Alzheimer's Disease

Alzheimer’s disease is a brain disorder that causes memory loss, thinking problems, and changes in daily function. A proactive plan starts by ruling out reversible causes of memory issues, then using Alzheimer’s-specific biomarkers if concern remains. Begin with basic blood tests (thyroid, vitamin B12, metabolic panel, complete blood count, A1c). If problems persist, add blood-based biomarkers that reflect Alzheimer’s biology—such as the amyloid beta (Aβ42/40) ratio and phosphorylated tau (p-tau)—often alongside neurofilament light (NfL) to gauge nerve-cell injury. When results are unclear—or when higher certainty is needed—your clinician may confirm with cerebrospinal fluid (CSF) biomarkers or imaging.
Testing can clarify whether findings fit Alzheimer’s biology, rule out common medical mimics, and establish a baseline for monitoring. Testing cannot diagnose on its own or replace a clinician’s exam, cognitive testing, or guideline imaging.

Signs, Symptoms & Related Situations

  • Cognitive changes: short-term memory loss, repeating questions, word-finding trouble, getting lost.

  • Daily function: problems managing bills, medications, shopping, or cooking.

  • Behavior/mood: anxiety, apathy, depression, irritability, sleep changes.

  • Medical clues to reversible causes: low thyroid, low vitamin B12, uncontrolled diabetes, medication effects, alcohol use.

  • When to seek urgent care: stroke-like symptoms (face droop, arm weakness, slurred speech), severe confusion after head injury, or rapid decline.
    All symptoms should be evaluated by a qualified clinician.

Why These Tests Matter

What testing can do

  • Triage and rule-out: identify or exclude reversible medical causes.

  • Risk stratification: show patterns consistent with Alzheimer’s biology using blood biomarkers.

  • Monitoring: set baselines and track trends over time with cognitive assessments.

What testing cannot do

  • Replace a full clinical evaluation or guideline imaging.

  • Serve as population screening for people without symptoms.

What These Tests Measure (at a glance)

  • TSH (thyroid-stimulating hormone): screens for hypothyroidism; low thyroid can mimic memory issues. Caveat:illness and some drugs affect levels.

  • Vitamin B12 (± methylmalonic acid): detects deficiency tied to cognition. Caveat: borderline results may need confirmatory markers.

  • Comprehensive Metabolic Panel & CBC: checks electrolytes, kidney/liver function, glucose, and anemia—common medical mimics. Caveat: abnormalities suggest medical issues, not Alzheimer’s itself.

  • Hemoglobin A1c: shows long-term glucose control; poor control can worsen thinking. Caveat: interpret with overall health.

  • Aβ42/40 ratio (blood): lower ratios suggest amyloid changes seen in Alzheimer’s biology. Caveat: platform differences; not diagnostic alone.

  • Phosphorylated tau (p-tau181 or p-tau217, blood): reflects tau pathology typical of Alzheimer’s. Caveat: use with amyloid measures and clinical context.

  • Neurofilament light (NfL, blood): marker of neuroaxonal injury across many conditions. Caveat: not specific to Alzheimer’s.

  • CSF biomarkers (Aβ42/40, total tau, p-tau): higher-confidence confirmation when indicated. Caveat: requires lumbar puncture and specialist review.

How the Testing Process Works

  1. Start smart: order basic lab set (TSH, B12, CMP, CBC, A1c) with focused history and cognitive screening.

  2. Add Alzheimer’s biomarkers: if concern remains, use a blood biomarker panel (Aβ42/40 + p-tau ± NfL).

  3. Secure results: view results in your online account; most blood tests return within days.

  4. Follow up: review results with your clinician; consider confirmatory CSF biomarkers or imaging if needed.

  5. Monitor over time: repeat selected labs/biomarkers and cognitive checks to track trends.

Interpreting Results (General Guidance)

  • Normal basic labs with ongoing symptoms may support moving to Alzheimer’s biomarkers.

  • Alzheimer’s-pattern blood biomarkers (low Aβ42/40 and elevated p-tau) increase the likelihood of Alzheimer’s biology but do not equal a diagnosis.

  • Borderline or mixed patterns may lead to repeat testing, CSF biomarkers, or imaging.

  • Emphasize trends over single values; always interpret with a qualified professional.

Choosing Panels vs. Individual Tests

  • First step (most adults with memory concerns): Basic rule-out panel (TSH, B12, CMP, CBC, A1c).

  • If concern persists: Choose an Alzheimer’s blood biomarker panel (Aβ42/40 + p-tau ± NfL) over single tests for stronger interpretation.

  • If results remain unclear or risk is high: Discuss confirmatory CSF biomarkers with your clinician.

  • After a negative work-up but ongoing concern: Revisit history, medications, sleep, mood, and consider repeat or alternative testing as directed.

FAQs

Is there a blood test that diagnoses Alzheimer’s?
Blood tests can reflect Alzheimer’s biology, but they do not diagnose on their own.

Should I get biomarkers if I’m only a little forgetful?
Start with basic labs to rule out common causes; add Alzheimer’s biomarkers if concerns persist.

Do I need APOE genetic testing?
APOE shows risk, not diagnosis; discuss pros and cons with your clinician.

When is brain imaging needed?
Imaging is considered when symptoms progress, results are unclear, or to check for other causes.

How often should I repeat testing?
Timing varies; many people repeat selected labs or biomarkers to track trends with their clinician.

Can thyroid or B12 problems look like Alzheimer’s?
Yes—both can affect memory and thinking, which is why rule-out labs come first.

Internal Links & Cross-References

  • Cognitive & Memory Tests Hub

  • Mild Cognitive Impairment (MCI)

  • Depression Screening

  • Parkinson’s Disease

  • Vitamin Deficiencies

  • Key Lab Tests: TSH • Vitamin B12 • Comprehensive Metabolic Panel • CBC • Hemoglobin A1c • Alzheimer’s Blood Biomarker Panel (Aβ42/40, p-tau) • Neurofilament Light

References

  1. National Institute on Aging & Alzheimer’s Association. 2018 Research Framework: Toward a Biological Definition of Alzheimer’s Disease.

  2. Alzheimer’s Association. Alzheimer’s Disease Facts and Figures.

  3. Appropriate Use Recommendations for Blood Biomarkers in Alzheimer’s Disease. Consensus statements.

  4. American Academy of Neurology. Practice Guideline Update on Mild Cognitive Impairment—Evaluation and Management.

  5. National Institute on Aging. Assessing Cognitive Impairment and Dementia in Primary Care—General Principles.

  6. Appropriate Use Criteria for Amyloid and Tau PET in Alzheimer’s Disease. Joint society recommendations.

  7. Consensus Guidance on CSF Biomarkers for Alzheimer’s Disease—Analytical and Clinical Considerations.

  8. ISTAART/AA Working Groups—Best Practices for Blood-Based Biomarker Testing and Reporting.

Available Tests & Panels

Your Alzheimer’s-related test menu is pre-populated in the Ulta Lab Tests system. Start with rule-out labs (TSH, B12, CMP, CBC, A1c), then add an Alzheimer’s blood biomarker panel (Aβ42/40 + p-tau ± NfL) .

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Blood Draw, Phlebotomist

The Advanced Methylation Precision Panel is Ulta Lab Tests’ most comprehensive evaluation of methylation-related health. This panel organizes laboratory testing across core methylation pathways, integrating nutrient status, functional biomarkers, genetic factors, inflammation, oxidative stress, and metabolic context.

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Panel Contains Test: MTHFR and Methylation Test, Genetic Methylation Pathway Panel, Folate, B-Vitamins & Genetics Test, Intermediate Epigenetic Health Panel, Genetic & Enzymatic Methylation Panel, Folate–B12–MTHFR Pathway Panel

The Methylation Pathway Optimization Panel provides a comprehensive evaluation of the key nutrients, functional biomarkers, and genetic factors that influence methylation efficiency. Methylation is a critical biochemical process involved in cardiovascular wellness, energy production, cognitive function, and cellular maintenance.

Blood, Serum
Phlebotomist
Panel Contains Test: Comprehensive Methylation Test, Advanced Epigenetic Health Panel, Methylation, Inflammation & Oxidative Stress Panel, Precision Nutrient & Gene Interaction Panel, Epigenetic Regulation & Methylation Panel, Cellular Repair

Blood, Urine
Blood Draw, Phlebotomist, Urine Collection

One in nine people ages 65 and older and live in the United States have Alzheimer’s disease. This is more than 11% of the population, and the number is only growing.

Even though the prevalence of the disease and the population of elderly individuals is increasing, there still isn’t a cure for Alzheimer’s. Recent research studies are showing promise, but nothing is proven.

Therefore, anyone who thinks that they or a loved one may have the condition needs to get Alzheimer’s blood tests. These can help patients and their providers detect Alzheimer’s early, and this early diagnosis can slow the progression of the disease.

Keep reading if you're interested in learning more about how these blood tests can help Alzheimer's patients.

What Is Alzheimer’s Disease?

Alzheimer's disease is a progressive neurological disorder. Over time, the cells of the brain die, and the brain shrinks in size. 

This loss of brain matter leads to a cognitive decline, meaning that patients may experience a loss of thinking, behavioral, and social skills.

Alzheimer's disease is the most common cause of dementia, a disease marked by a continuous decline in thinking ability.

What Are the Risk Factors for Alzheimer’s Disease?

The most notable risk factor is a person's age. As you get older, you're more likely to develop Alzheimer's disease.

With this information, it's important to distinguish the fact that Alzheimer's is not a normal part of aging. The degradation that comes with Alzheimer's disease is not the same as the degradation that comes with the aging process.

Another risk factor is genetics. If an immediate family member has the disease, it's more likely that you'll have it as well. 

Individuals that carry the Alzheimer's gene are likely to carry the ApoE genotype as well. However, having the gene for the disease does not necessarily mean that you're going to develop the condition.

Another risk factor for Alzheimer's disease is pre-existing Down syndrome. Although the scientific community doesn't understand the link between the two conditions, they tend to agree it has to do with the extra chromosome copy found in individuals with Down syndrome.

Some scientists believe that the link between Down syndrome and Alzheimer's exists because of an early susceptibility. Patients with Down syndrome are likely to begin developing signs and symptoms of Alzheimer's 10 to 20 years before those without the pre-existing condition. So, some researchers think that this early susceptibility gives the body more time to develop the condition.

What Causes Alzheimer’s Disease?

No one knows the exact causes of Alzheimer's disease. People have speculated over the years but haven't settled on a finite answer.

However, researchers believe that the development of the disease has to do with a regulation failure in the brain. More specifically, scientists believe that the proteins in the brain may not be working properly, which causes the cells to fail and triggers a series of toxic events.

Over time, this kills neurons and causes brain damage, leading to worsening signs and symptoms.

Scientists have also stated that they believe that the condition develops as a result of environmental and genetic influences. People with genetic ties to the condition have been able to conquer the gene; however, you shouldn't rely on lifestyle changes to ensure that you'll never develop the condition.

What Are the Signs and Symptoms of Alzheimer’s Disease?

The number one symptom of Alzheimer's disease is memory loss. You may start noticing that you or your loved one can't recollect everyday information.

They may not know family members' names or similar information.

Here are a few other signs of Alzheimer's disease that you may notice in a family member or friend who is developing the disease:

  • Repeating statements and/or questions.
  • Forgetting conversations, events, appointments, etc.
  • Getting lost in places that they've been before.
  • Misplacing items that they own.
  • Having trouble identifying everyday objects.
  • Making wrong decisions that are uncharacteristic for the individual.
  • Changing personality traits quickly.

If you are displaying these symptoms, you should see a doctor. Even if it's not Alzheimer's, there could be another issue that you need to address. You shouldn't wait until it's too late.

What Are the Lab Tests for Alzheimer’s Disease?

To detect Alzheimer’s disease, physicians have to look for several different kinds of biomarkers. Here are some of the most common lab tests that physicians use to test for Alzheimer's disease:

  • C-reactive protein - a general test to look at inflammation levels in the body.
  • Cardio IQ ApoE genotype - a test to determine if you have the Alzheimer's gene or not.
  • Complete blood count - evaluates the levels and presence of different types of blood cells.
  • Comprehensive metabolic panel - a test that provides a broad look at your health as it evaluates liver and kidney function and various nutrient levels.
  • Sedimentation rate - a general test to look at the rate of inflammation in the body.
  • Total T4 - a test that aids in the diagnosis of hypothyroidism and hyperthyroidism, which could be an alternative diagnosis for mental changes in a patient.
  • Thyroid-stimulating hormone - a test that can help in the diagnosis of hypothyroidism or hyperthyroidism.
  • Vitamin B12 - looks for the levels of B12 in the bloodstream to make sure that blood and DNA production is normal.

Together, all of these lab tests and results can help your physician determine whether or not you have Alzheimer's disease. At the same time, it can help them figure out if you're presenting other illnesses. These conditions could be contributing to extraneous symptoms or exacerbating existing symptoms.

Take control of your health today with Ulta Lab Tests.