The Cyclic Citrullinated Peptide (CCP) Antibody (IgG) test contains 1 test with 1 biomarker.
Brief Description: The Cyclic Citrullinated Peptide Antibody (CCP) test is a laboratory test used to detect the presence of CCP antibodies in the blood. CCP antibodies are autoantibodies that target proteins in the body that have undergone citrullination, a post-translational modification of amino acids. The CCP test is primarily used in the diagnosis of rheumatoid arthritis (RA), an autoimmune disease that causes chronic inflammation in the joints.
Also Known As: ACPA, Anti-CCP, Anti-citrulline Antibody, Anti-cyclic Citrullinated Peptide, Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG, CCP, CCP Antibody, Citrullinated Peptide (CCP) IgG, Cyclic Citrullinated Peptide Antibody, Cyclic Citrullinated Peptide CCP Antibody IgG.
Collection Method: Blood Draw
Specimen Type: Serum
Test Preparation: No preparation required
When is a Cyclic Citrullinated Peptide IgG Antibody test ordered?
A Cyclic Citrullinated Peptide Antibody test may be ordered in the following situations:
Diagnosis of Rheumatoid Arthritis: The test is commonly ordered when a person presents with symptoms consistent with rheumatoid arthritis, such as joint pain, swelling, stiffness, and fatigue. It helps to support the diagnosis of RA, especially when combined with other clinical and laboratory findings.
Early Detection of Rheumatoid Arthritis: The CCP test is particularly useful in the early stages of rheumatoid arthritis, as CCP antibodies are often present before the onset of symptoms. Early detection allows for prompt treatment and management of the disease.
What does a Cyclic Citrullinated Peptide IgG Antibody blood test check for?
Cyclic citrullinated peptide antibodies are autoantibodies directed against cyclic citrullinated peptides produced by the immune system. Anti-CCP antibodies are detected and measured in the blood with this test.
Citrulline is created in the body as a byproduct of the amino acid arginine metabolism. This conversion may occur at a faster rate in joints with rheumatoid arthritis. Citrulline alters the structure of proteins, triggering an immunological response that results in the production of autoantibodies against joint proteins. The CCP antibody test aids in the diagnosis of RA and can help identify persons with the disease's more quickly erosive type.
RA is a chronic, systemic autoimmune disease that affects the hands, foot, and other joints throughout the body, causing inflammation, discomfort, stiffness, and degenerative changes. It can strike anyone at any age, but it commonly strikes between the ages of 40 and 60, with women accounting for roughly 75 percent of those affected. The prognosis and course of RA are both unpredictable. It could take a long time to develop and progress, or it could happen quickly. In some people, it may go into remission, and in others, it may completely disappear. If left untreated, RA can impair a person's life expectancy and render many people unable to work within a few years.
There are a number of treatments available to help reduce the difficulties of RA, but they all hinge on getting a proper diagnosis and starting treatment before severe joint damage occurs. The basic blood test for detecting RA and distinguishing it from other types of arthritis and other inflammatory processes has been rheumatoid factor. However, RF's sensitivity and specificity aren't optimal; it can be negative in persons with RA symptoms but positive in those who don't. According to studies, the CCP antibody test has a sensitivity and specificity that is comparable to or better than RF, and it is more likely to be positive in patients with early RA.
CCP antibody testing, along with RF, is included in the American College of Rheumatology's (ACR) 2010 Rheumatoid Arthritis Classification Criteria for diagnosing rheumatoid arthritis. CCP antibodies can be found in roughly 50-60% of persons with early RA, as early as 3-6 months following the onset of symptoms, according to the ACR. Early detection and diagnosis of RA allows healthcare practitioners to start aggressive treatment early on, reducing complications and tissue damage.
Lab tests often ordered with a Cyclic Citrullinated Peptide IgG Antibody test:
When an anti-CCP test is ordered, it's often part of a broader evaluation of joint pain and autoimmune conditions. Here are some tests commonly ordered alongside it:
Rheumatoid Factor (RF):
- Purpose: To detect RF, an antibody present in many people with RA.
- Why Is It Ordered: RF is another common marker for RA, but it is less specific than anti-CCP. Both tests together increase the diagnostic accuracy for RA.
Complete Blood Count (CBC):
- Purpose: Provides a broad picture of overall blood health.
- Why Is It Ordered: To identify signs of anemia or infection, which can be associated with RA and other autoimmune diseases.
Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP):
- Purpose: Both are markers of inflammation.
- Why Is It Ordered: To assess the level of inflammation in the body, which can help in diagnosing RA and monitoring its activity or response to treatment.
ANA (Antinuclear Antibody) Test:
- Purpose: To screen for various autoimmune diseases.
- Why Is It Ordered: While not specific for RA, a positive ANA test can indicate the presence of an autoimmune disorder and may necessitate further investigation.
Kidney and Liver Function Tests:
- Purpose: To assess the health of the kidneys and liver.
- Why Is It Ordered: RA and medications used to treat it can affect liver and kidney function, making these tests important for monitoring overall health and treatment safety.
- Purpose: To measure the level of uric acid in the blood.
- Why Is It Ordered: To differentiate RA from gout, another form of arthritis caused by elevated levels of uric acid.
- Purpose: A genetic marker associated with certain types of autoimmune diseases, including ankylosing spondylitis.
- Why Is It Ordered: To help diagnose other types of arthritis or autoimmune conditions, especially if the clinical picture is unclear.
These tests, when ordered alongside a Cyclic Citrullinated Peptide IgG Antibody test, provide a comprehensive view of the patient’s joint health and can assist in diagnosing RA and other autoimmune or inflammatory conditions. The specific combination of tests will depend on the individual’s symptoms, clinical history, and initial test results.
Conditions where a Cyclic Citrullinated Peptide IgG Antibody test is recommended:
The Cyclic Citrullinated Peptide Antibody test is primarily used in the diagnosis of rheumatoid arthritis (RA). RA is a chronic autoimmune disease characterized by joint inflammation, pain, and deformity. Testing for CCP antibodies helps differentiate RA from other types of arthritis and assists in early diagnosis and treatment initiation.
How does my health care provider use a Cyclic Citrullinated Peptide IgG Antibody test?
Health care providers use the results of a Cyclic Citrullinated Peptide Antibody test in the following ways:
Diagnosis of Rheumatoid Arthritis: A positive test result, indicating the presence of CCP antibodies, supports the diagnosis of rheumatoid arthritis, especially when correlated with clinical signs and symptoms.
Prognosis and Disease Monitoring: CCP antibody levels can help predict the severity and progression of rheumatoid arthritis. Higher antibody levels are associated with more aggressive disease and increased risk of joint damage. Monitoring CCP antibody levels over time can aid in assessing the response to treatment and disease activity.
Treatment Planning: The presence of CCP antibodies may influence treatment decisions in rheumatoid arthritis. Individuals with positive CCP antibodies are more likely to benefit from early and aggressive treatment to reduce inflammation, manage symptoms, and slow disease progression.
It's important to note that the CCP test should be interpreted in conjunction with the individual's clinical history, physical examination, and other diagnostic tests. The results should be evaluated by a qualified health care provider experienced in the diagnosis and management of rheumatoid arthritis.
What do my CCP Antibody test results mean?
When persons with arthritis symptoms test positive for both CCP antibody and RF, they almost certainly have RA and are at risk of developing a more rapidly progressing and severe version of the illness. When patients show clinical indications of RA and are positive for CCP antibody but not RF, or have low levels of both, it is likely that they have early RA or will develop RA in the future.
When people have a positive RF but no CCP antibody, clinical signs and symptoms are more important in evaluating whether they have RA or another inflammatory illness. It is less likely that someone gets RA if they are negative for both CCP antibody and RF. However, it should be noted that RA is a clinical diagnosis that can be made even if autoantibody testing are negative.
Most Common Questions About the Cyclic Citrullinated Peptide Antibody test:
Understanding the Cyclic Citrullinated Peptide (CCP) Antibody Test
What is the Cyclic Citrullinated Peptide (CCP) Antibody test?
The Cyclic Citrullinated Peptide (CCP) Antibody test is a blood test that detects the presence of anti-CCP antibodies in the bloodstream. These antibodies are often present in people with rheumatoid arthritis (RA), making this test a valuable tool for diagnosing the disease.
Why would a Cyclic Citrullinated Peptide (CCP) Antibody test be performed?
This test is typically performed when RA is suspected. Symptoms might include joint pain, stiffness, swelling, or other signs of inflammation. The test can help confirm a diagnosis of RA and may also be useful in predicting the likelihood of developing RA in the future.
Interpreting Cyclic Citrullinated Peptide (CCP) Antibody Test Results
What does a positive Cyclic Citrullinated Peptide (CCP) Antibody test mean?
A positive CCP antibody test result generally indicates the presence of rheumatoid arthritis. However, it's worth noting that not all people with rheumatoid arthritis will test positive for anti-CCP antibodies, and not all people who test positive for these antibodies will have rheumatoid arthritis.
What does a negative Cyclic Citrullinated Peptide (CCP) Antibody test mean?
A negative test result means that CCP antibodies were not detected in the blood. However, this does not definitively rule out rheumatoid arthritis, as not all individuals with the disease will test positive for CCP antibodies.
CCP Antibody Test and Disease Management
How can the Cyclic Citrullinated Peptide (CCP) Antibody test be used in managing my rheumatoid arthritis?
The presence of anti-CCP antibodies can indicate a more aggressive form of rheumatoid arthritis. This can guide the selection of treatment strategies, with more aggressive treatments possibly being considered for those testing positive.
Can the Cyclic Citrullinated Peptide (CCP) Antibody test predict disease progression in rheumatoid arthritis?
Yes, studies have shown that people with a positive anti-CCP test are more likely to have a more severe form of the disease, which may result in more significant joint damage over time. Therefore, it can be used as a prognostic tool.
CCP Antibody Test and Other Tests
How does the Cyclic Citrullinated Peptide (CCP) Antibody test compare to the rheumatoid factor (RF) test?
Both tests are used in diagnosing rheumatoid arthritis. However, the anti-CCP test is more specific and less likely to give a positive result in conditions other than RA compared to the RF test.
Can the Cyclic Citrullinated Peptide (CCP) Antibody test distinguish between different types of arthritis?
Yes, the anti-CCP test is particularly useful in distinguishing rheumatoid arthritis from other types of arthritis, as these antibodies are not typically present in other forms of the disease.
Does having a positive Cyclic Citrullinated Peptide (CCP) Antibody test mean I will definitely develop rheumatoid arthritis?
A positive test increases the risk of developing rheumatoid arthritis, but it's not a guarantee. Some people with positive anti-CCP never develop the disease. However, it's important to monitor for symptoms and have regular check-ups with your healthcare provider.
Can the Cyclic Citrullinated Peptide (CCP) Antibody test be used to monitor the effectiveness of rheumatoid arthritis treatment?
While the anti-CCP test is not typically used to monitor treatment response, it can be used alongside other tests and assessments (like symptom evaluations and imaging) to monitor disease progression and treatment effectiveness.
Does the Cyclic Citrullinated Peptide (CCP) Antibody test show if my rheumatoid arthritis is active or inactive?
The anti-CCP test does not directly indicate disease activity. Its primary use is in diagnosis and prognosis. Other assessments, like physical examinations and measures of inflammation, are used to evaluate disease activity.
Can other conditions cause a positive Cyclic Citrullinated Peptide (CCP) Antibody test result?
While the test is highly specific for rheumatoid arthritis, it can occasionally be positive in some other autoimmune conditions, but this is less common.
If I have a family history of rheumatoid arthritis, should I have the Cyclic Citrullinated Peptide (CCP) Antibody test?
If you have a family history of RA and are showing symptoms of the disease, your healthcare provider may recommend the test. However, routine screening in asymptomatic individuals, even with a family history, is not typically recommended.
Can the Cyclic Citrullinated Peptide (CCP) Antibody test help predict if I will develop other autoimmune diseases?
While a positive anti-CCP test is associated with rheumatoid arthritis, it's not generally used to predict the development of other autoimmune diseases.
Does the presence of Cyclic Citrullinated Peptide (CCP) antibodies increase my risk of heart disease?
Research has suggested a potential link between anti-CCP positivity and increased risk of cardiovascular disease in patients with rheumatoid arthritis. However, more research is needed to confirm this connection.
Will the Cyclic Citrullinated Peptide (CCP) Antibody test need to be repeated over time?
If your initial test is positive and confirms the diagnosis of RA, you may not need to repeat the test. However, if the initial test is negative, but symptoms persist, your healthcare provider may recommend repeating the test or conducting other diagnostic evaluations.
Can Cyclic Citrullinated Peptide (CCP) antibodies disappear over time?
In some patients, the level of these antibodies can decrease with effective treatment, but they typically remain detectable.
Can smoking affect the Cyclic Citrullinated Peptide (CCP) Antibody test result?
Smoking is a risk factor for the development of rheumatoid arthritis and may influence the production of anti-CCP antibodies. However, it won't directly alter the test result.
Can Cyclic Citrullinated Peptide (CCP) Antibody test results vary between labs?
Test results can vary slightly between labs due to differences in equipment, techniques, and chemicals used. However, the interpretation of the result should remain consistent.
How soon after symptom onset can the Cyclic Citrullinated Peptide (CCP) Antibody test detect antibodies?
Anti-CCP antibodies can be detected years before the onset of symptoms in some individuals. In others, these antibodies may not appear until after symptoms have begun.
Are there any medications that can affect the Cyclic Citrullinated Peptide (CCP) Antibody test result?
There are no known medications that affect the production or detection of anti-CCP antibodies.
Can I have a positive Cyclic Citrullinated Peptide (CCP) Antibody test but no symptoms?
Yes, it's possible to test positive for anti-CCP antibodies and not have any symptoms of rheumatoid arthritis. Some people with a positive test may develop symptoms later, while others may never develop the disease.
Can a positive Cyclic Citrullinated Peptide (CCP) Antibody test affect my life insurance policy?
Insurance policies vary greatly, and the impact of a positive test would depend on the specific policy. It's best to consult directly with your insurance provider for this information.
What does it mean if my Cyclic Citrullinated Peptide (CCP) Antibody levels are very high?
High levels of anti-CCP antibodies are associated with a more aggressive form of rheumatoid arthritis and can indicate a greater risk of joint damage.
How should I prepare for a Cyclic Citrullinated Peptide (CCP) Antibody test?
There's no specific preparation needed for the anti-CCP test. You can eat and drink normally before the test. However, make sure to inform your healthcare provider of any medications you're taking as certain drugs might interfere with test results.
We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.