Menopause

Menopause marks the natural end of menstrual cycles after 12 months without a period. Perimenopause is the transition phase when hormones fluctuate and symptoms come and go. Because hot flashes, sleep changes, mood shifts, and fatigue can also be caused by thyroid disease, iron deficiency, pregnancy, diabetes, and other conditions, lab testing helps you and your clinician separate menopause from look-alikes and build a safe plan.

A practical, proactive approach starts with baselines (TSH, CBC/iron, A1c or glucose, lipids, vitamin D, CMP). When timing or symptoms are unclear, add FSH/LH and estradiol to clarify ovarian status, and progesterone to check ovulation in cycling women. If cycles continue, hCG can rule out pregnancy before treatment decisions. Tests support screeningdiagnostic work-ups, and monitoring, but they do not replace a clinician’s exam, imaging, or emergency care for severe symptoms.

Signs, Symptoms & Related Situations

  • Vasomotor & sleep: hot flashes, night sweats, insomnia, daytime fatigue

  • Mood & cognition: anxiety, low mood, irritability, brain fog, forgetfulness

  • Cycle & bleeding: irregular or heavier periods in perimenopause; postmenopausal bleeding needs prompt evaluation

  • Genitourinary: vaginal dryness, discomfort with sex, urinary urgency or infections

  • Body composition & metabolic: weight gain (especially central), rising LDL or triglycerides, higher blood sugar

  • Bone & joints: joint aches, height loss or low bone density history
    Seek urgent care for heavy bleeding with lightheadedness, chest pain, severe shortness of breath, one-sided weakness, or severe headache/vision changes.

Why These Tests Matter

What testing can do

  • Clarify status: help distinguish perimenopause vs. menopause when the story is unclear

  • Identify mimics: uncover thyroid disorders, iron deficiency, abnormal glucose, or other conditions that drive similar symptoms

  • Establish baselines & monitor: track cardiometabolic and liver/kidney health before and after any therapy choices

What testing cannot do

  • Choose an HRT type or dose by numbers alone—clinical response and safety guide decisions

  • Replace imaging or procedures (e.g., pelvic ultrasound, mammogram, DXA) when indicated

  • Provide a diagnosis from a single value; trends and timing matter

What These Tests Measure (at a glance)

  • FSH & LH: pituitary signals; often high after menopause, variable in perimenopause

  • Estradiol (E2): key estrogen; typically low after menopause. Low-level methods are preferred post-menopause

  • Progesterone (P4): confirms ovulation (mid-luteal draw) and helps assess irregular bleeding

  • TSH (± Free T4): screens for thyroid disease that can mimic hot flashes, fatigue, and weight change

  • hCG (pregnancy test): consider in perimenopause if cycles or bleeding persist

  • Androgens (as indicated): total/free testosterone, DHEA-S, SHBG—for acne, hirsutism, hair thinning, or low libido questions

  • CBC & Iron Studies (Ferritin, Iron/TIBC/Transferrin): detect anemia or iron deficiency—a common, fixable cause of fatigue

  • Metabolic & safety labs: A1c/GlucoseLipid Panel (± ApoB)Comprehensive Metabolic Panel (AST/ALT, creatinine, electrolytes)

  • Vitamin D (25-OH) ± Calcium: bone-health context; consider with fracture risk or low BMD

Quick Build Guide

Goal Start with Add if needed
Perimenopause symptoms, status unclear FSH/LH • Estradiol • TSH • CBC • Ferritin/Iron • A1c/Glucose hCG if cycles continue • Vitamin D
Menopause confirmation/monitoring FSH/LH • Estradiol • TSH • Lipids • A1c • CMP CBC • Ferritin if bleeding or fatigue
General fatigue work-up TSH • CBC • Ferritin/Iron • Vitamin D • A1c/Glucose • CMP Prolactin or androgens if symptoms suggest
Abnormal uterine bleeding CBC • hCG • TSH Iron studies; clinician-directed pelvic evaluation
HRT safety baseline CBC • CMP • Lipid Panel • A1c/Glucose • TSH Estradiol/Progesterone for context if symptoms persist

How the Testing Process Works

  1. Pick your starting panel using the Quick Build Guide.

  2. Prepare for accuracy: some tests are cycle-timed (day-3 FSH/LH/E2; mid-luteal progesterone). List all meds/supplements—biotinthyroid meds, and hormones can affect results.

  3. Get your draw/collection: blood tests (± urine hCG) at a nearby patient service center; results post securely.

  4. Review together: discuss labs with your clinician and align results with symptoms and goals.

  5. Plan follow-up: recheck after changes (often 3–6 months), then periodically once stable.

Interpreting Results (General Guidance)

  • High FSH with low estradiol supports menopause; in perimenopause, values can swing—look at symptoms and trends

  • Normal TSH makes a thyroid cause less likely; out-of-range values help explain fatigue or heat/cold intolerance

  • Low ferritin with or without anemia can drive fatigue, hair changes, and poor exercise tolerance

  • A1c/Glucose and Lipids track cardiovascular risk as hormones shift with age
    Always interpret labs with a qualified healthcare professional; numbers are only one part of the story.

Choosing Panels vs. Individual Tests

  • Baseline wellness (most women): TSH • CBC • Ferritin/Iron • A1c/Glucose • Lipids • CMP • Vitamin D

  • Status clarification: FSH/LH • Estradiol (± Progesterone if cycles continue) and hCG as needed

  • Symptom-targeted adds: Androgens (total/free T, DHEA-S, SHBG) or Prolactin when clinically suggested

  • On HRT: repeat safety labs (CBC, CMP, Lipids, A1c) and add hormone levels only if symptoms persist or change

FAQs

Do I need labs to diagnose menopause?
Often no after age 45 with typical symptoms and 12 months without periods. Labs help when younger, on hormonal contraception, or when the picture is unclear.

Which day should I test?
For cycle-timed checks: day-3 for FSH/LH/E2; mid-luteal for progesterone. If amenorrheic, timing is less critical—follow your order.

Do I need to fast?
Not for most hormones. Fasting may be requested for glucose/A1c and lipids—follow your order instructions.

Can birth control affect results?
Yes. Combined hormonal methods can alter SHBG, estradiol, and testosterone; share your method with your clinician.

Will estradiol levels set my HRT dose?
Not by themselves. Symptoms, safety labs, and preferences guide therapy more than a single number.

What if I have bleeding after menopause?
Check CBC and hCG as directed and seek prompt clinical evaluation; imaging may be needed.

Related Categories & Key Tests

  • Hormone Tests Hub

  • HRT for Women • Endocrine Tests • PCOS & Androgens • Thyroid Testing • Bone & Osteoporosis • Women’s Health Panels

  • Key Tests: FSH/LH • Estradiol • Progesterone • TSH (± Free T4) • hCG • Total & Free Testosterone • DHEA-S • SHBG • CBC • Ferritin/Iron/TIBC/Transferrin • A1c/Glucose • Lipid Panel (± ApoB) • Comprehensive Metabolic Panel • Vitamin D (25-OH)

References

  • North American Menopause Society — Position statements on midlife assessment and hormone therapy.
  • Endocrine Society — Clinical practice guidance on menopause and endocrine evaluation.
  • American College of Obstetricians and Gynecologists — Practice bulletins on perimenopause and abnormal uterine bleeding.
  • Androgen Excess & PCOS Society — Recommendations for evaluation of androgen excess.
  • American Thyroid Association — Thyroid testing in women of reproductive age and midlife.
  • Clinical reviews on iron deficiency (ferritin) and biotin assay interference.

Available Tests & Panels

Your Menopause Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to select status tests (FSH/LH, estradiol, progesterone), baseline health (TSH, CBC/iron, A1c/glucose, lipids, CMP, vitamin D), and pregnancy or androgen testing as needed. Follow timing instructions and review results with your clinician to plan next steps and monitoring.

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The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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The Estradiol (E2) Test measures levels of estradiol, the primary form of estrogen, to evaluate reproductive and hormonal health. It helps assess menstrual irregularities, fertility issues, menopause status, and estrogen-producing disorders. In men, it aids in diagnosing hormonal imbalances. Doctors use the estradiol test to monitor hormone therapy, ovarian function, and conditions affecting puberty, bone health, and overall endocrine balance.

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The Estradiol Free Test measures unbound estradiol, the biologically active form of estrogen, to evaluate hormonal balance. Free estradiol plays a critical role in reproductive health, menstrual regulation, bone strength, and cardiovascular function. Abnormal levels may indicate conditions such as infertility, polycystic ovary syndrome, menopausal transition, or estrogen-related endocrine disorders, aiding diagnostic and treatment decisions.

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The Estriol (E3) Test checks blood levels of estriol, an estrogen hormone important in pregnancy. It is commonly included in the second-trimester triple or quad screen to detect chromosomal disorders such as Down syndrome and assess placental function. Estriol testing helps monitor fetal growth and maternal hormone health. Low or abnormal levels may signal pregnancy complications, guiding further testing and prenatal care decisions.

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The Estrogen Total Test measures all forms of estrogen in blood, including estradiol, estrone, and estriol, to assess reproductive and hormonal health. Abnormal levels may indicate menstrual irregularities, menopause status, infertility, or hormone-related disorders. Doctors order this test to evaluate fertility, monitor hormone therapy, and investigate symptoms such as hot flashes, irregular cycles, or abnormal bleeding. It provides key insight into endocrine and reproductive function.

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The Estrone (E1) Test measures estrone, one of the three main estrogen hormones, to assess reproductive and hormonal health. It helps evaluate ovarian function, menstrual irregularities, menopause status, and estrogen-related disorders. In men, estrone testing may detect hormonal imbalances or excess estrogen. Doctors use this test to monitor hormone therapy, fertility treatments, and conditions affecting bone health, metabolism, and overall endocrine balance.

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The Follicle-Stimulating Hormone (FSH) Test measures FSH levels to evaluate reproductive and endocrine health in both men and women. In women, it helps assess infertility, irregular periods, menopause, or ovarian function. In men, it is used to check sperm production and testicular function. Abnormal results may indicate PCOS, pituitary disorders, or hormonal imbalance. Doctors order this test to guide fertility treatment, hormone therapy, and overall reproductive care.

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The hCG Total Qualitative Test detects the presence of human chorionic gonadotropin in blood to confirm pregnancy. Unlike the quantitative test, it provides a simple positive or negative result rather than exact levels. Doctors use this test to confirm suspected pregnancy, evaluate early symptoms, or screen before medical procedures.

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Did you know over 1 million women in the US alone start menopause each year? Menopause can cause a lot of symptoms that often leave women with questions.

The good news is there are menopause tests available that can let you know exactly where you stand. There is no reason to go through menopause in the dark.

Nowadays, we have the tools and technology to take our health into our own hands. So keep reading this guide to learn all about menopause and the proven benefits of menopause tests.

What is Menopause?

Menopause is the time in your life that signifies the end of your menstrual cycles. Menopause is a biological process between 40 and 50, with an average age of 51 in the US.

Women also experience a phase called perimenopause, when their body begins to transition towards menopause. Perimenopause can start at different ages but typically occurs in your 40s.

Your estrogen and hormone levels start dropping, which brings on the symptoms of menopause like hot flashes and mood changes. Doctors usually officially diagnose menopause after 12 consecutive months without a period.

Causes and Risk Factors for Menopause

Typically women enter menopause in their 40s and 50s, but certain risk factors can interrupt the normal flow of a woman's reproductive system. When this happens, menopause can occur before 40, referred to as premature ovarian failure.

Risk factors include previous pelvic surgery and removal of both ovaries. Other risks include chemotherapy and radiation, chromosomal defects, and autoimmune diseases like rheumatoid arthritis.

Signs and Symptoms of Menopause

In the years that lead up towards menopause, you'll start to experience different signs and symptoms, including:

  • Hot flashes
  • Irregular and missed periods
  • Night sweats and chills
  • Trouble sleeping
  • Changes in mood
  • Slower metabolism
  • Thinning of hair
  • Breast changes like loss of fullness

Remember, changes in menstruation vary, and most of the time, you'll experience irregular periods before they stop altogether. You'll also notice shorter menstrual cycles that occur closer together.

Complications of Menopause

After menopause, you no longer have the protection of estrogen and other reproductive hormones. This can increase your risk for conditions like:

Your risk for heart disease goes up when your estrogen levels decline. And high blood pressure and cholesterol levels during menopause increase this risk even further.

Your risk for osteoporosis goes up after menopause. During your first few years of menopause, your body is adjusting to the hormonal changes, and you can lose bone density at a faster rate during this time.

After menopause, your vagina and urethra lose their elasticity, causing you sometimes to experience a strong urge to urinate or a leakage of urine. 

You'll also notice a decreased desire for sexual activity. Menopause can cause vaginal dryness and discomfort during sexual intercourse. 

Menopause also causes changes in your metabolism, causing you to gain weight easier than you did before.

Diagnosis of Menopause

Most of the time, your signs and symptoms like no period for 12 consecutive months are enough to tell you that menopause is starting. 

But often, symptoms like irregular periods can be due to other medical causes, so your doctor often recommends specific blood tests to check your hormone levels.

Treatment of Menopause

Menopause doesn't require any specific medical treatment but instead, treatments focus on symptom relief and managing chronic conditions as you age.

One of the most effective treatments for menopause is estrogen therapy. Doctors often prescribe a low dose of estrogen for a short time. If you still have your uterus and ovaries, you'll often be prescribed progestin too. Short-term use of hormone therapy helps prevent bone loss and heart disease.

Vaginal estrogen is also an option and can be administered directly into your vagina via a vaginal cream or ring. Vaginal estrogen releases only a small amount of estrogen that gets absorbed by your vaginal tissues. You'll get relief from vaginal dryness and pain with sexual intercourse.

Some women also need a low dose of antidepressants for a time. Certain medications like serotonin reuptake inhibitors can decrease hot flashes and improve mood.

Lab Tests for Menopause

Testing for menopause and during menopause is a great way to diagnose menopause and to monitor the balance of your hormones and biomarkers.

You can find comprehensive lab tests for menopause at Ulta Lab Tests. Standard menopause lab tests include:

Follicle-stimulating hormone testing (FSH) is often measured to confirm menopause. Typically in menopause, your FSH will consistently remain elevated.

luteinizing hormone test (LH) measures how much of this hormone is in your blood. LH is involved with your ovulation, menstruation, and more. When you start menopause, your LH levels will rise.

Your total estrogen level is also measured. Estrogen is responsible for the development of female sex organs and regulating your menstrual cycles. Your total estrogen levels decrease once menopause begins.

Anti-Mullerian hormone (AMH) measures your ovarian reserve and predicts an average time when menopause will begin.

Other blood tests helpful for menopause testing include:

Frequently Asked Questions

Many women have the most questions about the hot flashes that occur in menopause. Although the exact cause isn't completely understood, hot flashes are thought to occur due to changes in your brain and hypothalamus.

If your hypothalamus senses you're too warm, it will try to cool you down by making you sweat. The good news is most hot flashes diminish after six months, though some women can have them for longer.

And remember, just because you've entered into menopause doesn't mean you don't need annual pap tests and mammograms. After menopause, these screenings become more crucial than ever.

Menopause Tests

Choose Ulta Lab Tests for all your menopause tests and needs. Our lab tests provide you with accurate results that allow you to control your health.

Our affordable pricing includes a doctor's order, and you don't need a referral or insurance either.

Once you order your menopause lab tests, you'll have secure and confidential results within 24 to 48 hours, depending on the test.

Take charge of your health by ordering your tests from Ulta Lab Tests.