Depression

Do you know if you or your loved ones have a mental illness? Do blood tests for depression help? Learn about the lab tests to order to help diagnose and monitor the condition.


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The tricyclics are used to treat depression. Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.


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Clinical Significance

Aripiprazole (Abilify®) is an atypical antipsychotic and antidepressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression. The analysis of aripiprazole is used to monitor compliance with drug therapy.


Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.

C-Reactive Protein Cardiac (hs CRP) Useful in predicting risk for cardiovascular disease.


Measurement of serum 25-OH vitamin D concentrations provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Lower than normal 25-OH vitamin D levels can result from a dietary deficiency, poor abosrption of the vitamin or impaired metabolism of the sterol in the liver. A 25-OH vitamin D deficiency can lead to bone diseases such as rickets and osteomalacia. Above normal levels can lead hypercalcemia. This assay employs liquid chromatography tandem mass spectrometry to independently measure and report the two common forms of 25-hydroxy vitamin D: 25OH D3 - the endogenous form of the vitamin and 25OH D2 - the analog form used to treat 25OH Vitamin D3 deficiency.

Carnitine, LC/MS/MS Includes: Carnitine, Total; Carnitine, Free; Carnitine, Esters; Esterified/Free Ratio

 

Clinical Significance

Serum carnitine analysis is useful in the diagnosis and monitoring of patients with carnitine deficiency (either primary or secondary). Primary carnitine deficiency is an autosomal recessively inherited genetic condition that affects carnitine uptake by cells and tissues through a defect in the plasma membrane carnitine transporter. Secondary carnitine deficiency can be seen in some disease states or in patients on carnitine-poor diets, but is also seen in a number of metabolic disorders. In these disorders, carnitine complexes with the accumulated substrate of the blocked metabolic step, and the resulting acylcarnitine ester is excreted in the urine, leading to a depletion of carnitine in the patient


 Specimens from children less than 4 years of age (i.e., less than 48 months) are not appropriate for this test. The test for children 4 years of age and younger is the Celiac Disease Comprehensive Panel, Infant (test code 15981).

Includes

Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

IMPORTANT - Note this is Reflex Test which if additional tests are run you will be charged for the specific tests that the lab peforms. Additional test will be run if the following criteria are met.


If the Tissue Transglutaminase IgA is positive,

1. Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255).

If the Endomysial Antibody Screen (IgA) is positive, 

2. Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

If the Total IgA is less than the lower limit of the reference range, based on age

3. Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.


The Digestive Health - Advanced contains the following tests

  • C-Reactive Protein (CRP) 
  • CBC (includes Differential and Platelets) 
  • Comprehensive Metabolic Panel (CMP)
  • Fecal Globin by Immunochemistry (InSure®) 
  • Ferritin
  • Folate, Serum
  • Iron and Total Iron Binding Capacity (TIBC)
  • QuestAssureD™ 25-Hydroxyvitamin D (D2, D3), LC/MS/MS 
  • Transferrin
  • Vitamin B12 (Cobalamin) 
  • Celiac Disease Comprehensive Panel (w/ Reflexes)

Specimens from children less than 4 years of age (i.e., less than 48 months) are not appropriate for this test. The test for children 4 years of age and younger is the Celiac Disease Comprehensive Panel, Infant (test code 15981).

Includes

Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

IMPORTANT - Note this is Reflex Test which if additional tests are run you will be charged for the specific tests that the lab peforms. Additional test will be run if the following criteria are met.


If the Tissue Transglutaminase IgA is positive, 

1. Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255).

If the Endomysial Antibody Screen (IgA) is positive, 

2. Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

If the Total IgA is less than the lower limit of the reference range, based on age

3. Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.


Digestive Health - Basic contains the following tests

  • CBC (includes Differential and Platelets) 
  • Comprehensive Metabolic Panel (CMP)
  • Fecal Globin by Immunochemistry (InSure®) 
  • Celiac Disease Comprehensive Panel (w/ Reflexes)

Specimens from children less than 4 years of age (i.e., less than 48 months) are not appropriate for this test. The test for children 4 years of age and younger is the Celiac Disease Comprehensive Panel, Infant (test code 15981).

Includes

Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

IMPORTANT - Note this is Reflex Test which if additional tests are run you will be charged for the specific tests that the lab peforms. Additional test will be run if the following criteria are met.


If the Tissue Transglutaminase IgA is positive, 

1. Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255).

If the Endomysial Antibody Screen (IgA) is positive, 

2. Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

If the Total IgA is less than the lower limit of the reference range, based on age

3. Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.


Digestive Health - Basic Plus contains the followwing tests: 

  • C-Reactive Protein (CRP) 
  • CBC (includes Differential and Platelets) 
  • Comprehensive Metabolic Panel (CMP)
  • Fecal Globin by Immunochemistry (InSure®) 
  • Ferritin
  • Iron and Total Iron Binding Capacity (TIBC)
  • Celiac Disease Comprehensive Panel (w/ Reflexes)

 Specimens from children less than 4 years of age (i.e., less than 48 months) are not appropriate for this test. The test for children 4 years of age and younger is the Celiac Disease Comprehensive Panel, Infant (test code 15981).

Includes

Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

IMPORTANT - Note this is Reflex Test which if additional tests are run you will be charged for the specific tests that the lab peforms. Additional test will be run if the following criteria are met.


If the Tissue Transglutaminase IgA is positive, 

1. Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255).

If the Endomysial Antibody Screen (IgA) is positive, 

2. Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

If the Total IgA is less than the lower limit of the reference range, based on age

3. Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.


Digestive Health - Comprehensive contains the following tests: 

  • C-Reactive Protein (CRP) 
  • CBC (includes Differential and Platelets) 
  • Comprehensive Metabolic Panel (CMP)
  • Fecal Globin by Immunochemistry (InSure®) 
  • Ferritin
  • Folate, Serum
  • Gliadin (Deamidated Peptide) Antibody (IgA) 
  • Gliadin (Deamidated Peptide) Antibody (IgG) 
  • Iron and Total Iron Binding Capacity (TIBC)
  • Lipid Panel with Ratios
  • Magnesium
  • Prealbumin 
  • QuestAssureD™ 25-Hydroxyvitamin D (D2, D3), LC/MS/MS 
  • Transferrin
  • TSH
  • Vitamin A (Retinol)
  • Vitamin B12 (Cobalamin) 
  • Vitamin K
  • Celiac Disease Comprehensive Panel (w/ Reflexes)

Specimens from children less than 4 years of age (i.e., less than 48 months) are not appropriate for this test. The test for children 4 years of age and younger is the Celiac Disease Comprehensive Panel, Infant (test code 15981).

Includes

Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

IMPORTANT - Note this is Reflex Test which if additional tests are run you will be charged for the specific tests that the lab peforms. Additional test will be run if the following criteria are met.


If the Tissue Transglutaminase IgA is positive, 

1. Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255).

If the Endomysial Antibody Screen (IgA) is positive, 

2. Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

If the Total IgA is less than the lower limit of the reference range, based on age, 

3. Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.


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Measuring the circulating levels of estradiol is important for assessing the ovarian function and monitoring follicular development for assisted reproduction protocols. Estradiol plays an essential role throughout the human menstrual cycle. Elevated estradiol levels in females may also result from primary or secondary ovarian hyperfunction. Very high estradiol levels are found during the induction of ovulation for assisted reproduction therapy or in pregnancy. Decreased estradiol levels in females may result from either lack of ovarian synthesis (primary ovarian hypofunction and menopause) or a lesion in the hypothalamus-pituitary axis (secondary ovarian hypofunction). Elevated estradiol levels in males may be due to increased aromatization of androgens, resulting in gynecomastia.

IMPORTANT - Note this Estradiol test is not for children that have yet to start their menstrual cycle.  If this test is ordered for a child that has yet to begin their menstrual cycle Quest Diagnostics labs will substitute in Estradiol, Ultrasensitive LC/MS/MS - #30289 at an additional charge of $34


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Serum glucose levels may be abnormally high (hyperglycemia) or abnormally low (hypoglycemia). Glucose measurements are used in the diagnosis and treatment of carbohydrate metabolic disorders including diabetes mellitus, idiopathic hypoglycemia, and pancreatic islet cell neoplasm.

A Hemoglobin (Hb) A1c Blood Test evaluates the average amount of glucose in the blood. The A1c test will help determine whether you are at a higher risk of developing diabetes; to help diagnose diabetes and prediabetes; to monitor diabetes and to aid in treatment decisions.

To assist with control of blood glucose levels, the American Diabetes Association (ADA) has recommended glycated hemoglobin testing (HbA1c) twice a year for patients with stable glycemia, and quarterly for patients with poor glucose control. Interpretative ranges are based on ADA guidelines.


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Elevated levels of homocysteine are observed in patients at risk for coronary heart disease and stroke.

Imipramine is a tricyclic antidepressnt drug used to treat depression. Therapeutic drug monitoring is used to optimize dose and to avoid toxicity.

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For diagnosis and monitoring of diabetes and insulin-secreting tumors.

Lyme disease is caused by a bacterium borrelia burgdorferi and is transmitted by ticks. EIA is the screening test with high sensitivity for antibody detection. Immunoblot testing qualitatively examines with high specificity antibodies in a patient's specimen. Immunoblot testing is appropriate for confirming a detected EIA test result.

Reflex
If Lyme Disease Antibody Screen is ≥0.90, then Lyme Disease Antibodies (IgG, IgM), Immunoblot will be performed at an additional charge of $63.00


Lyme disease is transmitted by a tick vector carrying Borrelia burgdorferi. Immunoblot testing qualitatively examines, with high specificity, antibodies in a patient's specimen. Immunoblot testing is appropriate for confirming a detected EIA or IFA test result.

Lyme disease is caused by a tick vector carrying borrelia burgdorferi. Immunoblot testing qualitatively examines with high specificity antibodies in a patient's specimen. Immunoblot testing is appropriate for confirming a detected EIA or IFA test result.

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Depression afflicts 264 million people across the world.

Amid a pandemic and other traumatic events, mental health is now more important than ever.

You may have down moments, but what if you're not sure if you actually have depression? Or maybe you are certain you are suffering from depression, but don't know why.

Depression can be caused by external factors, but it can also stem from other health issues. Depression blood tests may help you narrow down the cause so you can start working on a solution.

Here is what you need to know about depression and how lab tests for depression can help.

What Is Depression?

At its most simple description, depression causes feelings of sadness. It also causes you to lose interest in people or activities that you previously cared about. Depression is common, but that doesn't take away from the severity of this affliction.

Depression can interfere with personal relationships, work, and school. It's common to encounter grief after a sad event. But when symptoms continue for a long period, you may be dealing with mental illness.

Risk Factors for Depression

Depression can hit anyone. However, certain environmental and health factors can make you more susceptible. For instance, genetics can play a role in your risk for depression.

Other health issues can also increase your risk. Sleep issues, anxiety, and substance abuse can all be associated with depression. To complicate matters, these issues can interact and make it hard to tell which came first.

Significant events also put people more at risk for suffering from depression. Deaths, family conflicts, and loss of a job are common examples. Positive life events like marriage, retirement, or the birth of a baby can also be risk factors.

Causes of Depression

Sometimes you can cope with risk factors and avoid succumbing to depression. Other times it is unavoidable. But depression blood tests can help you get started on healing.

The body is complex. Different vital systems have effects on areas that you might not expect. For example, there is a strong connection between the brain and the gut.

Depression can start with insomnia or chronic pain from injury. Certain medications you take can also cause depression. Substance abuse is another common cause.

Various blood tests can help with the diagnosis and treatment of related conditions.

What Are the Signs and Symptoms of Depression?

Everyone feels sad, lonely, or disinterested at times. So how do you distinguish general grief from depression? The symptoms are similar, but depression lasts longer.

There are a few signs to watch for. If you feel them for a long period, you may be one of the many people dealing with depression.

Do you feel tired, restless, or irritated? Maybe you are having negative thoughts or are having a hard time concentrating. You may also be feeling hopeless or are no longer interested in your favorite activities.

Some of the symptoms are also physical. For instance, you may have stomach pain or headaches. Changes in diet or sleep habits are another strong indicator.

How Is Depression Diagnosed?

Given the many different causes and symptoms, diagnosing depression is tough. But depression blood tests are the first step toward diagnosis and treatment.

Diagnosing depression is often a two-part approach. A blood test can help narrow down the diagnosis. It can also help rule out other health issues.

You will need to have a consultation with a medical provider. A doctor will perform a physical exam and an interview to create a diagnosis. They will review your symptoms and test results with you before giving you your diagnosis.

The Lab Tests to Screen, Diagnose, and Monitor Depression

The causes and symptoms of depression can vary wildly. Starting with a lab test is an easy way to start to come to a diagnosis. And you don't need a doctor's approval or health insurance, either.

Studies in using lab tests to diagnose depression continue to uncover new information. But you can get started with tests for disorders like anemia or thyroid disease. Both of these conditions can be the cause of depression.

You can also take tests to assess your digestive health. Poor gut health is another common cause of depression.

Once you have a diagnosis and cause, treatment becomes much easier. With the help of a professional, you can begin making lifestyle changes to improve the condition. You can also take regular tests to monitor your progress.

Frequently Asked Questions About Depression and Lab Tests for Depression

How do I know if I have depression?

Watch for common signs of depression, such as being sad for a long period. If you are disinterested or anxious for a long time, you might be depressed. Undergoing a lab test can help you determine if you have depression for sure.

Do I need health insurance to get diagnosed?

Lab tests do not require health insurance or a referral from a doctor. You can simply purchase the tests you need with Ulta Lab Tests, and then schedule an appointment for your specimen collection at one of our authorized patient service centers near you.

How is depression treated?

There are many different causes of depression. Sometimes therapy may help treat depression. Other times, lifestyle changes like diet and meditation may help. Once you have a diagnosis, talk with your doctor to determine what treatment is best for you.

How long do lab tests for depression take?

Lab test results can come back within a few business days. After you purchase a test, you will need to schedule an appointment locally. Your results will be available online in your secure and confidential patient portal in 24 to 48 hours for most tests.

You Don't Need to Live with Depression

Combating your depression can feel hopeless at times. There is a path to healing, however, which starts with ordering lab tests for depression.

Finally, having a diagnosis is the first step to feeling better. Life has so much to offer, and when you rid yourself of depression, you can take advantage of it all. Order a test today to get started!