Peptic Ulcer

Peptic Ulcer Lab Testing and health information

The peptic ulcer test will test for the presence of antibodies to H. pylori to detect and identify peptic ulcers. Order from Ulta Lab Tests today with results sent confidentially online in 1 to 2 days.


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Helicobacter pylori is a gram-negative microaerophilic curved bacillus with an affinity for human gastric mucosa. H. pylori has been identified as an important pathogen in the upper GI tract. The casual relationship between H. pylori and chronic active gastritis, duodenal ulcers, and gastric ulcers has been well documented. BreathTek™ UBiT® for H. pylori is a non-invasive, non-radioactive method for detecting urease activity associated with H. pylori infection. It is FDA approved to confirm cure and offers 95.2% sensitivity and 89.7% specificity compared with endoscopic methods.

Helicobacter Pylori Ag, Eia, Stool

IMPORTANT: Patient Self Collection Required - Instructions 

  1. Patient to visit a Quest Patient Service Center to obtain the designated sterile collection container required for the test.
  2. Patient self-collects stool sample off site from PSC.
  3. Patient self-collects 0.5 mL or 0.5 grams of semi-solid stool or 20 mm diameter solid stool and transfer to properly labeled plastic, leak-proof container.
  4. Label the specimen collection container:
    1. Record the date and time on the specimen collection.
    2. Record the patients full name as on requisition and DOB.
  5. IMPORTANT: Watery, diarrheal stool is not acceptable.
  6. IMPORTANT: The stool sample must be refrigerated immediately after collection.
  7. The stool specimen must be packed with cold packs and returned to the Quest Patient Service Center with the Patient Requisition within 24 hours of collection.

 

Patient Preparation

For initial diagnostic purposes no special patient preparation is required. Patients are not required to be off of medications or to fast before this test. While positive test results from patients taking agents such as proton pump inhibitors and antimicrobials should be considered accurate, false negative results may be obtained. For this reason, physicians may suggest the patient go off medications for two weeks and repeat test if negative results are obtained.

To confirm eradication, testing should be done at least 4 weeks following the completion of treatment. However, a positive test result 7 days’ post therapy is indicative of treatment failure.

 

Clinical Background

Helicobacter pylori infection has been associated with duodenal and gastric ulcers and chronic active, chronic persistent, and atrophic gastritis in adults and children. Infected persons have a 2- to 6-fold increased risk of developing gastric cancer and mucosal-associated-lymphoid-type (MALT) lymphoma.

 

Noninvasive Assays

The UBT and stool antigen test are highly sensitive and specific for H pylori infection. These assays have been recommended by the American Gastroenterological Association (AGA) and the American College of Gastroenterologists (ACG) as the most accurate noninvasive tests for diagnosis of H pylori infection and for confirmation of eradication after therapy.



Description: Fecal Globulin by immunochemistry is a test that measures the amount of blood present in fecal samples. The results from the fecal globulin test can be used to detect a lower gastrointestinal disorder. It is recommended to be a part of the routine physical examination.

Also Known As: Fecal Immunochemical Test, Fecal Occult Blood Test, Stool Occult Blood Test, FIT, FOBT

Collection Method: Fecal specimen collected from toilet water and brushed onto InSure® FOBT test card

Specimen Type: Fecal Specimen

Test Preparation: No preparation required

When is a Fecal Globin test ordered?

When a person chooses fecal occult blood testing as a method of colon cancer screening, the American Cancer Society and other major healthcare organizations recommend yearly testing. The American Cancer Society and others recommend that colon cancer screening begin around age 50 for the general population, but it may begin earlier if a person has a family history of colon cancer.

An FOBT may be ordered by a doctor if a patient has unexplained anemia that could be caused by gastrointestinal bleeding.

What does a Fecal Globin test check for?

The majority of colon cancer cases begin with the formation of benign intestinal polyps. Benign polyps are quite common in adults over 50, and while the majority do not cause health problems, some can turn malignant and spread to other parts of the body. These finger-like growths protrude into the rectum or the intestinal cavity. They can be delicate and bleed on occasion, as when food debris rubs against them.

The blood expelled is normally not visible in the stool, but a fecal occult blood test or a fecal immunochemical test can detect it. The FOBT and FIT are effective colorectal cancer screening techniques because this small amount of blood may be the earliest and sometimes only evidence of early colon cancer. A guaiac-based test, an over-the-counter flushable reagent pad, and an immunochemical technique are all options for testing.

It is advised that at least three stool samples be taken on different days be tested. According to the American Cancer Society, a single test performed during a digital rectal exam at a doctor's office is not recommended since it may not be sensitive enough to detect cancer. Because collecting feces on three different days increases the chances of identifying cancer, the home FOBT or FIT is advised. Additionally, those who choose this type of colon cancer screening should be screened every year.

Lab tests often ordered with a Fecal Globin test:

  • Complete Blood Count (CBC)
  • Calprotectin

Conditions where a Fecal Globin test is recommended:

  • Colon Cancer

How does my health care provider use a Fecal Globin test?

The fecal occult blood test, also known as the fecal immunochemical test, is primarily used to screen for early colon cancer. The majority of colon cancer cases begin with the formation of benign intestinal polyps. People over the age of 50 are more likely to develop benign polyps. The majority are non-cancerous, however some can develop malignant.

Blood in the stool could be the only sign of early cancer, so if caught early, therapy can begin right away, increasing the chances of a cure.

What do my Fecal Occult Blood test results mean?

Normally, the fecal occult blood test is negative.

A positive test result for the guaiac-based FOBT shows that abnormal bleeding is occurring anywhere in the digestive tract. Ulcers, diverticulosis, polyps, inflammatory bowel disease, hemorrhoids, blood eaten owing to bleeding gums or nosebleeds, or benign or malignant tumors could all cause blood loss.

A positive result for the fecal immunochemical test shows abnormal bleeding in the lower digestive tract. Other sources of blood, such as those found in the diet, do not generate a positive result since this test only identifies human hemoglobin. Furthermore, hemoglobin from upper digestive tract hemorrhage is broken down before reaching the lower digestive tract and is undetectable by the FIT. As a result, the FIT is a more precise test than the gFOBT.

Follow-up testing is required after a positive result from either the guaiac-based FOBT or the immunochemical FIT. Direct imaging of the colon and rectum is generally used.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.


Description: A Hemoglobin (Hgb) test is a blood test that measures the amount of hemoglobin your red blood cells contain.

Also Known As: Hb Test, Hgb Test

Collection Method: Blood Draw

Specimen Type: Whole Blood

Test Preparation: No preparation required

When is a Hemoglobin test ordered?

The hemoglobin test may be requested as part of a general health assessment or when a person exhibits signs and symptoms of a red blood cell disorder such as anemia or polycythemia.

When someone has been diagnosed with recurrent bleeding difficulties, chronic anemias, or polycythemia, this test may be done numerous times or on a regular basis to check the effectiveness of treatment. It's also possible that it'll be ordered on a regular basis for those having therapy for cancers that are known to harm the bone marrow.

What does a Hemoglobin blood test check for?

Hemoglobin is an iron-containing protein found in all red blood cells, which gives them their distinctive red color. RBCs use hemoglobin to bind to oxygen in the lungs and transport it to tissues and organs all over the body. It also aids in the movement of a little amount of carbon dioxide, which is a byproduct of cell metabolism, from tissues and organs to the lungs, where it is exhaled.

The hemoglobin test determines how much hemoglobin is present in a person's blood sample. To swiftly assess an individual's red blood cells, a hemoglobin level can be used alone or in conjunction with a hematocrit, a test that assesses the fraction of blood made up of RBCs. Red blood cells, which account for roughly 40% of the amount of blood, are created in the bone marrow and released into the bloodstream when they are mature, or nearly so. RBCs have a 120-day lifespan, and the bone marrow must constantly manufacture new RBCs to replace those that have aged and degraded or have been lost due to hemorrhage.

RBCs, and thus the level of hemoglobin in the blood, can be affected by a variety of diseases and situations. When the quantity of red blood cells grows, the hemoglobin level and hematocrit both rise. When the synthesis of RBCs by the bone marrow decreases, RBC destruction increases, or blood is lost owing to hemorrhage, the hemoglobin level and hematocrit fall below normal. Anemia is a disorder in which the body's tissues and organs do not acquire enough oxygen, causing exhaustion and weakness. It is caused by a decline in RBC count, hemoglobin, and hematocrit. Polycythemia occurs when the body produces too many RBCs, causing the blood to thicken, resulting in sluggish blood flow and other complications.

Lab tests often ordered with a Hemoglobin test:

  • Complete Blood Count (CBC)
  • Hematocrit
  • Red Blood Cell Count (RBC Count)
  • Blood Smear
  • Iron Total
  • Ferritin
  • Reticulocyte Count
  • Vitamin B12
  • Folate
  • Red Cell Indices
  • G6PD
  • Erythropoietin
  • Hemoglobinopathy Evaluation

Conditions where a Hemoglobin test is recommended:

  • Anemia
  • Sickle Cell Anemia
  • Thalassemia
  • Myeloproliferative Neoplasms
  • Hemoglobin Abnormalities
  • Bone Marrow Disorders

How does my health care provider use a Hemoglobin test?

Anemia is commonly detected with a hemoglobin test in conjunction with a hematocrit or as part of a complete blood count. The test can be used to detect, diagnose, or track a variety of illnesses and disorders that impact red blood cells and/or hemoglobin levels in the blood. All red blood cells include hemoglobin, an iron-containing protein that allows RBCs to bind to oxygen in the lungs and transport it to tissues and organs throughout the body.

A hemoglobin test can be used for a variety of purposes, including:

  • Anemia and polycythemia are diagnosed, diagnosed, and measured.
  • Assess the patient's reaction to anemia or polycythemia treatment.
  • If the anemia is severe, you can help make decisions about blood transfusions or other therapies.

Some factors influence RBC production in the bone marrow, resulting in an increase or decrease in the quantity of mature RBCs discharged into the bloodstream. The longevity of RBCs in the circulation can be influenced by a variety of factors. The overall amount of RBCs and hemoglobin will diminish if there is greater destruction of RBCs or loss of RBCs through bleeding, and/or the bone marrow is unable to make new ones quickly enough, leading in anemia.

This test can tell you if you have an issue with red blood cell production or longevity, but it can't tell you what's causing it. A blood smear, reticulocyte count, iron studies, vitamin B12 and folate levels, and, in more severe cases, a bone marrow examination are some of the other tests that may be conducted at the same time or as follow-up to establish a reason.

What do my Hemoglobin test results mean?

Because hemoglobin levels are frequently measured as part of a complete blood count, the results of other components are taken into account. Hemoglobin levels must be interpreted in conjunction with other indicators such as RBC count, hematocrit, reticulocyte count, and/or red blood cell indices when they rise or fall. Other characteristics to consider are age, gender, and race. Hemoglobin reflects the RBC count and hematocrit results in general.

Anemia is defined as a low hemoglobin level combined with a low RBC count and a low hematocrit. Among the causes are:

  • Excessive blood loss-as a result of severe trauma or continuous bleeding from the digestive tract, bladder, or uterus.
  • Iron, folate, or B12 deficiency are examples of nutritional inadequacies.
  • Toxins, radiation, chemotherapy, infection, and medicines can all cause damage to the bone marrow.
  • Myelodysplastic syndrome, aplastic anemia, or tumors of the bone marrow, such as lymphoma, leukemia, multiple myeloma, or other cancers of the bone marrow
  • Renal failure—severe and chronic kidney illnesses cause the kidneys to produce less erythropoietin, a hormone that drives RBC synthesis in the bone marrow.
  • Inflammatory diseases or disorders that last a long time
  • Hemoglobin production is reduced.
  • Excessive destruction of red blood cells, such as hemolytic anemia caused by autoimmunity or faults in the red blood cell itself, such as hemoglobinopathy, RBC membrane abnormalities, or RBC enzyme.

Polycythemia is defined as a high hemoglobin level combined with a high RBC count and hematocrit. Among the causes are:

  • Lung disease-when a person's body is unable to breathe in and absorb enough oxygen. As a result, the body produces more red blood cells to compensate.
  • Congenital heart disease—in some cases, an improper connection between the two sides of the heart occurs, resulting in lower blood oxygen levels. The body responds by creating extra red blood cells in an attempt to compensate.
  • Excess erythropoietin-producing kidney tumors
  • Hemoglobin levels in heavy smokers are higher than in nonsmokers.
  • Genetic factors
  • Having to live at a high altitude
  • Dehydration causes hemoglobin to rise unnaturally when the volume of liquid in the blood declines.
  • Polycythemia vera-a rare condition in which the body creates too many RBCs.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.


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For the diagnosis and monitoring of gastrin-secreting tumors, gastric ulcer, Zollinger-Ellison syndrome. Increased in pernicious anemia.


Physicians diagnose 4.6 million people in the United States with peptic ulcer disease every single year. These sores cause abdominal pain, bloating, nausea, vomiting, and more. So, if you've been experiencing these symptoms, you're not alone.

However, if you haven't gotten a diagnosis for peptic ulcer disease yet, you may need a peptic ulcer test. Peptic ulcer testing can help you get a definitive answer as to whether or not you're suffering from the condition.

And, if your test comes back positive, you can get the medical attention and care that you need to prevent further complications.

To learn more about peptic ulcers and the benefits of a peptic ulcer test, keep reading. We have everything you need to know in this peptic ulcer test guide.

What Is a Peptic Ulcer?

Peptic ulcers are open sores that develop on the inside of the stomach. Specifically, they form on the inner lining of the stomach wall. Some peptic ulcerations even develop at the start of the small intestine.

Ulcerations that form in the stomach are called gastric ulcers. On the other hand, duodenal ulcers are those that form in the small intestine.

What Are the Risk Factors for a Peptic Ulcer?

The most common risk factor in patients with peptic ulcers is NSAID use. Patients who develop peptic ulcers tend to take more NSAIDs than patients who do not. However, this isn't the only risk factor associated with the condition.

Another common risk factor is alcohol consumption. If you drink alcohol regularly, the alcohol can irritate and erode the lining of your stomach. Thus, your body can develop ulcerations. 

Over time, erosion from alcohol can cause an increase in the amount of stomach acid that your body is producing, too. So, you may have more extreme symptoms such as burning and vomiting.

A lesser-known contributor to the development of peptic ulcers is smoking. In patients who have H. pylori infections, smoking can increase the risk for peptic ulcers.

Lastly, we'll touch on spicy foods and stress once again. These two things do not cause peptic ulcers. However, they are considered risk factors for the condition since they can exacerbate already-existing issues in the inner lining of the stomach.

What Causes Peptic Ulcers?

There are multiple causes of peptic ulcers.

The most common cause is an H. pylori infection. H. pylori, or Helicobacter pylori, is a kind of bacteria that can wreak havoc on the digestive system. Unfortunately, most people with H. pylori infections don't even realize that they have an infection because they do not develop symptoms.

Another common cause of developing peptic ulcers is long-term NSAID use. NSAIDs are non-steroidal anti-inflammatory drugs. This includes things like ibuprofen (Advil), Motrin, and naproxen sodium (Aleve).

Taking too many of these kinds of medications can weaken the inner lining of your stomach. Therefore, ulcerations can form as the stomach lining breaks down.

Some people believe that stress and spicy foods can cause ulcers. However, this isn't supported by gastroenteric research. Rather, these kinds of factors make already-existing ulcers worse.

So, you should still avoid these if you're experiencing symptoms of a peptic ulcer or if you have an official diagnosis of peptic ulcer disease.

What Are the Signs and Symptoms of a Peptic Ulcer?

Since peptic ulcers affect your gastric system, patients with them often feel symptoms associated with their abdomen. However, it's important to note that many patients with gastric ulcers don't feel any symptoms. Feelings of pain and bloating may come slowly over time.

Here are some of the most commonly reported symptoms in patients with peptic ulcers:

  • Burning pain in the abdomen, especially in the left upper quadrant where the stomach is located
  • A persistent feeling of fullness in the stomach despite not eating recently
  • Bloating in the abdomen
  • Repeated belching
  • Intolerance to foods that are high in fat
  • A burning sensation in the heart
  • Persistent nausea

The most common symptom is burning abdominal pain. However, this can become better after eating. If you aren't eating for long periods of time, the ulcerations in your stomach can become exposed to the acid. Thus, the pain worsens.

This also explains why patients find that the stomach pain gets worse in between meals and at night.

Some patients find that they can relieve their pain by eating foods that block the acid in the stomach. Alternatively, you can take a medication that reduces stomach acid.

What Happens If Peptic Ulcers Go Untreated?

Patients that have advanced peptic ulcers have even worse symptoms. And, they can develop secondary conditions from the damage that the ulcerations are causing.

Here are the severe signs and symptoms of peptic ulcers:

  • Persistent vomiting
  • Vomiting blood which may appear red or black
  • Producing bloody stools with may appear dark and/or tarry
  • Trouble breathing
  • Lightheadedness
  • Unintentional weight loss
  • Changes in appetite

If you're experiencing these more serious symptoms, you should see a physician as soon as possible. Without treatment, your condition will only worsen.

In fact, several complications can come with peptic ulcers. Here are some of the most common complications that can happen in patients with peptic ulcers:

  • Internal bleeding, which can lead to anemia and even fatal blood loss
  • A perforation in the stomach wall, which can put the patient at an increased risk for infection in the abdominal cavity
  • An obstruction in the digestive system can make it impossible to keep food down, leading to vomiting and weight loss
  • The development of gastric cancer

If you think you're experiencing blood loss, you need to test your iron levels.

All in all, you need to make sure that you see a physician as soon as possible if you've started developing symptoms. The sooner you can start treatment, the less damage that these ulcerations can do.

What Lab Tests Diagnose Peptic Ulcers?

To determine whether or not you have peptic ulcers, your physician may run peptic ulcer tests. More specifically, they'll be looking for H. pylori. They can detect whether or not H. pylori bacteria are present in your system.

Although physicians can perform this test through blood, stool, or breath samples, breath samples are the most accurate. 

To do a breath test, you must first eat something that contains radioactive carbon. If you have H. pylori in your system, the bacteria will break down the radioactive carbon into carbon dioxide. So, when you breathe into a bag later, elevated levels of carbon dioxide will show up in your sample.

For blood and stool tests, your physician will simply take the sample they need and examine the sample under a microscope to check for the bacteria. 

If these tests come back positive, your physician will create a treatment plan for your condition. However, if they come back negative, your physician may begin testing for other conditions that produce similar symptoms.

Are There Diagnostic Tests to Diagnose Peptic Ulcers?

There are two diagnostic tests that your physician may consider running instead of or in congruence with the aforementioned lab tests:

  1. An endoscopy
  2. An upper abdominal series

During an endoscopy, a physician uses a scope to look at your upper digestive system. He/She will use a hollow tube with a lens to look down your throat and into your stomach and small intestine. With this device, he/she can check for any ulcerations.

If the physician does see an ulcer, they will likely take a biopsy of the area. With this biopsy, a laboratory technician can determine whether or not you have H. pylori bacteria in your system.

Physicians tend to opt for endoscopies in older patients, display signs of bleeding, or have had recent weight loss or loss of appetite. Usually, these patients will need a follow-up endoscopy to determine whether or not their treatment was successful in healing the ulcerations.

An upper abdominal series is less invasive than an endoscopy, but it can still give your physician some useful information about how your gastrointestinal system works. An upper abdominal series, also known as a barium swallow, is a series of x-rays that look at your esophagus, stomach, and small intestine.

During the study, you'll swallow a white liquid that contains barium. This liquid coats the entire digestive system, making it easier for your physician to see any ulcerations that you may have in your stomach or small intestine. 

An upper abdominal series is preferred for patients who are less emergent.

Getting a Peptic Ulcer Test

If you're starting to show signs and symptoms of a peptic ulcer, you need to get a peptic ulcer test. This can help you determine whether or not you need to start making some changes.

Without the test, your condition could go untreated. Then, you could be looking at complications like infections and perforations.

So, what are you waiting for? At Ulta Lab Tests, we have secure and confidential results and you don't need any insurance or referral. All you need to do is order your peptic ulcer test, visit a local testing facility, and then wait 24 to 48 hours for your results.

It's better to be safe than sorry. So, order your test today.