Beta-2-Microglobulin, Serum

The Beta-2-Microglobulin, Serum test contains 1 test with 1 biomarker.

Description: The Beta 2 Microglobulin test is a blood test used to detect the protein Beta-2 Microglobulin in your blood’s serum, and is used in the examination of multiple myeloma and lymphoma.

Also Known As: B2M Test, β2-Microglobulin Test, Thymotaxin Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When is a Beta-2 Microglobulin test ordered?

This test may be requested during the initial examination of a patient with multiple myeloma in order to stage the condition as well as on an ongoing basis to assess disease activity and track the efficacy of treatment. When a person has myeloma or lymphoma, it may occasionally be requested to help evaluate their prognosis.

What does a Beta-2 Microglobulin test check for?

Almost every cell in the body has beta-2 microglobulin on its surface. Cells, notably B lymphocytes and tumor cells, release this protein into the blood. It is found in the majority of bodily fluids, and when the immune system is stimulated or when cell creation and/or destruction are increased, its level rises.

With tumors like multiple myeloma and lymphoma, as well as with inflammatory conditions and infections, B2M is typically high in the blood. B2M may be useful as a tumor marker because it is elevated in blood cell malignancies. This page concentrates on its usage as a tumor marker, despite the fact that it can be used to evaluate kidney function.

Blood cell malignancies that have migrated to the brain, such lymphoma, as well as some chronic diseases like multiple sclerosis and viral infections like HIV can cause a rise in the B2M level in the CSF of affected individuals.

Lab tests often ordered with a Beta-2 Microglobulin test:

  • Albumin
  • Tumor Markers

Conditions where a Beta-2 Microglobulin test is recommended:

  • Cancer
  • Multiple Myeloma
  • Lymphoma

How does my health care provider use a Beta-2 Microglobulin test?

On the surface of almost every cell in the body is beta-2 microglobulin. This protein is released into the blood by cells, particularly B lymphocytes and tumor cells. The majority of body fluids contain it, and its level increases when the immune system is activated or when cell formation and/or destruction are elevated.

B2M is generally elevated in the blood with cancers such multiple myeloma and lymphoma, as well as with inflammatory diseases and infections. Due to the fact that B2M is raised in blood cell malignancies, it may be useful as a tumor marker. Despite the fact that it can be used to assess kidney function, this page focuses on its use as a tumor marker.

A spike in the B2M level in the CSF of affected people can be brought on by blood cell malignancies that have spread to the brain, including lymphoma, as well as some chronic conditions like multiple sclerosis and viral infections like HIV.

What do my Beta-2 Microglobulin test results mean?

Increased levels of B2M in the blood and/or urine point to a problem but do not serve as a diagnosis for any particular illness or condition. They do, however, represent the level of cancer present and the severity of the disease. If the B2M level is highly raised, someone who has been diagnosed with multiple myeloma or lymphoma is likely to have a worse prognosis.

When multiple myeloma is being treated, a patient's levels should gradually decline over time to show whether the patient is improving. Levels that are stable or rising suggest that the subject is not responding.

Increases in the CSF in a person with an illness like HIV/AIDS suggest that the central nervous system is probably involved.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Beta2Microglobulin Serum

Beta 2 Microglobulin,

*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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