Ulta Lab Tests

Advanced Methylation Precision Panel

The Advanced Methylation Precision Panel is Ulta Lab Tests’ most comprehensive evaluation of methylation-related health. This panel organizes laboratory testing across core methylation pathways, integrating nutrient status, functional biomarkers, genetic factors, inflammation, oxidative stress, and metabolic context.

Plasma-Unspecified Vial Pour, Blood, Serum
Phlebotomist
MTHFR and Methylation Test, Genetic Methylation Pathway Panel, Folate, B-Vitamins & Genetics Test, Intermediate Epigenetic Health Panel, Genetic & Enzymatic Methylation Panel, Folate–B12–MTHFR Pathway Panel

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Amino Acid Analysis LCMS Plasma

1-Methylhistidine

3-Methylhistidine

Alanine

Alpha Amino Adipic Acid

Alpha Amino Butyric Acid

Arginine

Asparagine

Aspartic Acid

Beta Amino Isobutyric

Beta-Alanine

Citrulline

Cystathionine

Date Of Birth

Ethanolamine

Gamma Amino Butyric Acid

Glutamic Acid

Glutamine

Glycine

Histidine

Homocystine

Hydroxyproline

Interpretation

Isoleucine

Leucine

Lysine

Methionine

Ornithine

Phenylalanine

Proline

Sarcosine

Serine

Taurine

Threonine

Tryptophan

Tyrosine

Valine

Also known as: CBC, CBC includes Differential and Platelets, CBC/PLT w/DIFF, Complete Blood Count (includes Differential and Platelets)

NOTE: Ulta Lab Tests provides CBC test results from Quest Diagnostics as they are reported. Often, different biomarker results are made available at different time intervals. When reporting the results, Ulta Lab Tests denotes those biomarkers not yet reported as 'pending' for every biomarker the test might report. Only biomarkers Quest Diagnostics observes are incorporated and represented in the final CBC test results provided by Ulta Lab Tests.

Absolute Band Neutrophils (Only Reported If Detected)

Immature forms of neutrophils are called neutrophilic band cells. Neutrophils are a type of white blood cell that is responsible for much of the body's protection against infection. Neutrophils are produced in the bone marrow and released into the bloodstream to travel to wherever they are needed. Large numbers of immature forms of neutrophils, called neutrophilic band cells, are produced by the bone marrow when the demand is high.

Absolute Basophils

Basophils normally constitute 1% or less of the total white blood cell count but may increase or decrease in certain diseases and are thought to be involved in allergic reactions.

Absolute Blasts (Only Reported If Detected)

Blasts are immature forms of white blood cells.

Absolute Eosinophils

Eosinophils (eos) respond to infections caused by parasites and play a role in allergic reactions (hypersensitivities)

Absolute Lymphocytes

Lymphocytes are white blood cells that exist in both the blood and the lymphatic system. They are divided into three types. The B lymphocytes (B cells) are antibody-producing cells that are essential for acquired, antigen-specific immune responses. The second type are T lymphocytes (T cells) some T cells help the body distinguish between "self" and "non-self" antigens while others initiate and control the extent of an immune response, boosting it as needed and then slowing it as the condition resolves. Other types of T cells directly attack and neutralize virus-infected or cancerous cells. The third type are natural killer cells (NK cells) that directly attack and kill abnormal cells such as cancer cells or those infected with a virus.

Absolute Metamyelocytes (Only Reported If Detected)

Metamyelocytes are immature forms of white blood cells.

Absolute Monocytes

Monocytes (mono), similar to neutrophils, move to an area of infection and engulf and destroy bacteria. They are associated more often with chronic rather than acute infections. They are also involved in tissue repair and other functions involving the immune system.

Absolute Myelocytes (Only Reported If Detected)

Myelocytes are immature forms of white blood cells.

Absolute Neutrophils

Neutrophils (neu) normally make up the largest number of circulating WBCs. They move into an area of damaged or infected tissue, where they engulf and destroy bacteria or sometimes fungi. Young neutrophils, recently released into circulation, are called bands.

Absolute Nucleated Rbc (Only Reported If Detected)

Nucleated Red Blood Cells (nRBC) ) the presence of NRBCs in the adult blood is usually associated with malignant neoplasms, bone marrow diseases, and other serious disorders.

Absolute Promyelocytes (Only Reported If Detected)

Promyelocytes are immature forms of white blood cells.

Band Neutrophils (Only Reported If Detected)

Immature forms of neutrophils are called neutrophilic band cells. Neutrophils are a type of white blood cell that is responsible for much of the body's protection against infection. Neutrophils are produced in the bone marrow and released into the bloodstream to travel to wherever they are needed. Large numbers of immature forms of neutrophils, called neutrophilic band cells, are produced by the bone marrow when the demand is high.

Basophils

Basophils normally constitute 1% or less of the total white blood cell count but may increase or decrease in certain diseases and are thought to be involved in allergic reactions.

Blasts (Only Reported If Detected)

Blasts are immature forms of white blood cells.

Eosinophils

Eosinophils are specialized white blood cells produced in the bone marrow and released into the bloodstream, where they normally make up only 0–6 % of circulating leukocytes. Their cytoplasm is packed with reddish‑orange granules that contain potent enzymes (e.g., major basic protein, eosinophil cationic protein) and inflammatory mediators. When the immune system detects large, multicellular invaders—such as helminth (worm) parasites—eosinophils migrate out of the blood and surround the pathogen, releasing these granule contents to damage the parasite’s outer surface and aid its destruction. Beyond parasite defense, eosinophils act as key orchestras of the allergic response. They accumulate in tissues exposed to allergens (airways in asthma, skin in eczema, GI tract in eosinophilic esophagitis) and secrete cytokines and lipid mediators that amplify inflammation, recruit additional immune cells, and contribute to symptoms like swelling, mucus production, and itching. Because of this pro‑inflammatory role, persistently elevated eosinophil counts—termed eosinophilia—can signal allergic disorders, drug hypersensitivity, or certain autoimmune and malignant conditions. Conversely, counts drop toward zero after glucocorticoid therapy or in acute stress states, reflecting the cells’ sensitivity to hormonal and immune regulation.

Hematocrit

Hematocrit is a blood test that measures the percentage of the volume of whole blood that is made up of red blood cells. This measurement depends on the number of red blood cells and the size of red blood cells.

Hemoglobin

Serum hemoglobin is a blood test that measures the level of free hemoglobin in the liquid part of the blood (the serum). Free hemoglobin is the hemoglobin outside of the red blood cells. Most of the hemoglobin is found inside the red blood cells, not in the serum.

Lymphocytes

Lymphocytes are white blood cells that exist in both the blood and the lymphatic system. They are divided into three types. The B lymphocytes (B cells) are antibody-producing cells that are essential for acquired, antigen-specific immune responses. The second type are T lymphocytes (T cells) some T cells help the body distinguish between "self" and "non-self" antigens while others initiate and control the extent of an immune response, boosting it as needed and then slowing it as the condition resolves. Other types of T cells directly attack and neutralize virus-infected or cancerous cells. The third type are natural killer cells (NK cells) that directly attack and kill abnormal cells such as cancer cells or those infected with a virus.

MCH

Mean corpuscular hemoglobin (MCH) is a calculation of the average amount of oxygen-carrying hemoglobin inside a red blood cell.

MCHC

Mean corpuscular hemoglobin concentration (MCHC) is a calculation of the average percentage of hemoglobin inside a red cell.

MCV

Mean corpuscular volume (MCV) is a measurement of the average size of RBCs.

Metamyelocytes (Only Reported If Detected)

Metamyelocytes are immature forms of white blood cells.

Monocytes

Monocytes (mono), similar to neutrophils, move to an area of infection and engulf and destroy bacteria. They are associated more often with chronic rather than acute infections. They are also involved in tissue repair and other functions involving the immune system.

MPV

Mean Platelet Volume (MPV) - When it indicates average size of platelets are small; older platelets are generally smaller than younger ones and a low MPV may mean that a condition is affecting the production of platelets by the bone marrow. When it indicates a high number of larger, younger platelets in the blood; this may be due to the bone marrow producing and releasing platelets rapidly into circulation.

Myelocytes (Only Reported If Detected)

Myelocytes are immature forms of white blood cells.

Neutrophils

Neutrophils are a type of white blood cell that is responsible for much of the body's protection against infection. Neutrophils are produced in the bone marrow and released into the bloodstream to travel to wherever they are needed.

Nucleated Rbc (Only Reported If Detected)

Nucleated Red Blood Cells (nRBC) ) the presence of NRBCs in the adult blood is usually associated with malignant neoplasms, bone marrow diseases, and other serious disorders.

Platelet Count

A platelet count is a test to measure how many platelets you have in your blood. Platelets help the blood clot. They are smaller than red or white blood cells.

Promyelocytes (Only Reported If Detected)

Promyelocytes are immature forms of white blood cells.

RDW

Red cell distribution width (RDW), which may be included in a CBC, is a calculation of the variation in the size of RBCs.

Reactive Lymphocytes (Only Reported If Detected)

Lymphocytes are white blood cells that exist in both the blood and the lymphatic system. They are divided into three types. The B lymphocytes (B cells) are antibody-producing cells that are essential for acquired, antigen-specific immune responses. The second type are T lymphocytes (T cells) some T cells help the body distinguish between "self" and "non-self" antigens while others initiate and control the extent of an immune response, boosting it as needed and then slowing it as the condition resolves. Other types of T cells directly attack and neutralize virus-infected or cancerous cells. The third type are natural killer cells (NK cells) that directly attack and kill abnormal cells such as cancer cells or those infected with a virus.

Red Blood Cell Count

An RBC count is a blood test that tells how many red blood cells (RBCs) you have. RBCs contain hemoglobin, which carries oxygen. How much oxygen your body tissues get depends on how many RBCs you have and how well they work.

White Blood Cell Count

A WBC count is a test to measure the number of white blood cells (WBCs) in the blood. WBCs help fight infections. They are also called leukocytes. There are five major types of white blood cells: basophils, eosinophils, lymphocytes (T cells and B cells), monocytes and neutrophils

Also known as: Chem 12, Chemistry Panel, Chemistry Screen, CMP, Complete Metabolic Panel, Comprehensive Metabolic Panel CMP, SMA 12, SMA 20

Albumin

Albumin is a protein made by the liver. A serum albumin test measures the amount of this protein in the clear liquid portion of the blood.

Albumin/Globulin Ratio

The ratio of albumin to globulin (A/G ratio) is calculated from measured albumin and calculated globulin (total protein - albumin). Normally, there is a little more albumin than globulins, giving a normal A/G ratio of slightly over 1. Because disease states affect the relative amounts of albumin and globulin, the A/G ratio may provide a clue as to the cause of the change in protein levels. A low A/G ratio may reflect overproduction of globulins, such as seen in multiple myeloma or autoimmune diseases, or underproduction of albumin, such as may occur with cirrhosis, or selective loss of albumin from the circulation, as may occur with kidney disease (nephrotic syndrome). A high A/G ratio suggests underproduction of immunoglobulins as may be seen in some genetic deficiencies and in some leukemias. More specific tests, such as liver enzyme tests and serum protein electrophoresis, must be performed to make an accurate diagnosis. With a low total protein that is due to plasma expansion (dilution of the blood), the A/G ratio will typically be normal because both albumin and globulin will be diluted to the same extent.

Alkaline Phosphatase

Alkaline phosphatase (ALP) is a protein found in all body tissues. Tissues with higher amounts of ALP include the liver, bile ducts, and bone.

Alt

Alanine transaminase (ALT) is an enzyme found in the highest amounts in the liver. Injury to the liver results in release of the substance into the blood.

AST

AST (aspartate aminotransferase) is an enzyme found in high amounts in liver, heart, and muscle cells. It is also found in lesser amounts in other tissues.

Bilirubin, Total

Bilirubin is a yellowish pigment found in bile, a fluid made by the liver. A small amount of older red blood cells are replaced by new blood cells every day. Bilirubin is left after these older blood cells are removed. The liver helps break down bilirubin so that it can be removed from the body in the stool.

Bun/Creatinine Ratio

A ratio between a person’s BUN and blood creatinine to help determine what is causing these concentrations to be higher than normal. The ratio of BUN to creatinine is usually between 10:1 and 20:1. An increased ratio may be due to a condition that causes a decrease in the flow of blood to the kidneys, such as congestive heart failure or dehydration. It may also be seen with increased protein, from gastrointestinal bleeding, or increased protein in the diet. The ratio may be decreased with liver disease (due to decrease in the formation of urea) and malnutrition.

Calcium

You have more calcium in your body than any other mineral. Calcium has many important jobs. The body stores more than 99 percent of its calcium in the bones and teeth to help make and keep them strong. The rest is throughout the body in blood, muscle and the fluid between cells. Your body needs calcium to help muscles and blood vessels contract and expand, to secrete hormones and enzymes and to send messages through the nervous system.

Carbon Dioxide

CO2 is carbon dioxide. Measures the amount of carbon dioxide in the liquid part of your blood, called the serum. In the body, most of the CO2 is in the form of a substance called bicarbonate (HCO3-). Therefore, the CO2 blood test is really a measure of your blood bicarbonate level.

Chloride

Chloride is a type of electrolyte. It works with other electrolytes such as potassium, sodium, and carbon dioxide (CO2). These substances help keep the proper balance of body fluids and maintain the body's acid-base balance. This is a measure of the amount of chloride in the fluid portion (serum) of the blood.

Creatinine

The creatinine blood test measures the level of creatinine in the blood. This test is done to see how well your kidneys work.

Egfr African American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

Egfr Non-Afr. American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

GFR-AFRICAN AMERICAN

GFR-NON AFRICAN AMERICAN

Globulin

Globulins is the collective term for most blood proteins other than albumin. Identifying the types of globulins can help diagnose certain disorders. Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulines include various types of antibodies such as immunoglobulins (Ig) M, G, and A.

Glucose

A blood glucose test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including those in the brain. The hormones insulin and glucagon help control blood glucose levels.

Potassium

Potassium is a mineral that the body needs to work normally. It helps nerves and muscles communicate. It also helps move nutrients into cells and waste products out of cells. A diet rich in potassium helps to offset some of sodium's harmful effects on blood pressure.

Protein, Total

The total protein is the total amount of two classes of proteins, albumin and globulin that are found in the fluid portion of your blood. Proteins are important parts of all cells and tissues. Your albumin helps prevent fluid from leaking out of blood vessels and your globulins are an important part of your immune system.

Sodium

Sodium is a substance that the body needs to work properly it is vital to normal body processes, including nerve and muscle function

Urea Nitrogen (Bun)

BUN stands for blood urea nitrogen. Urea nitrogen is what forms when protein breaks down. BUN measures the amount of urea nitrogen in the blood.

Ferritin

Ferritin is a protein found inside cells that stores iron so your body can use it later. A ferritin test indirectly measures the amount of iron in your blood. The amount of ferritin in your blood (serum ferritin level) is directly related to the amount of iron stored in your body.

Also known as: Folate RBC, Folic Acid, Red Cell Folate

Folate, Rbc

Also known as: Folate Serum, Folic Acid

Folate, Serum

Folate is part of the B complex of vitamins and is measures the levels of folate in the liquid portion of the blood, the serum or plasma, to detect deficiencies. Folate is necessary for normal RBC formation, tissue and cellular repair, and DNA synthesis.. A deficiency inr folate can lead to macrocytic anemia. Megaloblastic anemia, a type of macrocytic anemia, is characterized by the production of fewer but larger RBCs called macrocytes, in addition to some cellular changes in the bone marrow.

Also known as: Homocysteine, Homocysteine Cardiovascular

HOMOCYSTEINE,

Also known as: C-Reactive Protein, Cardio CRP, Cardio hs-CRP, CRP, High Sensitivity CRP, High-sensitivity C-reactive Protein, High-sensitivity CRP, Highly Sensitive CRP, hsCRP, Ultra-sensitive CRP

Hs Crp

A high-sensitivity CRP (hs-CRP) test may be used by itself, in combination with other cardiac risk markers, or in combination with a lipoprotein-associated phospholipase A2 (Lp-PLA2) test that evaluates vascular inflammation. The hs-CRP test accurately detects low concentrations of C-reactive protein to help predict a healthy person's risk of cardiovascular disease (CVD). High-sensitivity CRP is promoted by some as a test for determining a person's risk level for CVD, heart attacks, and strokes. The current thinking is that hs-CRP can play a role in the evaluation process before a person develops one of these health problems.

Also known as: Methylenetetrahydrofolate Reductase MTHFR DNA Mutation Analysis, MTHFR

Methylenetetrahydrofolate

RESULT

Methylmalonic Acid

OxLDL

GLUTATHIONE

Also known as: B12, B12 Vitamin, Cobalamin, Cyanocobalamin, Vitamin B12 Cobalamin

Vitamin B12

Vitamin B12 is part of the B complex of vitamins and measurea the levels of vitamin B12 in the liquid portion of the blood, the serum or plasma, to detect deficiencies. Cobalamine, or vitamin B12, is found in animal products such as red meat, fish, poultry, milk, yogurt, and eggs and is not produced in the human body. In recent years, fortified cereals, breads, and other grain products have also become important dietary sources of B12. Vitamin B12 is necessary for normal RBC formation, tissue and cellular repair, and DNA synthesis. B12 is important for nerve health. A deficiency in B12 can lead to macrocytic anemia. Megaloblastic anemia, a type of macrocytic anemia, is characterized by the production of fewer but larger RBCs called macrocytes, in addition to some cellular changes in the bone marrow. B12 deficiency can lead to varying degrees of neuropathy, nerve damage that can cause tingling and numbness in the affected person's hands and feet.

Also known as: B2, Riboflavin, Vitamin B2, Vitamin B2 Riboflavin Plasma

Vitamin B2 (Riboflavin),

Also known as: B6, B6 Vitamin, Pyridoxal, Pyridoxal Phosphate, Pyridoxal Phosphate (PLP), Vitamin B6 Pyridoxal Phosphate

Vitamin B6

Also known as: ,25-Hydroxyvitamin D2, 25-Hydroxycholecalciferol (25OHD3), 25-OH-D2,D3 Vitamin, D2 Vitamin,25-Hydroxyvitamin D3,25-OH-D3, QuestAssureD 25Hydroxyvitamin D D2 D3 LCMSMS, Vitamin D, Vitamin D, 25-Hydroxy, Vitamin D2, 25-hydroxy,25-Hydroxyergocalciferol (25OHD2),Vitamin D3, 25-hydroxy

Vitamin D, 25-Oh, Total

Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. The chemical structures of the types of vitamin D are slightly different, and they are named vitamin D2 (ergocalciferol, which comes from plants) and vitamin D3 (cholecalciferol, which comes from animals). The D2 form is found in fortified foods and in most vitamin preparations and supplements. Vitamin D3 is the form produced in the body and is also used in some supplements. Vitamin D2 and D3 are equally effective when they are converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.
*Important Information on Lab Test Processing Times: Ulta Lab Tests is committed to informing you about the processing times for your lab tests processed through a national lab. Please note that the estimated processing time for each test, indicated in business days, is based on data from the past 30 days across the 13 laboratories for each test. These estimates are intended to serve as a guide and are not guarantees. Factors such as laboratory workload, weather conditions, holidays, and the need for additional testing or maintenance can influence actual processing times. We aim to offer estimates to help you plan accordingly. Please understand that these times may vary, and processing times are not guaranteed. Thank you for choosing Ulta Lab Tests for your laboratory needs.

The Advanced Methylation Precision Panel panel contains 16 tests with 104 biomarkers .

Comprehensive Functional, Genetic, Inflammatory, and Oxidative Assessment of Methylation Pathways

The Advanced Methylation Precision Panel is Ulta Lab Tests’ most comprehensive evaluation of methylation-related health. This panel organizes laboratory testing across core methylation pathways, integrating nutrient status, functional biomarkers, genetic factors, inflammation, oxidative stress, and metabolic context.

Methylation is a foundational biochemical process involved in cardiovascular wellness, neurological function, energy production, cellular repair, antioxidant balance, and gene regulation. This advanced panel is designed for individuals seeking a high-resolution view of the biological factors that influence methylation efficiency and overall metabolic health.

Why Advanced Methylation Testing Matters

Methylation efficiency may be influenced by:

  • Availability and utilization of key nutrients

  • Enzymatic cofactors required for methylation reactions

  • Genetic variants affecting folate metabolism

  • Oxidative stress and inflammatory burden

  • Iron status and metabolic demand

By grouping tests by pathway, this panel helps identify where methylation may be limited, not just whether abnormalities exist.

Tests Included in the Advanced Methylation Precision Panel

(Grouped by Functional Pathway)

1. Core Methylation Cycle Markers

These tests evaluate the central methylation pathway and methyl donor availability.

Included tests:

  • Homocysteine

  • Folate, Serum

  • Folate, RBC (Red Blood Cell Folate)

  • Vitamin B12 (Cobalamin)

  • Methylmalonic Acid (MMA)

Why this pathway matters:

  • Homocysteine sits at the center of the methylation cycle

  • Folate and vitamin B12 are required to recycle homocysteine into methionine

  • MMA provides functional insight into cellular B12 activity

  • RBC folate reflects long-term methyl donor availability, while serum folate reflects short-term intake

2. Enzymatic Cofactors Supporting Methylation

These nutrients act as essential cofactors for methylation and homocysteine metabolism.

Included tests:

  • Vitamin B2 (Riboflavin), Plasma

  • Vitamin B6 (Pyridoxal-5-Phosphate)

Why this pathway matters:

  • Vitamin B2 is required for optimal MTHFR enzyme activity

  • Vitamin B6 supports homocysteine clearance through transsulfuration pathways

  • Suboptimal cofactor levels may impair methylation even when folate and B12 appear adequate

3. Genetic Influence on Folate Metabolism

This test evaluates inherited factors that may affect methylation efficiency.

Included test:

  • Methylenetetrahydrofolate Reductase (MTHFR), DNA Mutation Analysis

Why this pathway matters:

  • Common MTHFR variants may influence how efficiently folate is converted into its active form

  • Genetic insight helps explain individual differences in nutrient utilization

  • Supports personalized nutrition and wellness discussions

4. Transsulfuration, Amino Acid, and Antioxidant Pathways

These tests evaluate how methylation connects to amino acid balance and antioxidant production.

Included tests:

  • Amino Acid Analysis, LC/MS, Plasma

  • Total Glutathione

Why this pathway matters:

  • Amino acids such as methionine, glycine, serine, and cysteine are closely linked to methylation

  • Transsulfuration pathways divert homocysteine toward glutathione production

  • Glutathione is the body’s primary intracellular antioxidant and reflects oxidative demand

5. Inflammation and Oxidative Stress Markers

These markers assess systemic stressors that can increase methylation demand.

Included tests:

  • High-Sensitivity C-Reactive Protein (hs-CRP)

  • Oxidized LDL (OxLDL)

Why this pathway matters:

  • Inflammation and oxidative stress increase the need for methyl donors and antioxidants

  • Elevated hs-CRP may help explain depleted glutathione or elevated homocysteine

  • Oxidized LDL provides advanced cardiometabolic context

6. Iron Status and Metabolic Demand

This test evaluates iron storage and its effect on enzymatic activity.

Included test:

  • Ferritin

Why this pathway matters:

  • Iron status influences enzymatic reactions involved in methylation

  • Low ferritin may impair energy production and enzyme efficiency

  • Excess iron can increase oxidative stress and glutathione demand

7. Global Hematologic and Metabolic Context

These panels provide essential systemic context for interpreting methylation-related findings.

Included tests:

  • Complete Blood Count (CBC), including Differential and Platelets

  • Comprehensive Metabolic Panel (CMP)

Why this pathway matters:

  • CBC helps assess anemia and red blood cell indices related to folate and B12 status

  • CMP evaluates liver and kidney function, which affect nutrient metabolism and clearance

  • Kidney function influences homocysteine and MMA interpretation

8. Vitamin D and Gene Regulation Support

This test evaluates vitamin D status as a regulator of immune and metabolic pathways.

Included test:

  • Vitamin D, 25-Hydroxy, Total

Why this pathway matters:

  • Vitamin D influences gene expression and immune regulation

  • Interacts with inflammatory and metabolic pathways

  • Commonly included in advanced wellness and longevity assessments

Who Should Consider the Advanced Methylation Precision Panel?

This panel may be appropriate for individuals who:

  • Want the most comprehensive methylation assessment available

  • Are participating in longevity or precision health programs

  • Have persistent or complex wellness concerns

  • Are optimizing nutrition and supplement protocols

  • Want insight into genetic, inflammatory, and oxidative influences on methylation

Specimen and Collection Information

  • Specimen Type: Blood

  • Collection Method: Standard blood draw

  • Laboratory: Quest Diagnostics

  • Fasting: Follow provider or lab instructions, if applicable

Important Notes and Disclaimers

  • This panel is intended for health information and monitoring purposes only

  • It is not intended to diagnose, treat, cure, or prevent disease

  • Results should be reviewed with a qualified healthcare professional

  • Interpretation should consider individual health history and clinical context

Related Panels You May Consider

  • Methylation Essentials Panel – Foundational baseline testing

  • Methylation Pathway Optimization Panel – Genetic and enzymatic focus

Core Methylation Cycle

What does the core methylation pathway control in the body?
The core methylation pathway supports DNA synthesis, nutrient metabolism, neurotransmitter balance, and cardiovascular wellness. It relies on adequate folate, vitamin B12, and proper recycling of homocysteine.

Why is homocysteine an important methylation marker?
Homocysteine sits at the center of the methylation cycle. Elevated levels may reflect reduced efficiency in folate- or vitamin B-dependent methylation processes.

Why measure both serum folate and RBC folate?
Serum folate reflects recent intake, while RBC folate reflects long-term folate status. Measuring both provides a more complete view of methyl donor availability.

Why include methylmalonic acid (MMA) with vitamin B12?
MMA helps assess functional vitamin B12 activity. Elevated MMA may indicate impaired B12 utilization even when serum B12 levels appear normal.

Enzymatic Cofactors

Why are vitamins B2 and B6 important for methylation?
Vitamin B2 supports the activity of enzymes involved in folate metabolism, while vitamin B6 helps regulate homocysteine clearance. Suboptimal levels may limit methylation efficiency.

Can methylation be impaired even if folate and B12 levels are normal?
Yes. Without adequate enzyme cofactors like B2 and B6, methylation reactions may not function optimally.

Genetic Influence (MTHFR)

What does MTHFR genetic testing evaluate?
MTHFR testing identifies common genetic variants that may affect how folate is converted into its active form used in methylation.

Does having an MTHFR variant mean something is wrong?
No. MTHFR variants are common. Results provide insight into nutrient processing differences and support personalized wellness discussions.

Transsulfuration & Antioxidant Pathways

How are amino acids related to methylation?
Amino acids such as methionine, glycine, serine, and cysteine are closely linked to methylation and antioxidant pathways.

Why is glutathione included in an advanced methylation panel?
Glutathione is the body’s primary intracellular antioxidant. Its production is connected to methylation pathways and reflects oxidative stress demand.

Inflammation & Oxidative Stress

Why measure hs-CRP in a methylation panel?
Inflammation increases methylation and antioxidant demand. hs-CRP helps provide context for elevated homocysteine or low glutathione.

What does oxidized LDL (OxLDL) indicate?
OxLDL reflects oxidative modification of LDL particles and provides advanced cardiometabolic context related to oxidative stress.

Iron Status & Metabolic Demand

Why is ferritin included in a methylation panel?
Ferritin reflects iron storage. Iron status influences enzymatic activity, energy metabolism, and oxidative balance, all of which can affect methylation efficiency.

Global Metabolic Context

Why include CBC and CMP in a methylation panel?
CBC and CMP provide essential systemic context. They help assess anemia, liver and kidney function, and metabolic health, which influence nutrient metabolism and biomarker interpretation.

Vitamin D & Gene Regulation

How does vitamin D relate to methylation?
Vitamin D plays a role in gene expression, immune balance, and inflammation. It provides additional context for metabolic and longevity-focused assessments.

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