Alzheimer's Disease

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This test determines the subtypes of apoe which will aid in the risk assessment of corornary heart disease (CHD) and hyperlipoproteinemia.

This panel is designed to evaluate a patient for the presence of potentially reversible (i.e., secondary) causes of dementia such as Vitamin B12 deficiency, hypothyroidism, hypoparathyroidism, anemia, hypoxia or hypercapnia, hepatic and renal encephalopathies, diabetes, and dehydration. The panel includes a Complete Blood Count, TSH, Vitamin B12, Folate, and a Comprehensive Metabolic Panel. It is modeled after the recommendations of the American Academy of Neurology (AAN), a National Institutes of Health Consensus Panel, the European Federation of Neurological Societies (EFNS), and others.1-4

Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.

Measurements are used in the diagnosis and treatment of numerous potentially serious disorders associated with changes in body acid-base balance.

Serum chloride is the major extracellular anion and counter-balances the major cation, sodium, maintaining electrical neutrality of the body fluids. Two thirds of the total anion concentration in extracellular fluids is chloride and it is significantly involved in maintaining proper hydration and osmotic pressure. Movement of chloride ions across the red blood cell membrane is essential for the transport of biocarbonate ions in response to changing concentrations of carbon dioxide. Chloride measurements are used in the diagnosis and treatment of electrolyte and metabolic disorders such as cystic fibrosis and diabetic acidosis.

A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia, and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)

NOTE: Only measurable biomarkers will be reported.

Reflex Parameters for Manual Slide Review
  Less than  Greater Than 
WBC  1.5 x 10^3  30.0 x 10^3 
Hemoglobin  7.0 g/dL  19.0 g/dL 
Hematocrit  None  75%
Platelet  100 x 10^3  800 x 10^3 
MCV  70 fL  115 fL 
MCH  22 pg  37 pg 
MCHC  29 g/dL  36.5 g/dL 
RBC  None  8.00 x 10^6 
RDW  None  21.5
Relative Neutrophil %  1% or ABNC <500  None 
Relative Lymphocyte %  1% 70%
Relative Monocyte %  None  25%
Eosinophil  None  35%
Basophil  None  3.50%
     
Platelet  <75 with no flags,
>100 and <130 with platelet clump flag present,
>1000 
Instrument Flags Variant lymphs, blasts,
immature neutrophils,  nRBC’s, abnormal platelets,
giant platelets, potential interference
     
The automated differential averages 6000+ cells. If none of the above parameters are met, the results are released without manual review.
CBC Reflex Pathway

Step 1 - The slide review is performed by qualified Laboratory staff and includes:

  • Confirmation of differential percentages
  • WBC and platelet estimates, when needed
  • Full review of RBC morphology
  • Comments for toxic changes, RBC inclusions, abnormal lymphs, and other
  • significant findings
  • If the differential percentages agree with the automated counts and no abnormal cells are seen, the automated differential is reported with appropriate comments

Step 2 - The slide review is performed by qualified Laboratory staff and includes: If any of the following are seen on the slide review, Laboratory staff will perform a manual differential:

  • Immature, abnormal, or toxic cells
  • nRBC’s
  • Disagreement with automated differential
  • Atypical/abnormal RBC morphology
  • Any RBC inclusions

Step 3 If any of the following are seen on the manual differential, a Pathologist will review the slide:

  • WBC<1,500 with abnormal cells noted
  • Blasts/immature cells, hairy cell lymphs, or megakaryocytes
  • New abnormal lymphocytes or monocytes
  • Variant or atypical lymphs >15%
  • Blood parasites
  • RBC morphology with 3+ spherocytes, RBC inclusions, suspect Hgb-C,
  • crystals, Pappenheimer bodies or bizarre morphology
  • nRBC’s

Comprehensive Metabolic Panel


This panel may be useful in screening drugs which are commonly encountered in acute toxicity cases. See individual tests for additional clinical significance. See specimen collection guide for additional drug screens.

See individual tests

F2-Isoprostane/Creatinine Ratio (Urine Test)

Clinical Significance

The F2-Isoprostane/Creatinine ratio is used to measure oxidative stress, particularly in individuals with lifestyle risks due to poor diet or smoking, those with a family history of cardiovascular disease or those with hyperlipidemia.

Alternative Name(s) 

IsoPF2,F2 Isoprostane,F2CR,F2-IsoPs


Excessive exposure to heavy metals can cause acute chronic toxicity. Heavy metals panel is intended to evaluate and monitor exposure to heavy metals and evaluate the process of detoxification. Excessive cadmium exposure can damage lungs, kidneys, and the digestive tract.

Includes

Arsenic, Cadmium, Lead, Mercury, Creatinine

Patient Preparation

Avoid seafood consumption for 48 hours prior to collection


Excessive exposure to Heavy Metals can cause acute and chronic toxicity. Heavy Metals Panel is intended to evaluate and monitor exposure to heavy metals and evaluate the process of detoxification.

Useful in the diagnosis of toxicity due to Arsenic, Lead or Mercury.

Includes

Arsenic, Mercury, Lead, Creatinine

Patient Preparation

Avoid seafood consumption for 48 hours prior to collection

Excessive exposure to heavy metals can cause acute and chronic toxicity. Heavy Metals Panel is intended to evaluate and monitor exposure to heavy metals and evaluate the process of detoxification.


Potassium measurements are useful in monitoring electrolyte balance in the diagnosis and treatment of disease conditions characterized by low or high blood potassium levels. Potassium is elevated in adrenal cortical insufficiency, acute renal failure and in some cases of diabetic acidosis. Potassium is decreased in diuretic administration and renal tubular acidosis.

RPR (Monitor) with Reflex to Titer 

Reference Range(s)

  • Non-Reactive

Clinical Significance

This is a non-treponemal screening test for syphilis. False positive results may occur due to systemic lupus erythematosus, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy. Monitoring of RPR is helpful in assessing effectiveness of therapy.

IMPORTANT

A positive RPR screen must be followed by a specific treponemal antibody test (e.g., FTA-ABS):

A positive result on the second method confirms the screening result and the affected person is diagnosed with syphilis.

A negative result on the treponemal test may mean that the initial RPR test was falsely positive. Further testing and investigation may be done to determine the cause of the false positive.

Limitations

False-positive results have been associated in patients with infections, pregnancy, autoimmune disease, old age, Gaucher disease, and malignancy.

Alternative Name(s) 

Syphilis


Useful in differentiating inflammatory and neoplastic diseases and as an index of disease severity. CRP is also useful in monitoring inflammatory disease states.

Sodium measurements are useful in the diagnosis and treatment of aldosteronism, diabetes insipidus, adrenal hypertension, Addison's Disease, dehydration, inappropriate antidiuretic hormone secretion, or other diseases involving electrolyte imbalance.

Most Popular

For diagnosis of hypothyroidism and hyperthyroidism.

Note: Free T4 Index (T7) will only be calculated and reported if test code code 861 (T3 Uptake) is ordered as well.


Most Popular

The Thyroid-stimulating Hormone (TSH) Blood Test is for differential diagnosis of primary, secondary, and tertiary hypothyroidism. The TSH test is also useful in screening for hyperthyroidism. This assay allows adjustment of exogenous thyroxine dosage in hypothyroid patients and in patients on suppressive thyroxine therapy for thyroid neoplasia.


Vitamin B12 is decreased in pernicious anemia, total or partial gastrectomy, malabsorption and certain congenital and biochemical disorders


Alzheimer's ReCODE Protocol (Baseline Labs) - Dr. Dale Bredesen MD

  • ApoE Genotype, Cardio IQ™
  • Arsenic, Blood
  • CBC (includes Differential and Platelets)
  • Comprehensive Metabolic Panel (CMP)
  • Copper
  • Cortisol, Total
  • DHEA Sulfate, Immunoassay
  • Estradiol
  • Ferritin
  • Hemoglobin A1c (HgbA1C)
  • Homocysteine
  • hs-CRP
  • Insulin
  • Lead, Blood
  • Lipid Panel with Ratios
  • Magnesium, RBC
  • MATRIX METALLOPROTEINASE 9 (MMP 9)
  • Mercury, Blood
  • Progesterone, Immunoassay
  • T3 Reverse (RT3), LC/MS/MS
  • T3, Free
  • T4, Free
  • Testosterone, Free (Dialysis) and Total MS
  • TSH
  • Vitamin B12 (Cobalamin) and Folate Panel, Serum
  • Vitamin D, 25-Hydroxy, Total, D (D2, D3), LC/MS/MS (QuestAssureD™)
  • Vitamin E
  • Zinc
     


One in nine people ages 65 and older and live in the United States have Alzheimer’s disease. This is more than 11% of the population, and the number is only growing.

Even though the prevalence of the disease and the population of elderly individuals is increasing, there still isn’t a cure for Alzheimer’s. Recent research studies are showing promise, but nothing is proven.

Therefore, anyone who thinks that they or a loved one may have the condition needs to get Alzheimer’s blood tests. These can help patients and their providers detect Alzheimer’s early, and this early diagnosis can slow the progression of the disease.

Keep reading if you're interested in learning more about how these blood tests can help Alzheimer's patients.

What Is Alzheimer’s Disease?

Alzheimer's disease is a progressive neurological disorder. Over time, the cells of the brain die, and the brain shrinks in size. 

This loss of brain matter leads to a cognitive decline, meaning that patients may experience a loss of thinking, behavioral, and social skills.

Alzheimer's disease is the most common cause of dementia, a disease marked by a continuous decline in thinking ability.

What Are the Risk Factors for Alzheimer’s Disease?

The most notable risk factor is a person's age. As you get older, you're more likely to develop Alzheimer's disease.

With this information, it's important to distinguish the fact that Alzheimer's is not a normal part of aging. The degradation that comes with Alzheimer's disease is not the same as the degradation that comes with the aging process.

Another risk factor is genetics. If an immediate family member has the disease, it's more likely that you'll have it as well. 

Individuals that carry the Alzheimer's gene are likely to carry the ApoE genotype as well. However, having the gene for the disease does not necessarily mean that you're going to develop the condition.

Another risk factor for Alzheimer's disease is pre-existing Down syndrome. Although the scientific community doesn't understand the link between the two conditions, they tend to agree it has to do with the extra chromosome copy found in individuals with Down syndrome.

Some scientists believe that the link between Down syndrome and Alzheimer's exists because of an early susceptibility. Patients with Down syndrome are likely to begin developing signs and symptoms of Alzheimer's 10 to 20 years before those without the pre-existing condition. So, some researchers think that this early susceptibility gives the body more time to develop the condition.

What Causes Alzheimer’s Disease?

No one knows the exact causes of Alzheimer's disease. People have speculated over the years but haven't settled on a finite answer.

However, researchers believe that the development of the disease has to do with a regulation failure in the brain. More specifically, scientists believe that the proteins in the brain may not be working properly, which causes the cells to fail and triggers a series of toxic events.

Over time, this kills neurons and causes brain damage, leading to worsening signs and symptoms.

Scientists have also stated that they believe that the condition develops as a result of environmental and genetic influences. People with genetic ties to the condition have been able to conquer the gene; however, you shouldn't rely on lifestyle changes to ensure that you'll never develop the condition.

What Are the Signs and Symptoms of Alzheimer’s Disease?

The number one symptom of Alzheimer's disease is memory loss. You may start noticing that you or your loved one can't recollect everyday information.

They may not know family members' names or similar information.

Here are a few other signs of Alzheimer's disease that you may notice in a family member or friend who is developing the disease:

  • Repeating statements and/or questions.
  • Forgetting conversations, events, appointments, etc.
  • Getting lost in places that they've been before.
  • Misplacing items that they own.
  • Having trouble identifying everyday objects.
  • Making wrong decisions that are uncharacteristic for the individual.
  • Changing personality traits quickly.

If you are displaying these symptoms, you should see a doctor. Even if it's not Alzheimer's, there could be another issue that you need to address. You shouldn't wait until it's too late.

What Are the Lab Tests for Alzheimer’s Disease?

To detect Alzheimer’s disease, physicians have to look for several different kinds of biomarkers. Here are some of the most common lab tests that physicians use to test for Alzheimer's disease:

  • C-reactive protein - a general test to look at inflammation levels in the body.
  • Cardio IQ ApoE genotype - a test to determine if you have the Alzheimer's gene or not.
  • Complete blood count - evaluates the levels and presence of different types of blood cells.
  • Comprehensive metabolic panel - a test that provides a broad look at your health as it evaluates liver and kidney function and various nutrient levels.
  • Drug screen - a routine test to determine if mental changes could be from other causes such as recreational drugs or prescription medications.
  • Sedimentation rate - a general test to look at the rate of inflammation in the body.
  • Total T4 - a test that aids in the diagnosis of hypothyroidism and hyperthyroidism, which could be an alternative diagnosis for mental changes in a patient.
  • Thyroid-stimulating hormone - a test that can help in the diagnosis of hypothyroidism or hyperthyroidism.
  • Vitamin B12 - looks for the levels of B12 in the bloodstream to make sure that blood and DNA production is normal.

Together, all of these lab tests and results can help your physician determine whether or not you have Alzheimer's disease. At the same time, it can help them figure out if you're presenting other illnesses. These conditions could be contributing to extraneous symptoms or exacerbating existing symptoms.

Where Can I Order Alzheimer’s Blood Tests?

Whether you're curious or concerned, the tests offered at Ulta Lab Tests can help you figure out if you have Alzheimer's disease. Order our comprehensive Alzheimer's panel today to get the answers that you need.

With Ulta Lab Tests you get:

  • Tests that are highly accurate and reliable
  • Access to 2100 authorized patient service centers
  • Secure and confidential results within 24 to 48 hours for most tests
  • No insurance is needed
  • No doctor’s referral required
  • Affordable pricing that includes a doctor’s order
  • 100% satisfaction guarantee

Take control of your health today with Ulta Lab Tests.