Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune arthritis in which the immune system attacks the lining of the joints, causing inflammation, pain, swelling, and stiffness. It often starts in the small joints of the hands and feet and can lead to progressive joint damage without early detection and monitoring. Because other conditions can look similar, rheumatoid arthritis blood tests are key to supporting diagnosis, understanding disease activity, and tracking flares over time.

Ulta Lab Tests offers RA-focused panels and individual markers—including rheumatoid factor (RF), anti-CCP antibodies, CRP, ESR, CBC, and CMP—with fast, secure results you can share with your clinician for screening, diagnosis, and monitoring.


Signs & Symptoms (When to consider testing)

  • Symmetrical joint pain and swelling: hands, wrists, feet, ankles; often on both sides of the body

  • Morning stiffness: typically >30–60 minutes, improves with gentle movement

  • Warmth and tenderness around joints; decreased grip strength

  • Fatigue and malaise; low-grade fevers during flares

  • Functional limits: difficulty with fine motor tasks (buttoning, opening jars)

  • Extra-articular features: rheumatoid nodules; dry eyes/mouth (sicca); lung involvement; anemia

  • Family history of autoimmune disease

Related search terms: rheumatoid arthritis blood test, anti-CCP test, RF test, autoimmune arthritis labs, inflammatory arthritis testing.


Why These Tests Matter

What RA labs can do

  • Detect autoantibodies linked to RA (RFanti-CCP)

  • Measure inflammation (CRP, ESR) to gauge flares and activity

  • Provide objective data to support diagnosis and monitor trends over time

  • Help differentiate RA from osteoarthritis and other arthritides

What they cannot do

  • Confirm RA on their own—diagnosis requires symptoms, exam, and often imaging (X-ray/ultrasound/MRI)

  • Show the degree of joint damage (imaging needed)

  • Replace specialist evaluation for complex cases


What These Tests Measure (at a glance)

  • Anti-CCP (anti–cyclic citrullinated peptide): highly specific RA autoantibody; useful early in disease

  • Rheumatoid factor (RF): RA-associated antibody; not exclusive to RA

  • CRP & ESRinflammation markers that rise during active disease/flares

  • CBC: anemia of chronic disease, platelet changes with inflammation

  • CMP: organ function context that can influence clinical decisions

  • ANA: may be positive in some autoimmune conditions; not specific for RA


How the Testing Process Works

  1. Order online: choose a rheumatoid arthritis panel or specific markers.

  2. Visit a local lab: quick blood draw at a nearby patient service center.

  3. Get results fast: most post within 24–48 hours to your secure account.

  4. Review with your clinician: interpret alongside symptoms and imaging.


Interpreting Results (general guidance)

  • Anti-CCP positive → strongly supports RA, especially with compatible symptoms

  • RF positive → supports RA but can occur in other conditions or even healthy adults

  • Elevated CRP/ESR → indicates active inflammation; useful for monitoring

  • Seronegative RA → some people have RA with negative RF and anti-CCP; imaging and exam remain crucial

Always interpret labs with a qualified healthcare professional.


Choosing Panels vs. Individual Tests

  • Initial evaluation: start with a comprehensive RA/inflammatory panel (RF, anti-CCP, CRP, ESR, CBC, ± ANA).

  • Targeted follow-up: add or repeat anti-CCP and inflammation markers to clarify diagnosis or track activity.

  • Monitoring: recheck CRP/ESR (and other markers) during flares or at clinician-directed intervals.


FAQs

What is the most specific blood test for RA?
Anti-CCP is highly specific for rheumatoid arthritis and often helps detect disease early.

Do all people with RA have positive RF or anti-CCP?
No. Some have seronegative RA; diagnosis relies on the whole picture—symptoms, exam, imaging, and labs.

How do RA labs differ from osteoarthritis?
RA often shows elevated CRP/ESR and positive RF/anti-CCP; osteoarthritis is typically seronegative with normal inflammation markers.

Should I stop medicines before testing?
Do not change medications unless your clinician advises it. Some drugs can affect lab values.

How quickly will I get results?
Most RA-related tests are available within 24–48 hours after your blood draw.

How often should I retest?
Timing depends on symptoms and care plan; many patients monitor CRP/ESR during flares or periodically as advised by their clinician.


Internal Links & Cross-References

  • Arthritis Testing Hub

  • All Arthritis Tests

  • Osteoarthritis

  • Ankylosing Spondylitis

  • Juvenile Rheumatoid Arthritis

  • Psoriatic Arthritis

  • Key Blood Tests: RF • anti-CCP • CRP • ESR • CBC • CMP • ANA


Available Tests & Panels

Tip: Begin with a comprehensive RA panel (RF + anti-CCP + CRP/ESR + CBC). Add ANA if your clinician is considering other autoimmune conditions.

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The Rheumatoid Arthritis - Comprehensive Panel is the most detailed and extensive diagnostic tool available for assessing and monitoring rheumatoid arthritis (RA) and related autoimmune conditions. This panel combines a wide array of tests to evaluate the presence and severity of RA, monitor treatment effectiveness, and check for potential complications or coexisting conditions. It is designed for individuals with confirmed RA, those with symptoms suggestive of RA or other autoimmune diseases, and patients under treatment for RA to provide a complete health overview.
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Blood Draw, Phlebotomist

The Rheumatoid Arthritis - Advanced Panel is a comprehensive set of tests specifically curated for a detailed evaluation of rheumatoid arthritis (RA) and other related autoimmune conditions. This panel not only aids in diagnosing RA but also in assessing the severity of the disease, monitoring treatment efficacy, and evaluating overall health and organ function. It is designed for those who exhibit symptoms of RA or for patients under treatment to monitor disease activity and manage treatment plans effectively.
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Blood Draw, Phlebotomist

The Rheumatoid Arthritis - Basic Plus Panel is an expanded diagnostic tool designed to provide a more comprehensive assessment of rheumatoid arthritis (RA) and related conditions. By evaluating key biomarkers associated with inflammation, autoimmunity, and joint health, this panel aids in the diagnosis and monitoring of RA. It is instrumental for clinicians in identifying RA at an early stage, assessing the disease's activity level, and formulating a tailored treatment approach.
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Blood Draw, Phlebotomist

The Rheumatoid Arthritis - Basic Panel is a targeted diagnostic tool designed to detect key indicators of rheumatoid arthritis (RA) and other autoimmune conditions. This panel is particularly useful in the early diagnosis and management of rheumatoid arthritis, aiding in distinguishing it from other forms of arthritis and autoimmune diseases.
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Blood Draw, Phlebotomist

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Blood Draw, Phlebotomist


The ANA Screen IFA with Reflex to Titer and Pattern Test detects antinuclear antibodies in blood to evaluate autoimmune activity. If positive, further testing identifies antibody concentration (titer) and fluorescence pattern, helping diagnose conditions like lupus, rheumatoid arthritis, or Sjögren’s syndrome. Doctors order this test to investigate symptoms such as joint pain, fatigue, rash, or swelling and to guide treatment for autoimmune and connective tissue disorders.

Also Known As: ANA Test, Antinuclear Antibody Screen Test


The Rheumatoid Factor IgA IgG IgM Antibodies Test measures multiple rheumatoid factor classes to aid in diagnosing rheumatoid arthritis and related autoimmune diseases. Elevated levels may suggest joint inflammation, Sjögren’s syndrome, lupus, or chronic infections. Doctors use this comprehensive test to confirm autoimmune involvement, investigate persistent pain or stiffness, and guide treatment planning by assessing disease activity across antibody types.

Also Known As: RF Antibodies Test, Rheumatoid Arthritis Factor Antibodies Test

The Rheumatoid Factor IgA Antibody Test measures IgA-class rheumatoid factor, an autoantibody linked to rheumatoid arthritis and other autoimmune diseases. Elevated levels may indicate joint inflammation, Sjögren’s syndrome, or chronic infections. Doctors use this blood test alongside other markers to confirm diagnosis, assess disease activity, and guide treatment decisions for patients with suspected autoimmune or inflammatory disorders.

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Blood Draw
Also Known As: RF IgA Test, Rheumatoid Arthritis Factor IgA Antibody Test

The Rheumatoid Factor IgG Antibody Test measures IgG-class rheumatoid factor, an autoantibody often linked to rheumatoid arthritis and autoimmune diseases. Elevated levels may indicate joint inflammation, Sjögren’s syndrome, or chronic infection. Doctors use this test with other markers to confirm diagnosis, assess autoimmune activity, and guide treatment for patients with persistent joint pain, swelling, or suspected inflammatory disorders.

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Blood Draw
Also Known As: RF IgG Test, Rheumatoid Arthritis Factor IgG Antibody Test

The Rheumatoid Factor (RF) Test measures RF antibodies in blood to help diagnose rheumatoid arthritis and other autoimmune conditions. High RF levels may indicate rheumatoid arthritis, Sjögren’s syndrome, or other connective tissue diseases, though they can also appear in some infections. Doctors order this test to investigate joint pain, stiffness, or swelling. Results provide important insight into autoimmune activity, joint health, and inflammatory disease management.

Blood
Blood Draw
Also Known As: RF Test, Rheumatoid Arthritis Factor Test

The C-Reactive Protein (CRP) Test measures CRP levels in blood to detect inflammation in the body. Elevated CRP may indicate infections, autoimmune disorders, or chronic diseases such as arthritis, cardiovascular disease, or inflammatory bowel disease. Doctors use this test to assess acute illness, monitor treatment response, and evaluate risk for heart disease. The CRP test provides key insight into inflammation, immune health, and overall wellness.

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Blood Draw
Also Known As: CRP Test, Inflammation Test

Most Popular

The Sed Rate Test, also called the ESR Test, measures how quickly red blood cells settle in a sample of blood. A faster rate may signal inflammation caused by infections, autoimmune diseases, arthritis, or other chronic conditions. Doctors use this test to investigate unexplained fever, joint pain, or muscle aches, and to monitor inflammatory disorders such as lupus or rheumatoid arthritis. The Sed Rate Test provides important insight into overall inflammatory activity.

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Blood Draw
Also Known As: Erythrocyte Sedimentation Rate Test, ESR Test, Sedimentation Rate Test, Westergren Sedimentation Rate Test

The Sedimentation Rate Blood Test, also called the Erythrocyte Sedimentation Rate (ESR) Test, measures how quickly red blood cells settle in a sample. A faster rate can signal inflammation linked to arthritis, autoimmune disease, or infection. Doctors order this test when patients have symptoms like joint pain, fever, or fatigue. While not diagnostic alone, results provide valuable insight into inflammatory activity and help guide further evaluation and treatment.

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Blood Draw
Also Known As: Sed Rate Test

Most Popular

The Cyclic Citrullinated Peptide (CCP) IgG Antibody Test helps diagnose rheumatoid arthritis by detecting antibodies strongly linked to autoimmune joint disease. A positive result may indicate early or developing RA, even before symptoms appear. Doctors order this test for patients with joint pain, stiffness, or swelling. Results, often used with the rheumatoid factor (RF) test, provide valuable insight into autoimmune activity and long-term joint health management.

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Blood Draw
Also Known As: Anti-CCP, Cyclic Citrullinated Peptide IgG Antibody Test

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

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Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Cardiolipin IgA Antibody Test detects IgA antibodies to cardiolipin, helping assess clotting disorders, autoimmune disease, and vascular complications. High levels are often linked to antiphospholipid syndrome, pregnancy loss, or thrombotic conditions. This test provides insight into immune activity, coagulation balance, and systemic disorders influenced by antibody-mediated vascular dysfunction.

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Blood Draw

The Cardiolipin IgG Antibody Test detects IgG antibodies to cardiolipin, often associated with autoimmune disease. Abnormal results may indicate antiphospholipid syndrome, blood clotting disorders, or pregnancy complications. This test provides insight into thrombotic risk, vascular health, systemic inflammation, and immune activity linked to autoimmune conditions and antibody-mediated disease.

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Blood Draw

The Cardiolipin IgM Antibody Test measures IgM antibodies linked to antiphospholipid syndrome and autoimmune disorders. It helps evaluate unexplained blood clots, recurrent miscarriages, or abnormal clotting events. By detecting immune system activity against phospholipids, this test supports the assessment of vascular health, autoimmune activity, and risks related to thrombosis or systemic lupus erythematosus.

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Blood Draw

The Complement Component C3c and C4c Test measures levels of two key proteins in the complement system, which supports immune defense and inflammation control. Abnormal results may indicate autoimmune disease, lupus, rheumatoid arthritis, or certain infections. Doctors use this test to investigate unexplained inflammation, monitor disease activity, and guide treatment decisions in patients with suspected immune or inflammatory disorders.

Also Known As: C3 and C4 Test, Complement C3 and C4 Test, Complement Test

The Complement Component C4c Test measures blood levels of C4c, a protein in the complement system that supports immune defense and inflammation control. Abnormal levels may indicate autoimmune disorders such as lupus, rheumatoid arthritis, or immune complex disease, as well as certain kidney conditions. Doctors use this test to evaluate complement activation, confirm diagnosis, and monitor treatment response in patients with suspected immune-related diseases.

Blood
Blood Draw
Also Known As: C4 Test, Complement C4 Test, Complement Test

The Complement Total CH50 Test measures overall activity of the complement system, a key part of the immune response that helps fight infections and regulate inflammation. Abnormal results may indicate autoimmune diseases such as lupus, complement deficiencies, or immune complex disorders. Doctors use this blood test to evaluate immune function, investigate recurrent infections, and monitor treatment in patients with suspected immune or autoimmune conditions.

Blood
Blood Draw
Also Known As: Total Complement Test, Total Complement Activity Test

Most Popular

The Cortisol AM Test measures morning cortisol levels in blood to evaluate adrenal gland function and stress response. Cortisol peaks in the morning, making this test critical for detecting adrenal insufficiency (Addison’s disease), Cushing’s syndrome, or other hormone imbalances. Doctors also use it to investigate fatigue, weight changes, or high blood pressure. This test provides important insight into endocrine health, metabolism, and long-term stress regulation.

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Blood Draw
Also Known As: Morning Cortisol Test

There are approximately 1.3 million sufferers of rheumatoid arthritis across the United States. Interestingly, the condition is 2.5 times more likely to impact women than men. 

While you might imagine the term arthritis with someone who is aging, it's also interesting to note that it's most common to get a rheumatoid arthritis diagnosis between the ages of 20 and 50. 

So, how do people with rheumatoid arthritis know they have it? What are the signs they experience that tell them they should be tested? Is a rheumatoid arthritis blood test the best way to find out if you suffer from this?

Read on to learn everything you need to know about people with RA and getting tested if you think you might have it.

What Is Rheumatoid Arthritis?

You might associate the term arthritis with aches, pains, and maybe some swelling. There are a few ways this type of arthritis is unique from other forms. 

Rheumatoid arthritis causes swelling in the joints, which isn't uncommon with arthritis. However, with rheumatoid arthritis, the swelling is symmetrical. You won't feel it just in your left hand. Instead, it's highly likely that you will get swelling in both hands.

The other way that rheumatoid arthritis is different is that it's classified as an autoimmune disease. While regular arthritis may cause wear and tear in the joints, RA develops and impacts those afflicted through the immune system. 

Understanding the Impact of Rheumatoid Arthritis

Rheumatoid arthritis impacts the joints in the body by causing swelling inside the lining of the joints. The swelling, if not treated, can cause bone erosion and joint deformity.

Another difference between wear and tear arthritis and rheumatoid arthritis is that RA can have an impact beyond the joints.  RA can impact other body systems including the skin, eyes, lungs, heart, and blood vessels, in severe cases. 

An RA sufferer who is early in the disease will often feel the impact in their smaller joints first. This might include their fingers, wrists, and hands. As the disease progresses or gets more severe, it will spread to larger joints and other parts of the body. 

Risks Factors Associated With Rheumatoid Arthritis

So, what can trigger the disease for you? There are some associated risk factors that come with rheumatoid arthritis.  

Females are more likely to get the disease than males. If someone in your family has rheumatoid arthritis, you have a higher likelihood of also having the disease. 

Smoking is another risk factor for the disease. It seems that if you're a smoker and have a family history, your chances are increased that you'll get RA. Smokers with RA also seem to have symptoms that are more severe. 

Causes of Rheumatoid Arthritis

In a healthy body, the immune system helps to fight off disease and infection. Remember that rheumatoid arthritis is an autoimmune disease. What happens with rheumatoid arthritis is that the immune system actually attacks the healthy tissues inside your joints. 

Scientists are unclear what causes your immune system to start this attack. There are some factors that seem to contribute to the likelihood of getting RA. There doesn't seem to be a direct genetic connection. Although if a person is exposed to certain environmental factors like an infection from certain bacteria or a virus, it can trigger the disease. 

There does seem to be a correlation between stress and the onset of RA too. 

Signs and Symptoms of Rheumatoid Arthritis

For those suffering from rheumatoid arthritis, you might find that you can get yourself into remission. In this case, your symptoms decrease, and you don't feel the impact of the disease. It doesn't mean it has gone away; it is just more dormant. Often those suffering from rheumatoid arthritis have no symptoms when in remission.

If you're having a flare-up, your symptoms come back and are exacerbated. Symptoms might include:

  • Joint pain
  • Joint swelling
  • Joint stiffness
  • Loss of joint function and deformities

Symptoms for those not in remission can also come and go. The severity of the symptoms can also vary. It's important not to ignore the symptoms when they flare-up, even if they seem mild. You want to keep them under control, so they don't get worse.

Testing for Rheumatoid Arthritis

Getting an RA diagnosis can take some time. It's likely your doctor will do a physical exam and look closely at your joints. If your doctor suspects you might be suffering from RA, you should have blood tests done. It's pretty common to continue to monitor with regular blood tests once you have an RA diagnosis.

Blood tests will look for the rheumatoid factor or RF antibody. The RF antibodies will line the tissue of your joints and are present for many people who suffer from RA. RF is not exclusive to rheumatoid arthritis but is often present. 

Some of the RF blood tests include:

Blood tests will also look for:

Testing for RA panels include:

Once there is an RF antibody located, doctors will also look for these other indicators. The RF antibody is called immunoglobulin IgM.

Answering Your Questions About Rheumatoid Arthritis and Getting Tested for It 

Let's answer some common questions related to rheumatoid arthritis. 

What early signs should you watch for in rheumatoid arthritis? Early signs of RA usually include swelling in the joints that causes pain and swelling. 

When will sufferers feel the most impact of the disease? It's likely that RA will impact sufferers more in the morning than at other times in the day.

What does a rheumatologist do? A rheumatologist studies rheumatology which includes:

  • Joints
  • Muscles
  • Bones
  • Autoimmune diseases
  • Soft tissue diseases

It's likely your family doctor will refer you to a rheumatologist for further treatment and diagnosis if you believe you're suffering from RA.

Benefits of Rheumatoid Arthritis Blood Test With Ulta Lab Tests 

Ulta Lab Tests offers our tests to be highly accurate and reliable so you can make informed decisions about your health.
• Secure and confidential results
• No insurance referral is needed
• Affordable pricing 
• 100% satisfaction guarantee

Order your rheumatoid arthritis lab test today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take Control of Your Symptoms and Get Tested Today for Rheumatoid Arthritis

Rheumatoid arthritis blood tests can help you get the answers you need. The sooner you can understand if you have RA, the sooner you can work to get control of it too. 

Take charge of your health and track your progress with Ulta Lab Tests.