Rheumatoid Arthritis

If you suspect you have rheumatoid arthritis, then you need to read this guide to rheumatoid arthritis blood test benefits, types, treatment options, and get tested.

The rheumatoid arthritis blood test can provide an accurate reading of your blood levels of Rheumatoid factor and antinuclear antibodies, often present in persons with rheumatic disease. Order from Ulta Lab Tests today, with confidential results available in 24 to 48 hours online.       

In the guide below the list of tests, we explain and answer your questions on Rheumatoid Arthritis tests.

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Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. 

Reflex Information: If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge.

ANAlyzeR™ ANA, IFA with Reflex Titer/Pattern, Systemic Autoimmune Panel 1


  • ANA Screen,IFA, with Reflex to Titer and Pattern
  • DNA (ds) Antibody, Crithidia IFA with Reflex to Titer
  • Chromatin (Nucleosomal) Antibody
  • Sm Antibody
  • Sm/RNP Antibody
  • RNP Antibody
  • Sjogren's Antibodies (SS-A, SS-B)
  • Scleroderma Antibody (Scl-70)
  • Jo-1 Antibody
  • Centromere B Antibody
  • Complement Component C3c and C4c
  • Cardiolipin Antibodies (IgA, IgG, IgM)
  • Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
  • Rheumatoid Factor (IgA, IgG, IgM)
  • Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
  • 14.3.3 eta Protein
  • Thyroid Peroxidase Antibodies (TPO)


  • If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).
  • If the DNA (ds) Antibody Screen is positive, then DNA (ds) Antibody Titer will be performed at an additional charge (CPT code(s): 86256).


Alternative Name(s)

Expanded ANA Antibodies,Systemic Autoimmune Disorder,ANA and Expanded AI Testing,ANA and Systemic Autoimmunity,Comprehensive AI Testing,Early Systemic Autoimmune Disease,Autoimmune Disorders

Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.

Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.

Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.

Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis and primary Sjögren's syndrome.

Decreased C3 and C4 levels may be associated with acute glomerulonephritis, membranoproliferative glomerulonephritis, immune complex disease, active systemic lupus erythematosis, cryoglobulinemia, congenital C4 deficiency and generalized autoimmune disease

Decreased C4 level is associated with acute systemic lupus erythematosis, glomerulonephritis, immune complex disease, cryoglobulinemia, congenital C4 deficiency and generalized autoimmune disease

CH50 is a screening test for total complement activity. Levels of complement may be depressed in genetic deficiency, liver disease, chronic glomerulonephritis, rheumatoid arthritis, hemolytic anemias, graft rejection, systemic lupus erythematosis, acute glomerulonephritis, subacute bacterial endocarditis and cryoglobulinemia. Elevated complement may be found in acute inflammatory conditions, leukemia, Hodgkin's Disease, sarcoma, and Behcet's Disease.

A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 7 a.m.-9 a.m.

Test for myocardial infarction and skeletal muscle damage. Elevated results may be due to: myocarditis, myocardial infarction (heart attack), muscular dystrophy, muscle trauma or excessive exercise

A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with Polycystic Ovarian Syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.

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Useful in the diagnosis of hypochromic, microcytic anemias. Decreased in iron deficiency anemia and increased in iron overload.

A Hemoglobin (Hb) A1c Blood Test evaluates the average amount of glucose in the blood. The A1c test will help determine whether you are at a higher risk of developing diabetes; to help diagnose diabetes and prediabetes; to monitor diabetes and to aid in treatment decisions.

To assist with control of blood glucose levels, the American Diabetes Association (ADA) has recommended glycated hemoglobin testing (HbA1c) twice a year for patients with stable glycemia, and quarterly for patients with poor glucose control. Interpretative ranges are based on ADA guidelines.

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Immunoglobulin A (IgA)

Test Highlight



Clinical Use

  • Diagnose IgA deficiencies

  • Determine etiology of recurrent infections

  • Diagnose infection

  • Diagnose inflammation

  • Diagnose IgA monoclonal gammopathy

Clinical Background

IgA is the first line of defense for the majority of infections at mucosal surfaces and consists of 2 subclasses. IgA1 is the dominant subclass, accounting for 80% to 90% of total serum IgA and greater than half of the IgA in secretions such as milk, saliva, and tears. IgA2, on the other hand, is more concentrated in secretions than in blood. IgA2 is more resistant to proteolytic cleavage and may be more functionally active than IgA1.

IgA deficiency is the most prevalent isotype deficiency, occurring in 1/400 to 1/700 individuals. Many patients with IgA deficiency are asymptomatic, while others may develop allergic disease, repeated sinopulmonary or gastroenterologic infections, and/or autoimmune disease. Individuals with complete absence of IgA (<5 mg/dL) may develop autoantibodies to IgA after blood or intravenous immunoglobulin infusions and may experience anaphylaxis on repeat exposure. 

Elevated serum IgA levels are associated with infection, inflammation, or IgA monoclonal gammopathy.


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For diagnosis and monitoring of diabetes and insulin-secreting tumors.

A lipid panel includes:Total cholesterol —this test measures all of the cholesterol in all the lipoprotein particles.High-density lipoprotein cholesterol (HDL-C) — measures the cholesterol in HDL particles; often called "good cholesterol" because it removes excess cholesterol and carries it to the liver for removal.Low-density lipoprotein cholesterol (LDL-C) — calculates the cholesterol in LDL particles; often called "bad cholesterol" because it deposits excess cholesterol in walls of blood vessels, which can contribute to atherosclerosis. Usually, the amount of LDL cholesterol (LDL-C) is calculated using the results of total cholesterol, HDL-C, and triglycerides.Triglycerides — measures all the triglycerides in all the lipoprotein particles; most is in the very low-density lipoproteins (VLDL).Very low-density lipoprotein cholesterol (VLDL-C) — calculated from triglycerides/5; this formula is based on the typical composition of VLDL particles.Non-HDL-C — calculated from total cholesterol minus HDL-C.Cholesterol/HDL ratio — calculated ratio of total cholesterol to HDL-C.

Lyme disease is transmitted by a tick vector carrying Borrelia burgdorferi. Immunoblot testing qualitatively examines, with high specificity, antibodies in a patient's specimen. Immunoblot testing is appropriate for confirming a detected EIA or IFA test result.

Clinical Significance

Prostaglandins are synthesized from arachidonic acid by cyclooxygenase (COX)-1 or -2, which converts the acid into PGH2. This is further processed by cytosolic or microsomal prostaglandin synthesis to become prostaglandin E2. PG E2 is produced in many tissues and the level is increased during inflammation, arthritis, fever, endometriosis, tissue injury, pheochromocytoma, VIP producing tumors and variety of cancers with amine peptide productions. Prostaglandin E2 production and circulating levels are reduced by aspiring and indomethacin treatment.

Alternative Name(s)


The major proteins seen in the serum are albumin and globulin-the latter being primarily alpha 1 and alpha 2 globulin, beta globulin and gamma globulin. Albumin accounts for more than 50% of the total serum proteins. The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. The normal A/G ratio is 0.8-2.0. The A/G ratio can be decreased in response to a low albumin or to elevated globulins. Total globulins may be increased in some chronic inflammatory diseases (TB, syphilis) multiple myeloma, collagen disease, and rheumatoid arthritis. Decreased levels are seen in hepatic dysfunction, renal disease and various neoplasms.

There are approximately 1.3 million sufferers of rheumatoid arthritis across the United States. Interestingly, the condition is 2.5 times more likely to impact women than men. 

While you might imagine the term arthritis with someone who is aging, it's also interesting to note that it's most common to get a rheumatoid arthritis diagnosis between the ages of 20 and 50. 

So, how do people with rheumatoid arthritis know they have it? What are the signs they experience that tell them they should be tested? Is a rheumatoid arthritis blood test the best way to find out if you suffer from this?

Read on to learn everything you need to know about people with RA and getting tested if you think you might have it.

What Is Rheumatoid Arthritis?

You might associate the term arthritis with aches, pains, and maybe some swelling. There are a few ways this type of arthritis is unique from other forms. 

Rheumatoid arthritis causes swelling in the joints, which isn't uncommon with arthritis. However, with rheumatoid arthritis, the swelling is symmetrical. You won't feel it just in your left hand. Instead, it's highly likely that you will get swelling in both hands.

The other way that rheumatoid arthritis is different is that it's classified as an autoimmune disease. While regular arthritis may cause wear and tear in the joints, RA develops and impacts those afflicted through the immune system. 

Understanding the Impact of Rheumatoid Arthritis

Rheumatoid arthritis impacts the joints in the body by causing swelling inside the lining of the joints. The swelling, if not treated, can cause bone erosion and joint deformity.

Another difference between wear and tear arthritis and rheumatoid arthritis is that RA can have an impact beyond the joints.  RA can impact other body systems including the skin, eyes, lungs, heart, and blood vessels, in severe cases. 

An RA sufferer who is early in the disease will often feel the impact in their smaller joints first. This might include their fingers, wrists, and hands. As the disease progresses or gets more severe, it will spread to larger joints and other parts of the body. 

Risks Factors Associated With Rheumatoid Arthritis

So, what can trigger the disease for you? There are some associated risk factors that come with rheumatoid arthritis.  

Females are more likely to get the disease than males. If someone in your family has rheumatoid arthritis, you have a higher likelihood of also having the disease. 

Smoking is another risk factor for the disease. It seems that if you're a smoker and have a family history, your chances are increased that you'll get RA. Smokers with RA also seem to have symptoms that are more severe. 

Causes of Rheumatoid Arthritis

In a healthy body, the immune system helps to fight off disease and infection. Remember that rheumatoid arthritis is an autoimmune disease. What happens with rheumatoid arthritis is that the immune system actually attacks the healthy tissues inside your joints. 

Scientists are unclear what causes your immune system to start this attack. There are some factors that seem to contribute to the likelihood of getting RA. There doesn't seem to be a direct genetic connection. Although if a person is exposed to certain environmental factors like an infection from certain bacteria or a virus, it can trigger the disease. 

There does seem to be a correlation between stress and the onset of RA too. 

Signs and Symptoms of Rheumatoid Arthritis

For those suffering from rheumatoid arthritis, you might find that you can get yourself into remission. In this case, your symptoms decrease, and you don't feel the impact of the disease. It doesn't mean it has gone away; it is just more dormant. Often those suffering from rheumatoid arthritis have no symptoms when in remission.

If you're having a flare-up, your symptoms come back and are exacerbated. Symptoms might include:

  • Joint pain
  • Joint swelling
  • Joint stiffness
  • Loss of joint function and deformities

Symptoms for those not in remission can also come and go. The severity of the symptoms can also vary. It's important not to ignore the symptoms when they flare-up, even if they seem mild. You want to keep them under control, so they don't get worse.

Testing for Rheumatoid Arthritis

Getting an RA diagnosis can take some time. It's likely your doctor will do a physical exam and look closely at your joints. If your doctor suspects you might be suffering from RA, you should have blood tests done. It's pretty common to continue to monitor with regular blood tests once you have an RA diagnosis.

Blood tests will look for the rheumatoid factor or RF antibody. The RF antibodies will line the tissue of your joints and are present for many people who suffer from RA. RF is not exclusive to rheumatoid arthritis but is often present. 

Some of the RF blood tests include:

Blood tests will also look for:

Testing for RA panels include:

Once there is an RF antibody located, doctors will also look for these other indicators. The RF antibody is called immunoglobulin IgM.

Answering Your Questions About Rheumatoid Arthritis and Getting Tested for It 

Let's answer some common questions related to rheumatoid arthritis. 

What early signs should you watch for in rheumatoid arthritis? Early signs of RA usually include swelling in the joints that causes pain and swelling. 

When will sufferers feel the most impact of the disease? It's likely that RA will impact sufferers more in the morning than at other times in the day.

What does a rheumatologist do? A rheumatologist studies rheumatology which includes:

  • Joints
  • Muscles
  • Bones
  • Autoimmune diseases
  • Soft tissue diseases

It's likely your family doctor will refer you to a rheumatologist for further treatment and diagnosis if you believe you're suffering from RA.

Benefits of Rheumatoid Arthritis Blood Test With Ulta Lab Tests 

Ulta Lab Tests offers our tests to be highly accurate and reliable so you can make informed decisions about your health.
• Secure and confidential results
• No insurance referral is needed
• Affordable pricing 
• 100% satisfaction guarantee

Order your rheumatoid arthritis lab test today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take Control of Your Symptoms and Get Tested Today for Rheumatoid Arthritis

Rheumatoid arthritis blood tests can help you get the answers you need. The sooner you can understand if you have RA, the sooner you can work to get control of it too. 

Take charge of your health and track your progress with Ulta Lab Tests.

A chronic autoimmune disease, rheumatoid arthritis, or RA causes joint deterioration, along with stiffness and pain, inflammation, and loss of mobility. There are other symptoms associated with Rheumatoid Arthritis, including fever, fatigue, malaise, and the development of nodules under the skin. Additionally, those with RA can develop anemia, systemic complications. There may also be co-existing disorders and symptoms, for example, dry mouth and dry eyes that are often associated with Sjogren’s syndrome. Typically, RA affects the joints in a symmetrical manner. The most common joints affected are the hands and wrists, but the feet, neck, elbows, shoulders, and hips can also be affected by RA.

Rheumatoid arthritis usually develops between 40 and 60 years old. However, it can develop at any age. Women are the most affected by RA, with 70% of RA patients being women. The National Institutes of Health state that in the United States, there are over 1.3 million people who have the condition. If RA is not treated, it can work quickly and leave a person unable to work and can shorten their lifespan. The prognosis and course of RA vary from person to person. Some people find that it develops and progresses slowly, while others experience quick development and progression. RA can go into remission, and in a small percentage of RA patients, it can go away. For pregnant women with RA, they typically have a decrease of symptoms while pregnant, and the symptoms usually worsen after giving birth.

Rheumatoid Arthritis differs from the common form of arthritis, osteoarthritis. Osteoarthritis is often referred to as degenerative joint disease and is associated with aging and joint injury. Rheumatoid Arthritis is inflammation that affects the synovium or lining of the joints. Unlike osteoarthritis, it is usually symmetrical, for example, if one hip is affected, the other hip is too. It is thought that the disease can be inherited through genes, but there are probably other factors involved. It is thought viruses or bacteria can trigger the gene. Some scientists theorize changes in certain hormones can promote RA in those with certain genes that have had exposure to the agent that can trigger the disease.

Rheumatoid Arthritis Tests

To diagnose RA, a clinical evaluation must be conducted through a physical exam and a discussion of symptoms. Also, laboratory and non-laboratory tests are often performed to help diagnose the disease. These tests help distinguish it among the other forms of arthritis and other conditions that can cause similar symptoms. Testing can also evaluate the severity of RA, monitor the condition, determine the response to treatment, and monitor for any side effects treatments can cause.

RA Laboratory tests

Rheumatoid factor (RF) is used to help diagnose Rheumatoid Arthritis. In most people with RA, RF is present in significant concentrations. However, RF can also be present in those with other diseases and even in those who are healthy. When RF is positive in a person with RA symptoms, the test can be used to confirm the diagnosis of RA.

Cyclic citrullinated peptide (CCP) antibody can also be used to diagnose or confirm a diagnosis of RA. CCP is useful during the early stages of the disease, possibly even before the patient is symptomatic.  It can also be used in those who are RF-negative.

Antinuclear antibody (ANA) is used as a screen for specific autoimmune disorders, which may include RA. However, this test is most commonly used to diagnose systemic lupus erythematosus (SLE).

Erythrocyte sedimentation rate (ESR) determines activity related to the disease and if there is the presence of inflammation in the body. It can be used to help with the diagnosis of RA and to monitor and evaluate the condition. For those with RA, but not osteoarthritis, ESR will be increased.

C-reactive protein (CRP) is also used to determine the presence of inflammation and RA’s activity. It can be used to diagnose, monitor, and evaluate Rheumatoid Arthritis. CRP levels are elevated in those with Rheumatoid Arthritis, but not in osteoarthritis.

Complete blood count (CBC) is a group of tests that evaluates hemoglobin and red and white blood cells. It can monitor a decrease in white blood cells and anemia.

Comprehensive metabolic panel (CMP) is a group of tests that can be used to monitor and evaluate liver and kidney function.