Malnutrition

Description: An Albumin test is a blood test used to screen for a diagnose kidney disease, liver disorders, and evaluate a patient’s nutritional status.

Also Known As: ALB Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 1 to 2 days

When is an Albumin test ordered?

A panel of tests is commonly ordered as part of a health check, including an albumin test.

If a person exhibits any of the following signs of a liver problem, an albumin test may be requested along with other tests:

• skin or eyes turning yellow
• weakness, exhaustion
• Unaccounted-for weight loss
• reduced appetite
• edema and/or pain in the abdomen
• Dark feces and pale urine
• Itching

When someone exhibits the following nephrotic syndrome symptoms, for example:

• Swelling or puffiness, especially in the face, wrists, abdomen, thighs, or ankles, or around the eyes
• Foamy, bloody, or coffee-colored urine
• a reduction in the urine's volume
• problems urinating, such as a burning sensation or an unusual discharge, or a change in frequency, particularly at night
• discomfort in the middle of the back, below the ribs, and next to the kidneys
• elevated blood pressure

An albumin test may also be requested by a medical professional to assess or track a patient's nutritional condition. A reduction in albumin, however, needs to be carefully examined because, in addition to starvation, albumin concentrations respond to a number of other diseases.

What does an Albumin blood test check for?

The liver produces a protein called albumin. It has numerous roles and makes up roughly 60% of the blood's overall protein content. The amount of albumin in the blood is determined by this test.

Albumin nourishes tissues, transports hormones, vitamins, medicines, and chemicals like calcium throughout the body, and prevents fluid from seeping out of blood vessels. When factors affect the liver's ability to produce albumin, increase protein breakdown, increase protein loss through the kidneys, and/or increase plasma volume, albumin levels may decline to a greater or lower extent.

Low blood albumin can result from two key factors, including:

• Severe liver disease: Since the liver produces albumin, its level may drop with loss of liver function; however, this is usually only the case in cases of severe liver illness.
• Kidney disease: One of the kidneys' numerous jobs is to preserve plasma proteins like albumin so that they don't pass through the urine production process with other waste materials. High levels of albumin are found in the blood, and when the kidneys are working well, very little albumin is excreted in the urine. However, the ability to preserve albumin and other proteins starts to deteriorate if a person's kidneys become harmed or ill. Chronic disorders like diabetes and hypertension are prone to this. Extremely large amounts of albumin are lost through the kidneys in nephrotic syndrome.

Lab tests often ordered with an Albumin test:

• Hepatic Function Panel
• Comprehensive Metabolic Panel
• Urine Albumin
• Urinalysis
• Total Protein
• Creatinine
• Blood Urea Nitrogen (BUN)
• Renal Panel

Conditions where an Albumin test is recommended:

• Liver Disease
• Kidney Disease
• Malnutrition
• Proteinuria

How does my health care provider use an Albumin test?

An albumin test is widely used to assess a person's general health state since it is typically included in the panels of tests run as part of a health check, such as a thorough metabolic panel.

Albumin may also be used in a variety of situations to aid in the diagnosis of disease, to track changes in health status due to therapy or disease progression, and as a screen that may suggest the need for other types of testing because it can be low in a range of diseases and disorders.

The liver produces albumin, a protein that nourishes cells, prevents fluid from seeping out of blood vessels, carries hormones, vitamins, medications, and other chemicals like calcium throughout the body.

A creatinine, blood urea nitrogen, or renal panel may be ordered in addition to an albumin test to assess liver function or in conjunction with one of these tests to assess kidney function. Additionally, albumin can be requested to assess a person's nutritional status.

What do my Albumin test results mean?

The results of an albumin test are assessed in conjunction with those from other tests carried out concurrently, such as those in a comprehensive metabolic panel or during follow-up.

A low albumin level could be a red flag and a sign that more research may be necessary. A low albumin level could indicate a short-term issue that will go away on its own or it could indicate an acute or chronic disease that calls for medical attention.

When conditions affect albumin production, increase protein breakdown, increase protein loss, and/or expand plasma volume, albumin levels may decline to a greater or lower extent. Additional testing may be carried out to look into a low result, depending on the patient's medical history, signs and symptoms, and physical examination.

Low albumin levels may signal liver illness. To pinpoint precisely which sort of liver illness may be present, liver enzyme tests or a liver panel may be prescribed. However, until the disease has progressed to an advanced degree, a person with liver disease may have normal or nearly normal albumin levels. For instance, albumin is frequently low in cirrhotic individuals while albumin is typically normal in most chronic liver illnesses that have not progressed to cirrhosis.

Low albumin levels can be a sign of illnesses where the kidneys are unable to stop albumin from leaking into the urine and being lost. In this situation, tests for creatinine, BUN, or a renal panel may be requested, along with measurements of the albumin or protein levels in the urine.

Inflammation, shock, and starvation are among conditions that can cause low albumin levels. They may exhibit symptoms of diseases like Crohn's disease or celiac disease, which affect how well the body absorbs and digests protein, as well as circumstances where significant amounts of protein are wasted from the intestines.

A low albumin level can also occur in a number of different illnesses, including:

• Infections
• Burns
• Surgery
• chronic disease
• Cancer
• Diabetes
• Hypothyroidism
• the cancer syndrome
• Plasma volume enlargement brought on by congestive heart failure and occasionally pregnancy
• Dehydration can cause high albumin levels, albeit this condition is not routinely tracked or detected by the test.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: The Alpha-1-Antitrypsin Quantitative test measures levels of the alpha-1-antitrypsin protein in the blood.

Also Known As: Alpha1-antitrypsin Test, A1AT Test, AAT Test, Alpha 1 Antitrypsin Serum Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 2 to 3 days

When is an Alpha-1-Antitrypsin test ordered?

When Alpha-1 antitrypsin tests may be prescribed:

• Jaundice that lasts more than a week or two in a baby, an enlarged spleen, fluid buildup in the belly, persistent itching, and other symptoms of liver damage are present.
• A person with COPD, elevated, sensitive skin lesions that develop into ulcers, granulomatosis with polyangiitis, or unexplained airway widening may be of any age.
• Wheezing, a persistent cough, bronchitis, shortness of breath after exercise, and/or other emphysema symptoms often appear in people under the age of 40. This is particularly true when the person is not a smoker, has not been exposed to known lung irritants, and when the lung damage appears to be low in the lungs.
• Someone has an alpha-1 antitrypsin deficiency that runs in their family.
• A person wants to know how likely it is that their child would experience the same problems as their impacted family member.

The American Thoracic Society advised AAT testing in their 2003 guidelines when people were diagnosed with diseases like:

• Young age for onset of emphysema and/or absence of clear risk factors for the condition, such as smoking
• Bronchiectasis
• difficult-to-treat asthma Unknown origin of liver disease
• Panniculitis with necrosis

The Alpha-1 Foundation suggests AAT testing for all people with:

• COPD
• illness of the liver with no known cause
• Panniculitis with necrosis
• Polyangiitis and granulomatosis
• mysterious bronchiectasis

The Alpha-1 Foundation also advises providing genetic counseling and AAT testing to people who have immediate or extended family members who have an aberrant AAT gene.

What does an Alpha-1-Antitrypsin blood test check for?

A blood protein called alpha-1 antitrypsin shields the lungs from harm from enzymes that have been activated. To help with the diagnosis of alpha-1 antitrypsin deficiency, laboratory tests detect the amount of AAT in blood or find aberrant forms of AAT that a person has inherited.

The most significant enzyme that AAT aids in inactivating is elastase. Elastase is a white blood cell termed a neutrophil that is created as part of the body's normal response to inflammation and injury. Elastase disassembles proteins so that the body can eliminate and recycle them. Elastase will also start to degrade and harm lung tissue if its activity is not controlled by AAT.

The gene that codes for AAT is inherited twice every person. The protease inhibitor gene is what it is known as. Because of the co-dominance of this gene, the body produces half of its AAT from each copy of the SERPINA1 gene. Less AAT and/or AAT with diminished function are produced if there is a change or mutation in one or both of the gene copies.

Alpha-1 antitrypsin deficiency is a condition that affects a person whose AAT production falls below 30% of normal. Emphysema, a progressive lung illness, is a serious danger for people with this disorder to experience in their early adult years. The lung damage likely to happen sooner and be more severe if they smoke or are exposed to occupational dust or fumes.

AAT that is dysfunctional of a particular sort builds up in the cells of the liver, where it is created. As AAT accumulates in these cells, it starts to produce aberrant protein chains, which then start to kill the cells and harm the liver. AAT-deficient neonates are jaundiced and suffer liver damage in about 10% of cases. These infants may need a liver transplant to survive in serious circumstances. The most frequent genetic cause of liver disease in children is presently AAT deficiency.

Adults with an AAT deficiency are more likely to develop liver cancer, cirrhosis, and chronic liver disease. Adults with AAT insufficiency rarely experience symptoms or indicators of liver damage, nevertheless. The hereditary gene mutation determines the amount and function of the AAT. The SERPINA1 gene contains more than 120 distinct alleles, however only a few of them are widespread. 90% of Americans have two copies of the typical, "wild type," M gene. S and Z are the aberrant genes that are most frequently found.

Lab tests often ordered with an Alpha-1-Antitrypsin test:

• Protein Electrophoresis
• Total Protein
• Hepatic Function Panel
• Blood Gases

Conditions where an Alpha-1-Antitrypsin test is recommended:

• Lung Disease
• Liver Disease
• Asthma

How does my health care provider use an Alpha-1-Antitrypsin test?

When a patient has early onset emphysema or chronic obstructive pulmonary disease but no clear risk factors, such as smoking or exposure to lung irritants like dust or fumes, alpha-1 antitrypsin testing is utilized to help diagnose alpha-1 antitrypsin deficiency as the cause. It may also be applied to asthmatics who continue to have breathing difficulties despite receiving treatment.

Other symptoms of unexplained liver injury, such as prolonged jaundice, are also diagnosed with the use of testing. This can be done on anyone of any age, but is typically done on infants and young children.

A person with a family history of alpha-1 antitrypsin deficiency may also undergo testing to identify whether they have one or two copies of the SERPINA1 gene.

There are typically three different AAT exam kinds. One or more of these could be applied to assess a person:

• The protein alpha-1 antitrypsin in blood is measured by alpha-1 antitrypsin.
• Testing for the phenotype of alpha-1 antitrypsin assesses the quantity and kind of AAT being produced and contrasts it with typical patterns.
• To determine if the typical wild type M allele or variant alleles are present in the SERPINA1 gene, alpha-1 antitrypsin genotyping testing can be utilized. This test won't find every variant, but it will find the most prevalent ones as well as those that might be frequent in a specific region or family. Other family members may be examined to determine their own risk of acquiring emphysema and/or liver dysfunction as well as the possibility that their children may inherit the condition after the sick person's SERPINA1 gene alleles have been determined.

Although gene sequencing for AAT is uncommon, it might be required to find uncommon alleles and make a precise diagnosis.

What do my Alpha-1-Antitrypsin test results mean?

Alpha-1 antitrypsin deficiency may be present in a person whose blood has a low amount of AAT, according to the test results. The risk of developing emphysema and other conditions linked to AAT insufficiency increases with decreasing AAT levels.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: A Calcium test is a blood test that is used to screen for, diagnose, and monitor a wide range of medical conditions.

Also Known As: Ca Test, Serum Calcium Test, Calcium Blood Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 1 to 2 days

When is a Calcium test ordered?

A blood calcium test is frequently requested during a general medical evaluation. It's usually part of the comprehensive metabolic panel or the basic metabolic panel, two sets of tests that can be done during an initial evaluation or as part of a routine medical checks.

Many people do not experience symptoms of high or low calcium until their levels are dangerously high or low.

When a person has certain types of cancer, kidney illness, or has had a kidney transplant, calcium monitoring may be required. When someone is being treated for abnormal calcium levels, monitoring may be required to determine the effectiveness of medications such as calcium or vitamin D supplements.

What does a Calcium blood test check for?

Calcium is one of the most plentiful and vital minerals in the human body. It is required for cell signaling as well as the proper operation of muscles, nerves, and the heart. Calcium is essential for blood clotting as well as bone growth, density, and maintenance. This test determines how much calcium is present in the blood.

Calcium is found complexed in the bones for 99 percent of the time, while the remaining 1% circulates in the blood. Calcium levels are closely monitored; if too little is absorbed or consumed, or if too much is lost through the kidney or stomach, calcium is removed from bone to keep blood concentrations stable. Approximately half of the calcium in the blood is metabolically active and "free." The other half is "bound" to albumin, with a minor proportion complexed to anions like phosphate, and both of these forms are metabolically inactive.

Blood calcium can be measured using two different tests. The free and bound forms of calcium are measured in the total calcium test. Only the free, physiologically active form of calcium is measured in the ionized calcium test.

Lab tests often ordered with a Calcium test:

• Phosphorus
• Vitamin D
• Magnesium
• PTH
• Albumin
• Basic Metabolic Panel (BMP)
• Comprehensive Metabolic Panel (CMP)

Conditions where a Calcium test is recommended:

• Kidney Disease
• Thyroid Disease
• Alcoholism
• Malnutrition
• Parathyroid Diseases
• Breast Cancer
• Multiple Myeloma

How does my health care provider use a Calcium test?

A blood calcium test is used to screen for, diagnose, and monitor a variety of bone, heart, nerve, kidney, and tooth disorders. If a person has signs of a parathyroid disease, malabsorption, or an overactive thyroid, the test may be ordered.

A total calcium level is frequently checked as part of a standard health check. It's part of the comprehensive metabolic panel and the basic metabolic panel, which are both collections of tests used to diagnose or monitor a range of ailments.

When a total calcium result is abnormal, it is interpreted as a sign of an underlying disease. Additional tests to assess ionized calcium, urine calcium, phosphorus, magnesium, vitamin D, parathyroid hormone, and PTH-related peptide are frequently performed to assist determine the underlying problem. PTH and vitamin D are in charge of keeping calcium levels in the blood within a narrow range of values.

Measuring calcium and PTH combined can assist identify whether the parathyroid glands are functioning normally if the calcium is abnormal. Testing for vitamin D, phosphorus, and/or magnesium can assist evaluate whether the kidneys are excreting the right amount of calcium, and measuring urine calcium can help detect whether additional deficits or excesses exist. The balance of these many compounds is frequently just as critical as their concentrations.

The total calcium test is the most common test used to determine calcium status. Because the balance between free and bound calcium is usually constant and predictable, it is a reliable reflection of the quantity of free calcium present in the blood in most cases. However, the balance between bound and free calcium is altered in some persons, and total calcium is not a good indicator of calcium status. Ionized calcium measurement may be required in certain cases. Critically sick patients, those receiving blood transfusions or intravenous fluids, patients undergoing major surgery, and persons with blood protein disorders such low albumin are all candidates for ionized calcium testing.

What do my Calcium test results mean?

The amount of calcium circulating in the blood is not the same as the amount of calcium in the bones.

A feedback loop including PTH and vitamin D regulates and stabilizes calcium uptake, utilization, and excretion. Conditions and disorders that disturb calcium control can induce abnormal acute or chronic calcium elevations or declines, resulting in hypercalcemia or hypocalcemia symptoms.

Total calcium is usually tested instead of ionized calcium since it is easier to do and requires no additional treatment of the blood sample. Because the free and bound forms of calcium make up about half of the total, total calcium is usually a decent depiction of free calcium. Because nearly half of the calcium in blood is bonded to protein, high or low protein levels might alter total calcium test findings. In these circumstances, an ionized calcium test is more appropriate for measuring free calcium.

A normal total or ionized calcium test, when combined with other normal laboratory findings, indicates that a person's calcium metabolism is normal and blood levels are properly managed.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Clinical Significance
Micronutrient, Calcium - Serum calcium is involved in the regulation of neuromuscular and enzyme activity, bone metabolism and blood coagulation. Calcium blood levels are controlled by a complex interaction of parathyroid hormone, vitamin D, calcitonin and adrenal cortical steroids. Calcium measurements are useful in the diagnosis of parathyroid disease, some bone disorders and chronic renal disease. A low level of calcium may result in tetany.

Patients must be 18 years of age or greater.

Reference Range(s) (mg/dL)
                        Male                  Female
18-19 years     8.9-10.4    8.9-10.4
20-49 years     8.6-10.3    8.6-10.2
>49 years        8.6-10.3    8.6-10.4
Reference range not available for individuals <18 years for this micronutrient test.

Clinical Significance
Micronutrients, Heavy Metals Panel, Blood

Patients must be 18 years of age or greater.

Includes

• Micronutrient, Arsenic, Blood
• Micronutrient, Cadmium, Blood
• Micronutrient, Cobalt, Blood
• Micronutrient, Lead, Blood
• Micronutrient, Mercury, Blood

Description: Ceruloplasmin is a blood test that measures that amount of Ceruloplasmin in the blood’s serum. Ceruloplasmin, or Copper Oxide, is a protein that is created in the liver and is used to transport copper from the liver to the parts of the body that need it, including the blood.

Also Known As: Copper Oxide Test, Wilson’s Disease Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 3 to 4 days

When is a Ceruloplasmin test ordered?

When somebody has symptoms that a health practitioner suspects are due to Wilson disease, a ceruloplasmin test may be ordered alone or in combination with blood and 24-hour urine copper testing.

What does a Ceruloplasmin blood test check for?

Ceruloplasmin is a copper-containing enzyme that aids in iron metabolism in the body. The level of ceruloplasmin in the blood is measured with this test.

Copper is a vital mineral that regulates iron metabolism, connective tissue creation, cellular energy production, and nervous system function. The intestines absorb it from meals and liquids, and it is subsequently transferred to the liver, where it is stored or used to make a variety of enzymes.

To make ceruloplasmin, the liver binds copper to a protein and then releases it into the bloodstream. Ceruloplasmin binds about 95 percent of the copper in the blood. As a result, the ceruloplasmin test can be performed in conjunction with one or more copper tests to assist diagnose Wilson disease, a genetic illness in which the liver, brain, and other organs store too much copper.

Lab tests often ordered with a Ceruloplasmin test:

• Copper

Conditions where a Ceruloplasmin test is recommended:

• Wilson’s Disease
• Liver Diseases

How does my health care provider use a Ceruloplasmin test?

Wilson disease is a rare genetic ailment characterized by excessive copper accumulation in the liver, brain, and other organs, as well as low levels of ceruloplasmin. Ceruloplasmin testing is performed in conjunction with blood and/or urine copper assays to assist diagnosis Wilson disease.

Copper is a mineral that plays an important role in the human body. Ceruloplasmin binds about 95 percent of the copper in the blood. In an unbound state, just a minimal quantity of copper is present in the blood.

A ceruloplasmin test may be ordered in conjunction with a copper test to assist diagnose problems in copper metabolism, copper deficiency, or Menkes kinky hair syndrome, a rare genetic condition.

What do my Ceruloplasmin test results mean?

Ceruloplasmin levels are frequently tested in conjunction with copper testing because they are not indicative of a specific illness.

Wilson disease can be identified by low ceruloplasmin and blood copper levels, as well as high copper levels in the urine.

About 5% of persons with Wilson disease who have neurological symptoms, as well as up to 40% of those with hepatic symptoms, especially if they are critically unwell, will have normal ceruloplasmin levels.

The person tested may have a copper deficiency if ceruloplasmin, urine, and/or blood copper values are low.

Anything that affects the body's ability to metabolize copper or the supply of copper has the potential to impact blood ceruloplasmin and copper levels.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: A CBC or Complete Blood Count with Differential and Platelets test is a blood test that measures many important features of your blood’s red and white blood cells and platelets. A Complete Blood Count can be used to evaluate your overall health and detect a wide variety of conditions such as infection, anemia, and leukemia. It also looks at other important aspects of your blood health such as hemoglobin, which carries oxygen. 

Also Known As: CBC test, Complete Blood Count Test, Total Blood Count Test, CBC with Differential and Platelets test, Hemogram test  

Collection Method: Blood Draw 

Specimen Type: Whole Blood 

Test Preparation: No preparation required 

Average Processing Time: 1 to 2 days

When is a Complete Blood Count test ordered?  

The complete blood count (CBC) is an extremely common test. When people go to the doctor for a standard checkup or blood work, they often get a CBC. Suppose a person is healthy and their results are within normal ranges. In that case, they may not need another CBC unless their health condition changes, or their healthcare professional believes it is necessary. 

When a person exhibits a variety of signs and symptoms that could be connected to blood cell abnormalities, a CBC may be done. A health practitioner may request a CBC to help diagnose and determine the severity of lethargy or weakness, as well as infection, inflammation, bruises, or bleeding. 

When a person is diagnosed with a disease that affects blood cells, a CBC is frequently done regularly to keep track of their progress. Similarly, if someone is being treated for a blood condition, a CBC may be performed on a regular basis to see if the treatment is working. 

Chemotherapy, for example, can influence the generation of cells in the bone marrow. Some drugs can lower WBC counts in the long run. To monitor various medication regimens, a CBC may be required on a regular basis. 

What does a Complete Blood Count test check for? 

The complete blood count (CBC) is a blood test that determines the number of cells in circulation. White blood cells (WBCs), red blood cells (RBCs), and platelets (PLTs) are three types of cells suspended in a fluid called plasma. They are largely created and matured in the bone marrow and are released into the bloodstream when needed under normal circumstances. 

A CBC is mainly performed with an automated machine that measures a variety of factors, including the number of cells present in a person's blood sample. The findings of a CBC can reveal not only the quantity of different cell types but also the physical properties of some of the cells. 

Significant differences in one or more blood cell populations may suggest the presence of one or more diseases. Other tests are frequently performed to assist in determining the reason for aberrant results. This frequently necessitates visual confirmation via a microscope examination of a blood smear. A skilled laboratory technician can assess the appearance and physical features of blood cells, such as size, shape, and color, and note any anomalies. Any extra information is taken note of and communicated to the healthcare provider. This information provides the health care provider with further information about the cause of abnormal CBC results. 

The CBC focuses on three different types of cells: 

WBCs (White Blood Cells) 

The body uses five different types of WBCs, also known as leukocytes, to keep itself healthy and battle infections and other types of harm. The five different leukocytes are eosinophiles, lymphocytes, neutrophiles, basophils, and monocytes. They are found in relatively steady numbers in the blood. Depending on what is going on in the body, these values may momentarily rise or fall. An infection, for example, can cause the body to manufacture more neutrophils in order to combat bacterial infection. The amount of eosinophils in the body may increase as a result of allergies. A viral infection may cause an increase in lymphocyte production. Abnormal (immature or mature) white cells multiply fast in certain illness situations, such as leukemia, raising the WBC count. 

RBCs (Red Blood Cells) 

The bone marrow produces red blood cells, also known as erythrocytes, which are transferred into the bloodstream after maturing. Hemoglobin, a protein that distributes oxygen throughout the body, is found in these cells. Because RBCs have a 120-day lifespan, the bone marrow must constantly manufacture new RBCs to replace those that have aged and disintegrated or have been lost due to hemorrhage. A variety of diseases, including those that cause severe bleeding, can alter the creation of new RBCs and their longevity. 

The CBC measures the number of RBCs and hemoglobin in the blood, as well as the proportion of RBCs in the blood (hematocrit), and if the RBC population appears to be normal. RBCs are generally homogeneous in size and shape, with only minor differences; however, considerable variances can arise in illnesses including vitamin B12 and folate inadequacy, iron deficiency, and a range of other ailments. Anemia occurs when the concentration of red blood cells and/or the amount of hemoglobin in the blood falls below normal, resulting in symptoms such as weariness and weakness. In a far smaller percentage of cases, there may be an excess of RBCs in the blood (erythrocytosis or polycythemia). This might obstruct the flow of blood through the tiny veins and arteries in extreme circumstances. 

Platelets 

Platelets, also known as thrombocytes, are small cell fragments that aid in the regular clotting of blood. A person with insufficient platelets is more likely to experience excessive bleeding and bruises. Excess platelets can induce excessive clotting or excessive bleeding if the platelets are not operating properly. The platelet count and size are determined by the CBC. 

Lab tests often ordered with a Complete Blood Count test: 

• Reticulocytes
• Iron and Total Iron Binding Capacity
• Basic Metabolic Panel
• Comprehensive Metabolic Panel
• Lipid Panel
• Vitamin B12 and Folate
• Prothrombin with INR and Partial Thromboplastin Times
• Sed Rate (ESR)
• C-Reactive Protein
• Epstein-Barr Virus
• Von Willebrand Factor Antigen

Conditions where a Complete Blood Count test is recommended: 

• Anemia
• Aplastic Anemia
• Iron Deficiency Anemia
• Vitamin B12 and Folate Deficiency
• Sickle Cell Anemia
• Heart Disease
• Thalassemia
• Leukemia
• Autoimmune Disorders
• Cancer
• Bleeding Disorders
• Inflammation
• Epstein-Barr Virus
• Mononucleosis

Commonly Asked Questions: 

How does my health care provider use a Complete Blood Count test? 

The complete blood count (CBC) is a common, comprehensive screening test used to measure a person's overall health status.  

What do my Complete Blood Count results mean? 

A low Red Blood Cell Count, also known as anemia, could be due many different causes such as chronic bleeding, a bone marrow disorder, and nutritional deficiency just to name a few. A high Red Blood Cell Count, also known as polycythemia, could be due to several conditions including lung disease, dehydration, and smoking. Both Hemoglobin and Hematocrit tend to reflect Red Blood Cell Count results, so if your Red Blood Cell Count is low, your Hematocrit and Hemoglobin will likely also be low. Results should be discussed with your health care provider who can provide interpretation of your results and determine the appropriate next steps or lab tests to further investigate your health. 

What do my Differential results mean? 

A low White Blood Cell count or low WBC count, also known as leukopenia, could be due to a number of different disorders including autoimmune issues, severe infection, and lymphoma. A high White Blood Cell count, or high WBC count, also known as leukocytosis, can also be due to many different disorders including infection, leukemia, and inflammation. Abnormal levels in your White Blood Cell Count will be reflected in one or more of your different white blood cells. Knowing which white blood cell types are affected will help your healthcare provider narrow down the issue. Results should be discussed with your health care provider who can provide interpretation of your results and determine the appropriate next steps or lab tests to further investigate your health. 

What do my Platelet results mean? 

A low Platelet Count, also known as thrombocytopenia, could be due to a number of different disorders including autoimmune issues, viral infection, and leukemia. A high Platelet Count, also known as Thrombocytosis, can also be due to many different disorders including cancer, iron deficiency, and rheumatoid arthritis. Results should be discussed with your health care provider who can provide interpretation of your results and determine the appropriate next steps or lab tests to further investigate your health. 

NOTE: Ulta Lab Tests provides CBC test results from Quest Diagnostics as they are reported. Often, different biomarker results are made available at different time intervals. When reporting the results, Ulta Lab Tests denotes those biomarkers not yet reported as 'pending' for every biomarker the test might report. Only biomarkers Quest Diagnostics observes are incorporated and represented in the final CBC test results provided by Ulta Lab Tests. 

NOTE: Only measurable biomarkers will be reported. Certain biomarkers do not appear in healthy individuals. 

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Reflex Parameters for Manual Slide Review

CBC Reflex Pathway

Step 1 - The slide review is performed by qualified Laboratory staff and includes:

• Confirmation of differential percentages
• WBC and platelet estimates, when needed
• Full review of RBC morphology
• Comments for toxic changes, RBC inclusions, abnormal lymphs, and other
• significant findings
• If the differential percentages agree with the automated counts and no abnormal cells are seen, the automated differential is reported with appropriate comments

Step 2 - The slide review is performed by qualified Laboratory staff and includes: If any of the following are seen on the slide review, Laboratory staff will perform a manual differential:

• Immature, abnormal, or toxic cells
• nRBC’s
• Disagreement with automated differential
• Atypical/abnormal RBC morphology
• Any RBC inclusions

Step 3 - If any of the following are seen on the manual differential, a Pathologist will review the slide:

• WBC<1,500 with abnormal cells noted
• Blasts/immature cells, hairy cell lymphs, or megakaryocytes
• New abnormal lymphocytes or monocytes
• Variant or atypical lymphs >15%
• Blood parasites
• RBC morphology with 3+ spherocytes, RBC inclusions, suspect Hgb-C,
• crystals, Pappenheimer bodies or bizarre morphology
• nRBC’s

Description: A Comprehensive Metabolic Panel or CMP is a blood test that is a combination of a Basic Metabolic Panel, a Liver Panel, and electrolyte panel, and is used to screen for, diagnose, and monitor a variety of conditions and diseases such as liver disease, diabetes, and kidney disease. 

Also Known As: CMP, Chem, Chem-14, Chem-12, Chem-21, Chemistry Panel, Chem Panel, Chem Screen, Chemistry Screen, SMA 12, SMA 20, SMA 21, SMAC, Chem test

Collection Method: Blood Draw 

Specimen Type: Serum 

Test Preparation: 9-12 hours fasting is preferred.

Average Processing Time: 1 to 2 days 

When is a Comprehensive Metabolic Panel test ordered:  

A CMP is frequently requested as part of a lab test for a medical evaluation or yearly physical. A CMP test consists of many different tests that give healthcare providers a range of information about your health, including liver and kidney function, electrolyte balance, and blood sugar levels. To confirm or rule out a suspected diagnosis, abnormal test results are frequently followed up with other tests that provide a more in depth or targeted analysis of key areas that need investigating. 

What does a Comprehensive Metabolic Panel blood test check for? 

The complete metabolic panel (CMP) is a set of 20 tests that provides critical information to a healthcare professional about a person's current metabolic status, check for liver or kidney disease, electrolyte and acid/base balance, and blood glucose and blood protein levels. Abnormal results, particularly when they are combined, can suggest a problem that needs to be addressed. 

The following tests are included in the CMP: 

• Albumin: this is a measure of Albumin levels in your blood. Albumin is a protein made by the liver that is responsible for many vital roles including transporting nutrients throughout the body and preventing fluid from leaking out of blood vessels. 

• Albumin/Globulin Ratio: this is a ratio between your total Albumin and Globulin  

• Alkaline Phosphatase: this is a measure of Alkaline phosphatase or ALP in your blood. Alkaline phosphatase is a protein found in all body tissues, however the ALP found in blood comes from the liver and bones. Elevated levels are often associated with liver damage, gallbladder disease, or bone disorder. 

• Alt: this is a measure of Alanine transaminase or ALT in your blood. Alanine Aminotransferase is an enzyme found in the highest amounts in the liver with small amounts in the heart and muscles. Elevated levels are often associated with liver damage. 

• AST: this is a measure of Aspartate Aminotransferase or AST. Aspartate Aminotransferase is an enzyme found mostly in the heart and liver, with smaller amounts in the kidney and muscles. Elevated levels are often associated with liver damage. 

• Bilirubin, Total: this is a measure of bilirubin in your blood. Bilirubin is an orange-yellowish waste product produced from the breakdown of heme which is a component of hemoglobin found in red blood cells. The liver is responsible for removal of bilirubin from the body. 

• Bun/Creatinine Ratio: this is a ratio between your Urea Nitrogen (BUN) result and Creatinine result.  

• Calcium: this is a measurement of calcium in your blood. Calcium is the most abundant and one of the most important minerals in the body as it essential for proper nerve, muscle, and heart function. 

• Calcium: is used for blood clot formation and the formation and maintenance of bones and teeth. 

• Carbon Dioxide: this is a measure of carbon dioxide in your blood. Carbon dioxide is a negatively charged electrolyte that works with other electrolytes such as chloride, potassium, and sodium to regulate the body’s acid-base balance and fluid levels.  

• Chloride: this is a measure of Chloride in your blood. Chloride is a negatively charged electrolyte that works with other electrolytes such as potassium and sodium to regulate the body’s acid-base balance and fluid levels. 

• Creatinine: this is a measure of Creatinine levels in your blood. Creatinine is created from the breakdown of creatine in your muscles and is removed from your body by the kidneys. Elevated creatinine levels are often associated with kidney damage. 

• Egfr African American: this is a measure of how well your kidneys are functioning. Glomeruli are tiny filters in your kidneys that filter out waste products from your blood for removal while retaining important substances such as nutrients and blood cells. 

• Egfr Non-Afr. American: this is a measure of how well your kidneys are functioning. Glomeruli are tiny filters in your kidneys that filter out waste products from your blood for removal while retaining important substances such as nutrients and blood cells. 

• Globulin: this is a measure of all blood proteins in your blood that are not albumin. 

• Glucose: this is a measure of glucose in your blood. Glucose is created from the breakdown of carbohydrates during digestion and is the body’s primary source of energy. 

• Potassium: this is a measure of Potassium in your blood. Potassium is an electrolyte that plays a vital role in cell metabolism, nerve and muscle function, and transport of nutrients into cells and removal of wastes products out of cells. 

• Protein, Total: this is a measure of total protein levels in your blood. 
  Sodium: this is a measure of Sodium in your blood. Sodium is an electrolyte that plays a vital role in nerve and muscle function. 

• Sodium: this is a measure of sodium in your blood's serum. Sodium is a vital mineral for nerve and muscle cell function.

• Urea Nitrogen (Bun): this is a measure of Urea Nitrogen in your blood, also known as Blood UreaNitrogen (BUN). Urea is a waste product created in the liver when proteins are broken down into amino acids. Elevated levels are often associated with kidney damage. 

Lab tests often ordered with a Comprehensive Metabolic Panel test: 

• Complete Blood Count with Differential and Platelets
• Iron and Total Iron Binding Capacity
• Lipid Panel
• Vitamin B12 and Folate
• Prothrombin with INR and Partial Thromboplastin Times
• Sed Rate (ESR)
• C-Reactive Protein

Conditions where a Comprehensive Metabolic Panel test is recommended: 

• Diabetes
• Kidney Disease
• Liver Disease
• Hypertension

Commonly Asked Questions: 

How does my health care provider use a Comprehensive Metabolic Panel test? 

The comprehensive metabolic panel (CMP) is a broad screening tool for assessing organ function and detecting diseases like diabetes, liver disease, and kidney disease. The CMP test may also be requested to monitor known disorders such as hypertension and to check for any renal or liver-related side effects in persons taking specific drugs. If a health practitioner wants to follow two or more separate CMP components, the full CMP might be ordered because it contains more information. 

What do my Comprehensive Metabolic Panel test results mean? 

The results of the tests included in the CMP are usually analyzed together to look for patterns. A single abnormal test result may indicate something different than a series of abnormal test findings. A high result on one of the liver enzyme tests, for example, is not the same as a high result on several liver enzyme tests. 

Several sets of CMPs, frequently performed on various days, may be examined to gain insights into the underlying disease and response to treatment, especially in hospitalized patients. 

Out-of-range findings for any of the CMP tests can be caused by a variety of illnesses, including kidney failure, breathing issues, and diabetes-related complications, to name a few. If any of the results are abnormal, one or more follow-up tests are usually ordered to help determine the reason and/or establish a diagnosis. 

Is there anything else I should know? 

A wide range of prescription and over-the-counter medications can have an impact on the results of the CMP's components. Any medications you're taking should be disclosed to your healthcare professional. Similarly, it is critical to provide a thorough history because many other circumstances can influence how your results are interpreted. 

What's the difference between the CMP and the BMP tests, and why would my doctor choose one over the other? 

The CMP consists of 14 tests, while the basic metabolic panel (BMP) is a subset of those with eight tests. The liver (ALP, ALT, AST, and bilirubin) and protein (albumin and total protein) tests are not included. If a healthcare provider wants a more thorough picture of a person's organ function or to check for specific illnesses like diabetes or liver or kidney disease, he or she may prescribe a CMP rather than a BMP. 

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Please note the following regarding BUN/Creatinine ratio: 

The lab does not report the calculation for the BUN/Creatinine Ratio unless one or both biomarkers’ results fall out of the published range. 

If you still wish to see the value, it's easy to calculate. Simply take your Urea Nitrogen (BUN) result and divide it by your Creatinine result.  

As an example, if your Urea Nitrogen result is 11 and your Creatinine result is 0.86, then you would divide 11 by 0.86 and get a BUN/Creatinine Ratio result of 12.79. 

Description: Copper is a blood test that measures the amount of copper in the blood's plasma. Copper levels in the blood can help to diagnose Wilson's Disease.

Also Known As: Cu Test, Blood Copper Test, Free Copper Test, Hepatic Copper Test, Copper Serum Test, Copper Plasma Test, Copper Blood Test

Collection Method: Blood Draw

Specimen Type: Plasma or Serum

Test Preparation: No preparation required

Average Processing Time: 4 to 5 days

When is a Copper test ordered?

When a health practitioner suspects Wilson disease, excess copper storage, or copper poisoning, one or more copper tests are requested along with ceruloplasmin.

When copper and ceruloplasmin results are abnormal or inconclusive, a hepatic copper test may be conducted to further evaluate copper storage.

What does a Copper blood test check for?

Copper is an important mineral that the body uses to make enzymes. These enzymes are involved in the regulation of iron metabolism, the development of connective tissue, cellular energy production, the production of melanin, and nervous system function. This test determines how much copper is present in the blood, urine, or liver.

Nuts, chocolate, mushrooms, seafood, whole grains, dried fruits, and liver are all high in copper. Copper may be absorbed into drinking water as it passes through copper pipes, and copper may be absorbed into food as it is cooked or served on copper dishes. Copper is absorbed from food or liquids in the intestines, converted to a non-toxic form by binding it to a protein, and transported to the liver in normal circumstances. To make the enzyme ceruloplasmin, the liver saves some copper and binds the remainder to another protein called apoceruloplasmin. Ceruloplasmin binds about 95 percent of the copper in the blood, with the rest attached to other proteins like albumin. In a free condition, only a little amount is present in the blood. Excess copper is excreted by the liver in the bile, which is then excreted by the body in the feces. Copper is also excreted in the urine in small amounts.

Copper excess and deficiency are uncommon. Wilson disease is a rare genetic ailment that causes the liver, brain, and other organs to store too much copper. Excess copper can arise when a person is exposed to and absorbs high amounts of copper in a short period of time or little amounts over a long period of time.

Copper deficiency can arise in patients with severe malabsorption diseases such cystic fibrosis and celiac disease, as well as infants who are exclusively fed cow-milk formulas.

Menkes kinky hair syndrome is a rare X-linked hereditary disorder that causes copper shortage in the brain and liver of affected babies. Seizures, delayed development, aberrant artery growth in the brain, and unique gray brittle kinky hair are all symptoms of the condition, which mostly affects men.

Lab tests often ordered with a Copper test:

• Ceruloplasmin
• Heavy Metals
• ACTH
• Aldosterone
• 17-Hydroprogesterone
• Growth Hormone

Conditions where a Copper test is recommended:

• Wilson Disease
• Malnutrition

How does my health care provider use a Copper test?

Copper testing is largely used to detect Wilson disease, a rare genetic ailment in which the liver, brain, and other organs accumulate an excessive amount of copper. A copper test is less usually used to detect copper excess caused by another ailment, to diagnose a copper deficit, or to track treatment for one of these conditions.

Copper is a necessary mineral, but too much of it can be harmful. The majority of it is bound to the enzyme ceruloplasmin in the blood, leaving only a little quantity "free" or unbound.

A whole blood copper test is usually ordered in conjunction with a ceruloplasmin level. If the findings of these tests are abnormal or ambiguous, a 24-hour urine copper test to monitor copper elimination and/or a copper test on a liver biopsy to check copper storage in the liver may be conducted.

A free blood copper test is sometimes ordered as well. If Wilson disease is suspected, genetic testing for mutations in the ATP7B gene may be undertaken. However, these tests are only available in a restricted number of locations and are usually carried out in specialized reference or research laboratories.

A copper test may be used to identify Menkes kinky hair syndrome, a rare inherited copper transport failure condition.

What do my Copper test results mean?

Copper test findings are frequently linked to ceruloplasmin levels and considered in context. Copper results that are abnormal are not indicative of a specific illness; rather, they signal that more research is needed. Because ceruloplasmin is an acute phase reactant, it might be raised if inflammation or severe infections are present, making interpretation difficult. Ceruloplasmin and copper levels rise during pregnancy, as well as with the use of estrogen and oral contraceptives.

Wilson disease is characterized by low blood copper concentrations, elevated urine copper levels, low ceruloplasmin levels, and increased liver copper.

Elevated copper concentrations in the blood and urine, as well as normal or increased ceruloplasmin levels, may suggest excessive copper exposure or be linked to disorders that reduce copper excretion, such as chronic liver disease, or release copper from tissues, such as acute hepatitis. Chronic diseases can cause an increase in hepatic copper levels.

Copper deficiency is indicated by lower copper concentrations in the blood and urine, as well as lower ceruloplasmin levels.

A normal hepatic copper test could mean that copper metabolism is normal, or that the distribution of copper in the liver is uneven, and that the sample isn't reflective of the person's health.

If a person is being treated for Wilson disease or copper toxicity with copper-binding medicines, their 24-hour urine copper levels may be high until their body copper stores are depleted. Copper concentrations in the blood and urine should return to normal over time.

If a person is being treated for a copper deficient disorder and their ceruloplasmin and total copper levels start to rise, the condition is likely responding to the treatment.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Clinical Significance
Micronutrient, Copper, Plasma - Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions and during the third trimester of pregnancy. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.

Patients must be 18 years of age or greater.

Reference Range(s)
≥18 years    70-175 mcg/dLReference range not available for individuals <18 years for this micronutrient test.

Description: Copper RBC is a blood test that measures the amount of copper in the blood's red blood cells. Copper levels in the blood can help to diagnose Wilson's Disease.

Also Known As: Cu RBC Test, Cu Test, Blood Copper Test, RBC Copper Test, Hepatic Copper Test, Copper Blood Test

Collection Method: Blood Draw

Specimen Type: Red Blood Cells

Test Preparation: No preparation required

Average Processing Time: 4 to 5 days

When is a Copper RBC test ordered?

When a health practitioner suspects Wilson disease, excess copper storage, or copper poisoning, one or more copper tests are requested along with ceruloplasmin.

When copper and ceruloplasmin results are abnormal or inconclusive, a hepatic copper test may be conducted to further evaluate copper storage.

What does a Copper RBC blood test check for?

Copper is an important mineral that the body uses to make enzymes. These enzymes are involved in the regulation of iron metabolism, the development of connective tissue, cellular energy production, the production of melanin, and nervous system function. This test determines how much copper is present in the blood, urine, or liver.

Nuts, chocolate, mushrooms, seafood, whole grains, dried fruits, and liver are all high in copper. Copper may be absorbed into drinking water as it passes through copper pipes, and copper may be absorbed into food as it is cooked or served on copper dishes. Copper is absorbed from food or liquids in the intestines, converted to a non-toxic form by binding it to a protein, and transported to the liver in normal circumstances. To make the enzyme ceruloplasmin, the liver saves some copper and binds the remainder to another protein called apoceruloplasmin. Ceruloplasmin binds about 95 percent of the copper in the blood, with the rest attached to other proteins like albumin. In a free condition, only a little amount is present in the blood. Excess copper is excreted by the liver in the bile, which is then excreted by the body in the feces. Copper is also excreted in the urine in small amounts.

Copper excess and deficiency are uncommon. Wilson disease is a rare genetic ailment that causes the liver, brain, and other organs to store too much copper. Excess copper can arise when a person is exposed to and absorbs high amounts of copper in a short period of time or little amounts over a long period of time.

Copper deficiency can arise in patients with severe malabsorption diseases such cystic fibrosis and celiac disease, as well as infants who are exclusively fed cow-milk formulas.

Menkes kinky hair syndrome is a rare X-linked hereditary disorder that causes copper shortage in the brain and liver of affected babies. Seizures, delayed development, aberrant artery growth in the brain, and unique gray brittle kinky hair are all symptoms of the condition, which mostly affects men.

Lab tests often ordered with a Copper RBC test:

• Ceruloplasmin
• Heavy Metals
• ACTH
• Aldosterone
• 17-Hydroprogesterone
• Growth Hormone

Conditions where a Copper RBC test is recommended:

• Wilson Disease
• Malnutrition

How does my health care provider use a Copper RBC test?

Copper testing is largely used to detect Wilson disease, a rare genetic ailment in which the liver, brain, and other organs accumulate an excessive amount of copper. A copper test is less usually used to detect copper excess caused by another ailment, to diagnose a copper deficit, or to track treatment for one of these conditions.

Copper is a necessary mineral, but too much of it can be harmful. The majority of it is bound to the enzyme ceruloplasmin in the blood, leaving only a little quantity "free" or unbound.

A whole blood copper test is usually ordered in conjunction with a ceruloplasmin level. If the findings of these tests are abnormal or ambiguous, a 24-hour urine copper test to monitor copper elimination and/or a copper test on a liver biopsy to check copper storage in the liver may be conducted.

A free blood copper test is sometimes ordered as well. If Wilson disease is suspected, genetic testing for mutations in the ATP7B gene may be undertaken. However, these tests are only available in a restricted number of locations and are usually carried out in specialized reference or research laboratories.

A copper test may be used to identify Menkes kinky hair syndrome, a rare inherited copper transport failure condition.

What do my Copper RBC test results mean?

Copper test findings are frequently linked to ceruloplasmin levels and considered in context. Copper results that are abnormal are not indicative of a specific illness; rather, they signal that more research is needed. Because ceruloplasmin is an acute phase reactant, it might be raised if inflammation or severe infections are present, making interpretation difficult. Ceruloplasmin and copper levels rise during pregnancy, as well as with the use of estrogen and oral contraceptives.

Wilson disease is characterized by low blood copper concentrations, elevated urine copper levels, low ceruloplasmin levels, and increased liver copper.

Elevated copper concentrations in the blood and urine, as well as normal or increased ceruloplasmin levels, may suggest excessive copper exposure or be linked to disorders that reduce copper excretion, such as chronic liver disease, or release copper from tissues, such as acute hepatitis. Chronic diseases can cause an increase in hepatic copper levels.

Copper deficiency is indicated by lower copper concentrations in the blood and urine, as well as lower ceruloplasmin levels.

A normal hepatic copper test could mean that copper metabolism is normal, or that the distribution of copper in the liver is uneven, and that the sample isn't reflective of the person's health.

If a person is being treated for Wilson disease or copper toxicity with copper-binding medicines, their 24-hour urine copper levels may be high until their body copper stores are depleted. Copper concentrations in the blood and urine should return to normal over time.

If a person is being treated for a copper deficient disorder and their ceruloplasmin and total copper levels start to rise, the condition is likely responding to the treatment.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: A Ferritin test is a blood test that measures Ferritin levels in your blood’s serum to evaluate the level of iron stored in your body.

Also Known As: Ferritin Serum Test, Ferritin Test, Ferritin Blood Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 1 to 2 days

When is a Ferritin test ordered?

When a CBC test’s implies iron deficiency anemia due to small red blood cells or low hematocrit and hemoglobin levels, the ferritin test, and other iron tests, may be requested, even if other clinical symptoms have not yet arisen.

There are frequently no physical symptoms in the early stages of iron insufficiency. Symptoms rarely develop before hemoglobin falls below dangerous levels. However, when the iron deficit continues, symptoms emerge, prompting a doctor to order ferritin and other iron-related testing. The following are the most prevalent symptoms of iron deficiency anemia:

• Chronic tiredness/fatigue
• Weakness
• Dizziness
• Headaches
• Skin that is pale

Shortness of breath, ringing in the ears, sleepiness, and irritability may occur as iron levels are reduced. Chest pain, headaches, limb pains, shock, and even heart failure may occur as the anemia worsens. Learning impairments can occur in children. There are some symptoms that are specific to iron deficiency, in addition to the usual signs of anemia. Pica, a burning feeling in the tongue or a smooth tongue, ulcers at the corners of the mouth, and spoon-shaped finger- and toe-nails are only a few of the symptoms.

When iron overload is suspected, a ferritin level may be requested. Iron overload symptoms differ from person to person and tend to worsen over time. They are caused by an excess of iron in the blood and tissues. Among the signs and symptoms are:

• Joint discomfort
• Weakness and exhaustion
• Loss of weight
• Energy deficiency
• Pain in the abdomen
• Suffering from a lack of sexual desire
• Hair loss on the body
• Congestive heart failure is an example of a cardiac issue

Other iron tests including a genetic test for hereditary hemochromatosis may be conducted to confirm the existence of iron excess.

What does a Ferritin blood test check for?

Ferritin is an iron-containing protein that stores iron in cells in its most basic form. The amount of total iron stored in the body is reflected in the little amount of ferritin released into the blood. This test determines how much ferritin is present in the blood.

About 70% of the iron consumed by the body is integrated into the hemoglobin of red blood cells in healthy humans. The remaining 30% is stored primarily as ferritin or hemosiderin, which is a combination of iron, proteins, and other elements. Hemosiderin and ferritin are typically found in the liver, although they can also be found in the bone marrow, spleen, and skeletal muscles.

Iron stores are depleted and ferritin levels fall when available iron is insufficient to meet the body's needs. This can happen owing to a lack of iron, poor absorption, or an increased need for iron, such as during pregnancy or if you have a condition that causes persistent blood loss. Before any indicators of iron shortage appear, significant loss of iron reserves may occur.

When the body absorbs more iron than it needs, iron storage and ferritin levels rise. Chronic iron absorption causes a gradual buildup of iron compounds in organs, which can eventually lead to organ malfunction and failure. Even on a typical diet, this happens in hemochromatosis, a hereditary disorder in which the body absorbs too much iron.

Lab tests often ordered with a Ferritin test:

• Complete Blood Count
• Iron Total
• Iron Total and Total Iron binding capacity
• Transferrin
• Comprehensive Metabolic Panel
• Lipid Panel
• Zinc Protoporphyrin

Conditions where a Ferritin test is recommended:

• Anemia
• Hemochromatosis
• Lead poisoning
• Pregnancy
• Restless Leg Syndrome

How does my health care provider use a Ferritin test?

The ferritin test is used to determine the amount of iron a person has in their body. To determine the existence and severity of iron shortage or iron overload, the test is sometimes ordered in conjunction with an iron test and a TIBC test.

One source of iron overload can be the use of iron supplements.

What does my ferritin lab test result mean?

Ferritin levels are frequently measured alongside other iron tests.

Ferritin levels are low in iron deficient people and high in people who have hemochromatosis or have had several blood transfusions.

Ferritin is an acute phase reactant that can be elevated in persons who have inflammation, liver illness, chronic infection, autoimmune disorders, or cancer. Ferritin isn't commonly utilized to detect or monitor these problems.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Ferritin, Iron and Total Iron Binding Capacity (TIBC)

• Ferritin
• Iron and Total Iron Binding Capacity (TIBC)

Description: A Folate test measures the levels of folic acid in the blood. These results can be used to determine a folate deficiency and evaluate a person's nutritional status. Anemia and Neuropathy can also be evaluated using the results from this test.

Also Known As: Folate Serum Test, Folic Acid Test, Vitamin B9 Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 1 to 2 days

When is a Folate test ordered?

When a complete blood count and/or blood smear, performed as part of a health checkup or anemia evaluation, reveal a low red blood cell count with the presence of big RBCs, B12 and folate levels may be ordered. A high mean corpuscular volume, in particular, implies that the RBCs are enlarged.

When a person exhibits the following signs and symptoms of a deficit, testing for folate levels may be necessary.

• Diarrhea
• Dizziness
• Muscle weakness, fatigue
• Appetite loss.
• Skin that is pale
• Irregular heartbeats, rapid heart rate
• Breathing problems
• Tongue and mouth ache
• In the feet, hands, arms, and legs, there is tingling, numbness, and/or burning 
• Confusion or obliviousness
• Paranoia

When a person is at risk of deficiency, such as those with a history of malnutrition or a condition associated to malabsorption, folate testing may be ordered.

Individuals being treated for malnutrition or a folate deficit may have these tests done on a frequent basis to see how effective their treatments are. This could be part of a long-term therapy plan for people who have a disease that causes chronic deficiency.

What does a Folate blood test check for?

The B complex of vitamins includes vitamins including vitamin B12 and folate. They are required for the creation of normal red blood cells, tissue and cell repair, and the synthesis of DNA, the genetic material in cells. Both are nutrients that the body cannot make and must be obtained from the diet.

Vitamin B9 tests, also known as folate tests, diagnose vitamin deficiencies by measuring vitamin levels in the liquid section of the blood. The amount of folate in red blood cells is sometimes tested as well.

Folate is a naturally occurring form of the vitamin, whereas folic acid is a supplement that can be added to foods and beverages. Leafy green vegetables, dry beans and peas, citrus fruits, yeast, and liver all contain it. Vitamin B12, also known as cobalamin, can be found in animal-based foods such red meat, fish, poultry, milk, yogurt, and eggs. Fortified cereals, breads, and other grain products have become key sources of B12 and folate in recent years

A lack of folate can cause macrocytic anemia, a condition in which red blood cells are bigger than normal. Megaloblastic anemia is a kind of macrocytic anemia marked by the generation of fewer but larger RBCs known as macrocytes, as well as cellular abnormalities in the bone marrow. Reduced white blood cell and platelet counts are two more test results linked to megaloblastic anemia.

Folate is required for cell division, which occurs in the developing fetus. In a growing fetus, a lack of folate during early pregnancy can raise the chance of neural tube abnormalities such spina bifida.

Folate deficiency is most commonly caused by inadequate intake of the vitamin through diet or supplements, poor absorption, or increased bodily requirement, as observed during pregnancy:

• Dietary deficiencies are uncommon in the United States since many meals and beverages are fortified with vitamins that the body stores. Adults normally have around three months' worth of folate stored in their liver. Dietary deficiencies normally do not manifest symptoms until the body's vitamin supplies have been exhausted.
• Increased demand—this can occur as a result of a range of diseases and disorders. When a woman is pregnant or nursing, in early childhood, with malignancies, or with chronic hemolytic anemias, there is an increased demand for folate.

Lab tests often ordered with a Folate test:

• Complete Blood Count
• Methylmalonic Acid
• Homocysteine
• Vitamin B1
• Vitamin B3
• Vitamin B5
• Vitamin B6
• Vitamin B7
• Vitamin B12
• Intrinsic Factor Antibody
• Parietal Cell Antibody
• Reticulocyte Count

Conditions where a Folate test is recommended:

• Neural Tube Defects
• Vitamin B12 and Folate Deficiencies
• Anemia
• Alcoholism
• Malnutrition
• Celiac Disease
• Malabsorption
• Neuropathy
• Nervous System Disorders
• Inflammatory Bowel Disease

How does my health care provider use a Folate test?

Separate tests for vitamin B12 and folate are frequently used in conjunction to detect deficiencies and to aid in the diagnosis of anemias such as pernicious anemia, an inflammatory condition that inhibits B12 absorption.

B12 and folate are two vitamins that the body cannot generate and must be obtained from the diet. They're needed for red blood cell creation, tissue and cell repair, and DNA synthesis, which is the genetic material in cells. B12 is required for normal nerve function.

B12 and folate tests can also be used to assess someone who is experiencing mental or behavioral changes, especially in the elderly. A B12 test can be ordered with or without folate, as well as with other screening laboratory tests like a complete blood count, comprehensive metabolic panel, antinuclear antibody, C-reactive protein, and rheumatoid factor, to help determine why a person is exhibiting signs and symptoms of a nerve disorder.

B12 and folate tests can also be performed in conjunction with a variety of other tests to assess a person's overall health and nutritional status if they have signs and symptoms of substantial malnutrition or dietary malabsorption. People with alcoholism, liver disease, stomach cancer, or malabsorption diseases including celiac disease, inflammatory bowel disease, or cystic fibrosis may fall into this category.

Testing may be performed to assess the success of treatment in patients with known B12 and folate deficits. This is especially true for people who cannot absorb B12 and/or folate effectively and must be treated for the rest of their lives.

Folate levels in the blood's liquid part might fluctuate depending on a person's recent diet. Because red blood cells contain 95 percent of circulating folate, a test to evaluate folate levels inside RBCs could be employed instead of or in addition to the serum test. Some doctors believe that the RBC folate test is a better predictor of long-term folate status and is more clinically useful than serum folate, however there is no consensus on this.

Homocysteine and methylmalonic acid are two more laboratory tests that can be used to detect B12 and folate deficits. In B12 deficiency, both homocysteine and MMA are high, whereas in folate deficit, only homocysteine, not MMA, is elevated. This distinction is critical because treating anemia with folate treats the anemia but not the brain damage, which may be irreparable.

What do my Folate Serum test results mean?

Normal folate levels may indicate that a person does not suffer from a deficiency and that the signs and symptoms are caused by something else. Normal levels, on the other hand, may indicate that a person's stored folate has not yet been depleted.

A low folate level in a person with signs and symptoms implies a deficiency, although it does not always indicate the severity of the anemia or related neuropathy. Additional tests are frequently performed to determine the source of the deficit. Low folate levels can be caused by a variety of factors.

Dietary folate deficiency is uncommon in the United States. It can be evident in people who are malnourished in general and vegans who do not eat any animal products. Folate deficiency has become extremely rare since the development of fortified cereals, breads, and other grain products.

Folate deficits can be caused by diseases that prevent them from being absorbed in the small intestine. These may include the following:

• Pernicious anemia.
• Celiac disease
• Crohn's disease and ulcerative colitis
• Bacterial overgrowth or the presence of parasites in the intestines, such as tapeworms
• Long-term usage of antacids or H2 proton pump inhibitors reduces stomach acid production.
• Absorption can be considerably reduced by surgery that removes part of the stomach or the intestines, such as gastric bypass.
• Insufficiency of the pancreas
• Chronic alcoholism or heavy drinking
• Some treatments, such as metformin, omeprazole, methotrexate, or anti-seizure medications like phenytoin.
• Increased requirement for healthy fetal development, all pregnant women require an increased amount of folate and are advised to consume 400 micrograms of folic acid every day. People who have cancer that has spread or who have chronic hemolytic anemia require more folate.
• Smoking

If a person is taking supplements to treat a folate deficiency, normal or higher findings indicate that the treatment is working.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Clinical Significance
Micronutrient, Folate

Patients must be 18 years of age or greater.

Reference Range(s)
≥18 years    >5.4 ng/mL
Reference range not available for individuals <18 years for this micronutrient test.

Clinical Significance
Micronutrients, Antioxidants Panel

Patients must be 18 years of age or greater.

Includes
Micronutrient, Coenzyme Q10 (CoQ10)
Micronutrient, Vitamin A (Retinol)
Micronutrient, Vitamin C
Micronutrient, Vitamin E

Patient Preparation
Overnight fasting required.
Avoid taking Coenzyme Q10 supplements the morning of the test.
Refrain from eating fruits or taking vitamin C supplements 24 hours prior to collection.

Reference Range(s)
Coenzyme Q10 (CoQ10)    >35 ug/mL
Vitamin A (Retinol)
18-19 years    26-72 mcg/dL
>19 years    38-98 mcg/dL
Reference range not available for individuals <18 years for this micronutrient test.

Vitamin C
Male ≥18 years    0.2-2.1 mg/dL
Female ≥18 years    0.3-2.7 mg/dL
Reference range not available for individuals <18 years for this micronutrient test.

Vitamin E
Alpha Tocopherol    ≥18 years    5.7-19.9 mg/L
Beta-Gamma Tocopherol    ≥18 years    <4.4 mg/L
Reference range not available for individuals <18 years for this micronutrient test.

Description: Iron and Total Iron Binding Capacity is a blood panel used to determine iron levels in your blood, your body’s ability to transport iron, and help diagnose iron-deficiency and iron overload.

Also Known As: Serum Iron Test, Serum Fe Test, Iron Binding Capacity Test, IBC Test, Serum Iron-Binding Capacity Siderophilin Test, TIBC Test, UIBC Test, Iron Lab Test, TIBC Blood test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 1 to 2 days

When is a Iron and Total Iron Binding Capacity test ordered?

When a doctor feels that a person's symptoms are caused by iron overload or poisoning, an iron and TIBC test, as well ferritin assays, may be done. These may include the following:

• Joint discomfort
• Weakness and exhaustion
• Energy deficiency
• Pain in the abdomen
• Suffering from a lack of sexual desire
• Problems with the heart

When a child is suspected of ingesting too many iron tablets, a serum iron test is required to detect the poisoning and to determine its severity.

A doctor may also request iron and TIBC when the results of a standard CBC test are abnormal, such as a low hematocrit or hemoglobin, or when a doctor suspects iron deficiency based on signs and symptoms such as:

• Chronic tiredness/fatigue
• Dizziness
• Weakness
• Headaches
• Skin that is pale

What does a Iron and Total Iron Binding Capacity blood test check for?

Iron is a necessary ingredient for survival. It is a vital component of hemoglobin, the protein in red blood cells that binds and releases oxygen in the lungs and throughout the body. It is required in small amounts to help form normal red blood cells and is a critical part of hemoglobin, the protein in RBCs that binds oxygen in the lungs and releases it as blood circulates to other parts of the body.

By detecting numerous components in the blood, iron tests are ordered to determine the quantity of iron in the body. These tests are frequently ordered at the same time, and the data are analyzed together to determine the diagnosis and/or monitor iron deficiency or overload.

The level of iron in the liquid component of the blood is measured by serum iron.

Total iron-binding capacity is a measurement of all the proteins in the blood that may bind to iron, including transferrin.

The percentage of transferrin that has not yet been saturated is measured by the UIBC. Transferrin levels are also reflected in the UIBC.

Low iron levels can cause anemia, resulting in a decrease in the production of microcytic and hypochromic RBCs. Large amounts of iron, on the other hand, might be hazardous to the body. When too much iron is absorbed over time, iron compounds build up in tissues, particularly the liver, heart, and pancreas.

Normally, iron is absorbed from food and distributed throughout the body by binding to transferrin, a liver protein. About 70% of the iron delivered is used in the synthesis of hemoglobin in red blood cells. The rest is stored as ferritin or hemosiderin in the tissues, with minor amounts being utilized to make other proteins like myoglobin and enzymes.

Insufficient intake, limited absorption, or increased dietary requirements, as observed during pregnancy or with acute or chronic blood loss, are all signs of iron deficiency. Excessive intake of iron pills can cause acute iron overload, especially in children. Excessive iron intake, genetic hemochromatosis, multiple blood transfusions, and a few other disorders can cause chronic iron overload.

Lab tests often ordered with a Iron and Total Iron Binding Capacity test:

• Complete Blood Count
• Ferritin
• Transferrin
• Zinc Protoporphyrin

Conditions where a Iron and Total Iron Binding Capacity test is recommended:

• Anemia
• Hemochromatosis

How does my health care provider use a Iron and Total Iron Binding Capacity test?

The amount of circulating iron in the blood, the capacity of the blood to carry iron, and the amount of stored iron in tissues can all be determined by ordering one or more tests. Testing can also assist distinguish between different types of anemia

The level of iron in the blood is measured by serum iron.

Total iron-binding capacity is a measurement of all the proteins in the blood that may bind to iron, including transferrin. The TIBC test is a useful indirect assessment of transferrin because it is the predominant iron-binding protein. In response to the requirement for iron, the body generates transferrin. Transferrin levels rise when iron levels are low, and vice versa. About one-third of the binding sites on transferrin are used to transport iron in healthy humans.

The reserve capacity of transferrin, or the part of transferrin that has not yet been saturated, is measured by UIBC. Transferrin levels are also reflected in the UIBC.

The iron test result, as well as TIBC or UIBC, are used to calculate transferrin saturation. It represents the proportion of transferrin that is iron-saturated.

Ferritin is the major storage protein for iron inside cells, and serum ferritin represents the quantity of stored iron in the body.

These tests are frequently ordered together, and the results can assist the doctor figure out what's causing the iron deficit or overload.

Additional information about iron

A balance between the quantity of iron received into the body and the amount of iron lost is required to maintain normal iron levels. Because a tiny quantity of iron is lost each day, a deficiency will develop if too little iron is consumed. In healthy persons, there is usually enough iron to prevent iron deficiency and/or iron deficiency anemia, unless they eat a bad diet. There is a greater need for iron in some circumstances. People who have persistent gut bleeding or women who have heavy menstrual periods lose more iron than they should and can develop iron deficiency. Females who are pregnant or breastfeeding lose iron to their babies and may develop an iron shortage if they do not consume enough supplemental iron. Children may require additional iron, especially during periods of rapid growth, and may suffer iron shortage.

Low serum iron can also arise when the body is unable to adequately utilize iron. The body cannot correctly utilize iron to generate additional red cells in many chronic disorders, particularly malignancies, autoimmune diseases, and chronic infections. As a result, transferrin production slows, serum iron levels drop because little iron is absorbed from the stomach, and ferritin levels rise. Malabsorption illnesses like sprue syndrome can cause iron deficiency.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: Iron is a blood test used to determine iron levels in your blood, your body’s ability to transport iron, and help diagnose iron-deficiency and iron overload.

Also Known As: Serum Iron Test, Serum Fe Test, Iron Total Test, IBC Test, Iron Lab Test, Iron Blood test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: The patient should be fasting 9-12 hours prior to collection and collection should be done in the morning.

Average Processing Time: 1 to 2 days

When is an Iron Total test ordered?

When a doctor feels that a person's symptoms are caused by iron overload or poisoning, an iron test, as well ferritin assays, may be done. These may include the following:

• Joint discomfort
• Weakness and exhaustion
• Energy deficiency
• Pain in the abdomen
• Suffering from a lack of sexual desire
• Problems with the heart

When a child is suspected of ingesting too many iron tablets, a serum iron test is required to detect the poisoning and to determine its severity.

A doctor may also request iron testing when the results of a standard CBC test are abnormal, such as a low hematocrit or hemoglobin, or when a doctor suspects iron deficiency based on signs and symptoms such as:

• Chronic tiredness/fatigue
• Dizziness
• Weakness
• Headaches
• Skin that is pale

What does an Iron Total blood test check for?

Iron is a necessary ingredient for survival and is a critical component of hemoglobin, the protein in red blood cells that binds oxygen in the lungs and releases it to other parts of the body. It is required in small amounts to help form normal red blood cells and is a critical part of hemoglobin, the protein in RBCs that binds oxygen in the lungs and releases it as blood circulates to other parts of the body.

By detecting numerous components in the blood, iron tests are ordered to determine the quantity of iron in the body. These tests are frequently ordered at the same time, and the data are analyzed together to determine the diagnosis and/or monitor iron deficiency or overload.

The level of iron in the liquid component of the blood is measured by serum iron.

Low iron levels can cause anemia, resulting in a decrease in the production of microcytic and hypochromic RBCs. Large amounts of iron, on the other hand, might be hazardous to the body. When too much iron is absorbed over time, iron compounds build up in tissues, particularly the liver, heart, and pancreas.

Normally, iron is absorbed from food and distributed throughout the body by binding to transferrin, a liver protein. About 70% of the iron delivered is used in the synthesis of hemoglobin in red blood cells. The rest is stored as ferritin or hemosiderin in the tissues, with minor amounts being utilized to make other proteins like myoglobin and enzymes.

Insufficient intake, limited absorption, or increased dietary requirements, as observed during pregnancy or with acute or chronic blood loss, are all signs of iron deficiency. Excessive intake of iron pills can cause acute iron overload, especially in children. Excessive iron intake, genetic hemochromatosis, multiple blood transfusions, and a few other disorders can cause chronic iron overload.

Lab tests often ordered with an Iron Total test:

• Complete Blood Count
• Ferritin
• Transferrin
• Zinc Protoporphyrin

Conditions where an Iron Total test is recommended:

• Anemia
• Hemochromatosis

How does my health care provider use an Iron Total test?

The amount of circulating iron in the blood, the capacity of the blood to carry iron, and the amount of stored iron in tissues can all be determined by ordering one or more tests. Testing can also assist distinguish between different types of anemia

The level of iron in the blood is measured by serum iron.

Total iron-binding capacity is a measurement of all the proteins in the blood that may bind to iron, including transferrin. The TIBC test is a useful indirect assessment of transferrin because it is the predominant iron-binding protein. In response to the requirement for iron, the body generates transferrin. Transferrin levels rise when iron levels are low, and vice versa. About one-third of the binding sites on transferrin are used to transport iron in healthy humans.

The reserve capacity of transferrin, or the part of transferrin that has not yet been saturated, is measured by UIBC. Transferrin levels are also reflected in the UIBC.

The iron test result, as well as TIBC or UIBC, are used to calculate transferrin saturation. It represents the proportion of transferrin that is iron-saturated.

Ferritin is the major storage protein for iron inside cells, and serum ferritin represents the quantity of stored iron in the body.

These tests are frequently ordered together, and the results can assist the doctor figure out what's causing the iron deficit or overload.

Additional information about iron

A balance between the quantity of iron received into the body and the amount of iron lost is required to maintain normal iron levels. Because a tiny quantity of iron is lost each day, a deficiency will develop if too little iron is consumed. In healthy persons, there is usually enough iron to prevent iron deficiency and/or iron deficiency anemia, unless they eat a bad diet. There is a greater need for iron in some circumstances. People who have persistent gut bleeding or women who have heavy menstrual periods lose more iron than they should and can develop iron deficiency. Females who are pregnant or breastfeeding lose iron to their babies and may develop an iron shortage if they do not consume enough supplemental iron. Children may require additional iron, especially during periods of rapid growth, and may suffer iron shortage.

Low serum iron can also arise when the body is unable to adequately utilize iron. The body cannot correctly utilize iron to generate additional red cells in many chronic disorders, particularly malignancies, autoimmune diseases, and chronic infections. As a result, transferrin production slows, serum iron levels drop because little iron is absorbed from the stomach, and ferritin levels rise. Malabsorption illnesses like sprue syndrome can cause iron deficiency.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Clinical Significance
Micronutrient, Iron - Serum measurements are useful in the diagnosis of iron deficiency and hemochromatosis.

Patients must be 18 years of age or greater.

Patient Preparation
Samples should be taken in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia.
 

Reference Range(s)

Reference range not available for individuals <18 years for this micronutrient test.

Clinical Significance
Micronutrients, Mineral/Element Panel

Patients must be 18 years of age or greater.

Overnight fasting is required.
Refrain from taking vitamins or mineral supplements 3 days before specimen collection and from eating legumes and leafy vegetables 2 days before specimen collection.

Includes

• Micronutrient, Calcium
• Micronutrient, Chromium, Blood
• Micronutrient, Copper, Plasma
• Micronutrient, Iron
• Micronutrient, Magnesium, RBC
• Micronutrient, Manganese, Blood
• Micronutrient, Molybdenum, Blood
• Micronutrient, Selenium, Blood
• Micronutrient, Zinc, Plasma

Description: Leptin is a hormone that the body uses to monitor your appetite. When leptin is being produced it is telling your body that it is full, and you do not need to continue eating. Leptin can also control the amount of energy that is burnt throughout the day.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 5 to 6 days

When is a Leptin test ordered?

Leptin is typically ordered during clinical investigations to further investigate leptin's role.

Leptin testing is rarely requested outside of research, however it may be requested when a child is diagnosed as fat, particularly if there is a family history of early-onset obesity.

When analyzing an obese person, some doctors may conduct a leptin test to see if they have a deficiency or an excess of the hormone.

What does a Leptin blood test check for?

Leptin is a hormone that signals hunger satisfaction and helps to regulate appetite. This test detects a leptin shortage that may be linked to obesity by measuring the quantity of leptin in the blood.

Leptin is largely produced by fat cells, with minor contributions from other tissues such as the placenta in pregnant women. It travels via the brain's hypothalamus via blood receptors. When enough food has been ingested, the body signals that it is no longer hungry. A low amount of leptin induces hunger and an increase in food consumption in a typical feedback response. Hunger decreases and food consumption decreases as leptin levels rise due to an increase in fat cells.

As the body seeks to defend itself from perceived underfeeding, insufficient leptin can produce persistent hunger. Rare hereditary leptin deficits can lead to severe obesity, resulting in persistent hunger and eating that begins in childhood. Leptin replacement therapy has been demonstrated to help some of persons who are impacted.

Elevated leptin levels are most typically linked to obesity. This is hypothesized to be caused by leptin resistance, which is comparable to the insulin resistance found in obesity. People who are impacted are resistant to leptin's activity, and they continue to feel hungry even after eating enough food. In an attempt to compensate for the perceived hunger, the body continues to create more leptin. However, it is estimated that roughly 10% of obese people have some level of leptin insufficiency.

The relationship between leptin and obesity has piqued researchers' interest. Obesity is a major public health concern in the United States because it raises the risk of a variety of conditions, including high blood pressure, dyslipidemias, type 2 diabetes, joint problems, sleep apnea, coronary heart disease, stroke, and certain cancers. Obesity has consistently climbed in all age groups over the last 20 years, and the Centers for Disease Control and Prevention estimates that more than one-third of adults and 17% of adolescents and teens in the United States are obese. The body mass index, or BMI, is used to classify people.

According to a new study, a leptin level may be more accurate than the standard body mass index in determining how much excess fat a person carries in some people. The higher the level of leptin in a person's system, the more fat tissue they have. This was notably evident in the study with older women and those with strong muscles or solid bones, where the BMI score could be deceiving.

The study of leptin's functions in the body, as well as the relationships between leptin and obesity and successful weight loss, is ongoing. There's also a lot of curiosity about whether a leptin-based medication could help obese people who are also leptin deficient.

Lab tests often ordered with a Leptin test:

• Lipid Panel
• Thyroid Panel
• Glucose
• Hemoglobin A1c
• Insulin
• Comprehensive Metabolic Panel

Conditions where a Leptin test is recommended:

• Metabolic Syndrome
• Diabetes
• Adrenal Insufficiency
• Addison Disease
• Cushing Syndrome
• Thyroid Diseases
• Insulin Resistance
• Heart Disease
• Malnutrition

How does my health care provider use a Leptin test?

The leptin test is not commonly ordered, and its utility in medical settings is still unknown. As the role of leptin is examined further, most testing is still done in a laboratory context.

A leptin test is most likely to be ordered on an obese child in a clinical environment, especially if there is a family history of early-onset obesity. It's commonly ordered on an obese person with frequent, persistent hunger symptoms to see if they have a leptin shortage or excess.

The test may be done in conjunction with other tests, such as a lipid profile, thyroid panel, glucose, insulin, and/or A1c, to assess an obese person's health status and detect underlying issues that are contributing to or exacerbating their situation.

What do my Leptin test results mean?

Reduced leptin levels in the obese may indicate a deficiency, whilst increasing concentrations are thought to be linked to resistance to leptin's actions. The majority of obese persons will have elevated levels, but about 10% of them may have a leptin shortage.

Significantly lower leptin levels may signal a hereditary leptin deficit associated to extreme obesity in rare cases.

Leptin secretion has a circadian pattern, which means that its concentration in the blood varies throughout a 24-hour period.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: A Lipid Panel is a blood test that measures your cholesterol levels to evaluate your risk of cardiovascular disease.

Also Known As: Lipid Profile Test, Lipid Test, Cholesterol Profile Test, Cholesterol Panel Test, Cholesterol Test, Coronary Risk Panel Test, lipid blood test, Lipid w/Ratios Test, Cholesterol Ratio test, blood cholesterol Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: Patient should be fasting 9-12 hours prior to collection.

Average Processing Time: 1 to 2 days

When is a Lipid Panel with Ratios test ordered?

A fasting lipid profile should be done about every five years in healthy persons who have no additional risk factors for heart disease. A single total cholesterol test, rather than a complete lipid profile, may be used for initial screening. If the screening cholesterol test result is high, a lipid profile will almost certainly be performed.

More regular testing with a full lipid profile is indicated if other risk factors are present or if earlier testing revealed a high cholesterol level.

Other risk factors, in addition to high LDL cholesterol, include:

• Smoking
• Obesity or being overweight
• Unhealthy eating habits
• Not getting enough exercise and being physically inactive
• Older age
• Having hypertension
• Premature heart disease in the family
• Having experienced a heart attack or having pre-existing heart disease

Diabetes or pre-diabetes is a condition in which a person has High HDL is a "negative risk factor," and its existence permits one risk factor to be removed from the total.

The American Academy of Pediatrics recommends routine lipid testing for children and young adults. Children and teenagers who are at a higher risk of developing heart disease as adults should be screened with a lipid profile earlier and more frequently. A family history of heart disease or health problems such as diabetes, high blood pressure, or being overweight are some of the risk factors, which are comparable to those in adults. According to the American Academy of Pediatrics, high-risk children should be examined with a fasting lipid profile between the ages of 2 and 8.

A lipid profile can also be done at regular intervals to assess the effectiveness of cholesterol-lowering lifestyle changes like diet and exercise, as well as pharmacological therapy like statins.

What does a Lipid Panel with Ratios blood test check for?

Lipids are a class of fats and fat-like compounds that are essential components of cells and energy sources. The level of certain lipids in the blood is measured by a lipid profile.

Lipoprotein particles transport two key lipids, cholesterol and triglycerides, through the bloodstream. Protein, cholesterol, triglyceride, and phospholipid molecules are all present in each particle. High-density lipoproteins, low-density lipoproteins, and very low-density lipoproteins are the three types of particles assessed with a lipid profile.

It's critical to keep track of and maintain optimal levels of these lipids in order to stay healthy. While the body creates the cholesterol required for normal function, some cholesterol is obtained from the diet. A high amount of cholesterol in the blood can be caused by eating too many foods high in saturated fats and trans fats or having a hereditary tendency. The excess cholesterol may form plaques on the inside walls of blood vessels. Plaques can constrict or block blood channel openings, causing artery hardening and raising the risk of a variety of health problems, including heart disease and stroke. Although the explanation for this is unknown, a high level of triglycerides in the blood is linked to an increased risk of developing cardiovascular disease.

A lipid profile consists of the following elements:

• Cholesterol total
• HDL Cholesterol - commonly referred to as "good cholesterol" since it eliminates excess cholesterol from the body and transports it to the liver for elimination.
• LDL Cholesterol - commonly referred to as "bad cholesterol" because it deposits excess cholesterol in the walls of blood arteries, contributing to atherosclerosis.
• Triglycerides
• Ratio of LDL to HDL cholesterol

Lab tests often ordered with a Lipid Panel with Ratios test:

• CBC (Blood Count Test) with Smear Review
• Comprehensive Metabolic Panel
• Direct LDL
• VLDL
• Lp-PLA2
• Apolipoprotein A1
• Apolipoprotein B
• Lipoprotein (a)
• Lipoprotein Fractionation Ion Mobility (LDL Particle Testing)

Conditions where a Lipid Panel with Ratios test is recommended:

• Hypertension
• Cardiovascular Disease
• Heart Disease
• Stroke

Commonly Asked Questions:

How does my health care provider use a Lipid Panel with Ratios test?

The lipid profile is used as part of a cardiac risk assessment to help determine an individual's risk of heart disease and, if there is a borderline or high risk, to help make treatment options.

Lipids are a class of fats and fat-like compounds that are essential components of cells and energy sources. It's critical to keep track of and maintain optimal levels of these lipids in order to stay healthy.

To design a therapy and follow-up strategy, the results of the lipid profile are combined with other recognized risk factors for heart disease. Treatment options may include lifestyle changes such as diet and exercise, as well as lipid-lowering drugs such as statins, depending on the results and other risk factors.

A normal lipid profile test measures the following elements:

• Total cholesterol is a test that determines how much cholesterol is present in all lipoprotein particles.
• HDL Cholesterol — measures hdl cholesterol in particles, sometimes referred to as "good cholesterol" since it eliminates excess cholesterol and transports it to the liver for elimination.
• LDL Cholesterol – estimates the cholesterol in LDL particles; sometimes known as "bad cholesterol" since it deposits excess cholesterol in blood vessel walls, contributing to atherosclerosis. The amount of LDL Cholesterol is usually estimated using the total cholesterol, HDL Cholesterol, and triglycerides readings.
• Triglycerides – triglycerides are measured in all lipoprotein particles, with the highest concentration in very-low-density lipoproteins.
• As part of the lipid profile, several extra information may be presented. The results of the above-mentioned tests are used to determine these parameters.
• VLDL Cholesterol — derived using triglycerides/5; this calculation is based on the typical VLDL particle composition.
• Non-HDL Cholesterol - the result of subtracting total cholesterol from HDL Cholesterol.
• Cholesterol/HDL ratio — total cholesterol to HDL Cholesterol ratio computed.

An expanded profile may include the amount and concentration of low-density lipoprotein particles. Rather than assessing the amount of LDL cholesterol, this test counts the number of LDL particles. This figure is thought to more accurately reflect the risk of heart disease in some persons.

What do my Lipid Panel test results mean?

Healthy lipid levels, in general, aid in the maintenance of a healthy heart and reduce the risk of heart attack or stroke. A health practitioner would analyze the results of each component of a lipid profile, as well as other risk factors, to assess a person's total risk of coronary heart disease, if therapy is required, and, if so, which treatment will best serve to reduce the person's risk of heart disease.

The Adult Treatment Panel III of the National Cholesterol Education Program published guidelines for measuring lipid levels and selecting treatment in 2002. The American College of Cardiology and the American Heart Association announced updated cholesterol therapy guidelines in 2013 to minimize the risk of cardiovascular disease in adults. These guidelines suggest a different treatment method than the NCEP guidelines. Cholesterol-lowering medications are now chosen based on the 10-year risk of atherosclerotic cardiovascular disease and other criteria, rather than on LDL-C or non-HDL-C objectives.

The revised guidelines include an evidence-based risk calculator for ASCVD that may be used to identify people who are most likely to benefit from treatment. It's for adults between the ages of 40 and 79 who don't have a heart condition. The computation takes into account a number of characteristics, including age, gender, race, total cholesterol, HDL-C, blood pressure, diabetes, and smoking habits. The new guidelines also suggest comparing therapeutic response to LDL-C baseline readings, with decrease criteria varying depending on the degree of lipid-lowering medication therapy.

Unhealthy lipid levels, as well as the presence of additional risk factors like age, family history, cigarette smoking, diabetes, and high blood pressure, may indicate that the person being examined needs to be treated.

The NCEP Adult Treatment Panel III guidelines specify target LDL cholesterol levels based on the findings of lipid testing and these other main risk factors. Individuals with LDL-C levels over the target limits will be treated, according to the guidelines.

According to the American Academy of Pediatrics, screening youths with risk factors for heart disease with a full, fasting lipid panel is advised. Fasting is not required prior to lipid screening in children who do not have any risk factors. For non-fasting lipid screening, non-high-density lipoprotein cholesterol is the preferred test. Non-HDL-C is computed by subtracting total cholesterol and HDL-C from total cholesterol and HDL-C.

Is there anything else I should know?

The measurement of triglycerides in people who haven't fasted is gaining popularity. Because most of the day, blood lipid levels reflect post-meal levels rather than fasting levels, a non-fasting sample may be more representative of the "usual" circulating level of triglyceride. However, because it is still unclear how to interpret non-fasting levels for assessing risk, the current recommendations for fasting before lipid tests remain unchanged.

A fasting lipid profile is usually included in a routine cardiac risk assessment. In addition, research into the utility of additional non-traditional cardiac risk markers, such as Lp-PLA2, is ongoing. A health care provider may use one or more of these markers to help determine a person's risk, but there is no consensus on how to use them and they are not widely available.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: A Magnesium test is a blood test that measures magnesium levels in your blood’s serum and is useful in determining the cause of abnormal levels of magnesium, calcium, and or potassium, and is useful in the evaluation of a wide variety of disorders such as diabetes, kidney disease, and malabsorption.

Also Known As: Magnesium Serum Test, Mg Test, Mag Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

Average Processing Time: 1 to 2 days

When is a Magnesium test ordered?

Magnesium tests may be requested by health professionals as a follow-up to chronically low calcium and potassium levels in the blood. It may also be ordered if a person is experiencing muscle weakness, cramping, twitching, disorientation, seizures, or cardiac arrhythmias, which could be caused by a magnesium deficit.

As part of an evaluation of malabsorption, malnutrition, diarrhea, or alcoholism, a health practitioner may prescribe a magnesium level to check for a deficit. Testing may also be done if someone is taking drugs that cause the kidneys to excrete magnesium. When magnesium and/or calcium supplementation is required, the level of magnesium in the blood can be measured at regular intervals to ensure that the medication is working.

A magnesium test, along with kidney function tests such as a BUN and creatinine, may be given on a regular basis when someone has a kidney problem or uncontrolled diabetes to help monitor renal function and ensure that the person is not excreting or retaining excessive quantities of magnesium.

What does a Magnesium Serum test check for?

The magnesium test measures the amount of magnesium in your blood’s serum. Magnesium is a mineral that supports healthy bones, neuron function, muscle contraction and energy production. It enters the body through the diet and is then processed by the small intestine and colon. Tissues, cells, and bones all contain the element magnesium. It is challenging to determine the total magnesium content from blood tests alone since only 1% of the magnesium present in the body is accessible in the blood. However, this test is still useful for figuring out a person's magnesium levels.

Small levels of magnesium can be found in a range of meals, including green vegetables like spinach, whole grains, and nuts. Magnesium is commonly found in foods that contain dietary fiber. The body regulates how much magnesium it receives and excretes or conserves in the kidneys to keep its magnesium level stable.

Magnesium deficiency can occur as a result of malnutrition, malabsorption-related disorders, or excessive magnesium loss via the kidneys. Magnesium overload can occur as a result of taking magnesium-containing antacids or a decrease in the kidneys' ability to eliminate magnesium.

There may be no or few nonspecific symptoms in someone with mild to severe magnesium insufficiency. Loss of appetite, nausea, muscle cramps, confusion, exhaustion, seizures, changes in heart rate, and tingling or numbness are all symptoms of persistent or severe deficits. They can also wreak havoc on calcium metabolism and worsen calcium deficiency. Muscle weakness, nausea, loss of hunger or cravings, and an erratic heart rate are some of the symptoms of excess magnesium, which are similar to those of deficiency.

Lab tests often ordered with a Magnesium test:

• Complete Blood Count
• Calcium
• Iron Total and Total Iron binding capacity
• Potassium
• Comprehensive Metabolic Panel
• Lipid Panel
• Phosphorus
• Parathyroid Hormone
• Vitamin D
• Glucose

Conditions where a Magnesium test is recommended:

• Hypomagnesemia
• Hypermagnesemia
• Kidney Disease
• Hypothyroidism
• Diabetes
• Alcoholism
• Malnutrition
• Malabsorption
• Diarrhea
• Dehydration
• Parathyroid Diseases
• Addison Disease
• Adrenal Insufficiency

How does my health care provider use a Magnesium test?

Magnesium levels in the blood are measured with a magnesium test. Atypical magnesium levels are most frequently found in conditions or illnesses that result in insufficient or excessive renal excretion of magnesium or impaired intestinal absorption of magnesium. Magnesium levels can be measured to determine the severity of kidney issues, uncontrolled diabetes, as well as to diagnose gastrointestinal diseases.

Because a low magnesium blood level can lead to chronically low calcium and potassium levels over time, it may be tested to help diagnose calcium, phosphorus, potassium, and/or parathyroid hormone – another component of calcium regulation – problems.

Magnesium levels can be checked on a regular basis to monitor the response to oral or intravenous magnesium supplements, and calcium supplementation can be monitored using calcium and phosphorus tests.

What does my Magnesium test result mean?

Low magnesium levels in the blood can suggest that a person isn't getting enough magnesium or is excreting too much. Deficiencies are most commonly encountered in:

• Low nutritional intake 
• Gastrointestinal conditions
• Diabetes that is uncontrolled
• Hypoparathyroidism
• Use of a diuretic for a long time
• diarrhea that lasts for a long time
• Following surgery
• Burns that are severe
• Pregnancy toxicity

Magnesium levels in the blood are rarely elevated as a result of food sources, but rather as a result of an excretion problem or excessive supplementation. Increased levels can be cause by:

• Failure of the kidneys
• Hyperparathyroidism
• Hypothyroidism
• Dehydration
• Diabetic acidosis
• Addison's disese
• Use of antacids or laxatives containing magnesium

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Description: A Magnesium test is a blood test that measures magnesium levels in your blood’s red blood cells and is useful in determining the cause of abnormal levels of magnesium, calcium, and or potassium, and is useful in the evaluation of a wide variety of disorders such as diabetes, kidney disease, and malabsorption.

Also Known As: Magnesium RBC Test, Magnesium Red Bood Cell Test, Mg Test, Mag test

Collection Method: Blood Draw

Specimen Type: Red Blood Cells

Test Preparation: No preparation required

Average Processing Time: 4 to 5 days

When is a Magnesium RBC test ordered?

Magnesium tests may be requested by health professionals as a follow-up to chronically low calcium and potassium levels in the blood. It may also be prescribed if a person exhibits symptoms of a magnesium deficiency, such as twitching, muscle weakness, cramping, disorientation, seizures, or cardiac arrhythmias.

As part of an evaluation of malabsorption, malnutrition, diarrhea, or alcoholism, a health practitioner may prescribe a magnesium level to check for a deficit. Testing may also be done if someone is taking drugs that cause the kidneys to excrete magnesium. When magnesium and/or calcium supplementation is required, the level of magnesium in the blood can be measured at regular intervals to ensure that the medication is working.

A magnesium test, along with kidney function tests such as a BUN and creatinine, may be given on a regular basis when someone has a kidney problem or uncontrolled diabetes to help monitor renal function and ensure that the person is not excreting or retaining excessive quantities of magnesium.

What does a Magnesium RBC test check for?

The magnesium test measures the amount of magnesium in your blood’s serum. Magnesium is a mineral that supports healthy bones, muscle contraction, neuron function, and energy production. It enters the body through the diet and is then absorbed by the small intestine and colon. Bones, cells, and tissues all contain the element magnesium. It is challenging to determine the total magnesium content from blood tests alone since only 1% of the magnesium present in the body is accessible in the blood. However, this test is still useful for figuring out a person's magnesium levels.

Small levels of magnesium can be found in a range of meals, including green vegetables like spinach, whole grains, and nuts. Magnesium is commonly found in foods that contain dietary fiber. The body regulates how much magnesium it receives and excretes or conserves in the kidneys to keep its magnesium level stable.

Magnesium deficiency can occur as a result of malnutrition, malabsorption-related disorders, or excessive magnesium loss via the kidneys. Magnesium overload can occur as a result of taking magnesium-containing antacids or a decrease in the kidneys' ability to eliminate magnesium.

There may be no or few nonspecific symptoms in someone with mild to severe magnesium insufficiency. Nausea, loss of appetite, exhaustion, confusion, muscle cramps, seizures, changes in heart rate, and numbness or tingling are all symptoms of persistent or severe deficits. They can also wreak havoc on calcium metabolism and worsen calcium deficiency. Nausea, muscle weakness, loss of appetite, and an erratic heart rate are some of the symptoms of excess magnesium, which are similar to those of deficiency.

Lab tests often ordered with a Magnesium RBC test:

• Complete Blood Count
• Calcium
• Iron Total and Total Iron binding capacity
• Potassium
• Comprehensive Metabolic Panel
• Lipid Panel
• Phosphorus
• Parathyroid Hormone
• Vitamin D
• Glucose

Conditions where a Magnesium RBC test is recommended:

• Kidney Disease
• Hypothyroidism
• Diabetes
• Alcoholism
• Malnutrition
• Malabsorption
• Diarrhea
• Dehydration
• Parathyroid Diseases
• Addison Disease
• Adrenal Insufficiency

How does my health care provider use a Magnesium RBC test?

Magnesium levels in the blood are measured with a magnesium test. Atypical magnesium levels are most frequently found in conditions or illnesses that result in insufficient or excessive renal excretion of magnesium or impaired intestinal absorption of magnesium. Magnesium levels can be measured to determine the severity of kidney issues, uncontrolled diabetes, and/or uncontrolled diabetes as well as to diagnose gastrointestinal diseases.

Because a low magnesium blood level can lead to chronically low calcium and potassium levels over time, it may be tested to help diagnose calcium, phosphorus, potassium, and/or parathyroid hormone – another component of calcium regulation – problems.

Magnesium levels can be checked on a regular basis to monitor the response to oral or intravenous magnesium supplements, and calcium supplementation can be monitored using calcium and phosphorus tests.

What does my Magnesium RBC test result mean?

Low magnesium levels in the blood can suggest that a person isn't getting enough magnesium or is excreting too much. Deficiencies are most commonly encountered in:

• Low nutritional intake 
• Gastrointestinal conditions
• Diabetes that is uncontrolled
• Hypoparathyroidism
• Use of a diuretic for a long time
• diarrhea that lasts for a long time
• Following surgery
• Burns that are severe
• Pregnancy toxicity

Magnesium levels in the blood are rarely elevated as a result of food sources, but rather as a result of an excretion problem or excessive supplementation. Increased levels can be cause by:

• Failure of the kidneys
• Hyperparathyroidism
• Hypothyroidism
• Dehydration
• Diabetic acidosis
• Addison's disese
• Use of antacids or laxatives containing magnesium

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

Clinical Significance
Micronutrient, Magnesium, RBC - Magnesium is an essential trace element. Deficiency leads to irritability, neuromuscular abnormalities, cardiac and renal damage. Its salts are used as antacids and cathartics. Excessive amount may cause CNS depression, loss of muscle tone, respiratory and cardiac arrest.

Patients must be 18 years of age or greater.

Patient Preparation
Patient should refrain from taking vitamins, or mineral herbal supplements for at least one week before sample collection.

Reference Range(s)
≥18 years    4.0-6.4 mg/dLReference range not available for individuals <18 years for this micronutrient test.