Chronic Inflammation

The chronic inflammation test measures the level of c-reactive protein (CRP) in your blood that is sent into your bloodstream in response to inflammation if you've been injured or have an infection. Order yours today from Ulta Lab Tests and get your results confidentially online.


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Aids in the diagnosis of primary disease of skeletal muscle myocardial infarction and viral hepatitis.


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The major sources of amylase are the pancreas and the salivary glands. The most common cause of elevation of serum amylase is inflammation of the pancreas (pancreatitis). In acute pancreatitis, serum amylase begins to rise within 6-24 hours, remains elevated for a few days and returns to normal in 3-7 days. Other causes of elevated serum amylase are inflammation of salivary glands (mumps), biliary tract disease and bowel obstruction. Elevated serum amylase can also be seen with drugs (e.g., morphine) which constrict the pancreatic duct sphincter preventing excretion of amylase into the intestine.

Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. 

Reflex Information: If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge.


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Measurement of the levels of bilirubin is used in the diagnosis and treatment of liver, hemolytic, hematologic, and metabolic disorders, including hepatitis and gall bladder obstruction. The assessment of direct bilirubin is helpful in the differentiation of hepatic disorders. The increase in total bilirubin associated with obstructive jaundice is primarily due to the direct (conjugated) fraction. Both direct and indirect bilirubin are increased in the serum with hepatitis.

Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.


C-Reactive Protein Cardiac (hs CRP) Useful in predicting risk for cardiovascular disease.


Clinical Significance

Used to diagnose inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, or to differentiate IBD from irritable bowel syndrome (IBS).

 

Collection Instructions

Collect undiluted feces in clean, dry sterile leak-proof container. Do not add fixative or preservative.

 


Low levels of fibrinogen are associated with bleeding most commonly secondary to liver disease or disseminated intravascular coagulation (DIC). Fibrinogen is an acute phase reactant and thus elevated levels may be associated with inflammation. Increased concentrations are also associated with increased risk of atherosclerosis.

A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)


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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 7 a.m.-9 a.m.


Test for myocardial infarction and skeletal muscle damage. Elevated results may be due to: myocarditis, myocardial infarction (heart attack), muscular dystrophy, muscle trauma or excessive exercise

A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with Polycystic Ovarian Syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.


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Useful in the diagnosis of hypochromic, microcytic anemias. Decreased in iron deficiency anemia and increased in iron overload.


Ferritin, Iron and Total Iron Binding Capacity (TIBC)

  • Ferritin
  • Iron and Total Iron Binding Capacity (TIBC)

Low levels of fibrinogen are associated with bleeding most commonly secondary to liver disease or Disseminated Intravascular Coagulation (DIC). Fibrinogen is an acute phase reactant and thus elevated levels may be associated with inflammation. Increased concentrations are also associated with increased risk of atherosclerosis.

Elevated GGT is found in all forms of liver disease. Measurement of GGT is used in the diagnosis and treatment of alcoholic cirrhosis, as well as primary and secondary liver tumors. It is more sensitive than alkaline phosphatase, the transaminases, and leucine aminopeptidase in detecting obstructive jaundice, cholangitis, and cholecystitis. Normal levels of GGT are seen in skeletal diseases; thus, GGT in serum can be used to ascertain whether a disease, suggested by elevated alkaline phosphatase, is skeletal or hepatobiliary.

Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.

Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.

A Hemoglobin (Hb) A1c Blood Test evaluates the average amount of glucose in the blood. The A1c test will help determine whether you are at a higher risk of developing diabetes; to help diagnose diabetes and prediabetes; to monitor diabetes and to aid in treatment decisions.

To assist with control of blood glucose levels, the American Diabetes Association (ADA) has recommended glycated hemoglobin testing (HbA1c) twice a year for patients with stable glycemia, and quarterly for patients with poor glucose control. Interpretative ranges are based on ADA guidelines.


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Elevated levels of homocysteine are observed in patients at risk for coronary heart disease and stroke.

Monoclonal increases in IgG or IgA are often associated with diseases such as multiple myeloma, lymphomas or leukemia. A monoclonal increase in IgM is commonly associated with Waldenström's macroglobulinemia.


Inflammation is typically a normal part of the healing process. The process of inflammation activates your immune system and helps your body rid itself of toxins or pathogens that pose a threat. It can also prompt your body to repair damaged tissues. Acute inflammation is easily recognizable because of the short-term effects, but chronic inflammation often occurs at a low, consistent level that makes it almost undetectable without testing.

About Chronic Inflammation

Chronic inflammation occurs when your body continually reacts to some internal or external stressor by maintaining a low-grade immune response. Chronic inflammation can cause a breakdown in immune tolerance. Immune tolerance is your body’s ability to recognize certain substances as safe and non-threatening. Damaging your immune tolerance can cause your body to treat safe substances or objects like healthy cells as threats and attack them needlessly. 

Another side effect of chronic inflammation is an impaired immune system that can’t respond adequately to threats like viruses and bacteria. Since vaccines are meant to trigger an immune response, a weak immune system makes vaccinations less effective.

Risk Factors and Causes of Chronic Inflammation

Aging

To a certain extent, aging is an almost unavoidable risk factor for chronic inflammation. Cell senescence, the permanent end of a cell’s growth and ability to reproduce that occurs as people age, triggers the production of certain proteins linked to inflammation. However, there are also many lifestyle factors that put people at risk of developing chronic inflammation.

Diet

Research shows that diseases related to chronic inflammation, such as cardiovascular disease, cancer, and diabetes, are more common in Westernized countries than those that have more unprocessed and raw diets. Inflammatory diets that include large amounts of red meat, processed food, refined sugars, and high fructose corn syrup put individuals at risk of increased inflammation. 

A Sedentary Lifestyle

A processed, refined diet is one risk factor and cause of inflammation, but a lack of physical activity is also a cause. One small study found that people that were physically active had a lower circulation of inflammatory proteins and cholesterol than inactive people. 

Environmental Factors

In some cases, environmental factors can cause chronic inflammation. Toxic chemicals can irritate and cause inflammation in certain parts of the body, like the throat or skin. Smoking is a known risk factor for inflammation, but consistent exposure to secondhand smoke can also have a similar effect.

Oxidative Stress

Physical inactivity and a poor diet can put oxidative stress on your body. Oxidative stress is defined as an imbalance of oxidants and antioxidants in the body. Some oxidants that interact harmfully with other molecules and cause cell death and damaged proteins are called reactive oxygen species. Oxidants are normally released during acute inflammation, but chronic inflammation causes a buildup of these molecules that the body can’t adequately eliminate. A diet that’s low in antioxidants means a person can’t fight oxidative stress. 

Signs and Symptoms of Chronic Inflammation

The signs and symptoms of chronic inflammation are often almost unnoticeable because of their subtlety. If a person’s chronic inflammation has contributed to a disease like osteoporosis or cardiovascular disease, they may notice symptoms related to that disease and its progression.

Someone with chronic inflammation might have no visible symptoms. With lab testing, however, you can find invisible signs of chronic inflammation.

Lab Tests for Chronic Inflammation

Lab tests for chronic inflammation measure your blood's levels of certain inflammation markers by running your sample through a series of tests. One of these is an erythrocyte sedimentation rate or sed rate test. This test can indirectly determine your body’s current inflammatory response to stressors like a disease.

One sign of inflammation may be raised levels of C-reactive protein (CRP). The C-Reactive protein (CRP) test measures the amount of this protein, which is made by the liver. An increase in CRP levels in a person's bloodstream can indicate a condition that causes inflammation. A CRP test can detect inflammation caused by acute conditions and can help monitor the severity of disease in chronic conditions.

Chronic inflammation tests might also test for lipids like cholesterol, iron, and uric acid. These tests are the best way to determine your body’s inflammation. 

FAQs

How Can You Tell If You Have Chronic Inflammation?

The best way to tell if you have chronic inflammation is through a test. Symptoms can be undetectable and you may not feel any different. If you have inflammatory conditions related to chronic inflammation, like Crohn's Disease or ulcerative colitis, the symptoms of this disease are signs of inflammation.

How Do You Stop Chronic Inflammation?

Adopting a healthy lifestyle can reduce chronic inflammation. Increasing your physical activity and adopting a diet similar to the ones found in the Mediterranean region are two ways to support the anti-inflammatory process. Eating foods rich in antioxidants can help fend off oxidative stress, which can be a cause of inflammation.

Is There A Test for Chronic Inflammation?

Yes, Ulta Lab Tests offers tests for chronic inflammation that examine a number of substances in the blood, including gamma-glutamyl transferase (GGT)lipidsiron and C-reactive protein. Our chronic inflammation test also includes antinuclear antibodyCBCSED ratecomprehensive metabolic panel and rheumatoid factor tests.  

Benefits of Chronic Inflammation Testing with Ulta Lab Tests

Ulta Lab Tests offers highly accurate and reliable tests so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance or doctor's referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

Our chronic inflammation tests can help you determine your risk factor for illnesses associated with inflammation and give you another tool to stop the progression of inflammation before it becomes severe. Order your chronic inflammation lab tests today, and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control of your health today with Ulta Lab Tests.