Vasculitis

Are you suffering from a chronic illness?

Order a vasculitis blood test to evaluate if you have inflammation and damage to your blood vessels.

If so, you might be wondering if it’s time to get tested for vasculitis. Vasculitis is an inflammation of blood vessels that can affect the kidneys and other organs in your body. It can also cause damage to large arteries or veins.

If you’re experiencing any of the following, a vasculitis blood test may be able to help diagnose your condition. Symptoms include fatigue, weight loss, fever, joint pain, and skin rashes. Some people also experience abdominal pain or nausea with vomiting and diarrhea. If you’ve been diagnosed with an autoimmune disease such as lupus or rheumatoid arthritis, then this test is recommended for further evaluation of your condition.

Testing for vasculitis with blood tests will give you information about red cells in your body that are called erythrocytes (red blood cells), which carry oxygen throughout the body to every cell. The number of red cells in our bodies is important because if they decrease too much, it can lead to anemia (low red cell count). You can also look at the white cells in our bodies called leukocytes (white blood cells) which fight infection by destroying bacteria and viruses that enter our bodies through cuts or other injuries. You can also measure these levels using a complete Blood Count Test panel that includes results for hemoglobin level, hematocrit level, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), platelet count, and white cell differential counts, among others so you can get the information needed to understand it what might be. The ANCA test is used to help diagnose vasculitis. It can also be helpful in differentiating between Wegener’s granulomatosis and microscopic polyangiitis, two types of vasculitis that are very similar. This test measures the level of anti-neutrophil cytoplasmic antibodies (ANCA) in your blood. If these antibodies are found at high levels, it may indicate an autoimmune disorder called systemic necrotizing vasculitides or small vessel vasculitides. These diseases cause inflammation and damage to the smallest blood vessels throughout your body, which can lead to serious complications if not treated properly.

If you suspect you have vasculitis, order a vasculitis blood test today! Ulta Lab Tests provides affordable lab testing services with quick results and excellent customer service. You can order your blood test for vasculitis today from Ulta Lab Tests!

Order the right vasculitis blood tests from the list of tests below.

Click here for additional information on Lab Tests for Vasculitis.


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A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia, and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)

NOTE: Only measurable biomarkers will be reported.

Reflex Parameters for Manual Slide Review
  Less than  Greater Than 
WBC  1.5 x 10^3  30.0 x 10^3 
Hemoglobin  7.0 g/dL  19.0 g/dL 
Hematocrit  None  75%
Platelet  100 x 10^3  800 x 10^3 
MCV  70 fL  115 fL 
MCH  22 pg  37 pg 
MCHC  29 g/dL  36.5 g/dL 
RBC  None  8.00 x 10^6 
RDW  None  21.5
Relative Neutrophil %  1% or ABNC <500  None 
Relative Lymphocyte %  1% 70%
Relative Monocyte %  None  25%
Eosinophil  None  35%
Basophil  None  3.50%
     
Platelet  <75 with no flags,
>100 and <130 with platelet clump flag present,
>1000 
Instrument Flags Variant lymphs, blasts,
immature neutrophils,  nRBC’s, abnormal platelets,
giant platelets, potential interference
     
The automated differential averages 6000+ cells. If none of the above parameters are met, the results are released without manual review.
CBC Reflex Pathway

Step 1 - The slide review is performed by qualified Laboratory staff and includes:

  • Confirmation of differential percentages
  • WBC and platelet estimates, when needed
  • Full review of RBC morphology
  • Comments for toxic changes, RBC inclusions, abnormal lymphs, and other
  • significant findings
  • If the differential percentages agree with the automated counts and no abnormal cells are seen, the automated differential is reported with appropriate comments

Step 2 - The slide review is performed by qualified Laboratory staff and includes: If any of the following are seen on the slide review, Laboratory staff will perform a manual differential:

  • Immature, abnormal, or toxic cells
  • nRBC’s
  • Disagreement with automated differential
  • Atypical/abnormal RBC morphology
  • Any RBC inclusions

Step 3 If any of the following are seen on the manual differential, a Pathologist will review the slide:

  • WBC<1,500 with abnormal cells noted
  • Blasts/immature cells, hairy cell lymphs, or megakaryocytes
  • New abnormal lymphocytes or monocytes
  • Variant or atypical lymphs >15%
  • Blood parasites
  • RBC morphology with 3+ spherocytes, RBC inclusions, suspect Hgb-C,
  • crystals, Pappenheimer bodies or bizarre morphology
  • nRBC’s

Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.

Comprehensive Metabolic Panel


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Serum creatinine is useful in the evaluation of kidney function and in monitoring renal dialysis. A serum creatinine result within the reference range does not rule out renal function impairment: serum creatinine is not sensitive to early renal damage since it varies with age, gender and ethnic background. The impact of these variables can be reduced by an estimation of the glomerular filtration rate using an equation that includes serum creatinine, age and gender.

Useful in differentiating inflammatory and neoplastic diseases and as an index of disease severity. CRP is also useful in monitoring inflammatory disease states.

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Dipstick urinalysis is important in accessing the chemical constituents in the urine and the relationship to various disease states. Microscopic examination helps to detect the presence of cells and other formed elements.

NOTE: Only measurable biomarkers will be reported.


Decreased C3 and C4 levels may be associated with acute glomerulonephritis, membranoproliferative glomerulonephritis, immune complex disease, active systemic lupus erythematosis, cryoglobulinemia, congenital C4 deficiency and generalized autoimmune disease

Decreased C3 may be associated with acute glomerulonephritis, membranoproliferative glomerulonephritis, immune complex disease, active systemic lupus erythematosis, and generalized autoimmune processes.

Decreased C4 level is associated with acute systemic lupus erythematosis, glomerulonephritis, immune complex disease, cryoglobulinemia, congenital C4 deficiency and generalized autoimmune disease

CH50 is a screening test for total complement activity. Levels of complement may be depressed in genetic deficiency, liver disease, chronic glomerulonephritis, rheumatoid arthritis, hemolytic anemias, graft rejection, systemic lupus erythematosis, acute glomerulonephritis, subacute bacterial endocarditis and cryoglobulinemia. Elevated complement may be found in acute inflammatory conditions, leukemia, Hodgkin's Disease, sarcoma, and Behcet's Disease.

Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases (e.g., crescentic glomerulonephritis, microscopic polyarteritis and Churg-Strauss syndrome), bowel disease (Crohn's Disease, ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis) as well as with other autoimmune diseases (drug-induced lupus, SLE, Felty's syndrome). ANCA has classically been divided into C-ANCA and P-ANCA depending on the immunofluorescent pattern observed. More recently the specific antigens responsible for these patterns have been described and isolated. The antigen that gives the C-ANCA pattern is proteinase-3 (PR-3). Multiple antigens are responsible for P-ANCA pattern, the principle antigen being myeloperoxidase (MPO). Patients with vascular diseases will generally have either a C-ANCA pattern or P-ANCA pattern, and give positive results in specific tests for PR-3 or MPO. Patients with bowel disease have been shown to have antibodies that give a P-ANCA or C-ANCA pattern. These antibodies however, may not be directed towards MPO. Patients with drug induced lupus, etc., often present with a P-ANCA pattern that is associated with antibodies against MPO.

Includes

  • ANA Screen,IFA, with Reflex to Titer and Pattern
  • DNA (ds) Antibodies
  • Scleroderma Antibodies (SCL-70)
  • Sm and Sm/RNP Antibodies
  • Sjogren's Antibodies (SSA, SSB)

If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge - $13.00

 


Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. 

Reflex Information: If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge.


Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases, inflammatory bowel disease, as well as other autoimmune diseases.

Additional test processing fees will be charged if initial results dictate Reflex (further) testing.


Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA and/or atypical P-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases, inflammatory bowel disease, as well as other autoimmune diseases.

Reference Range(s)

  • ADMA (Asymmetric dimethylarginine)<100 ng/mL 
  • SDMA (Symmetric dimethylarginine)73-135 ng/mL

Clinical Significance

ADMA and SDMA may be measured in individuals with multiple risk factors for the development of cardiovascular disease


This test is useful in evaluating patients presenting with sarcoidosis, Gaucher's disease and lymphoangiomyomatosis in that the enzyme is increased in these clinical settings.

This assay is intended for the qualitative determination of angiotensin converting enzyme gene insertion/deletion polymorphism and should be performed on the people who are at risk for coronary events and restenosis after precutaneous transluminal coronary angioplasty.

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than Cardiolipin Antibody that may express reactivity in patients with syphilis and other infectious diseases

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Cardio IQ® Myeloperoxidase (MPO)

Clinical Significance

Myeloperoxidase testing may be used for individuals with multiple risk factors for cardiovascular disease, or those with established disease.

The test was developed and its performance characteristics determined by Cleveland HeartLab, Inc. 

Performing Laboratory 

Cleveland HeartLab, Inc 

6701 Carnegie Avenue, Suite 500

Cleveland, OH 44103-4623

 


Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.


Vasculitis is a term that is used to describe a group of conditions characterized by inflamed blood vessels. If there is not a clear, obvious cause for the condition, then it is typically referred to as primary vasculitis. When there is a cause, it is called secondary vasculitis. There are a lot of things that can cause secondary vasculitis, such as allergic reactions to medication, infection with hepatitis C, auto-immune diseases such as rheumatoid arthritis, and even complications related to lymphoma or leukemia. 

Vasculitis can affect veins, arteries, and capillaries, resulting in narrowed vessels that limit the circulation of blood and can cause tissue or organ damage. A weakened vessel can lead to an aneurysm, which may, in turn, cause life-threatening internal bleeding. 

There are a lot of different kinds of vasculitis, and they are classified based on the size and type of the blood vessel affected. Understanding the different types and they’re sometimes confusing or nebulous symptoms is important for recognizing the condition so that people can get appropriate treatment. 

The Types of Vasculitis and their Symptoms 

Vasculitis is a systemic illness. This means that symptoms can often be non-specific. Some of the most common symptoms are easily confused with other diseases that cause inflammation, for example: 

  • Loss of appetite 
  • Fatigue 
  • Weight loss 
  • Aches and pains 
  • Fever 

The symptoms might come on suddenly or could gradually surface over a period of several months. The order of onset, presentation, and type of symptoms can vary massively. Some people experience localized symptoms specific to the type of vasculitis that they are suffering from, and this can help to characterize the condition more clearly in some cases, but not everyone’s condition results in the same symptoms, so diagnosis is not easy. 

Laboratory Test

Complete Blood Count (CBC) testing is a test that checks the red blood cells and hemoglobin and can help to diagnose anemia. It also looks at the white blood cell count, which may be increased if someone has an infection, or reduced if they have had treatments that may weaken the immune system. Some types of vasculitis can cause increased white blood cell counts. One example is Eosinophilic Granulomatosis with Polyangiitis (EGPA). 

C-reactive protein (CRP) testing can identify cases of inflammation within the body. 

Erythrocyte sedimentation rate (ESR) testing is another test that can detect inflammation, and it can identify certain types of vasculitis,  with this test also detects the presence of inflammation and can be increased in several types of vasculitis, such as microscopic polyangiitis and granulomatosis with polyangiitis being one example. 

Creatinine testing is used to assess the functioning of the kidneys. Reduced kidney function is sometimes present in vasculitis. 

Liver panels help to determine if liver function is impaired. 

Urinalysis looks for red blood cells and protein in the urine, which can be a sign of kidney inflammation. 

Anti-neutrophil cytoplasmic antibody (ANCA) testing looks for a marker that can be often be found in patients with certain systemic vasculitis diseases. 

Complement is a test for the part of the immune response, which is something that is often reduced in people with vasculitis.