Depression

Depression is a clinical condition, but many medical issues can mimic or worsen depressive symptoms—including thyroid disease, anemia, vitamin and iron deficiencies, diabetes, hormone changes, infections, and some medicines or substances. Blood testing does not diagnose depression itself; instead, it helps find reversible contributors, establish baselines before or during treatment, and monitor overall health.

A proactive plan usually starts with CBC/CMPthyroid (TSH ± Free T4)vitamin B12 with methylmalonic acid (MMA)vitamin DA1c/fasting glucose, and iron studies. Depending on age and symptoms, add testosterone (men, morning)prolactinestradiol/FSH (perimenopause), inflammation markers (CRP/hs-CRP), and cortisol when adrenal concerns arise. In selected cases, clinicians add HIV/syphilis screening or other tests. Use these labs to screentriage, and monitor trends alongside your clinician’s evaluation.

Signs, Symptoms & Related Situations

  • Mood, energy, cognition: persistent sadness, loss of interest, fatigue, slowed thinking, trouble concentrating, sleep changes

  • Physical clues: weight or appetite change, headaches, body aches, GI upset, low libido

  • Medical contexts: thyroid symptoms (cold intolerance, hair thinning), heavy periods or blood loss, diabetes or prediabetes, chronic pain/inflammation, postpartum or perimenopausal change, low testosterone signs in men

  • Medication/substance factors: alcohol/heavy drinking, sedatives/opioids/stimulants, new supplements

  • Urgent help now: thoughts of harming yourself or others, or inability to care for basic needs—seek emergency care immediately

Symptoms require evaluation by a qualified clinician.

Why These Tests Matter

What testing can do

  • Reveal medical contributors (e.g., hypothyroidism, anemia, low B12/folate, vitamin D or iron deficiency, diabetes, low testosterone)

  • Clarify risk patterns (metabolic or inflammatory) that may affect mood and energy

  • Establish baselines and support treatment safety monitoring (liver, kidney, electrolytes)

What testing cannot do

  • Diagnose depression or replace a mental-health assessment

  • Determine psychological, social, or sleep contributors on its own

  • Provide treatment or dosing advice—review results with your clinician

What These Tests Measure (at a glance)

  • CBC (Complete Blood Count): checks for anemia or infection that can cause fatigue or low mood.

  • CMP (Comprehensive Metabolic Panel): electrolyteskidney/liver function; low sodium or abnormal LFTs may affect symptoms and medication safety.

  • Thyroid Panel (TSH ± Free T4): rules out hypo-/hyperthyroidism; consider TPO antibodies if autoimmune disease is suspected.

  • Vitamin B12 with MMA ± Folate: MMA rises with functional B12 deficiency, even when B12 looks “normal.”

  • Vitamin D (25-OH): low levels can relate to low energy and bone/muscle health.

  • Iron Studies (Ferritin, Iron/TIBC, Transferrin Saturation): low stores contribute to fatigue, brain fog, and restless legs.

  • Glucose/A1c (± fasting insulin): screens for prediabetes/diabetes that can lower energy and mood.

  • Inflammation (CRP/hs-CRP, ± ESR): identifies systemic inflammation that may correlate with somatic symptoms.

  • Hormones (as indicated):

    • Men: Total testosterone (morning) ± free T/SHBGprolactin

    • Perimenopause: Estradiol/FSH (clinician-directed)

  • Adrenal context: AM cortisol (± ACTH) in selected cases with clear clinical suspicion.

  • Infections (as indicated): HIV 4th-generationsyphilis tests when risk factors or exam point that way.

Quick Build Guide

Goal Start with Add if needed
First-line medical screen for depression CBC • CMP • TSH • B12 + MMA • Vitamin D • A1c Ferritin/Iron/TIBC • CRP/hs-CRP
Marked fatigue/brain fog CBC • Ferritin • B12 + MMA • TSH Vitamin D • CMP
Weight/sleep or metabolic concerns A1c • CMP • TSH Lipid panel • CRP/hs-CRP
Men with low libido/ED AM Total Testosterone Free T/SHBG • Prolactin • TSH
Perimenopausal symptoms TSH • Ferritin • Vitamin D Estradiol/FSH (clinician-directed)
Medication safety baseline CMP • CBC Add others per clinician plan
Atypical features/risk factors CBC • CMP • TSH • B12 + MMA HIV 4th-gen • Syphilis tests (as indicated)

How the Testing Process Works

  1. Choose your starting set based on symptoms and goals (see Quick Build Guide).

  2. Provide samples: standard blood draw; fasting only if your order includes fasting lipids/glucose.

  3. Check pre-analytical details: schedule morning testosterone for men; list current meds/supplements on your order.

  4. View results securely: most post within a few days.

  5. Plan next steps: review results with your clinician; add targeted tests or monitoring as needed.

Interpreting Results (General Guidance)

  • Low B12 with elevated MMA → suggests true B12 deficiency; discuss causes and follow-up.

  • TSH abnormal → thyroid imbalance can drive mood, energy, and sleep symptoms.

  • Low ferritin or anemia → can cause fatigue and cognitive complaints; confirm and address with your clinician.

  • High A1c/glucose → metabolic drivers may affect mood and energy; trends matter.

  • Elevated CRP/hs-CRP → signals inflammation; interpret with history and exam.

  • Low morning testosterone (men) → repeat AM and consider free T/SHBG and prolactin.
    Always interpret patterns over time with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Foundational screen: CBC • CMP • TSH • B12 + MMA • Vitamin D • A1c

  • Fatigue/iron focus: Ferritin • Iron/TIBC • Transferrin Saturation

  • Hormone add-ons: AM Total Testosterone ± Free T/SHBG • Prolactin (men); Estradiol/FSH(clinician-directed)

  • Inflammation/metabolic: CRP/hs-CRP • Lipid panel

  • Targeted infection screen: HIV 4th-gen • Syphilis tests when indicated

FAQs

Can blood tests diagnose depression?
No. They identify medical contributors and set baselines. Diagnosis requires a clinician’s assessment.

Which labs are most common for depression workups?
CBC, CMP, TSH, B12 + MMA, vitamin D, A1c, and often iron studies.

Do I need to fast?
Only if your order includes fasting lipids or fasting glucose.

Why test B12 and MMA together?
MMA rises when tissues are short on B12, even if serum B12 looks normal—useful for early deficiency.

Can hormones play a role?
Yes. Low testosterone in men or perimenopausal shifts can affect mood and energy. Testing is tailored to symptoms.

What if my labs are normal but I still feel depressed?
Labs are one piece. Continue working with your clinician on comprehensive care and supports.

I’m in crisis—what should I do?
If you’re thinking about self-harm, seek emergency help immediately (call local emergency services or go to the nearest ER).

Related Categories & Key Tests

  • Neurological Disorders Tests Hub

  • Brain Health • All Cognitive Health Tests • Thyroid Tests • Men’s/Women’s Hormone Health • Diabetes Health • Vitamin & Nutrient Tests • Inflammation Tests

  • Key Tests: CBC • CMP • TSH • Free T4 • TPO Antibodies • Vitamin B12 • MMA • Folate • Vitamin D (25-OH) • Ferritin • Iron/TIBC • Transferrin Saturation • A1c • Fasting Glucose • CRP/hs-CRP • Lipid Panel • Total Testosterone (AM) • Free T/SHBG • Prolactin • Estradiol/FSH • AM Cortisol • HIV 4th-generation • Syphilis tests

References

  • American Psychiatric Association. Practice Guideline for the Treatment of Patients with Major Depressive Disorder.
  • National Institute for Health and Care Excellence (NICE). Depression in adults: recognition and management.
  • American Academy of Family Physicians. Initial evaluation of depression: laboratory and medical conditions.
  • American Thyroid Association. Thyroid Function Testing Guidance.
  • Endocrine Society. Testosterone Deficiency Guideline (men).
  • American Diabetes Association. Standards of Medical Care in Diabetes.
  • NIH Office of Dietary Supplements. Vitamin B12 and Vitamin D fact sheets.
  • Centers for Disease Control and Prevention. HIV and Syphilis testing recommendations.

Available Tests & Panels

Your Depression Tests menu is pre-populated in the Ulta Lab Tests system. Start with a foundational screen (CBC, CMP, TSH, B12 + MMA, vitamin D, A1c), then use filters to add iron studiesinflammation markershormone tests, and targeted infection screens as needed. Follow collection instructions and review results with your clinician to confirm findings and plan monitoring.

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Blood
Blood Draw

 The Anemia Health - Advanced panel is a thorough diagnostic tool designed to evaluate various factors that contribute to anemia. This panel extends beyond basic anemia screening by including tests that assess inflammation, iron metabolism, red blood cell production, and potential hereditary conditions. It comprises C-Reactive Protein, Complete Blood Count with Differential and Platelets, Comprehensive Metabolic Panel, Ferritin, Folate Serum, Iron and Total Iron Binding Capacity, Reticulocyte Count, Sickle Cell Screen, and Transferrin.
Blood
Blood Draw

 The Anemia Health - Basic panel is a foundational diagnostic tool designed to evaluate the key components necessary for diagnosing anemia and understanding its potential causes. This panel includes a Complete Blood Count with Differential and Platelets, Iron and Total Iron Binding Capacity, and Transferrin tests. These tests provide crucial insights into the quantity and quality of red blood cells, iron availability, and iron transport capabilities within the body.
Blood
Blood Draw

 The Anemia Health - Basic Plus panel enhances the foundational assessment of anemia by incorporating additional tests that provide insights into inflammation and iron storage, alongside the essential evaluations of blood components and iron metabolism. This panel includes C-Reactive Protein, Complete Blood Count with Differential and Platelets, Comprehensive Metabolic Panel, Ferritin, Iron and Total Iron Binding Capacity, and Transferrin tests.
Blood
Blood Draw

 The Anemia Health - Comprehensive panel is the most extensive diagnostic suite offered for evaluating anemia and its underlying causes. This panel combines a wide array of tests, including markers for inflammation, iron metabolism, vitamin levels, and red blood cell production, to provide a thorough assessment of factors contributing to anemia. It includes C-Reactive Protein, Complete Blood Count with Differential and Platelets, Comprehensive Metabolic Panel, Erythropoietin, Fecal Globin by Immunochemistry, Ferritin, Folate Serum, Homocysteine, Iron and Total Iron Binding Capacity, Reticulocyte Count, Sickle Cell Screen, Transferrin, and Vitamin B12.
Blood, Varied
Blood Draw, Phlebotomist

Blood
Blood Draw

The C-Reactive Protein (CRP) Test measures CRP levels in blood to detect inflammation in the body. Elevated CRP may indicate infections, autoimmune disorders, or chronic diseases such as arthritis, cardiovascular disease, or inflammatory bowel disease. Doctors use this test to assess acute illness, monitor treatment response, and evaluate risk for heart disease. The CRP test provides key insight into inflammation, immune health, and overall wellness.

Blood
Blood Draw
Also Known As: CRP Test, Inflammation Test

Most Popular

The High-Sensitivity C-Reactive Protein (hs-CRP) Test measures very low levels of CRP in blood to evaluate inflammation and cardiovascular risk. Elevated hs-CRP may indicate increased risk for heart disease, heart attack, or stroke even before symptoms appear. Doctors use this test along with cholesterol and other markers to assess overall heart health, guide prevention strategies, and monitor treatment. It also helps evaluate chronic inflammation and metabolic conditions.

Blood
Blood Draw
Also Known As: Cardiac CRP Test, High Sensitivity C-Reactive Protein Test

The Cardio IQ Vitamin D test, also known as a 25-hydroxy vitamin D test, measures the levels of total vitamin D in the blood, including both vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). It provides information about an individual's overall vitamin D status.

Blood
Blood Draw
Also Known As: Ergocalciferol Test, Vitamin D2 Test, Cholecalciferol Test, Vitamin D3 Test, Calcidiol Test, 25-hydroxyvitamin D Test, Calcifidiol Test, 25-hydroxy-vitamin D Test

The Carnitine Test measures carnitine levels in the blood to evaluate fatty acid metabolism and energy production. Abnormal results may indicate primary or secondary carnitine deficiency, often linked to metabolic disorders, malnutrition, or certain medications. Doctors use this test to investigate muscle weakness, hypoglycemia, or developmental delays and to monitor patients receiving treatment for metabolic or mitochondrial disease.

Blood
Blood Draw

The Celiac Disease Comprehensive Panel screens for celiac disease by measuring Tissue Transglutaminase (tTG) Antibody IgA and total IgA. If tTG IgA is positive, an Endomysial Antibody Screen IgA is added for confirmation. If IgA levels are low, tTG IgG is performed to ensure accurate detection. Doctors use this blood panel to identify gluten sensitivity, confirm diagnosis, and guide treatment for patients with suspected celiac disease.

Also Known As: Comprehensive Celiac Disease Panel, Celiac Disease Test

Blood, Varied
Blood Draw, Phlebotomist

Blood, Varied
Blood Draw, Phlebotomist

Blood, Varied
Blood Draw, Phlebotomist

Blood, Varied
Blood Draw, Phlebotomist

Most Popular

The Estradiol (E2) Test measures levels of estradiol, the primary form of estrogen, to evaluate reproductive and hormonal health. It helps assess menstrual irregularities, fertility issues, menopause status, and estrogen-producing disorders. In men, it aids in diagnosing hormonal imbalances. Doctors use the estradiol test to monitor hormone therapy, ovarian function, and conditions affecting puberty, bone health, and overall endocrine balance.

Blood
Blood Draw
Also Known As: E2 Test, Estrogen 2 Test

Most Popular

The Glucose Test measures blood sugar levels to evaluate energy metabolism and screen for diabetes or prediabetes. Abnormal glucose may indicate hyperglycemia, hypoglycemia, or metabolic disorders. Doctors use this test during routine exams, to investigate symptoms like fatigue, excessive thirst, or frequent urination, and to monitor treatment for diabetes. It provides essential insight into how the body regulates blood sugar and overall metabolic health.

Blood
Blood Draw
Also Known As: Fasting Glucose Test, Fasting Blood Sugar Test

The Hemoglobin A1c (HbA1c) Test measures average blood glucose over 2–3 months by detecting sugar attached to hemoglobin in red blood cells. It is used to diagnose diabetes, identify prediabetes, and monitor long-term blood sugar control. Doctors rely on the HbA1c test to evaluate treatment effectiveness, guide adjustments, and assess risk for complications, making it essential for diabetes care and metabolic health screening.

Blood
Blood Draw
Also Known As: A1c Test, HbA1c Test, Glycated Hemoglobin Test

Most Popular

The Homocysteine Test measures homocysteine levels in blood to assess risk for heart disease, stroke, and vascular problems. Elevated homocysteine may result from vitamin B6, B12, or folate deficiency and is linked to blood clots, cognitive decline, and osteoporosis. Doctors use this test to evaluate cardiovascular risk, monitor nutritional deficiencies, and guide treatment for metabolic or genetic conditions affecting homocysteine metabolism.

Blood
Blood Draw
Also Known As: Homocysteine Cardiac Risk Test

Blood
Blood Draw

Most Popular

The Insulin Test measures insulin levels in blood to assess how the body regulates glucose and metabolism. It helps diagnose insulin resistance, hypoglycemia, type 2 diabetes, and metabolic syndrome. Doctors also use it to evaluate pancreatic function and monitor treatment effectiveness. Frequently ordered with glucose testing, the insulin test provides critical insight into endocrine health, blood sugar control, and risk for diabetes-related complications.

Blood
Blood Draw
Also Known As: Fasting Insulin Blood Test

The Lyme Disease Antibody Test with Reflex to Blot IgG IgM screens for antibodies to Borrelia burgdorferi, the bacteria that cause Lyme disease. If results are positive or equivocal, a Western blot IgG/IgM is reflexively performed for confirmation. Doctors order this test for patients with tick exposure, rash, joint pain, or neurological symptoms. Results help confirm infection, guide treatment decisions, and support early detection to prevent complications.

Blood
Blood Draw
Also Known As: Borrelia burgdorferi Test, Lyme Disease Antibodies IgG IgM Immunoblot Test, Lyme Disease Ab Test

The Lyme Disease IgG IgM Antibodies Immunoblot Test detects antibodies to Borrelia burgdorferi, the bacteria causing Lyme disease. IgM indicates recent infection, while IgG suggests past or ongoing infection. Doctors order this test to confirm exposure after ELISA screening or when symptoms such as rash, fatigue, joint pain, or neurological issues appear. Results provide critical insight for diagnosing and managing Lyme disease with greater accuracy.

Blood
Blood Draw
Also Known As: Borrelia burgdorferi Test, Lyme Disease Antibodies Test

The Lyme Disease IgG Antibody Immunoblot Test confirms exposure to Borrelia burgdorferi, the bacteria that cause Lyme disease. It detects IgG antibodies, which usually appear weeks after infection and remain present for months to years. Doctors use this test to confirm a positive screening result, evaluate late-stage Lyme symptoms, and support diagnosis in patients with joint pain, fatigue, or neurological complications from suspected Lyme disease.

Blood
Blood Draw

The Magnesium Micronutrient RBC Test measures magnesium levels within red blood cells, providing a more accurate assessment of long-term magnesium status than serum tests. Magnesium is vital for muscle and nerve function, energy production, bone strength, and heart health. This test helps detect deficiencies or imbalances from poor diet, absorption issues, or medical conditions, supporting overall wellness.

Patient must be 18 years of age or older.
Other
Phlebotomist
Also Known As:

Magnesium Red Bood Cell Test, Mg Test, Mag Test


Depression afflicts 264 million people across the world.

Amid a pandemic and other traumatic events, mental health is now more important than ever.

You may have down moments, but what if you're not sure if you actually have depression? Or maybe you are certain you are suffering from depression, but don't know why.

Depression can be caused by external factors, but it can also stem from other health issues. Depression blood tests may help you narrow down the cause so you can start working on a solution.

Here is what you need to know about depression and how lab tests for depression can help.

What Is Depression?

At its most simple description, depression causes feelings of sadness. It also causes you to lose interest in people or activities that you previously cared about. Depression is common, but that doesn't take away from the severity of this affliction.

Depression can interfere with personal relationships, work, and school. It's common to encounter grief after a sad event. But when symptoms continue for a long period, you may be dealing with mental illness.

Risk Factors for Depression

Depression can hit anyone. However, certain environmental and health factors can make you more susceptible. For instance, genetics can play a role in your risk for depression.

Other health issues can also increase your risk. Sleep issues, anxiety, and substance abuse can all be associated with depression. To complicate matters, these issues can interact and make it hard to tell which came first.

Significant events also put people more at risk for suffering from depression. Deaths, family conflicts, and loss of a job are common examples. Positive life events like marriage, retirement, or the birth of a baby can also be risk factors.

Causes of Depression

Sometimes you can cope with risk factors and avoid succumbing to depression. Other times it is unavoidable. But depression blood tests can help you get started on healing.

The body is complex. Different vital systems have effects on areas that you might not expect. For example, there is a strong connection between the brain and the gut.

Depression can start with insomnia or chronic pain from injury. Certain medications you take can also cause depression. Substance abuse is another common cause.

Various blood tests can help with the diagnosis and treatment of related conditions.

What Are the Signs and Symptoms of Depression?

Everyone feels sad, lonely, or disinterested at times. So how do you distinguish general grief from depression? The symptoms are similar, but depression lasts longer.

There are a few signs to watch for. If you feel them for a long period, you may be one of the many people dealing with depression.

Do you feel tired, restless, or irritated? Maybe you are having negative thoughts or are having a hard time concentrating. You may also be feeling hopeless or are no longer interested in your favorite activities.

Some of the symptoms are also physical. For instance, you may have stomach pain or headaches. Changes in diet or sleep habits are another strong indicator.

How Is Depression Diagnosed?

Given the many different causes and symptoms, diagnosing depression is tough. But depression blood tests are the first step toward diagnosis and treatment.

Diagnosing depression is often a two-part approach. A blood test can help narrow down the diagnosis. It can also help rule out other health issues.

You will need to have a consultation with a medical provider. A doctor will perform a physical exam and an interview to create a diagnosis. They will review your symptoms and test results with you before giving you your diagnosis.

The Lab Tests to Screen, Diagnose, and Monitor Depression

The causes and symptoms of depression can vary wildly. Starting with a lab test is an easy way to start to come to a diagnosis. And you don't need a doctor's approval or health insurance, either.

Studies in using lab tests to diagnose depression continue to uncover new information. But you can get started with tests for disorders like anemia or thyroid disease. Both of these conditions can be the cause of depression.

You can also take tests to assess your digestive health. Poor gut health is another common cause of depression.

Once you have a diagnosis and cause, treatment becomes much easier. With the help of a professional, you can begin making lifestyle changes to improve the condition. You can also take regular tests to monitor your progress.

Frequently Asked Questions About Depression and Lab Tests for Depression

How do I know if I have depression?

Watch for common signs of depression, such as being sad for a long period. If you are disinterested or anxious for a long time, you might be depressed. Undergoing a lab test can help you determine if you have depression for sure.

Do I need health insurance to get diagnosed?

Lab tests do not require health insurance or a referral from a doctor. You can simply purchase the tests you need with Ulta Lab Tests, and then schedule an appointment for your specimen collection at one of our authorized patient service centers near you.

How is depression treated?

There are many different causes of depression. Sometimes therapy may help treat depression. Other times, lifestyle changes like diet and meditation may help. Once you have a diagnosis, talk with your doctor to determine what treatment is best for you.

How long do lab tests for depression take?

Lab test results can come back within a few business days. After you purchase a test, you will need to schedule an appointment locally. Your results will be available online in your secure and confidential patient portal in 24 to 48 hours for most tests.

You Don't Need to Live with Depression

Combating your depression can feel hopeless at times. There is a path to healing, however, which starts with ordering lab tests for depression.

Finally, having a diagnosis is the first step to feeling better. Life has so much to offer, and when you rid yourself of depression, you can take advantage of it all. Order a test today to get started!