Fibromyalgia

If you want to learn more about fibromyalgia tests, you're in the right place! Find out what you should know about the types of fibromyalgia symptoms, causes, treatments, tests, and more here.


Name Matches

Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. 

Reflex Information: If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge.


Measurement of serum 25-OH vitamin D concentrations provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Lower than normal 25-OH vitamin D levels can result from a dietary deficiency, poor abosrption of the vitamin or impaired metabolism of the sterol in the liver. A 25-OH vitamin D deficiency can lead to bone diseases such as rickets and osteomalacia. Above normal levels can lead hypercalcemia. This assay employs liquid chromatography tandem mass spectrometry to independently measure and report the two common forms of 25-hydroxy vitamin D: 25OH D3 - the endogenous form of the vitamin and 25OH D2 - the analog form used to treat 25OH Vitamin D3 deficiency.

 Specimens from children less than 4 years of age (i.e., less than 48 months) are not appropriate for this test. The test for children 4 years of age and younger is the Celiac Disease Comprehensive Panel, Infant (test code 15981).

Includes

Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

IMPORTANT - Note this is Reflex Test which if additional tests are run you will be charged for the specific tests that the lab peforms. Additional test will be run if the following criteria are met.


If the Tissue Transglutaminase IgA is positive,

1. Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255).

If the Endomysial Antibody Screen (IgA) is positive, 

2. Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

If the Total IgA is less than the lower limit of the reference range, based on age

3. Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.


A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia, and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)

NOTE: Only measurable biomarkers will be reported.

Reflex Parameters for Manual Slide Review
  Less than  Greater Than 
WBC  1.5 x 10^3  30.0 x 10^3 
Hemoglobin  7.0 g/dL  19.0 g/dL 
Hematocrit  None  75%
Platelet  100 x 10^3  800 x 10^3 
MCV  70 fL  115 fL 
MCH  22 pg  37 pg 
MCHC  29 g/dL  36.5 g/dL 
RBC  None  8.00 x 10^6 
RDW  None  21.5
Relative Neutrophil %  1% or ABNC <500  None 
Relative Lymphocyte %  1% 70%
Relative Monocyte %  None  25%
Eosinophil  None  35%
Basophil  None  3.50%
     
Platelet  <75 with no flags,
>100 and <130 with platelet clump flag present,
>1000 
Instrument Flags Variant lymphs, blasts,
immature neutrophils,  nRBC’s, abnormal platelets,
giant platelets, potential interference
     
The automated differential averages 6000+ cells. If none of the above parameters are met, the results are released without manual review.
CBC Reflex Pathway

Step 1 - The slide review is performed by qualified Laboratory staff and includes:

  • Confirmation of differential percentages
  • WBC and platelet estimates, when needed
  • Full review of RBC morphology
  • Comments for toxic changes, RBC inclusions, abnormal lymphs, and other
  • significant findings
  • If the differential percentages agree with the automated counts and no abnormal cells are seen, the automated differential is reported with appropriate comments

Step 2 - The slide review is performed by qualified Laboratory staff and includes: If any of the following are seen on the slide review, Laboratory staff will perform a manual differential:

  • Immature, abnormal, or toxic cells
  • nRBC’s
  • Disagreement with automated differential
  • Atypical/abnormal RBC morphology
  • Any RBC inclusions

Step 3 If any of the following are seen on the manual differential, a Pathologist will review the slide:

  • WBC<1,500 with abnormal cells noted
  • Blasts/immature cells, hairy cell lymphs, or megakaryocytes
  • New abnormal lymphocytes or monocytes
  • Variant or atypical lymphs >15%
  • Blood parasites
  • RBC morphology with 3+ spherocytes, RBC inclusions, suspect Hgb-C,
  • crystals, Pappenheimer bodies or bizarre morphology
  • nRBC’s

Comprehensive Metabolic Panel


Test for myocardial infarction and skeletal muscle damage. Elevated results may be due to: myocarditis, myocardial infarction (heart attack), muscular dystrophy, muscle trauma or excessive exercise

A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

Fibromyalgia Exclusion Panel - contains tests to identify conditions that have symptoms like fibromyalgia, which include Sjögren syndrome, rheumatoid arthritis, lupus, and thyroid disease


Measurement of serum 25-OH vitamin D concentrations provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Lower than normal 25-OH vitamin D levels can result from a dietary deficiency, poor absorption of the vitamin or impaired metabolism of the sterol in the liver. A 25-OH vitamin D deficiency can lead to bone diseases such as rickets and osteomalacia. Above normal levels can lead hypercalcemia. This assay employs liquid chromatography tandem mass spectrometry to independently measure and report the two common forms of 25-hydroxy vitamin D: 25OH D3 - the endogenous form of the vitamin and 25OH D2 - the analog form used to treat 25OH Vitamin D3 deficiency. While this assay will produce accurate Vitamin D results on patients of any age, it is specifically indicated for infants less than 3 years of age.


Most Popular
Elevated RF is found in collagen vascular diseases such as SLE, rheumatoid arthritis, scleroderma, Sjögren's Syndrome, and in other conditions such as leprosy, tuberculosis, syphilis, malignancy, thyroid disease and in a significant percentage of otherwise normal elderly patients.

Rheumatoid factor is commonly used as a blood test for the diagnosis of rheumatoid arthritis. However, rheumatoid factor can also be present in individuals with other conditions such as lupus, infectious hepatitis, syphilis, mononucleosis, tuberculosis, liver disease, and sarcoidosis. Rheumatoid factor is an antibody that is detectable in the blood of 80% of adults with rheumatoid arthritis. Rheumatoid can be detected in the blood of normal individuals and of those with other autoimmune diseases that are not rheumatoid arthritis. In people with rheumatoid arthritis, high levels of rheumatoid factor can indicate a tendency toward more aggressive disease and/or a tendency to develop rheumatoid nodules and rheumatoid lung disease. Rheumatoid factor is actually an antibody that can bind to other antibodies. Antibodies are normal proteins in our blood that are important parts of our immune system. Rheumatoid factor is an antibody that is not usually present in the normal individual. Rheumatoid factor is commonly used as a blood test for the diagnosis of rheumatoid arthritis. Rheumatoid factor is present in about 80% of adults (but a much lower proportion of children) with rheumatoid arthritis.

Rheumatoid factor is commonly used as a blood test for the diagnosis of rheumatoid arthritis. However, rheumatoid factor can also be present in individuals with other conditions such as lupus, infectious hepatitis, syphilis, mononucleosis, tuberculosis, liver disease, and sarcoidosis. Rheumatoid factor is an antibody that is detectable in the blood of 80% of adults with rheumatoid arthritis. Rheumatoid can be detected in the blood of normal individuals and of those with other autoimmune diseases that are not rheumatoid arthritis. In people with rheumatoid arthritis, high levels of rheumatoid factor can indicate a tendency toward more aggressive disease and/or a tendency to develop rheumatoid nodules and rheumatoid lung disease. Rheumatoid factor is actually an antibody that can bind to other antibodies. Antibodies are normal proteins in our blood that are important parts of our immune system. Rheumatoid factor is an antibody that is not usually present in the normal individual. Rheumatoid factor is commonly used as a blood test for the diagnosis of rheumatoid arthritis. Rheumatoid factor is present in about 80% of adults (but a much lower proportion of children) with rheumatoid arthritis.

Useful in differentiating inflammatory and neoplastic diseases and as an index of disease severity. CRP is also useful in monitoring inflammatory disease states.

Anti-skeletal muscle antibody titers of >1: 80 have been reported to be present in the serum of 30% of patients with Myasthenia Gravis, 95% of patients with Myasthenia Gravis and thymoma, and 25% of patients with thymoma.

Most Popular
The assay may be useful in the diagnosis of nonthyroidal illness (NTI). Patients with NTI have low T3 concentrations and increased concentrations of rT3. RT3 may be useful in neonates to distinguish euthyroid sick syndrome from central hypothyroidism.

Most Popular
Total T3 measurements are used to diagnose and monitor treatment of hyperthyroidism and are essential for recognizing T3 toxicosis

Most Popular
This test is used to diagnose hyperthyroidism and to clarify thyroid status in the presence of a possible protein binding abnormality.

Most Popular

For diagnosis of hypothyroidism and hyperthyroidism.

Note: Free T4 Index (T7) will only be calculated and reported if test code code 861 (T3 Uptake) is ordered as well.


Most Popular
The free T4 are tests thelps evaluate thyroid function. The free T4 test is used to help diagnose hyperthyroidism and hypothyroidism. Free T4 is the active form of thyroxine and is usually ordered along with or following a TSH test. This helps the doctor to determine whether the thyroid hormone feedback system is functioning as it should, and the results of the tests help to distinguish between different causes of hyperthyroidism and hypothyroidism.

Thyroid Peroxidase Antibodies (TPO) and Thyroglobulin Antibodies

Measurement of thyroglobulin antibodies and thyroid peroxidase antibodies (TPO) is useful in the diagnosis and management of a variety of thyroid disorders including autoimmune thyroiditis, Hashimoto's Disease, Graves Disease and certain types of goiter.

 "IMPORTANT - Please note that Quest returns values up to 900 for the Thyroid Peroxidase Antibodies test.  If tracking requires values above 900 for the Thyroid Peroxidase Antibodies, then order test TPO Antibody Endpoint (Test Code # 15116).


Most Popular

The Thyroid-stimulating Hormone (TSH) Blood Test is for differential diagnosis of primary, secondary, and tertiary hypothyroidism. The TSH test is also useful in screening for hyperthyroidism. This assay allows adjustment of exogenous thyroxine dosage in hypothyroid patients and in patients on suppressive thyroxine therapy for thyroid neoplasia.


TSI stands for thyroid stimulating immunoglobulin. TSI tells the thyroid gland to swell and release excess amounts of thyroid hormone into the blood.

Measurement of serum 25-OH vitamin D concentrations provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Lower than normal 25-OH vitamin D levels can result from a dietary deficiency, poor absorption of the vitamin or impaired metabolism of the sterol in the liver. A 25-OH vitamin D deficiency can lead to bone diseases such as rickets and osteomalacia. Above normal levels can lead hypercalcemia.


Measurement of serum 25-OH vitamin D concentrations provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Lower than normal 25-OH vitamin D levels can result from a dietary deficiency, poor absorption of the vitamin or impaired metabolism of the sterol in the liver. A 25-OH vitamin D deficiency can lead to bone diseases such as rickets and osteomalacia. Above normal levels can lead hypercalcemia. This assay employs liquid chromatography tandem mass spectrometry to independently measure and report the two common forms of 25-hydroxy vitamin D: 25OH D3 - the endogenous form of the vitamin and 25OH D2 - the analog form used to treat 25OH Vitamin D3 deficiency.


Fibromyalgia is a disease about which much is not yet known. Because of the nature of the symptoms, it is often misdiagnosed as other conditions. For this reason, fibromyalgia tests can be a good idea for those who suspect they may be suffering from this condition.

If you suspect that you may have this disorder, you will want to learn more about some of the fibromyalgia lab tests that are available to you. Read on to find out about the symptoms, causes, management, and diagnosis of this disease.

Fibromyalgia Lab Tests

For some time, there was no known way to test specifically for fibromyalgia. For this reason, diagnosis often consists of testing to rule out other diseases. Doctors most often identify a condition as fibromyalgia by process of elimination.

Some of the diseases that have similar symptoms to fibromyalgia include hypothyroidism, chronic fatigue syndrome, lupus, rheumatoid arthritis. Often, doctors will perform blood tests to rule out these conditions. This includes testing such as a complete blood count test, an antinuclear antibody test to rule out rheumatoid arthritis, and thyroid hormone tests to rule out hypothyroidism.

Recently, there has been promising evidence to suggest that something called an FM/a test may be effective in diagnosing fibromyalgia. This test focuses on the level of cytokines within a blood sample. Abnormal levels of cytokines have been linked to fibromyalgia.

However, more clinical trials are needed to confirm the efficacy of this method of testing. The process of elimination is still a widely used method of a fibromyalgia diagnosis. 

What Is Fibromyalgia?

Fibromyalgia is a disease that affects the central nervous system. It is characterized by widespread pain throughout the body. People with fibromyalgia may be more physically sensitive. This is due to abnormalities in how the nervous system processes pain.

Fibromyalgia typically manifests itself in adults between the ages of 30 and 50. It is estimated that around 4 million adults (or 2% of the population) in the US suffer from this condition.

Risk Factors for Fibromyalgia

Although much is still not known about this disease and its causes, there are some things that can put you at a higher risk. Women, for example, are around 7 times more likely to have fibromyalgia than men. It is more common in adults, although children and elderly people can also develop it.

Certain diseases, such as lupus and rheumatoid arthritis can put patients at a higher risk of developing fibromyalgia. It is now believed that in many cases, family history may also have a part to play.

Causes of Fibromyalgia

The exact causes of fibromyalgia are still unknown. However, there are certain situations or conditions that can be triggers for the development of fibromyalgia.

Going through a stressful or traumatic event can precipitate the development of fibromyalgia. This could be a death of a loved one, an abusive relationship, a car accident, or any other type of physically or mentally stressful situation. Post-traumatic stress disorder has been linked to the development of fibromyalgia.

There is also some evidence to suggest that there could be a hereditary element to the condition. Scientists believe people may be more likely to develop fibromyalgia because of genes inherited from their parents.

Signs and Symptoms of Fibromyalgia

Fibromyalgia symptoms are similar to those of many other conditions. This makes it oftentimes difficult to diagnose.

The most common and prominent symptom is pain throughout the entire body. Even the slightest touch can feel painful to someone with fibromyalgia.

Pain can feel like a dull ache or a sharp sensation. For those with fibromyalgia, pain tends to be widespread and long-lasting. Patients may also experience sensitivity to other things such as light, sound, and temperature.

Other symptoms include fatigue, difficulty sleeping, brain fog, and stiffness in the joints. Fibromyalgia sufferers can find themselves experiencing difficulty moving after holding the same position for too long. Brain fog can come in the form of difficulty learning new things, memory loss, and feelings of dizziness.

In some patients, fibromyalgia can cause other conditions such as IBS, anxiety, or depression to develop. In women, it can often cause painful periods.

Fibromyalgia and Fibromyalgia Tests: Frequently Asked Questions

Because we do not know enough about fibromyalgia, it is common for patients not to have heard of it or know how it is diagnosed. Below are some of the most frequently asked questions pertaining to fibromyalgia and fibromyalgia tests.

Is there a Cure for Fibromyalgia?

At the moment, there is no known cure for fibromyalgia. It is a chronic disease, meaning it tends to last a long time in most patients. However, lifestyle changes and medication can help with the symptoms.

How Is Fibromyalgia Treated?

There are many different courses of treatment for fibromyalgia. Often, painkillers are prescribed to help with the pain levels. Doctors often also recommend antidepressants to many patients.

Other treatments, such as cognitive-behavioral therapy and occupational therapy, can have a positive effect. Your doctor may also suggest lifestyle changes such as exercise programs, a special diet, or relaxation techniques.

How Can I Be Tested for Fibromyalgia?

Research is being carried out into FM/a testing for fibromyalgia. However, the most common method of diagnosis remains via the process of elimination.

Tests such as erythrocyte sedimentation ratecyclic citrullinated peptide test, and rheumatoid factor will be carried out to rule out various conditions. Doctors also look for the presence of pain in four of five key areas of the body that has lasted for more than three months.

Order Your Fibromyalgia Lab Tests Today

Take charge of your health and track your progress with Ulta Lab Tests. With Ulta Lab Tests, you can be confident in the accuracy and reliability of your test results. You will receive your results securely and confidentially online in 24 to 48 hours for most tests.

Affordable, accessible, and confidential testing is guaranteed. If you're looking for answers and peace of mind regarding your health, order your fibromyalgia tests today.