Osteoarthritis

Want to learn more about Osteoarthritis tests? Learn what's available, the benefits of testing, what tests to order, and more!

The osteoarthritis tests evaluate and exclude diseases that can cause secondary osteoarthritis and exclude other arthritis conditions that can mimic osteoarthritis. Order your tests from Ulta Lab Tests and learn about your health today!      

In the guide below the list of tests, we explain and answer your questions on Osteoarthritis tests.


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Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. 

Reflex Information: If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge.


Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.

A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)


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A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

A lipid panel includes:Total cholesterol —this test measures all of the cholesterol in all the lipoprotein particles.High-density lipoprotein cholesterol (HDL-C) — measures the cholesterol in HDL particles; often called "good cholesterol" because it removes excess cholesterol and carries it to the liver for removal.Low-density lipoprotein cholesterol (LDL-C) — calculates the cholesterol in LDL particles; often called "bad cholesterol" because it deposits excess cholesterol in walls of blood vessels, which can contribute to atherosclerosis. Usually, the amount of LDL cholesterol (LDL-C) is calculated using the results of total cholesterol, HDL-C, and triglycerides.Triglycerides — measures all the triglycerides in all the lipoprotein particles; most is in the very low-density lipoproteins (VLDL).Very low-density lipoprotein cholesterol (VLDL-C) — calculated from triglycerides/5; this formula is based on the typical composition of VLDL particles.Non-HDL-C — calculated from total cholesterol minus HDL-C.Cholesterol/HDL ratio — calculated ratio of total cholesterol to HDL-C.



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Elevated RF is found in collagen vascular diseases such as SLE, rheumatoid arthritis, scleroderma, Sjögren's Syndrome, and in other conditions such as leprosy, tuberculosis, syphilis, malignancy, thyroid disease and in a significant percentage of otherwise normal elderly patients.

Useful in differentiating inflammatory and neoplastic diseases and as an index of disease severity. CRP is also useful in monitoring inflammatory disease states.


Did you know over 54 million adults in the US have osteoarthritis (OA)? In addition, over 24 million adults are limited in the activities they can do because of OA.

When you're in pain, it's all too easy to feel alone. But you can take charge of your symptoms by getting the osteoarthritis tests you need to get the answers you deserve.

Remember, there is help available for the pain that osteoarthritis brings. But your most powerful tool is educating yourself about OA and what you can do to manage your symptoms.

So if you want to learn more about osteoarthritis and osteoarthritis tests, keep reading this guide to find out everything you need to know!

What is Osteoarthritis

Osteoarthritis is the most common form of arthritis. Osteoarthritis occurs when the cartilage that protects your joints wears down over the years. 

Cartilage is the slippery tissue that allows your joints to remain moving in a fluid motion. When your cartilage breaks down, it enables your bone to surfaces to become rough and jagged. 

Cartilage doesn't have blood vessels or blood supplies, so for this reason, damaged cartilage can't repair itself.

Osteoarthritis can occur in any joint, but it's most common in your spine, hips, hands, and knees.

It's vital to remember OA is progressive. OA progresses in stages from 0 to 4. The first stage indicates a normal joint, and stage 4 means severe OA. As OA goes through the stages, you'll have increased pain, swelling, inflammation, decreased range of motion, and unstable joints.

Causes of Osteoarthritis

Osteoarthritis is often referred to as wear and tear disease.  As you age, your joints naturally start to break down.

But there are risk factors and other disease conditions that put you at higher risk for developing OA.

Risk factors for Osteoarthritis

Risk factors that can make osteoarthritis a reality include:

Obesity is one of the most significant risk factors as it puts extra stress on your joints, especially the knees and hips.

Past joint injuries or surgery can put you at greater risk for OA, as can congenital joint abnormalities at birth.

A job or hobby that requires you to make repeated motions over and over again can increase your chances of getting OA.

If you have had a joint inflammatory condition like rheumatoid arthritis, it can lead to your joints breaking down faster.

Diabetes and changes in hormone levels can cause inflammation and lead to arthritis. And menopause brings changes to the estrogen levels that protect your bones and joints. Once estrogen levels fall, you're at higher risk for OA.

Osteoarthritis Symptoms

When you have osteoarthritis, the symptoms slowly worsen in time in stages. But when you have osteoarthritis, you'll notice things like:

  • Joint pain with movement
  • Joint stiffness, especially after waking up in the morning
  • Your joints lose flexibility
  • Your joints feel tender upon touch
  • You may notice your joints pop and crack
  • Joint swelling

Sometimes extra bits of bone (bone spurs) form around your joints which feel like hard lumps. If your joint pain and stiffness won't let up, then it's time to contact your doctor.

Complications of Osteoarthritis

Osteoarthritis is degenerative, meaning it continues to get worse over time. Joint pain can become severe, making daily tasks almost impossible.

Osteoarthritis Treatment

The damage from osteoarthritis can't be reversed, but treatments are available to reduce your joint pain and improve your quality of life.

The first line of treatment includes medications to help relieve your symptoms. Your doctor will typically recommend over-the-counter medicines like Tylenol, Advil, or prescription anti-inflammatory medication, depending on your situation.

The next line of treatment involves physical therapy for exercises to strengthen the muscles around your joint and improve flexibility.

You may also need occupational therapy if you're having trouble with everyday tasks. An occupational therapist will help you learn different ways of moving to put less stress on your joints.

Some people might need assistive devices like a bench in the shower to alleviate the strain.

If medications and therapy don't work for you, other treatments are available, like steroid injections into your joints. In severe cases, joint replacement surgery may be the best solution.

Lifestyle Changes

One of the most important things you can do to manage the symptoms and progression of OA is making lifestyle changes. Exercise and weight loss go a long way in reducing the pain and stiffness that come with OA.

Gentle exercise like swimming or walking is a great way to keep active. You can also try biking or water aerobics. But the important thing is to make it a part of your daily routine. The worst thing you can do when you have OA is sitting and not moving.

When you carry extra weight, you put stress on your already arthritic joints. Even losing just 10lbs can make a massive difference for your joints. If you struggle with weight, talk to your doctor or a dietician to help you come up with a plan.

Other options

Yoga, tai chi, and deep breathing work amazingly well to improve your joint flexibility and stress at the same time. Choose yoga that's gentle and easy and avoid any movements that stress your joints.

Applying both heat and cold to your joints can relax your muscles and reduce pain. You can do this after exercise or at the end of the day.

Some people also find relief from using Capsaicin cream. Capsaicin is the active ingredient in chili peppers, and when applied as a topical cream, it can change the way your body responds to pain. 

Many people find relief using this cream, but it can cause some skin irritation. So talk to your doctor first if you think it might be for you.

Osteoarthritis Diagnosis

You'll first see your doctor and have a physical exam. Your doctor will check your joints for tenderness, swelling, and redness.

To get a clear picture of your joints, your doctor may order X-rays to rule out any other problems. If you have severe symptoms, you might also have an MRI to look at your bones and soft tissues.

Although there isn't one single blood test that can diagnose arthritis, your doctor will order a series of blood tests to rule out other issues like rheumatoid arthritis.

Lab Tests for Osteoarthritis

In general, the goal of ordering a blood osteoarthritis test is to distinguish osteoarthritis from other inflammatory or autoimmune conditions.

comprehensive Osteoarthritis panel from Ulta Lab Tests is a great way to get all the tests you need.

First, your doctor will want to check your rheumatoid factor (RF). This test will determine if your symptoms are caused by rheumatoid arthritis RA instead. Your rheumatoid factor will be negative with RA.

Another test commonly ordered is an Erythrocyte sedimentation rate (ESR) test. The ESR detects inflammation in your body and will be increased with RA, but not with osteoarthritis. Also, a C-reactive protein (CRP) detects inflammation and is elevated with RA.

Your doctor will also check your complete blood count (CBC) and comprehensive metabolic panel (CMP). These panels will assess your overall health status and see how well you'll be able to tolerate any OA medications you might need.

Sometimes your doctor may want to do a joint fluid analysis. OA, infections, and other inflammatory conditions can change the way your joint fluid appears. Fluid is drawn out from your joint and analyzed under a microscope.

Osteoarthritis FAQS

Did you know osteoarthritis is the leading cause of disability in the United States, and more women are more likely to develop OA than men?

Joint surgery is effective and considered to be one of the most successful operations in medicine today. For example, if you get hip replacement surgery, you have over a 95% chance of success at a full recovery. 

You've likely heard that cracking your joints causes arthritis? This is a myth, so you don't have to worry that your knuckle-cracking habit will land you with OA.

It's also a myth that osteoarthritis isn't a serious health problem. While OA may take a back seat to cancer and heart disease, it still affects over 50 million people a year and with healthcare costs of over 150 billion.

Osteoarthritis Tests

Ulta Lab Tests offers tests that are highly accurate and reliable so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

For your osteoarthritis testing needs, choose Ulta Lab Tests. We offer accurate
and reliable tests that give results you can trust.

And the best part is you don't need insurance or a referral. Our affordable prices include a doctor's order, so you're never alone.

Once you order your osteoarthritis tests, you'll have secure and confidential results available to you within 24 to 48 hours in most cases. 

Take control of your health today with Ulta Lab Tests.

One of the most common forms of arthritis is known as osteoarthritis, which affects over 30 million people in the United States alone. Also known as degenerative joint disease, it tends to affect people older in age or those with joint injuries. In most cases, it is the joints that are severely affected by osteoarthritis, including those in the hips, knees, fingers, and spine.

Osteoarthritis is a progressive disease that will lead to the overall deterioration of joint cartilage as well as the formation of bone spurs at the joint edges. Synovial fluid and cartilage are designed to create a low friction transition between the ending of the bones. However, once cartilage begins to lose its elasticity, the movement in the joints will become less fluid. In some cases, the cartilage will completely disappear, allowing the bone ends to rub together. This can lead to joint pain that is either chronic or intermittent throughout the day or night, as well as fragments of bone and cartilage in any remaining synovial fluid, which over time can lead to loss of coordination and mobility.

It is rare to see individuals under the age of 40 years old with osteoarthritis. More males than females will be diagnosed with osteoarthritis before the age of 45; however, it is more common in females after the age of 45. Regardless, it is typically more women, mainly elderly women, who will develop osteoarthritis. While it is believed that it is generally related to menopausal hormone loss, it is not yet fully understood why this is the case.

Also, athletes who have sustained multiple joint injuries over their career may be affected by osteoarthritis. The primary cause for this is purely mechanical in nature, due to joint damage that has been caused by excessive weight-bearing activities or running. An example of this would be how recreational runners are more prone to hip osteoarthritis, which tends to be the reverse for professional runners. It should be considered that any significant injury to ligaments, tendons, joints, or bones may lead to an increased risk of osteoarthritis. Also, specific heavy weight-bearing activities and repetitive motions throughout several occupations and leisurely activities may contribute to the development of osteoarthritis.

While it is a rare, osteoarthritis may be due to chemical, genetic, or metabolic variables. Specific studies have shown that 50% of all hip and hand cases were due to a positive family history of osteoarthritis. Also, anatomic misalignments and muscle weaknesses may lead to increased development of osteoarthritis.

Studies have shown that the expected number of cases may double in the year 2020 due to the general prevalence of obesity and the global population, as well as the increased lifespan. Individuals with an increased body weight live with significant stress on the knees, which leads to overbearing stress on the knee joints.

Medical Testing

The overall goals of specific medical tests are to help distinguish osteoarthritis from other causes of joint pain as well as other forms of arthritis and monitor any side effects due to various treatments.

Laboratory Testing

In many cases, blood testing is generally not useful in the diagnosis of osteoarthritis. Typically, physicians will diagnose an individual by getting their family history, performing x-rays, physical exams as well as an examination of synovial fluid from the affected joint. Other tests may be ordered to help rule out other conditions and evaluate the individual’s health, including:

  • Cyclic citrullinated peptide antibody and Rheumatoid factor which are used in the diagnosis of rheumatoid arthritis and helps to differentiate it from osteoarthritis.
  • Synovial fluid analysis is used to check for signs of joint infection as well as the detection of uric acid crystals that could indicate gout, which may contribute to joint damage in osteoarthritis.
  • Erythrocyte sedimentation rate is a test that is used to detect the amount of inflammation in the body and may be increased in RA but not necessarily osteoarthritis.
  • C-reactive protein can be used to test for the activity of the disease as well as inflammation. It can help distinguish between osteoarthritis and rheumatoid arthritis. An overall increased level of CRP occurs in rheumatoid arthritis but not osteoarthritis.
  • The complete blood count is used to help evaluate white and red blood cells as well as hemoglobin and may be ordered by the physician to monitor the overall side effects of some osteoarthritis treatments.
  • comprehensive metabolic panel is used in the evaluation and monitoring of liver and kidney functions.