Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis. It’s a degenerative joint disease where cartilage gradually wears down, leading to pain, stiffness, swelling, and reduced mobility—most often in the knees, hips, hands, and spine. Symptoms usually worsen with activity and improve with rest. Risk factors include age, prior joint injury, repetitive overuse, excess body weight, and family history.

Blood tests do not diagnose OA directly, but they are valuable to rule out inflammatory and autoimmune arthritis(such as rheumatoid arthritis or lupus) and to evaluate other causes of joint pain, like gout. Ulta Lab Tests offers quick access to relevant markers so you and your clinician can move confidently from questions to next steps.


Signs & Symptoms (When to consider testing)

  • Mechanical joint pain: worse with movement or at day’s end; eased by rest

  • Brief morning stiffness: typically <30 minutes

  • Swelling or effusion: intermittent puffiness after activity

  • Crepitus: grinding or crackling sounds during movement

  • Bony enlargement: finger nodes (Heberden’s/Bouchard’s), enlarged knee contours

  • Reduced range of motion & function: difficulty kneeling, gripping, climbing stairs

  • Alignment changes: bow-legged or knock-knee appearance in advanced knee OA

  • Systemic symptoms usually absent: fevers, weight loss, and marked fatigue suggest inflammatory arthritis rather than OA

Related search terms: osteoarthritis blood tests, rule out rheumatoid arthritis, OA vs RA, knee osteoarthritis, hip osteoarthritis, degenerative joint disease (DJD).


Why These Tests Matter

What OA-related labs can do

  • Help differentiate OA from inflammatory/autoimmune arthritis using markers of systemic inflammation and autoantibodies

  • Support evaluation for gout or other mimics when symptoms overlap

  • Provide baseline health context that informs overall joint care

What they cannot do

  • Confirm osteoarthritis or show joint damage—imaging (X-ray/MRI/ultrasound) and clinical exam are needed

  • Replace a clinician’s assessment or guide treatment on their own


What These Tests Measure (at a glance)

  • CRP & ESR: inflammation markers—often normal in OA; elevated levels suggest an inflammatory process or flare from another condition

  • Rheumatoid factor (RF) & anti-CCP: autoantibodies that support rheumatoid arthritis if positive; typically negative in OA

  • ANA: screens for connective-tissue disease (e.g., lupus) when symptoms suggest a systemic autoimmune cause

  • Uric Acid: helps evaluate gout, a crystal-induced arthritis that can mimic OA flares

  • CBC/CMP: overall health context (anemia of chronic disease, organ function) that may inform management


How the Testing Process Works

  1. Order online: choose an arthritis screen or individual markers.

  2. Visit a nearby lab: quick blood draw at a patient service center.

  3. Get results fast: most post within 24–48 hours in your secure account.

  4. Review with your clinician: interpret labs alongside symptoms, exam, and imaging.


Interpreting Results (general guidance)

  • Normal CRP/ESR with negative RF/anti-CCP/ANA → findings favor OA over inflammatory arthritis

  • Elevated CRP/ESR → consider inflammatory causes or coexisting conditions

  • High uric acid with acute, swollen, tender joint → evaluate for gout

  • Normal labs do not exclude pain from mechanical OA; imaging shows joint space narrowing, osteophytes, and subchondral changes

Always interpret results with a qualified healthcare professional.


Choosing Panels vs. Individual Tests

  • If the cause of joint pain is unclear: start with a broad arthritis screen (CRP, ESR, RF, anti-CCP, ± ANA).

  • If gout is suspected: add Uric Acid.

  • If OA is likely and stable: labs may be limited or normal; imaging becomes central for confirmation and staging.


FAQs

Can blood tests diagnose osteoarthritis?
No. Blood tests mainly help rule out inflammatory or autoimmune arthritis. OA diagnosis relies on history, physical exam, and imaging.

Which blood tests help differentiate OA from RA?
CRP, ESR, RF, and anti-CCP. RA often shows elevated inflammation and positive autoantibodies; OA typically does not.

Do I need lab tests if my X-ray already shows OA?
Often, no additional labs are required unless your clinician suspects another condition (e.g., gout, RA) or wants baseline health data.

What are early signs of OA?
Activity-related pain, brief morning stiffness, crepitus, and gradual loss of flexibility or function.

How quickly will I get results?
Most Ulta Lab Tests results are available within 24–48 hours after your blood draw.

Do I need a referral to order tests?
No referral is required to order through Ulta Lab Tests. Review the results with your clinician for diagnosis and planning.


Internal Links & Cross-References

  • Upward: Arthritis Testing Hub

  • Sideways: All Arthritis Tests • Rheumatoid Arthritis • Ankylosing Spondylitis • Juvenile Rheumatoid Arthritis • Psoriatic Arthritis

  • Downward: CRP • ESR • RF • anti-CCP • ANA • Uric Acid • CBC • CMP


Available Tests & Panels

Tip: If symptoms are unclear, begin with a screening panel (CRP/ESR + RF/anti-CCP ± ANA). Add Uric Acid if gout is in the differential.

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Blood Draw

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Blood Draw, Phlebotomist

Blood
Blood Draw, Phlebotomist

Blood
Blood Draw

The ANA Screen IFA with Reflex to Titer and Pattern Test detects antinuclear antibodies in blood to evaluate autoimmune activity. If positive, further testing identifies antibody concentration (titer) and fluorescence pattern, helping diagnose conditions like lupus, rheumatoid arthritis, or Sjögren’s syndrome. Doctors order this test to investigate symptoms such as joint pain, fatigue, rash, or swelling and to guide treatment for autoimmune and connective tissue disorders.

Also Known As: ANA Test, Antinuclear Antibody Screen Test

The C-Reactive Protein (CRP) Test measures CRP levels in blood to detect inflammation in the body. Elevated CRP may indicate infections, autoimmune disorders, or chronic diseases such as arthritis, cardiovascular disease, or inflammatory bowel disease. Doctors use this test to assess acute illness, monitor treatment response, and evaluate risk for heart disease. The CRP test provides key insight into inflammation, immune health, and overall wellness.

Blood
Blood Draw
Also Known As: CRP Test, Inflammation Test

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

Blood
Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

Blood
Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

Most Popular

The Cyclic Citrullinated Peptide (CCP) IgG Antibody Test helps diagnose rheumatoid arthritis by detecting antibodies strongly linked to autoimmune joint disease. A positive result may indicate early or developing RA, even before symptoms appear. Doctors order this test for patients with joint pain, stiffness, or swelling. Results, often used with the rheumatoid factor (RF) test, provide valuable insight into autoimmune activity and long-term joint health management.

Blood
Blood Draw
Also Known As: Anti-CCP, Cyclic Citrullinated Peptide IgG Antibody Test

The Lipid Panel with Ratios Test measures seven key markers: total cholesterol, HDL, LDL, non-HDL cholesterol, triglycerides, Chol/HDL ratio, and LDL/HDL ratio. This advanced panel evaluates cardiovascular risk by assessing cholesterol balance and fat metabolism. Doctors use it to detect high cholesterol, atherosclerosis risk, and heart disease, and to monitor treatment. Often part of routine exams, it provides insight into long-term heart and metabolic health.

Also Known As: Lipid Profile Test, Cholesterol Panel Test, Lipid Blood Test

The Rheumatoid Factor (RF) Test measures RF antibodies in blood to help diagnose rheumatoid arthritis and other autoimmune conditions. High RF levels may indicate rheumatoid arthritis, Sjögren’s syndrome, or other connective tissue diseases, though they can also appear in some infections. Doctors order this test to investigate joint pain, stiffness, or swelling. Results provide important insight into autoimmune activity, joint health, and inflammatory disease management.

Blood
Blood Draw
Also Known As: RF Test, Rheumatoid Arthritis Factor Test

Most Popular

The Sed Rate Test, also called the ESR Test, measures how quickly red blood cells settle in a sample of blood. A faster rate may signal inflammation caused by infections, autoimmune diseases, arthritis, or other chronic conditions. Doctors use this test to investigate unexplained fever, joint pain, or muscle aches, and to monitor inflammatory disorders such as lupus or rheumatoid arthritis. The Sed Rate Test provides important insight into overall inflammatory activity.

Blood
Blood Draw
Also Known As: Erythrocyte Sedimentation Rate Test, ESR Test, Sedimentation Rate Test, Westergren Sedimentation Rate Test

The Sedimentation Rate Blood Test, also called the Erythrocyte Sedimentation Rate (ESR) Test, measures how quickly red blood cells settle in a sample. A faster rate can signal inflammation linked to arthritis, autoimmune disease, or infection. Doctors order this test when patients have symptoms like joint pain, fever, or fatigue. While not diagnostic alone, results provide valuable insight into inflammatory activity and help guide further evaluation and treatment.

Blood
Blood Draw
Also Known As: Sed Rate Test

Did you know over 54 million adults in the US have osteoarthritis (OA)? In addition, over 24 million adults are limited in the activities they can do because of OA.

When you're in pain, it's all too easy to feel alone. But you can take charge of your symptoms by getting the osteoarthritis tests you need to get the answers you deserve.

Remember, there is help available for the pain that osteoarthritis brings. But your most powerful tool is educating yourself about OA and what you can do to manage your symptoms.

So if you want to learn more about osteoarthritis and osteoarthritis tests, keep reading this guide to find out everything you need to know!

What is Osteoarthritis

Osteoarthritis is the most common form of arthritis. Osteoarthritis occurs when the cartilage that protects your joints wears down over the years. 

Cartilage is the slippery tissue that allows your joints to remain moving in a fluid motion. When your cartilage breaks down, it enables your bone to surfaces to become rough and jagged. 

Cartilage doesn't have blood vessels or blood supplies, so for this reason, damaged cartilage can't repair itself.

Osteoarthritis can occur in any joint, but it's most common in your spine, hips, hands, and knees.

It's vital to remember OA is progressive. OA progresses in stages from 0 to 4. The first stage indicates a normal joint, and stage 4 means severe OA. As OA goes through the stages, you'll have increased pain, swelling, inflammation, decreased range of motion, and unstable joints.

Causes of Osteoarthritis

Osteoarthritis is often referred to as wear and tear disease.  As you age, your joints naturally start to break down.

But there are risk factors and other disease conditions that put you at higher risk for developing OA.

Risk factors for Osteoarthritis

Risk factors that can make osteoarthritis a reality include:

Obesity is one of the most significant risk factors as it puts extra stress on your joints, especially the knees and hips.

Past joint injuries or surgery can put you at greater risk for OA, as can congenital joint abnormalities at birth.

A job or hobby that requires you to make repeated motions over and over again can increase your chances of getting OA.

If you have had a joint inflammatory condition like rheumatoid arthritis, it can lead to your joints breaking down faster.

Diabetes and changes in hormone levels can cause inflammation and lead to arthritis. And menopause brings changes to the estrogen levels that protect your bones and joints. Once estrogen levels fall, you're at higher risk for OA.

Osteoarthritis Symptoms

When you have osteoarthritis, the symptoms slowly worsen in time in stages. But when you have osteoarthritis, you'll notice things like:

  • Joint pain with movement
  • Joint stiffness, especially after waking up in the morning
  • Your joints lose flexibility
  • Your joints feel tender upon touch
  • You may notice your joints pop and crack
  • Joint swelling

Sometimes extra bits of bone (bone spurs) form around your joints which feel like hard lumps. If your joint pain and stiffness won't let up, then it's time to contact your doctor.

Complications of Osteoarthritis

Osteoarthritis is degenerative, meaning it continues to get worse over time. Joint pain can become severe, making daily tasks almost impossible.

Osteoarthritis Treatment

The damage from osteoarthritis can't be reversed, but treatments are available to reduce your joint pain and improve your quality of life.

The first line of treatment includes medications to help relieve your symptoms. Your doctor will typically recommend over-the-counter medicines like Tylenol, Advil, or prescription anti-inflammatory medication, depending on your situation.

The next line of treatment involves physical therapy for exercises to strengthen the muscles around your joint and improve flexibility.

You may also need occupational therapy if you're having trouble with everyday tasks. An occupational therapist will help you learn different ways of moving to put less stress on your joints.

Some people might need assistive devices like a bench in the shower to alleviate the strain.

If medications and therapy don't work for you, other treatments are available, like steroid injections into your joints. In severe cases, joint replacement surgery may be the best solution.

Lifestyle Changes

One of the most important things you can do to manage the symptoms and progression of OA is making lifestyle changes. Exercise and weight loss go a long way in reducing the pain and stiffness that come with OA.

Gentle exercise like swimming or walking is a great way to keep active. You can also try biking or water aerobics. But the important thing is to make it a part of your daily routine. The worst thing you can do when you have OA is sitting and not moving.

When you carry extra weight, you put stress on your already arthritic joints. Even losing just 10lbs can make a massive difference for your joints. If you struggle with weight, talk to your doctor or a dietician to help you come up with a plan.

Other options

Yoga, tai chi, and deep breathing work amazingly well to improve your joint flexibility and stress at the same time. Choose yoga that's gentle and easy and avoid any movements that stress your joints.

Applying both heat and cold to your joints can relax your muscles and reduce pain. You can do this after exercise or at the end of the day.

Some people also find relief from using Capsaicin cream. Capsaicin is the active ingredient in chili peppers, and when applied as a topical cream, it can change the way your body responds to pain. 

Many people find relief using this cream, but it can cause some skin irritation. So talk to your doctor first if you think it might be for you.

Osteoarthritis Diagnosis

You'll first see your doctor and have a physical exam. Your doctor will check your joints for tenderness, swelling, and redness.

To get a clear picture of your joints, your doctor may order X-rays to rule out any other problems. If you have severe symptoms, you might also have an MRI to look at your bones and soft tissues.

Although there isn't one single blood test that can diagnose arthritis, your doctor will order a series of blood tests to rule out other issues like rheumatoid arthritis.

Lab Tests for Osteoarthritis

In general, the goal of ordering a blood osteoarthritis test is to distinguish osteoarthritis from other inflammatory or autoimmune conditions.

comprehensive Osteoarthritis panel from Ulta Lab Tests is a great way to get all the tests you need.

First, your doctor will want to check your rheumatoid factor (RF). This test will determine if your symptoms are caused by rheumatoid arthritis RA instead. Your rheumatoid factor will be negative with RA.

Another test commonly ordered is an Erythrocyte sedimentation rate (ESR) test. The ESR detects inflammation in your body and will be increased with RA, but not with osteoarthritis. Also, a C-reactive protein (CRP) detects inflammation and is elevated with RA.

Your doctor will also check your complete blood count (CBC) and comprehensive metabolic panel (CMP). These panels will assess your overall health status and see how well you'll be able to tolerate any OA medications you might need.

Sometimes your doctor may want to do a joint fluid analysis. OA, infections, and other inflammatory conditions can change the way your joint fluid appears. Fluid is drawn out from your joint and analyzed under a microscope.

Osteoarthritis FAQS

Did you know osteoarthritis is the leading cause of disability in the United States, and more women are more likely to develop OA than men?

Joint surgery is effective and considered to be one of the most successful operations in medicine today. For example, if you get hip replacement surgery, you have over a 95% chance of success at a full recovery. 

You've likely heard that cracking your joints causes arthritis? This is a myth, so you don't have to worry that your knuckle-cracking habit will land you with OA.

It's also a myth that osteoarthritis isn't a serious health problem. While OA may take a back seat to cancer and heart disease, it still affects over 50 million people a year and with healthcare costs of over 150 billion.

Osteoarthritis Tests

Ulta Lab Tests offers tests that are highly accurate and reliable so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

For your osteoarthritis testing needs, choose Ulta Lab Tests. We offer accurate
and reliable tests that give results you can trust.

And the best part is you don't need insurance or a referral. Our affordable prices include a doctor's order, so you're never alone.

Once you order your osteoarthritis tests, you'll have secure and confidential results available to you within 24 to 48 hours in most cases. 

Take control of your health today with Ulta Lab Tests.