Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune arthritis in which the immune system attacks the lining of the joints, causing inflammation, pain, swelling, and stiffness. It often starts in the small joints of the hands and feet and can lead to progressive joint damage without early detection and monitoring. Because other conditions can look similar, rheumatoid arthritis blood tests are key to supporting diagnosis, understanding disease activity, and tracking flares over time.

Ulta Lab Tests offers RA-focused panels and individual markers—including rheumatoid factor (RF), anti-CCP antibodies, CRP, ESR, CBC, and CMP—with fast, secure results you can share with your clinician for screening, diagnosis, and monitoring.


Signs & Symptoms (When to consider testing)

  • Symmetrical joint pain and swelling: hands, wrists, feet, ankles; often on both sides of the body

  • Morning stiffness: typically >30–60 minutes, improves with gentle movement

  • Warmth and tenderness around joints; decreased grip strength

  • Fatigue and malaise; low-grade fevers during flares

  • Functional limits: difficulty with fine motor tasks (buttoning, opening jars)

  • Extra-articular features: rheumatoid nodules; dry eyes/mouth (sicca); lung involvement; anemia

  • Family history of autoimmune disease

Related search terms: rheumatoid arthritis blood test, anti-CCP test, RF test, autoimmune arthritis labs, inflammatory arthritis testing.


Why These Tests Matter

What RA labs can do

  • Detect autoantibodies linked to RA (RFanti-CCP)

  • Measure inflammation (CRP, ESR) to gauge flares and activity

  • Provide objective data to support diagnosis and monitor trends over time

  • Help differentiate RA from osteoarthritis and other arthritides

What they cannot do

  • Confirm RA on their own—diagnosis requires symptoms, exam, and often imaging (X-ray/ultrasound/MRI)

  • Show the degree of joint damage (imaging needed)

  • Replace specialist evaluation for complex cases


What These Tests Measure (at a glance)

  • Anti-CCP (anti–cyclic citrullinated peptide): highly specific RA autoantibody; useful early in disease

  • Rheumatoid factor (RF): RA-associated antibody; not exclusive to RA

  • CRP & ESRinflammation markers that rise during active disease/flares

  • CBC: anemia of chronic disease, platelet changes with inflammation

  • CMP: organ function context that can influence clinical decisions

  • ANA: may be positive in some autoimmune conditions; not specific for RA


How the Testing Process Works

  1. Order online: choose a rheumatoid arthritis panel or specific markers.

  2. Visit a local lab: quick blood draw at a nearby patient service center.

  3. Get results fast: most post within 24–48 hours to your secure account.

  4. Review with your clinician: interpret alongside symptoms and imaging.


Interpreting Results (general guidance)

  • Anti-CCP positive → strongly supports RA, especially with compatible symptoms

  • RF positive → supports RA but can occur in other conditions or even healthy adults

  • Elevated CRP/ESR → indicates active inflammation; useful for monitoring

  • Seronegative RA → some people have RA with negative RF and anti-CCP; imaging and exam remain crucial

Always interpret labs with a qualified healthcare professional.


Choosing Panels vs. Individual Tests

  • Initial evaluation: start with a comprehensive RA/inflammatory panel (RF, anti-CCP, CRP, ESR, CBC, ± ANA).

  • Targeted follow-up: add or repeat anti-CCP and inflammation markers to clarify diagnosis or track activity.

  • Monitoring: recheck CRP/ESR (and other markers) during flares or at clinician-directed intervals.


FAQs

What is the most specific blood test for RA?
Anti-CCP is highly specific for rheumatoid arthritis and often helps detect disease early.

Do all people with RA have positive RF or anti-CCP?
No. Some have seronegative RA; diagnosis relies on the whole picture—symptoms, exam, imaging, and labs.

How do RA labs differ from osteoarthritis?
RA often shows elevated CRP/ESR and positive RF/anti-CCP; osteoarthritis is typically seronegative with normal inflammation markers.

Should I stop medicines before testing?
Do not change medications unless your clinician advises it. Some drugs can affect lab values.

How quickly will I get results?
Most RA-related tests are available within 24–48 hours after your blood draw.

How often should I retest?
Timing depends on symptoms and care plan; many patients monitor CRP/ESR during flares or periodically as advised by their clinician.


Internal Links & Cross-References

  • Arthritis Testing Hub

  • All Arthritis Tests

  • Osteoarthritis

  • Ankylosing Spondylitis

  • Juvenile Rheumatoid Arthritis

  • Psoriatic Arthritis

  • Key Blood Tests: RF • anti-CCP • CRP • ESR • CBC • CMP • ANA


Available Tests & Panels

Tip: Begin with a comprehensive RA panel (RF + anti-CCP + CRP/ESR + CBC). Add ANA if your clinician is considering other autoimmune conditions.

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The Creatine Kinase (CK) Total Test measures CK enzyme levels in blood to detect muscle injury, inflammation, or stress. Elevated CK may indicate muscle disorders, heart attack, strenuous exercise, or conditions such as rhabdomyolysis, while low levels are less common. Doctors use this test to evaluate unexplained muscle pain, weakness, or chest pain and to monitor recovery. It provides insight into muscle, cardiac, and overall metabolic health.

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Also Known As: CK Total Test, Creatine Phosphokinase, CPK Test

Most Popular

The DHEA Sulfate (DHEA-S) Test measures levels of DHEA-S, a hormone made by the adrenal glands, to evaluate adrenal function and hormone balance. It helps detect adrenal tumors, hyperplasia, or insufficiency and assess abnormal hair growth, infertility, or early/late puberty. Doctors also use it to investigate irregular menstrual cycles, monitor androgen disorders, and evaluate symptoms of hormone imbalance affecting reproductive and metabolic health.

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Blood Draw
Also Known As: DHEA Sulfate Test, Dehydroepiandrosterone Sulfate Test

Most Popular

The Ferritin Test measures ferritin, a protein that stores iron in the body, to evaluate iron levels and detect deficiency or overload. It helps diagnose anemia, iron deficiency, hemochromatosis, and chronic disease-related inflammation. Doctors often order the ferritin test to investigate fatigue, weakness, or unexplained symptoms. It is also used to monitor iron supplementation, treatment effectiveness, and overall iron metabolism health.

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Also Known As: Iron Storage Test

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The Hemoglobin A1c (HbA1c) Test measures average blood glucose over 2–3 months by detecting sugar attached to hemoglobin in red blood cells. It is used to diagnose diabetes, identify prediabetes, and monitor long-term blood sugar control. Doctors rely on the HbA1c test to evaluate treatment effectiveness, guide adjustments, and assess risk for complications, making it essential for diabetes care and metabolic health screening.

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Also Known As: Hemoglobin A1c Test, HbA1c Test, Glycated Hemoglobin Test

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The Immunoglobulin A (IgA) Test measures IgA antibody levels in blood to evaluate immune system health and mucosal defense in the respiratory and digestive tracts. Low IgA may indicate immune deficiency, celiac disease, or recurrent infections, while high levels may suggest autoimmune disorders, liver disease, or chronic inflammation. Doctors use this test to assess unexplained illness or immune imbalance. Results provide key insight into antibody function and overall immunity.

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Also Known As: Immunoglobulin A Test, Immunoglobulin A Antibody Test, IgA Antibody Test

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The Insulin Test measures insulin levels in blood to assess how the body regulates glucose and metabolism. It helps diagnose insulin resistance, hypoglycemia, type 2 diabetes, and metabolic syndrome. Doctors also use it to evaluate pancreatic function and monitor treatment effectiveness. Frequently ordered with glucose testing, the insulin test provides critical insight into endocrine health, blood sugar control, and risk for diabetes-related complications.

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Blood Draw
Also Known As: Fasting Insulin Blood Test

The Lipid Panel with Ratios Test measures seven key markers: total cholesterol, HDL, LDL, non-HDL cholesterol, triglycerides, Chol/HDL ratio, and LDL/HDL ratio. This advanced panel evaluates cardiovascular risk by assessing cholesterol balance and fat metabolism. Doctors use it to detect high cholesterol, atherosclerosis risk, and heart disease, and to monitor treatment. Often part of routine exams, it provides insight into long-term heart and metabolic health.

Also Known As: Lipid Profile Test, Cholesterol Panel Test, Lipid Blood Test

The Lyme Disease IgG IgM Antibodies Immunoblot Test detects antibodies to Borrelia burgdorferi, the bacteria causing Lyme disease. IgM indicates recent infection, while IgG suggests past or ongoing infection. Doctors order this test to confirm exposure after ELISA screening or when symptoms such as rash, fatigue, joint pain, or neurological issues appear. Results provide critical insight for diagnosing and managing Lyme disease with greater accuracy.

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Also Known As: Borrelia burgdorferi Test, Lyme Disease Antibodies Test

The Protein Total and Albumin Test measures overall protein levels and albumin, the main blood protein made by the liver. Abnormal levels may indicate liver disease, kidney disorders, malnutrition, or chronic inflammation. Doctors order this test for patients with swelling, fatigue, or abnormal lab results. Results provide critical insight into nutritional status, liver and kidney function, and help guide diagnosis and treatment of metabolic or chronic conditions.

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The RNP Antibody Test detects antibodies to ribonucleoprotein, an autoantigen linked to connective tissue and autoimmune diseases. Elevated levels may indicate mixed connective tissue disease, systemic lupus erythematosus, or other autoimmune disorders. This test provides valuable insight into immune system activity and is often performed alongside ANA and ENA panels for a broader evaluation of autoimmune health.

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The Salicylate Test measures salicylate levels in the blood to evaluate therapeutic use or potential toxicity from aspirin and related medications. Elevated concentrations may indicate overdose, metabolic disturbance, or risk of salicylate poisoning. This test supports monitoring in patients treated for pain, inflammation, or cardiovascular conditions and helps guide clinical management of suspected overdose cases.

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The Testosterone Free and Total Test measures total testosterone and free, bioavailable testosterone in blood for both men and women. It helps diagnose hormone imbalance, infertility, low libido, erectile dysfunction in men, irregular periods, or PCOS in women. Doctors also order it to assess fatigue, mood changes, or muscle weakness and to monitor hormone therapy. This test provides key insight into reproductive, endocrine, and overall metabolic health.

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Also Known As: Bound and Unbound Testosterone, Uncapped Testosterone Test

The Thiopurine Metabolites Test evaluates active metabolites of thiopurine drugs, including 6-thioguanine nucleotides and 6-methylmercaptopurine, to assess treatment effectiveness and safety. Elevated or low metabolite levels may indicate risk of toxicity, under-dosing, or non-adherence. This test provides critical insight for managing patients on immunosuppressive therapy, guiding personalized dosing, and monitoring long-term response.

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Also Known As: 6 MMP Test, 6 Tg Test

The Total Glutathione Test measures glutathione, a key antioxidant that protects cells from oxidative stress and supports liver detoxification, immune defense, and cellular repair. Low levels may indicate chronic illness, toxin exposure, poor nutrition, or high oxidative stress, while high levels may reflect supplementation. Doctors use this test to assess antioxidant capacity, monitor therapy, and guide treatment for overall metabolic and immune health.

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The Thyroid Stimulating Hormone (TSH) Test measures TSH levels in blood to assess thyroid function and diagnose hypothyroidism or hyperthyroidism. It evaluates how the thyroid controls metabolism, energy, weight, and heart rate. Doctors use the TSH test to investigate symptoms such as fatigue, hair loss, or mood changes. Frequently included in routine health exams, it is also key for monitoring thyroid disease treatment and overall endocrine balance.

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Blood Draw
Also Known As: Thyroid Stimulating Hormone Test, Thyrotropin Test

The Vitamin B12 Micronutrient Test measures blood levels of vitamin B12, essential for red blood cell production, nerve health, and DNA synthesis. Deficiency can cause anemia, fatigue, neurological issues, and cognitive changes. This test helps identify dietary deficiencies, absorption problems, or related health conditions, supporting diagnosis and ongoing management of overall wellness.

Patient must be 18 years of age or older.
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Blood Draw
Also Known As: B12 Test, Cobalamin Test

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The Vitamin B12 Test measures cobalamin levels in blood to evaluate nutritional health, red blood cell production, and nervous system function. Low B12 can cause anemia, fatigue, weakness, memory problems, and nerve damage, while high levels may indicate liver or kidney disease. Doctors use this test to detect B12 deficiency, monitor treatment, and assess malabsorption conditions like pernicious anemia, Crohn’s disease, or celiac disease.

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Blood Draw
Also Known As: B12 Test, Cobalamin Test

The Vitamin D 25-Hydroxy Total Test measures levels of 25-hydroxyvitamin D in blood to evaluate vitamin D status, bone health, and calcium balance. It helps detect deficiency, insufficiency, or toxicity, which can affect immune function, muscle strength, and risk of osteoporosis. Doctors use this test to assess overall nutritional health, monitor supplementation, and support diagnosis of metabolic or endocrine disorders linked to vitamin D.

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Also Known As: 25-hydroxyvitamin D Test, Vitamin D 25-OH Test, Total 25-OH D Test

 The Rheumatoid Arthritis Test is a specialized diagnostic panel designed to detect specific markers commonly associated with Rheumatoid Arthritis (RA), an autoimmune disorder that primarily affects the joints.
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Blood Draw, Phlebotomist

Also Known As: : anti-MCV,RA,Rheumatoid arthritis

The Methylation Essentials Panel provides a comprehensive baseline evaluation of core laboratory markers involved in the body’s methylation process. Methylation is a fundamental biochemical pathway that supports nutrient metabolism, cardiovascular wellness, energy production, and cellular maintenance.

Blood, Serum
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Panel Contains Test: Basic Methylation Test, Folate and Vitamin B12 Methylation Panel, Homocysteine and Nutrient Metabolism Test, Entry-Level Epigenetic Health Panel, One-Carbon Metabolism Panel (Basic), Folate & Homocysteine Assessment, 

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Blood Draw, Phlebotomist

There are approximately 1.3 million sufferers of rheumatoid arthritis across the United States. Interestingly, the condition is 2.5 times more likely to impact women than men. 

While you might imagine the term arthritis with someone who is aging, it's also interesting to note that it's most common to get a rheumatoid arthritis diagnosis between the ages of 20 and 50. 

So, how do people with rheumatoid arthritis know they have it? What are the signs they experience that tell them they should be tested? Is a rheumatoid arthritis blood test the best way to find out if you suffer from this?

Read on to learn everything you need to know about people with RA and getting tested if you think you might have it.

What Is Rheumatoid Arthritis?

You might associate the term arthritis with aches, pains, and maybe some swelling. There are a few ways this type of arthritis is unique from other forms. 

Rheumatoid arthritis causes swelling in the joints, which isn't uncommon with arthritis. However, with rheumatoid arthritis, the swelling is symmetrical. You won't feel it just in your left hand. Instead, it's highly likely that you will get swelling in both hands.

The other way that rheumatoid arthritis is different is that it's classified as an autoimmune disease. While regular arthritis may cause wear and tear in the joints, RA develops and impacts those afflicted through the immune system. 

Understanding the Impact of Rheumatoid Arthritis

Rheumatoid arthritis impacts the joints in the body by causing swelling inside the lining of the joints. The swelling, if not treated, can cause bone erosion and joint deformity.

Another difference between wear and tear arthritis and rheumatoid arthritis is that RA can have an impact beyond the joints.  RA can impact other body systems including the skin, eyes, lungs, heart, and blood vessels, in severe cases. 

An RA sufferer who is early in the disease will often feel the impact in their smaller joints first. This might include their fingers, wrists, and hands. As the disease progresses or gets more severe, it will spread to larger joints and other parts of the body. 

Risks Factors Associated With Rheumatoid Arthritis

So, what can trigger the disease for you? There are some associated risk factors that come with rheumatoid arthritis.  

Females are more likely to get the disease than males. If someone in your family has rheumatoid arthritis, you have a higher likelihood of also having the disease. 

Smoking is another risk factor for the disease. It seems that if you're a smoker and have a family history, your chances are increased that you'll get RA. Smokers with RA also seem to have symptoms that are more severe. 

Causes of Rheumatoid Arthritis

In a healthy body, the immune system helps to fight off disease and infection. Remember that rheumatoid arthritis is an autoimmune disease. What happens with rheumatoid arthritis is that the immune system actually attacks the healthy tissues inside your joints. 

Scientists are unclear what causes your immune system to start this attack. There are some factors that seem to contribute to the likelihood of getting RA. There doesn't seem to be a direct genetic connection. Although if a person is exposed to certain environmental factors like an infection from certain bacteria or a virus, it can trigger the disease. 

There does seem to be a correlation between stress and the onset of RA too. 

Signs and Symptoms of Rheumatoid Arthritis

For those suffering from rheumatoid arthritis, you might find that you can get yourself into remission. In this case, your symptoms decrease, and you don't feel the impact of the disease. It doesn't mean it has gone away; it is just more dormant. Often those suffering from rheumatoid arthritis have no symptoms when in remission.

If you're having a flare-up, your symptoms come back and are exacerbated. Symptoms might include:

  • Joint pain
  • Joint swelling
  • Joint stiffness
  • Loss of joint function and deformities

Symptoms for those not in remission can also come and go. The severity of the symptoms can also vary. It's important not to ignore the symptoms when they flare-up, even if they seem mild. You want to keep them under control, so they don't get worse.

Testing for Rheumatoid Arthritis

Getting an RA diagnosis can take some time. It's likely your doctor will do a physical exam and look closely at your joints. If your doctor suspects you might be suffering from RA, you should have blood tests done. It's pretty common to continue to monitor with regular blood tests once you have an RA diagnosis.

Blood tests will look for the rheumatoid factor or RF antibody. The RF antibodies will line the tissue of your joints and are present for many people who suffer from RA. RF is not exclusive to rheumatoid arthritis but is often present. 

Some of the RF blood tests include:

Blood tests will also look for:

Testing for RA panels include:

Once there is an RF antibody located, doctors will also look for these other indicators. The RF antibody is called immunoglobulin IgM.

Answering Your Questions About Rheumatoid Arthritis and Getting Tested for It 

Let's answer some common questions related to rheumatoid arthritis. 

What early signs should you watch for in rheumatoid arthritis? Early signs of RA usually include swelling in the joints that causes pain and swelling. 

When will sufferers feel the most impact of the disease? It's likely that RA will impact sufferers more in the morning than at other times in the day.

What does a rheumatologist do? A rheumatologist studies rheumatology which includes:

  • Joints
  • Muscles
  • Bones
  • Autoimmune diseases
  • Soft tissue diseases

It's likely your family doctor will refer you to a rheumatologist for further treatment and diagnosis if you believe you're suffering from RA.

Benefits of Rheumatoid Arthritis Blood Test With Ulta Lab Tests 

Ulta Lab Tests offers our tests to be highly accurate and reliable so you can make informed decisions about your health.
• Secure and confidential results
• No insurance referral is needed
• Affordable pricing 
• 100% satisfaction guarantee

Order your rheumatoid arthritis lab test today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take Control of Your Symptoms and Get Tested Today for Rheumatoid Arthritis

Rheumatoid arthritis blood tests can help you get the answers you need. The sooner you can understand if you have RA, the sooner you can work to get control of it too. 

Take charge of your health and track your progress with Ulta Lab Tests.