Pelvic Inflammatory Disease (PID)

Pelvic inflammatory disease (PID) is an infection-related inflammation of the upper genital tract (uterus, tubes, ovaries). It often follows chlamydia or gonorrhea, but trichomonasMycoplasma genitalium, and mixed vaginal/enteric bacteria can also play a role. PID can cause pelvic pain, fever, abnormal bleeding, and discharge—or be mild and easy to miss. Because symptoms overlap with appendicitisovarian cysts/torsionurinary infections, and ectopic pregnancylab testing is essential to clarify what’s going on and to protect fertility.

A proactive plan pairs site-specific STI testing with pregnancy testing, basic inflammation and safety labs, and—in select cases—additional pathogen testing. Labs support screeningdiagnostic triage, and monitoring, but they do notreplace a clinician’s exam, pelvic imaging when indicated, or urgent care for severe symptoms.

Signs, Symptoms & Related Situations

  • Pelvic & abdominal

    • Lower abdominal/pelvic pain, cervical motion or uterine/adnexal tenderness

    • Pain with sex, mid-cycle or post-coital bleeding, new or worsening cramping

  • Vaginal/urogenital

    • Abnormal discharge or odor, burning with urination, intermenstrual bleeding

  • Systemic

    • Fever/chills, fatigue, nausea/vomiting

  • Risk & exposure

    • New or multiple partners, recent untreated STI, douching, recent instrumentation

  • When to seek urgent care

    • Positive pregnancy test with pain/bleeding (possible ectopic), severe or escalating pain, high fever, fainting, confusion, heavy bleeding, or inability to keep fluids down

All symptoms should be evaluated by a qualified clinician.

Why These Tests Matter

What testing can do

  • Detect causative STIs with highly sensitive NAATs (nucleic acid amplification tests) at the right body sites

  • Differentiate PID mimics (e.g., UTI, early pregnancy complications) with urinalysis and hCG testing

  • Establish baselines (CBC, CRP/ESR) and support decisions about imaging and follow-up

What testing cannot do

  • Diagnose PID by itself—PID remains a clinical diagnosis supported by labs and, when indicated, imaging

  • Pinpoint every organism in mixed infections; results guide but do not replace clinical judgment

  • Provide treatment or dosing advice (work with your clinician for management)

What These Tests Measure (at a glance)

  • Chlamydia & Gonorrhea NAAT (preferred): first-catch urine or vaginal/cervical swab; consider rectal or pharyngeal swabs when those sites are exposed.

  • Trichomonas vaginalis NAAT: sensitive detection for a common PID-associated organism.

  • Mycoplasma genitalium NAAT: consider in persistent or recurrent cervicitis/PID when CT/GC are negative.

  • Pregnancy Test (hCG, urine or serum): rules out pregnancy-related causes; essential in pelvic pain.

  • CBC with Differential: WBC patterns for infection/inflammation context.

  • CRP and/or ESR: nonspecific inflammation markers; trends support severity context.

  • Urinalysis ± urine culture: differentiates UTI when urinary symptoms are present.

  • HIV 4th-Gen & Syphilis (treponemal + RPR): recommended baseline STI screening.

  • BV/Vaginitis testing (wet prep or molecular): clue cells or bacterial-vaginosis results support an ascending-infection environment.

  • Hepatitis B/C screening: per risk and clinician guidance.

  • (Clinician-directed) Pelvic ultrasound for tubo-ovarian abscess or alternative diagnoses.

Quick Build Guide

Clinical goal Start with Add if needed
Acute pelvic pain, PID suspected Pregnancy test (hCG) • CT/GC NAAT (vaginal/cervical or urine) • CBC • CRP/ESR • Urinalysis Trichomonas NAAT • BV/vaginitis panel
Persistent/recurrent cervicitis/PID CT/GC NAAT • Trichomonas NAAT Mycoplasma genitalium NAAT • HIV • Syphilis
Extragenital exposures Genital CT/GC NAAT Rectal/pharyngeal CT/GC NAAT based on exposure
Baseline STI screen (partners, new relationship) HIV 4th-gen • Syphilis • CT/GC NAAT Hep B/C per risk
Fever, significant tenderness CBC • CRP/ESR • CT/GC NAAT • hCG Clinician-directed pelvic ultrasound to assess abscess
Urinary symptoms present Urinalysis ± culture STI NAATs to rule in/out overlapping infections

How the Testing Process Works

  1. Match tests to symptoms & exposure: start with hCGCT/GC NAAT, and basic inflammation/safety labs.

  2. Collect the right specimens: first-catch urine or vaginal/cervical swabs (self-collected vaginal swabs are acceptable in many settings); add rectal/pharyngeal swabs if those sites were exposed. No fasting required.

  3. Results & timing: most NAATs post in 1–3 days; blood tests often sooner.

  4. Review together: combine results with a clinician exam and, when indicated, pelvic ultrasound.

  5. Plan follow-up: retest per clinical guidance (e.g., repeat STI screening at 3 months to check for reinfection).

Interpreting Results (General Guidance)

  • Positive CT/GC or Trichomonas NAAT: confirms infection; with pelvic tenderness/findings, supports PID as the working diagnosis.

  • Negative NAATs with classic exam: PID can still be present—PID is clinical; discuss imaging and broader evaluation.

  • Positive hCG: pregnancy-related causes must be addressed immediately (ectopic risk).

  • Elevated WBC/CRP/ESR: supports inflammation but is not specific.

  • UA positive: may indicate UTI; coinfections can occur—treatments are clinician-directed.
    Always interpret results with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Core PID panel (most symptomatic users): hCG + CT/GC NAAT + CBC + CRP/ESR ± UA

  • Add-ons by scenario: Trichomonas NAATM. genitalium NAAT (persistent symptoms), HIV/syphilis baseline screen, BV/vaginitis testing

  • Extragenital testing: include rectal/pharyngeal NAAT when exposure sites warrant

FAQs

Do labs alone diagnose PID?
No. PID is a clinical diagnosis supported by labs and, when needed, imaging.

Which sample is best—urine or swab?
Vaginal/cervical swabs are highly sensitive; first-catch urine is convenient and effective for many CT/GC tests. Follow your order’s instructions.

Why is a pregnancy test required?
Pelvic pain with a positive hCG can be an ectopic pregnancy, which needs urgent care.

Do I need throat or rectal testing?
If those sites were exposed, yes—order site-specific NAATs.

Can PID be present if chlamydia/gonorrhea tests are negative?
Yes. Mixed bacteria, trichomonas, or M. genitalium can be involved, and PID may occur even with negative NAATs.

Should my partner be tested?
Partners often need STI testing and clinical guidance. Your clinician will advise next steps.

Do I need to fast?
No. These are swab, urine, and standard blood tests—no fasting required.

Related Categories & Key Tests

  • Inflammation Tests Hub

  • Infection STD Tests • Women’s Health & Pregnancy Testing • Urinary & Reproductive Health • Vaginitis/BV Testing • Pelvic & Abdominal Pain

  • Key Tests: Chlamydia trachomatis NAAT • Neisseria gonorrhoeae NAAT • Trichomonas NAAT • Mycoplasma genitalium NAAT • Pregnancy test (hCG) • CBC with Differential • CRP/ESR • Urinalysis ± culture • HIV 4th-Gen • Syphilis (treponemal + RPR) • BV/Vaginitis panel

References

  • Centers for Disease Control and Prevention — Pelvic Inflammatory Disease (PID) and STI testing guidelines.
  • U.S. Preventive Services Task Force — Screening for chlamydia and gonorrhea.
  • American College of Obstetricians and Gynecologists — Evaluation of acute pelvic pain and PID.
  • Infectious Diseases Society of America — Diagnostic approaches for cervicitis and urethritis, including M. genitalium.
  • World Health Organization — Reproductive tract infections: laboratory considerations.
  • Clinical microbiology reviews — Performance of NAATs and site-specific STI testing.

Available Tests & Panels

Your PID Tests menu is pre-populated in the Ulta Lab Tests system. Start with pregnancy testing, chlamydia/gonorrhea NAATs, CBC, CRP/ESR, and urinalysis. Add trichomonas and M. genitalium NAATs for persistent or recurrent symptoms, and include HIV/syphilis screening as a baseline. Use site-specific swabs where exposed, and review results with your clinician to plan imaging, follow-up, and partner evaluation.

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Name Matches

The C-Reactive Protein (CRP) Test measures CRP levels in blood to detect inflammation in the body. Elevated CRP may indicate infections, autoimmune disorders, or chronic diseases such as arthritis, cardiovascular disease, or inflammatory bowel disease. Doctors use this test to assess acute illness, monitor treatment response, and evaluate risk for heart disease. The CRP test provides key insight into inflammation, immune health, and overall wellness.

Blood
Blood Draw
Also Known As: CRP Test, Inflammation Test

Most Popular

The Chlamydia trachomatis RNA TMA Urine Test detects genetic material of C. trachomatis using transcription-mediated amplification (TMA), a highly sensitive method for diagnosing infection. Doctors order this noninvasive urine test for patients with symptoms like discharge, pain, or burning urination, or for routine STD screening. Results help confirm infection, guide treatment, and prevent complications such as infertility, pelvic inflammatory disease, or transmission.

Varied
Phlebotomist
Also Known As: Chlamydia Trachomatis Test, Chlamydia STD Test, Chlamydia Urine Test

The Chlamydia/Neisseria gonorrhoeae RNA, TMA Urine Test screens for both chlamydia and gonorrhea infections by detecting RNA from these bacteria. Using advanced molecular technology, it offers high accuracy for diagnosing active infections. Doctors order this urine-based test to confirm infection, support early treatment, and protect sexual partners. It is an essential tool for sexual health screening, helping reduce long-term health risks and control STD spread.

Varied
Phlebotomist
Also Known As: Gonorrhea and Chlamydia Test

Blood
Blood Draw

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

Blood
Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Culture Urine Routine Test detects and identifies bacteria or yeast in urine that cause urinary tract infections (UTIs). By growing microorganisms in a lab, this test determines the type of infection and guides effective treatment. Doctors use it to evaluate symptoms such as painful urination, frequent urges, or fever and to monitor recurrent UTIs. Results provide critical insight for diagnosis, antibiotic selection, and urinary health management.

Urine
Urine Collection
Also Known As: Urine Culture Test, Urine Culture and Sensitivity, UTI test

Most Popular

The Neisseria gonorrhoeae RNA TMA Urine Test detects gonorrhea infection by identifying bacterial RNA using transcription-mediated amplification. This highly sensitive urine test helps diagnose current gonorrhea infections, even in asymptomatic cases. Doctors use it for early detection, accurate diagnosis, and timely treatment to prevent complications. Results support effective STD management and help reduce the risk of transmission.

Varied
Phlebotomist
Also Known As: GC Test, Neisseria Gonorrhoeae test, Gonorrhoeae test, Gonorrhea Urine Test

The hCG Qualitative Urine Test detects human chorionic gonadotropin in urine to confirm pregnancy. It provides a simple positive or negative result, making it similar to an at-home pregnancy test but performed in a clinical setting for greater accuracy. Doctors order this test to evaluate missed periods, early pregnancy symptoms, or before medical procedures.

Urine
Urine Collection
Also Known As: Pregnancy Urine Test, Urine hCG Test, Qualitative Human Chorionic Gonadotropin

The hCG Total Qualitative Test detects the presence of human chorionic gonadotropin in blood to confirm pregnancy. Unlike the quantitative test, it provides a simple positive or negative result rather than exact levels. Doctors use this test to confirm suspected pregnancy, evaluate early symptoms, or screen before medical procedures.

Blood
Blood Draw
Also Known As:

Pregnancy Blood Test, Beta hCG Test, Qualitative Human Chorionic Gonadotropin


Most Popular

The Sed Rate Test, also called the ESR Test, measures how quickly red blood cells settle in a sample of blood. A faster rate may signal inflammation caused by infections, autoimmune diseases, arthritis, or other chronic conditions. Doctors use this test to investigate unexplained fever, joint pain, or muscle aches, and to monitor inflammatory disorders such as lupus or rheumatoid arthritis. The Sed Rate Test provides important insight into overall inflammatory activity.

Blood
Blood Draw
Also Known As: Erythrocyte Sedimentation Rate Test, ESR Test, Sedimentation Rate Test, Westergren Sedimentation Rate Test

The Sedimentation Rate Blood Test, also called the Erythrocyte Sedimentation Rate (ESR) Test, measures how quickly red blood cells settle in a sample. A faster rate can signal inflammation linked to arthritis, autoimmune disease, or infection. Doctors order this test when patients have symptoms like joint pain, fever, or fatigue. While not diagnostic alone, results provide valuable insight into inflammatory activity and help guide further evaluation and treatment.

Blood
Blood Draw
Also Known As: Sed Rate Test

The Urinalysis Complete Test evaluates urine for physical, chemical, and microscopic properties to assess kidney health, urinary tract infections, diabetes, and metabolic disorders. It measures appearance, concentration, pH, protein, glucose, ketones, blood, bilirubin, nitrites, leukocyte esterase, and microscopic cells or crystals. Doctors use this test in routine exams, to diagnose urinary symptoms, and to monitor chronic kidney or metabolic disease.

Urine
Urine Collection
Also Known As: Urine Analysis Test, UA Test, Complete Urinalysis Test

The Urinalysis Complete Test with Reflex to Culture screens urine for abnormalities in color, clarity, pH, protein, glucose, ketones, blood, and microscopic elements like red and white cells. If infection is suspected, it reflexes to a urine culture to identify bacteria. Doctors use this test to detect urinary tract infections (UTIs), kidney disease, diabetes, and metabolic disorders, guiding accurate diagnosis, treatment, and ongoing health management.

Urine
Urine Collection
Also Known As: Urine Analysis with Reflex Test, UA with Reflex Test, UTI Test

What is Pelvic Inflammatory Disease?

Pelvic Inflammatory Disease (PID) is an infection of the female reproductive organs. The fallopian tubes, uterus, and ovaries can all be affected by PID. The infection may spread beyond the reproductive organs into the abdominal (peritoneal) cavity if left untreated.

About Pelvic Inflammatory Disease

PID is particularly common in younger women. Some women may have PID for years without developing any noticeable symptoms. Other women may experience significant symptoms almost as soon as they are infected.

Left untreated, PID may affect fertility and cause considerable pain and discomfort. Ectopic pregnancy is also more common in PID sufferers. As younger women are more prone to PID, they must regularly test for this common condition to minimize the risk of unwanted reproductive complications later in life.

Risk Factors for Pelvic Inflammatory Disease

Common risk factors for Pelvic Inflammatory Disease include:

  • Being a younger, sexually active woman. Women under the age of 25 are at particular risk of developing PID
  • Becoming sexually active at a young age.
  • Having several sexual partners.
  • Having unprotected sex (sex without a condom).
  • Having unprotected sex with a partner who has had multiple sexual partners.
  • Using vaginal douching as a hygiene measure.
  • Having a history of PID.

It's important to note that although multiple sexual partners increase the risk of introducing bacteria into the reproductive area that can lead to PID, women don't have to be sexually promiscuous to contract PID.

In some instances, PID is caused by infection following trauma to the vaginal tract. IUD insertion, childbirth, an abortion, a medical procedure involving the vagina, or a miscarriage.

Discreet, early testing can pick up PID, enabling it to be swiftly treated and resolved in most cases.

Causes of Pelvic Inflammatory Disease

PID is caused by bacteria entering the vaginal canal. In most cases, the bacteria go no further than the cervix. If the infection remains untreated, the bacteria may pass up into the uterus, which may begin to multiply, creating inflammation. Over time, the infection may spread further into the Fallopian tubes and ovaries.

Sexually Transmitted Diseases (STDs) due to bacteria (rather than viruses) are a common cause of PID. These include chlamydia, mycoplasma genitalium, and gonorrhea.

In addition, bacteria that naturally occur in the vaginal canal (Gardnerella vaginalis, Streptococcus agalactiae, or Haemophilus influenza) may also cause PID if they penetrate through the cervix into the uterus.

Signs and Symptoms of Pelvic Inflammatory Disease

The signs and symptoms of PID may be pretty subtle, which means they can be easily missed. Some women remain asymptomatic until the infection is quite advanced, meaning considerable damage may already have been done. 

If you are concerned about your PID risk or want peace of mind that you're not suffering from PID and aren't aware of it, a pelvic inflammatory disease lab test is the most accurate way of finding out if you're infected.

The main signs and symptoms of PID include:

  • An abnormal vaginal discharge, which may be discolored and/or have an unpleasant odor.
  • Abnormal vaginal bleeding between periods and/or after sex.
  • Pain in the lower abdominal area. The duration and severity of the pain may fluctuate over time.
  • Difficulties and/or pain during urination (taking a pee).
  • Pain during or after sex.
  • A fever (which may cause chills, sweating, and a general feeling of unwellness).

If you have any of these symptoms, it's important to get properly tested to find out the cause. Although a PID test can be used to identify whether PID-causing bacteria are present in abnormal numbers, it can't pick up other causes of pain, bleeding, or discharge. In rare cases, these symptoms can be a sign of cancer, so early diagnosis is really important.

Occasionally, a PID infection can become particularly severe. If you experience the following symptoms, it's important to visit your care provider as soon as possible or attend at ER.

  • Severe vomiting (especially if you can't keep down water).
  • Severe abdominal pain.
  • A high fever (more than 101 degrees Fahrenheit).
  • A foul-smelling vaginal discharge.

Remember that, in most cases, a course of suitable antibiotics is all that's needed to treat PID successfully.

If left untreated, in the long-term, PID may cause:

  • Chronic pain
  • Infertility
  • An increased risk of ectopic pregnancy
  • Abscesses in the ovaries and/or Fallopian tubes.

Prompt PID testing is safe, discreet, and fast, giving you the answers you need to make informed decisions about your health.

Lab Tests for Pelvic Inflammatory Disease

A definitive diagnosis of PID usually involves both a swab test (a swab is inserted into the vagina to collect a sample) and a blood test to investigate whether an unusually high number of white blood cells (WBC) are present. An elevated WBC count frequently indicates an infection.

Typically, PID Lab Tests include:

  • Swab test for Chlamydia
  • Swab test for Gonorrhoea
  • Complete Blood Count (blood test)
  • urinalysis (to rule out a UTI as the cause of the symptoms)
  • CRP (C-reactive Protein). A positive CRP may be a sign of an infection.
  • A pregnancy test 
  • A cervical culture - this test investigates bacteria levels on the cervix and can be used to try and identify the cause of PID.

FAQs About Pelvic Inflammatory Disease

Is PID linked to promiscuity?

STDs cause a proportion of PID infections, but this isn't always the case. Many other cases occur due to pregnancy, childbirth, or trauma. For a fair percentage of cases, the cause of the infection isn't clear. PID lab tests offer the best way to diagnose PID, enabling it to be effectively treated quickly.

Can Damage Caused by PID be Reversed?

While effective treatment can halt PID damage, it's unfortunately rare that the damage can be reversed. This is why prompt PID diagnosis, using pelvic inflammatory disease lab testing alongside other diagnostic methods, is important. 

FAQs About Lab Testing for Pelvic Inflammatory Disease

How long will I have to wait for my results?

In most cases, your results will be ready in one to two business days.

Do I have to tell anyone about my results?

Your results are entirely confidential. However, we would urge you to share your results with your physician to get the care and treatment you need.

Ulta Lab Tests provides a cost-effective, accurate, fast, secure, and confidential PID testing service. By getting tested, you can take control of your health and make informed decisions while monitoring the changes in your health.

Order your low-cost pelvic inflammatory disease lab tests today.

Testing for PID

If you're showing signs of Pelvic Inflammatory Disease (PID), you need to be proactive. If left untreated, the infection can spread and get worse.

Ulta Lab Tests offers highly accurate and reliable tests so that you can make informed decisions about your health. Here are a few great things to love about Ulta Lab Tests:

  • You'll get secure and confidential results.
  • You don't need health insurance.
  • You don't need a physician's referral.
  • You'll get affordable pricing.
  • We offer a 100% satisfaction guarantee.

Order your PID lab tests today, and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.