Metabolism

Order metabolism tests to evaluate the substances in the blood that provide essential information about your body's chemical balance and how the body uses food and energy. Order from Ulta Lab Tests today, with confidential results available in 24 to 48 hours online.


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5-Hydroxyindoleacetic Acid (5-HIAA), 24-Hour Urine, with Creatinine

Patient Preparation: Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant.

Collection Instructions : Collect 24-hour urine with 6N HCL to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Keep urine refrigerated during collection if preservative is not used. Shipping refrigerated acceptable, shipping frozen acceptable. Record 24-hour urine volume on test request form and urine vial. Record patient's age on test request form and urine vial.

Clinical Significance: 5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently.

Limitations: Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea.


Amino acid analysis is necessary for the diagnosis of a variety of inborn errors of metabolism. These include, but are not limited to, phenylketonuria, tyrosimemia, citrullinemia, non-ketotic hyperglycinemia, maple syrup urine disease, and homocystinuria. The assay is also key for the continued monitoring of treatment plans for these disorders and useful for assessing nutritional status of patients. Our methodology is highly accurate at very low levels as well as at elevated levels.

This is a fasting test:  Minimun 4 hours after your last meal, or overnite for most accurate reading.  Non fasting specimens are acceptable for Pediatrics

 


IMPORTANT - The specimen for this test must be collected at a patient service center that can collect, store and transport frozen samples as outlined below.  

IMPORTANT: Before ordering this lab test, check and confirm with the selected patient service center to ensure that they can collect, store and transport frozen samples as outlined below.

Preferred Specimen(s) 

2 mL frozen plasma collected in an EDTA (lavender-top) tube

Collection Instructions 

Collect blood from stasis-free vein of patient (e.g., no tourniquet). Patient should not clench fist during collection, as muscular exertion often increases venous ammonia levels. Patient should avoid smoking prior to phlebotomy since smoking increases plasma ammonia levels. Tubes should be filled completely and kept tightly stoppered at all times. Place immediately on ice. Separate plasma from cells within 20 minutes and freeze plasma immediately.

Transport Temperature 

Frozen

Specimen Stability 

Room temperature: Unstable
Refrigerated: Unstable
Frozen -20° C: 72 hours
Frozen -70° C: 7 days

Reject Criteria 

Hemolysis • Lipemia • Received thawed • PPT Potassium EDTA (white-top) tube

Clinical Significance

Ammonia is one of the by-products of protein metabolism. Elevated blood ammonia levels have been associated with severe liver dysfunction such as hepatic encephalopathy, coma resulting from cirrhosis, severe hepatitis, Reye's syndrome, and drug hepatotoxicity. Also, elevated blood ammonia has been reported in cardiac failure, azotemia, and pulmonary emphysema. Correlation between plasma ammonia and the degree of encephalopathy can be erratic.


Apolipoprotein A1 (APO A1) has been reported to be a better predictor than HDL cholesterol and triglycerides for Coronary Artery Disease (CAD). Low levels of APO A1 in serum are associated with increased risk of CAD. The measurement of APO A1 may be of value in identifying patients with atherosclerosis. Apolipoprotein B (APO B) has been reported to be a more powerful indicator of CAD than total cholesterol or LDL cholesterol in angiographic CAD and in survivors of myocardial infarction. In some patients with CAD, APO B is elevated even in the presence of normal LDL cholesterol.

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Collection Instructions

Allow sample to clot for 30 minutes, spin at 3,000 RPM for 10 minutes and transfer serum to plastic, amber vial. If amber vial is not available, wrap tube in aluminum foil to protect from light. Freeze within 30 minutes and send frozen.


C-Reactive Protein Cardiac (hs CRP) Useful in predicting risk for cardiovascular disease.


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Serum calcium is involved in the regulation of neuromuscular and enzyme activity, bone metabolism and blood coagulation. Calcium blood levels are controlled by a complex interaction of parathyroid hormone, vitamin D, calcitonin and adrenal cortical steroids. Calcium measurements are useful in the diagnosis of parathyroid disease, some bone disorders and chronic renal disease. A low level of calcium may result in tetany.

Carbamazepine and its metabolite (10, 11-carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders. The metabolism of carbamazepine in epileptic patients has several different pathways that can be altered when the patient is co-medicated with other anticonvulsants and, therefore, its therapeutic level should be monitored along with its metabolite in their free and protein bound states.

Carbamazepine and its metabolite (10, 11-carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders. The metabolism of carbamazepine in epileptic patients has several different pathways that can be altered when the patient is co-medicated with other anticonvulsants and, therefore, it's therapeutic level should be monitored along with its metabolite in their free and protein bound states.

Carbamazepine and its metabolite (10, 11-Carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders. The metabolism of carbamazepine in epileptic patients has several different pathways that can be altered when the patient is co-medicated with other anticonvulsants and, therefore, its therapeutic level should be monitored along with its metabolite in their free and protein bound states

There is a correlation between increased risk of premature heart disease with decreasing size of LDL particles. Ion mobility offers the only direct measurement of lipoprotein particle size and concentration for each lipoprotein from HDL3 to large VLDL.

Serum Triglyceride analysis has proven useful in the diagnosis and treatment of patients with diabetes mellitus, nephrosis, liver obstruction, other diseases involving lipid metabolism, and various endocrine disorders. In conjunction with high density lipoprotein and total serum cholesterol, a triglyceride determination provides valuable information for the assessment of coronary heart disease risk.

Measurement of serum 25-OH vitamin D concentrations provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Lower than normal 25-OH vitamin D levels can result from a dietary deficiency, poor abosrption of the vitamin or impaired metabolism of the sterol in the liver. A 25-OH vitamin D deficiency can lead to bone diseases such as rickets and osteomalacia. Above normal levels can lead hypercalcemia. This assay employs liquid chromatography tandem mass spectrometry to independently measure and report the two common forms of 25-hydroxy vitamin D: 25OH D3 - the endogenous form of the vitamin and 25OH D2 - the analog form used to treat 25OH Vitamin D3 deficiency.

Approximately 1 in every 2500 individuals has inherited a defective enzyme or a deficiency of the enzyme (Pseudocholinesterase) that metabolizes succinylcholine (an anesthetic agent). With a "normal" dosage, these individuals have prolonged apnea. Such individuals are responsive at much smaller concentrations of this anesthetic agent than the general population. Low concentrations of Pseudocholinesterase are observed in individuals exposed to organophosphorous insecticides and in patients with hepatic dysfunction.

A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)


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Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions and during the third trimester of pregnancy. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Urinary copper concentrations are also useful to monitor patients on chealation therapy

Clinical Significance

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.


Creatinine is the endproduct of creatine metabolism. Creatine is present primarily in muscle and the amount of creatinine produced is related to total skeletal muscle mass. Daily creatinine production is fairly constant except when there is massive injury to muscle. The kidneys excrete creatinine very efficiently and blood levels and daily urinary excretion of creatinine fluctuates very little in healthy normal people. Since blood and daily urine excretion of creatinine shows minimal fluctuation, creatinine excretion is useful in determining whether 24-hour urine specimens for other analytes (e.g., protein) have been completely and accurately collected.

Cyclosporine (Cyclosporin A) is an immunosuppressant therapeutic agent used in the prevention of organ graft rejection. Clinical measurement of blood levels is required due to the inter-individual variability of metabolism as well as the toxicity associated with excessive dosage.

Cyclosporine (Cyclosporin A) is an immunosuppressant therapeutic agent used in the prevention of organ graft rejection. Measurement of blood levels is recommended due to the inter-individual variability of metabolism as well as the toxicity associated with excessive dosage.

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Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women.


The Differences Between Fast Metabolism and Slow Metabolism Tests

If you've got a metabolism that you just can't figure out, we understand. Everyone's metabolism is different. Plus, your metabolism can change over time and often does. You've probably noticed that you gain weight easier now that you're older than you did when you were in your teens, and this is completely normal. In fact, this is typical for many people. However, if you're a younger person and gain weight easily, there's no need to fret, as that's also common.

You've probably heard that people with a fast metabolism can eat anything and get away with it -- but why is this? How does a person's metabolism work? What is metabolism testing? We know you probably have a lot of questions, so without any further ado let's dive in. 

Fast Metabolism Vs. Slow Metabolism

Metabolism is a term that's thrown around quite a bit, but for all intents and purposes, it describes the internal process of how your body uses energy and gets rid of calories. This includes blood circulating through the body, breathing, and your organs functioning. A person with a fast metabolism might have a body with more muscle mass that uses more energy to perform everyday tasks than someone with a slow metabolism, meaning they need to consume more calories to keep everything stable. Think of a fast metabolism as a gas-guzzling pickup truck and a slow metabolism as a fuel-efficient smart car -- the pickup truck needs more fuel to function!

Someone with a fast metabolism burns calories faster naturally, while someone with a slow metabolism burns them more slowly. However, most people have average metabolisms, meaning they align with the 2,000 calorie diet which is recommended for most people. 

What this means is two people with different metabolisms who eat the same amount of food will absorb calories differently. A young, busy athlete might need to eat twice as much as someone ten years older who lives a sedentary lifestyle to maintain the same amount of weight as them. However, age plays a key role in how your metabolism functions. Typically speaking, the older you get, the more your metabolism slows down. 

What Determines the Kind of Metabolism You Have? 

This news might be disappointing, but your metabolism is mostly influenced by genetics. Since you can't do much to change your DNA, there's no real way to alter how your metabolism functions. However, diet and exercise play huge roles in how your body absorbs nutrients and converts food into energy, so knowing what kind of metabolism you have can make it much easier to achieve your ideal weight or maintain a healthy lifestyle -- regardless of the metabolism you were born with. 

How Can You Find Out What Kind of Metabolism You Have?

If you find yourself full after smaller meals or don't seem to need to eat that much to live a normal life, then you might have a slow metabolism. The same is true if you don't feel like you eat that much but still struggle with weight gain or find it difficult to lose weight. However, it would be best to consider how much exercise you get and examine the amount of calories you're taking in on average. You might not need that much fuel because you don't use that much energy on a regular basis. However, if you're constantly hungry and can snack all day and never seem to gain any weight, then you probably have a faster metabolism. 

Metabolism tests are, without a doubt, the easiest way to know for sure what kind of metabolism you're working with. While it's fairly obvious for most people, sometimes other factors get in the way and make it difficult to know for sure. Factors that can affect how your metabolism functions include the kind of food you're eating, the amount of activity you perform every day, and any illnesses or medical conditions you might have. Metabolism tests can set your mind at ease and confirm whether you have a fast metabolism or a slow one. 

What Kinds of Metabolic Testing Is There? 

Lab Tests

While home tests might seem to be a convenient option when it comes to conducting any sort of test, this isn't really the case. They come with a list of problems. First and foremost, they are not entirely reliable. The samples are not collected by trained technicians in an appropriate environment. It's very easy for at-home tests to show incorrect results. Second, those tests are not generally accepted by doctors and hospitals. If you were to show those results to your doctor, they would most likely recommend that you repeat the testing with a blood draw at a national lab. Third, only a limited number of tests are available that restrict the insight into your health.

Our comprehensive metabolic testing solution does not suffer from any of these problems. All of our tests are considered highly accurate and reliable. They are also accepted by all doctors and health organizations, unlike at-home tests. Why? Because the samples are gathered and tested in the same way as doctors expect them to be. All samples are handled by certified professionals in a certified institution. All of those certifications help guarantee quality and accuracy.

Metabolic Discovery Panel - It contains 8 tests with 68 biomarkers. This comprehensive set of tests helps assess your metabolism. Are you storing too much fat and sugar or perhaps too little? Are you insulin resistant with subsequent inflammation? You can run this panel to discover whether your diet, fitness, and nutritional habits are providing you the metabolic health and longevity you deserve. Don't settle for one-size-fits-all health advice. Your diet, fitness lifestyle, and nutritional intake should improve your energy, weight, and inner metabolic health. But don't merely trust it's working. Run this Metabolic Discovery panel quarterly to take a snapshot of your insulin response, blood sugars, and lipids and adjust your lifestyle based upon your results.

  • CBC (includes Differential and Platelets)
  • Comprehensive Metabolic Panel (CMP) includes fasting Glucose
  • Ferritin
  • Hemoglobin A1c
  • Insulin
  • Lipid Panel with Ratios
  • Vitamin B12 (Cobalamin)
  • Vitamin D, 25-Hydroxy, Total, Immunoassay

The Metabolic Discovery Comprehensive Panel - It contains 15 tests with 78 biomarkers and all of the tests in the Metabolic Discovery Panel, plus:

  • Adiponectin
  • Iron and Total Iron Binding Capacity (TIBC)
  • Leptin
  • T3, Free
  • T4, Free
  • TSH

Metabolism Lab Panel - it contains 6 tests with 27 biomarkers.

  • Fasting Insulin
  • Glucose (In CMP)
  • Hemoglobin A1c
  • TSH
  • Free T3
  • Free T4
  • Comprehensive Metabolic Panel (CMP)

RMR Testing

There are various methods used to test what kind of metabolism a person has. These include determining a person's resting metabolic rate, or RMR. This refers to how many calories your body burns while at rest. Someone with a faster metabolism will burn more calories while doing nothing at all. 

VO2 Max Testing

Another kind of metabolic testing measures your maximum volume of oxygen, or VO2 Max, which refers to how your body utilizes oxygen while exercising. An athletic person will have a higher VO2 max and therefore have a higher capacity for high-intensity exercise, while someone who doesn't exercise all that much won't use oxygen as effectively. 

Lactate Threshold Testing

When your muscles become fatigued, this is due to a buildup of lactic acid, which your body makes when it can't use oxygen to produce energy. Usually, a buildup occurs during exercise. While your body naturally eliminates lactic acid, when exercising you will eventually reach a point where your body is making too much to be eliminated, causing you to become tired and your muscles to feel strained, stiff, and tired. Your lactate threshold refers to when your body is producing lactic acid in the blood faster than it can eliminate it. 

How Do I Test My Metabolism? 

Ulta Lab Tests offers highly accurate and reliable tests so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

Order your metabolism lab tests today, and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control of your health today with Ulta Lab Tests.