing • Adrenal Insufficiency & Addison Disease • Cushing Syndrome • Men’s Hormones • Women’s Hormones & PCOS • Diabetes & Insulin Resistance • Calcium & Bone Health

  • Key Tests (downward): TSH • Free T4/Free T3 • TPO/Tg/TRAb Antibodies • AM Cortisol • ACTH • Cosyntropin Test • Late-Night Saliva Cortisol • 1-mg DST • 24-hr Urinary Free Cortisol • Renin & Aldosterone • Plasma/Urine Metanephrines • Total/Free Testosterone & SHBG • Estradiol • Progesterone • LH/FSH • Prolactin • IGF-1 • PTH • Calcium • Vitamin D • A1c/Glucose • CMP/Electrolytes

References

  • Endocrine Society — Clinical practice guidelines on thyroid disease, adrenal insufficiency, Cushing syndrome, and hypogonadism.
  • American Thyroid Association — Thyroid testing and antibody guidance.
  • American Association of Clinical Endocrinology — Endocrine testing best practices.
  • Pituitary Society — Evaluation of pituitary disorders and prolactinomas.
  • American Diabetes Association — Standards of Care in Diabetes (A1c/glucose testing).
  • National Osteoporosis Foundation — Calcium, vitamin D, and bone-health guidance.
  • Endocrine Disorders and Lab Testing - What You Need to Know

Available Tests & Panels

Your Endocrine Tests menu is pre-populated in the Ulta Lab Tests system. Start with a core set (TSH, A1c/glucose, CMP/electrolytes, Vitamin D), then add adrenal, pituitary, reproductive, or calcium-bone markers to match your symptoms. Follow any timing/fasting instructions and review results with your clinician to decide on confirmatory testing and follow-up.

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The Estriol (E3) Test checks blood levels of estriol, an estrogen hormone important in pregnancy. It is commonly included in the second-trimester triple or quad screen to detect chromosomal disorders such as Down syndrome and assess placental function. Estriol testing helps monitor fetal growth and maternal hormone health. Low or abnormal levels may signal pregnancy complications, guiding further testing and prenatal care decisions.

Blood
Blood Draw
Also Known As: E3 Test, Estrogen 3 Test

Most Popular

The Estrone (E1) Test measures estrone, one of the three main estrogen hormones, to assess reproductive and hormonal health. It helps evaluate ovarian function, menstrual irregularities, menopause status, and estrogen-related disorders. In men, estrone testing may detect hormonal imbalances or excess estrogen. Doctors use this test to monitor hormone therapy, fertility treatments, and conditions affecting bone health, metabolism, and overall endocrine balance.

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Blood Draw
Also Known As: E1 Test, Estrogen 1 Test

Most Popular

The Follicle-Stimulating Hormone (FSH) Test measures FSH levels to evaluate reproductive and endocrine health in both men and women. In women, it helps assess infertility, irregular periods, menopause, or ovarian function. In men, it is used to check sperm production and testicular function. Abnormal results may indicate PCOS, pituitary disorders, or hormonal imbalance. Doctors order this test to guide fertility treatment, hormone therapy, and overall reproductive care.

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Blood Draw
Also Known As: Follicle Stimulating Hormone Test, Follitropin Test

Most Popular

The Glucose-6-Phosphate Dehydrogenase (G6PD) Test measures enzyme activity to detect G6PD deficiency, a genetic condition that can lead to hemolytic anemia when exposed to certain foods, infections, or medications. Doctors order this test to assess unexplained anemia, jaundice, or family history of G6PD deficiency. Results help identify individuals at risk for red blood cell breakdown, guiding treatment, prevention, and safe medication use.

Blood
Blood Draw
Also Known As: Glucose-6-Phosphate Dehydrogenase Test, G6PD Enzyme Test, G6PD Deficiency Test

The Glutamic Acid Decarboxylase-65 (GAD65) Antibody Test detects antibodies against the GAD65 enzyme, often linked to autoimmune type 1 diabetes and latent autoimmune diabetes in adults (LADA). Positive results indicate immune-related damage to insulin-producing beta cells. Doctors use this test to distinguish type 1 from type 2 diabetes, evaluate unexplained hyperglycemia, and assess risk in patients with suspected autoimmune endocrine disorders.

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Blood Draw
Also Known As: GAD-65 Test

The Growth Hormone Test with 10 specimens measures hormone levels at ten collection times to evaluate pituitary gland function and hormone regulation. Monitoring growth hormone patterns throughout the day helps detect growth disorders, short stature, gigantism, acromegaly, and deficiency, while supporting assessment of metabolism, bone health, tissue repair, and overall endocrine system balance.

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Blood Draw

The Growth Hormone Test with 2 specimens measures growth hormone levels at two collection times to evaluate pituitary gland function and hormone regulation. Tracking these changes helps assess growth disorders, short stature, gigantism, or acromegaly, while providing insight into metabolic balance, bone development, and overall endocrine system health.

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Blood Draw

The Growth Hormone Test with 3 specimens measures hormone levels at three collection times to evaluate pituitary gland function and overall hormone regulation. Tracking growth hormone across intervals provides insight into growth disorders, short stature, gigantism, and acromegaly, while supporting assessment of metabolism, bone development, tissue repair, and endocrine health.

Blood
Blood Draw

The Growth Hormone Test with 4 specimens measures hormone levels at four collection times to evaluate pituitary gland function and hormone regulation. Monitoring growth hormone changes helps detect growth disorders, short stature, gigantism, and acromegaly, while providing insight into metabolism, bone development, tissue repair, and overall endocrine health.

Blood
Blood Draw

The Growth Hormone Test with 5 specimens measures hormone levels at five collection times to evaluate pituitary gland function and hormone regulation. Tracking growth hormone across the day provides insight into growth disorders, short stature, gigantism, acromegaly, and hormone deficiency, while supporting assessment of metabolism, tissue repair, bone health, and overall endocrine balance.

Blood
Blood Draw

The Growth Hormone Test with 6 specimens measures hormone levels at six collection times to evaluate pituitary gland function and hormone regulation. Monitoring growth hormone patterns provides insight into growth disorders, short stature, gigantism, acromegaly, and deficiency, while supporting assessment of metabolism, tissue repair, bone development, and overall endocrine balance.

Blood
Blood Draw

The Growth Hormone Test with 7 specimens measures hormone levels at seven collection times to evaluate pituitary gland function and hormone balance. Monitoring growth hormone throughout the day helps assess growth disorders, short stature, gigantism, acromegaly, and deficiency, while supporting evaluation of metabolism, bone health, tissue repair, and overall endocrine system regulation.

Blood
Blood Draw

The Growth Hormone Test with 8 specimens measures hormone levels at eight collection times to evaluate pituitary gland function and hormone regulation. Tracking growth hormone patterns across the day helps assess growth disorders, short stature, gigantism, acromegaly, and deficiency, while providing insight into metabolism, bone health, tissue repair, and overall endocrine system balance.

Blood
Blood Draw

The Growth Hormone Test with 9 specimens measures hormone levels at nine collection times to evaluate pituitary gland function and hormone balance. Monitoring growth hormone patterns throughout the day helps detect growth disorders, short stature, gigantism, acromegaly, and deficiency, while providing insight into metabolism, bone development, tissue repair, and overall endocrine system health.

Blood
Blood Draw

The Hemoglobin and Hematocrit Test measures hemoglobin levels and the percentage of red blood cells in blood to assess oxygen-carrying capacity. Low values may indicate anemia, blood loss, or nutritional deficiencies, while high levels may suggest dehydration, lung disease, or polycythemia. Doctors use this test to investigate fatigue, weakness, or shortness of breath. Results provide vital insight into red blood cell health, oxygen delivery, and overall hematologic function.

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Blood Draw
Also Known As: HCT Test, Crit Test, Hgb Test

The Inhibin B Test evaluates inhibin B concentration in blood to help assess reproductive health in both men and women. In women, it is used as an indicator of ovarian reserve, follicular function, and fertility potential, while in men, it reflects Sertoli cell activity, spermatogenesis, and testicular health. This test aids in understanding hormonal balance, fertility disorders, and reproductive system function.

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Most Popular

The Leptin Test measures leptin hormone levels in blood to evaluate metabolism, appetite regulation, and body fat balance. Abnormal levels may indicate obesity, metabolic syndrome, insulin resistance, or leptin deficiency. Doctors use this test to assess unexplained weight gain, difficulty losing weight, or potential endocrine disorders. It also supports research on energy balance, fertility, and overall metabolic health management.

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Blood Draw

Most Popular

The Lipase Test measures levels of lipase, an enzyme made by the pancreas that helps digest fats. Elevated lipase may indicate acute or chronic pancreatitis, pancreatic cancer, gallbladder disease, kidney failure, or bowel obstruction. Doctors order this test to investigate severe abdominal pain, nausea, or vomiting and to monitor pancreatic disorders. Results provide vital insight into digestive health, pancreatic function, and overall gastrointestinal balance.

Blood
Blood Draw
Also Known As: LPS Test

The Metanephrines Fractionated Free Plasma Test measures free metanephrine and normetanephrine levels to evaluate adrenal gland function and catecholamine metabolism. Elevated concentrations may indicate pheochromocytoma, paraganglioma, or other endocrine tumors. Providers use this test to investigate unexplained hypertension, palpitations, headaches, or symptoms linked to excess catecholamine production.

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Blood Draw

The Metanephrines Fractionated 24 Hour Urine Test measures breakdown products of catecholamines, including normetanephrine and metanephrine, to help detect pheochromocytoma and paraganglioma. By analyzing hormone metabolites over a full day, it offers valuable insights into adrenal gland activity, sympathetic nervous system function, and unexplained symptoms such as hypertension, headaches, and palpitations.

Urine
Urine Collection

The Metanephrines Fractionated Random Urine Test measures metanephrine and normetanephrine levels, metabolites of catecholamines that reflect adrenal gland activity. Elevated values may indicate pheochromocytoma or paraganglioma, rare tumors producing excess catecholamines. This test aids in evaluating unexplained hypertension, palpitations, or episodes of sweating, offering clinical insight into adrenal function and neuroendocrine health.

Urine
Urine Collection
Also Known As: Random Urine Metanephrines Fractionated Test

The Norepinephrine Plasma Test measures plasma norepinephrine, a catecholamine that regulates blood pressure, stress response, and cardiovascular function. Elevated levels may indicate pheochromocytoma, paraganglioma, or autonomic dysfunction, while low levels can reflect neuropathy or adrenal insufficiency. This test helps evaluate unexplained hypertension, tachycardia, or other symptoms tied to catecholamine imbalance.

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Blood Draw

The Comprehensive Organic Acids Quantitative Urine Test analyzes a broad spectrum of metabolites—organic acids—in urine to assess metabolic pathway function. By quantifying markers of detoxification, mitochondrial energy, and microbial metabolism, this test can help detect inborn errors, mitochondrial dysfunction, or dysbiosis.

Urine
Urine Collection
Also Known As: Organic Acids, Comprehensive, Quantitative, Urine Test

The Pancreastatin Test measures blood levels of pancreastatin, a peptide derived from chromogranin A that regulates insulin and metabolism. Elevated levels may be associated with neuroendocrine tumors, impaired glucose tolerance, or metabolic dysfunction. This test aids in evaluating hormone secretion, monitoring tumor activity, and assessing metabolic disturbances linked to pancreatic and gastrointestinal disorders.

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Blood Draw

The Pancreatic Polypeptide Test measures pancreatic polypeptide levels in blood to evaluate pancreatic endocrine function. Elevated results may occur with pancreatic tumors, endocrine disorders, or autonomic nervous system dysfunction. This test helps assess abnormal hormone secretion, monitor suspected neuroendocrine tumors, and provide clinical insight into metabolic and gastrointestinal regulation.

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Blood Draw

Have you been experiencing fluctuations in weight, mood swings, hair loss, or insomnia? If so, it may be a hormone imbalance. 

Your endocrine system is responsible for producing hormones in your body. If your hormones are unbalanced, they can throw your whole body off. 

Metabolism, sexual function, reproduction, sleep, weight, and mood are all regulated by hormones. Keeping your endocrine system running well is essential. 

If you're feeling like there is something disrupting your hormones, it is important that you look into endocrine tests to find out what is actually going on. 

Let's look into this deeper.

What Are Endocrine Disorders?

Your endocrine system is one of the most important parts of your body. In simple terms, an endocrine disorder is when your endocrine system is malfunctioning, and a gland in the body isn't doing its job correctly. 

Diabetes is one of the most commonly known endocrine disorders. Thyroid diseases such as Hypothyroidism, Hyperthyroidism, Hashimoto's, Graves Disease, and Addison's Disease are more common than you might think. And then there are some diseases like Cushing's Syndrome, Prolactinoma, adrenal dysfunction, and Polycystic Ovary Syndrome that are much less talked about.

Your endocrine system needs to be running efficiently in order for all of your organs to work properly. With too much cortisol, you may find yourself in a constant state of "fight or flight." Too much testosterone can cause excessive hair growth, hair loss, and acne. The imbalance of your thyroid hormones can cause rapid weight gain with the inability to lose weight. 

Risk Factors & Causes

There are many internal and external factors that can increase your risk for endocrine system disorders. 

Externally, lack of nutrition, a poor diet, injury, sedentary lifestyle, and lack of exercise can have significant adverse effects on your endocrine system. 

Internally, infection, elevated cholesterol levels, tumors, and genetic disorders are common causes and risk factors. Personal history of autoimmune disease can also be a large risk factor for endocrine diseases and disorders. 

Women are far more likely to have an endocrine disorder than men, and menstruation and pregnancy are likely part of the reason. Pregnancy is known for throwing your hormones out of sync. 

Signs & Symptoms

Medical professionals often misread symptoms of endocrine disorders. Anxiety and depression are two of the main symptoms. If your doctor is only treating the symptom, the disorder itself could only get worse. 

Other signs and symptoms of endocrine disorders can also be commonly misdiagnosed. Unexplained weight changes, fatigue, insomnia, hair loss, constipation, excessive thirst, and heat or cold intolerance are all symptoms. 

If your doctor isn't taking your symptoms and concerns seriously, it is important to be your own advocate. Ulta Lab Tests makes this easy with the ability to order your own tests. 

Rare endocrine disorders can produce symptoms such as confusion, memory loss, low heart rate or blood pressure, and eye and vision problems. If you are experiencing any of these and it seems life-threatening, you should seek medical attention immediately. 

Endocrine Tests

When diagnosing, Endocrine Disorders tests are always needed. Endocrine Disorders tests will all look into the hormones in your body and making sure they are in the normal range.  

The Endocrine Advanced Panel includes the tests ordered most often to identify endocrine disorders. This Endocrine lab test panel contains 20 tests with 83 biomarkers used to identify a malfunctioning endocrine gland.

  • C-Reactive Protein (CRP)
  • CBC (includes Differential and Platelets)
  • Comprehensive Metabolic Panel (CMP)
  • Cortisol, A.M.
  • DHEA Sulfate, Immunoassay
  • Estradiol
  • FSH and LH
  • Hemoglobin A1c (HgbA1C)
  • IGF-I, LC/MS
  • Lipid Panel
  • Progesterone, Immunoassay
  • Prolactin
  • T3 Total
  • T3, Free
  • T4 (Thyroxine), Total
  • T4, Free
  • Testosterone, Free (Dialysis) and Total MS
  • TSH
  • Vitamin D, 25-Hydroxy, Total, Immunoassay
  • Vitamin B12 (Cobalamin) and Folate Panel, Serum

Once your doctor reviews your labs and can see which hormones are out of balance and which biomarkers are out of functional reference ranges, she can work towards a specific direction she thinks your diagnoses could go in and order more specific tests.

It is possible that your doctor will want to do ultrasounds on the gland they think is malfunctioning. Computerized tomography (CT) scans and Magnetic resonance imaging (MRI) will provide highly detailed scans for your doctor to help diagnose and treat your endocrine disorder. 

There are many tests for endocrine disorders, but the first step is to get initial blood tests done.  

FAQ About Endocrine Disorders & Tests

You may have a lot of questions concerning endocrine disorders and endocrine disorders tests. Here are some common questions. If you have any further questions, make an appointment to see a doctor. 

When Should I See My Doctor?

Any time you think your body isn't functioning correctly, you should see your doctor; however, if your doctor isn't as attentive or proactive as you would like, order tests from Ulta Lab Tests and be your own advocate. 

Is My Weight Gain Because of an Endocrine Disorder?

It is definitely possible that your weight is fluctuating because of an Endocrine Disorder. Make sure to mention this symptom to your doctor. 

What Tests Should I Order?

Start with Ulta Lab Tests Endocrine Advanced Panel This will cover most of the bases for any severe endocrine disorders. These 20 tests will give you 83 biomarkers, and the most common types of endocrine disorders will be able to be identified with these tests

Is My Endocrine Disorder Curable?

Technically, no, but they can be managed. Most Endocrine Disorders are something you will have to monitor for the rest of your life. If your hormones are unbalanced because of a cyst, tumor, or trauma, then it is possible that the disorder can be corrected. 

Lab Testing With Ulta Lab Tests

Ulta Lab Tests offers tests that are highly accurate and reliable, so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

Order your endocrine lab tests today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control of your health today with Ulta Lab Tests.

 The endocrine system is a network that is made up of different glands throughout the human body. The endocrine system and the nervous system work together to regulate and control many of the internal functions of the body. The nervous system makes use of nerve impulses as its means for control; the endocrine system utilizes hormones, which are chemical messenger molecules. These hormones are created, stored, as well as secreted by an integrated network of different glands. When endocrine glands release different hormones into the blood, they will target specific organs, tissues, or cells. Every target will have dedicated receptors for that specific hormone, which can be explained as a key that fits into a lock.  

This network is made up of several parts. One of these is the hypothalamus, which is the endocrine gland situated in the brain. Another includes the pituitary gland, located in its own dedicated place inside of the sella turcica, just under the hypothalamus. The signals sent by the brain instruct the hypothalamus to create many types of hormones that either inhibit or stimulate the pituitary. These are the signals that make the pituitary either decrease or increase the hormones that it produces, followed by releasing them into the blood. Hormones that the pituitary releases in different amounts will travel through the blood to the endocrine glands. Some of these glands include the ovaries and testicles, adrenal, and thyroid glands. Many other tissues and organs in the body are also classified as hormone targets.  

Many of the endocrine glands are governed by specific feedback systems to prevent hormone imbalance. An example of this includes the hypothalamus that first stimulates the pituitary gland, followed by the adrenal gland to regulate the way it functions. The hypothalamus will first release CRH (corticotropin-releasing hormone), which stimulates the pituitary gland into releasing corticotropin (commonly known as an adrenocorticotrophic hormone or ACTH). ACTH then stimulates the adrenal gland into producing cortisol. When cortisol levels reach a specific threshold, the pituitary and the hypothalamus glands start to lower ACTH and CRH production, which creates a feedback loop that is negative.  

Certain hormones, like cortisol, have a monthly or a daily pattern or sequence of release. Levels of cortisol are usually higher in the mornings and lower in the evenings. The pituitary hormone levels of FSH (follicle-stimulating hormone) and LH (luteinizing hormone) decrease and increase in a regular pattern, which regulates the monthly menstrual cycles in women. Other types of hormones in the blood are typically present in far smaller quantities, will release in specific types of situations. An example of this is when adrenaline (epinephrine) is released from the adrenal glands as a direct response to a stressful situation.  

This gland network and the endocrine system are, in most cases, interdependent, which means any type of disorder which affects one of these glands can cause diseases that are linked to the other glands present in this system. For example, disorders that affect the hypothalamus might also impact on the pituitary gland along with the “downstream” targeted organs. The endocrine syndromes are often categorized by the affected gland.  

Primary disorders will affect one of the target organs, such as the adrenal or thyroid glands.  

Secondary disorders directly affect glands that perform the function of regulating the target organs. This is most commonly the pituitary gland.  

Tertiary disorders are linked to the hypothalamus.  

The Common Causes of Endocrine Syndromes 

Hormones influence multiple systems in the body, which includes the development of female and male characteristics, growth, fertility, digestion, stress response, glucose utilization, energy consumption, water/fluid balance, maintaining the correct blood pressure, and bone metabolism. When the glands are producing too little or too much of a hormone, it can affect these natural processes. This is a condition that is more commonly known as hormonal imbalances. These conditions also go by certain names, like Cushing syndrome (linked with excess cortisol), as they are associated with typical sets of complications and symptoms.  

Endocrine gland dysfunction might occur when the actual gland has a problem, an issue with the feedback-system, or/and when the target tissues are failing to respond to the hormone. When hormone production decreases, it can relate to infections when the immune system is damaged, trauma, crowding of hormone-producing cells caused by the presence of a tumor. Other causes also arise from a gene mutation (inherited) that affects the quality, quantity, or the overall structure of the hormone. When these glands are failing to release or produce enough hormone amounts to stimulate a targeted gland into releasing and producing its hormone, it might also lower production.  

An increase in the production of a hormone can be associated with an imbalance with the feedback system. An example of this is when the pituitary produces an excess amount of ACTH, which will disrupt and interfere with the feedback-system. An increase in production can also be linked to enlarged glands (hyperplasia) or tumors of the cells that produce these hormones. It can also occur when the tissue response is lacking, the use of certain types of medications, or inherited conditions.  

The endocrine tumors which are responsible for producing too many hormones are typically benign and small. Many of these are situated inside the gland that is affected, and that gland only produces one specific hormone type. These tumors rarely become cancerous. It is also very rare that an endocrine-disrupting tumor will be situated anywhere else inside the body. The tumor itself may be responsible for causing symptoms due to the hormone levels that it produces, as its growth will eventually crowd out and lower the production of any other hormone in the affected gland. This is also caused by the size of the tumor that puts pressure on the surrounding structures and nerves.  

Many of the endocrine conditions that are inherited are typically rare and are typically linked to dysfunctional or deficient production associated with one hormone. Or with the hormone production of glands, such as congenital hypothyroidism. There are, however, a few genetic syndromes or conditions that will affect several glands. The two that are identified to affect many of the endocrine glands include MEN-1 and MEN-2. This stands for Multiple Endocrine Neoplasia, Type 1 and Type 2.  

These are the conditions that relate to an alteration in genes. They also increase the likelihood that the affected person will develop a tumor or tumors in one or many of the endocrine glands in their body.  

The common tests used to detect endocrine syndromes and disorders include: 

hCG Tumor Marker 

Catecholamines 

Antidiuretic Hormone (ADH) 

Plasma Free Metanephrines 

Urine Metanephrines