Immunity

Immunity tests evaluate how well your immune system responds to infections and vaccines. They include antibody titers (evidence of past vaccination or exposure) and immune-function screens (immunoglobulins, lymphocyte subsets, and complement). People use these labs to document immunity for school or work, to check vaccine response, or to investigate frequent infections.

A proactive approach starts with what you need to answer: Do I have protective antibodies? (vaccine titers), Is my immune system balanced? (IgG/IgA/IgM, IgG subclasses), ... See more

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Blood
Blood Draw, Phlebotomist

 The Immunity Panel is a set of laboratory tests designed to assess an individual's immunity status against specific infectious diseases. By measuring the presence and levels of specific antibodies in the blood, the panel provides valuable insights into whether an individual has been previously exposed to these pathogens or has been vaccinated against them, thus offering protection.
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Blood Draw, Phlebotomist

 The Immunity Panel Plus is a comprehensive set of tests designed to evaluate an individual's immunity to certain infectious diseases. This panel includes tests for Hepatitis A Antibody Total, Hepatitis B Surface Antibody, Quantitative, Measles IgG Antibody, Mumps IgG Antibody, Rubella IgG Antibody, and Varicella-Zoster Virus IgG Antibody. It is often used to determine if an individual has immunity, either from previous infections or vaccinations, against these specific diseases.
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Blood Draw, Phlebotomist

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

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Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Cytomegalovirus (CMV) IgG Antibody Test detects IgG antibodies to CMV, indicating past infection or immunity. This blood test helps determine prior exposure, assess immune status in pregnancy, transplant patients, or immunocompromised individuals, and guide risk evaluation. A positive result shows past CMV infection, while results are used with IgM testing to distinguish recent vs. past infection.

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Blood Draw
Also Known As: CMV IgG Antibody Test, Cytomegalovirus IgG Test

The Cytomegalovirus (CMV) IgM Antibody Test detects IgM antibodies, indicating a recent or active CMV infection. This blood test helps diagnose primary CMV, reactivation, or reinfection, especially important for pregnant women, transplant candidates, and immunocompromised patients. Used with CMV IgG testing, it helps distinguish new infections from past exposure for accurate clinical evaluation.

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Blood Draw
Also Known As: CMV IgM Antibody Test, Cytomegalovirus IgM Test

The Diphtheria Titer Test measures antibody levels to evaluate immune protection against Corynebacterium diphtheriae, the bacterium that causes diphtheria. This test helps determine whether immunity is adequate following vaccination or exposure. By assessing diphtheria antibody titers, it provides insight into immune system response, vaccine effectiveness, and long-term protection against this serious infection.

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Blood Draw
Also Known As: Diphtheria Antitoxoid Test

The Hepatitis A IgM Antibody Test is a qualitative blood test that detects IgM antibodies to the hepatitis A virus (HAV) and reports results as Reactive or Non-Reactive. A reactive result usually indicates a recent or current hepatitis A infection, while a non-reactive result means no active infection. Doctors use this test to confirm acute hepatitis A in patients with symptoms like jaundice, nausea, fatigue, or abdominal pain and to guide timely treatment and prevention.

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Blood Draw
Also Known As: Hep A IgM test, HAV IgM Ab Test

The Hepatitis B Core Antibody Total Test is a qualitative blood test that detects antibodies to the hepatitis B core antigen (anti-HBc) and reports results as Reactive or Non-Reactive. A reactive result may indicate past or ongoing infection, while a non-reactive result suggests no exposure. This test does not distinguish between IgM and IgG antibodies. Doctors use it to evaluate hepatitis B exposure, confirm infection history, and assess overall immune response.

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Blood Draw
Also Known As: HBcAb Total Test, HBc Total Test, Hep B Core Ab Total Test

The Hepatitis B Immunity Panel Test evaluates immune status by measuring Hepatitis B surface antibody levels in the blood. A positive result typically indicates immunity from vaccination or past infection, while a negative result suggests susceptibility. This test is important for verifying protection, monitoring vaccine response, or determining if additional vaccination or further evaluation for Hepatitis B exposure is needed.


The Hepatitis B Surface Antibody Quantitative Test measures the exact level of anti-HBs antibodies in blood to determine past exposure and whether protective immunity has developed from infection or vaccination. A higher antibody level generally indicates adequate immune response, while a low level suggests limited or no protection. Doctors use this test to confirm vaccine effectiveness, assess immune status, and support hepatitis B screening or preventive care.

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Blood Draw
Also Known As: HBsAb Qn Test, Hepatitis B Titer Test

The Hepatitis B Surface Antigen (HBsAg) Test with Reflex to Confirmation screens for hepatitis B surface antigen in blood and, if reactive, automatically performs confirmatory testing. A reactive confirmed result indicates an active hepatitis B infection, while a non-reactive result shows no infection. Doctors use this test to diagnose acute or chronic hepatitis B, investigate abnormal liver tests, and guide treatment, monitoring, and infection control decisions.

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Blood Draw
Also Known As: HBsAg Test, Hep B Surface Ag Test, HBs Antigen Test, Hep B Test

The Hepatitis B Test (Hepatitis B Surface Antigen with Reflex to Confirmation) screens for hepatitis B surface antigen (HBsAg) in the blood to identify active infection. If the result is positive, a confirmation test is automatically performed to verify accuracy and support proper diagnosis.

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Blood Draw

The Herpes 1 IgG Antibody Test detects IgG antibodies to HSV-1, the virus that commonly causes oral herpes (cold sores). IgG develops weeks after exposure and remains for life, making this test useful for confirming past infection and exposure history. Doctors order it for patients with oral sores, blisters, or concerns about herpes transmission. Results help confirm HSV-1 infection, guide treatment, and support counseling and prevention strategies.

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Blood Draw
Also Known As: Herpes Simplex Virus 1 IgG Type-Specific Antibody HerpeSelect® Test, Herpes 1 IgG Test, Oral Herpes Test

The Herpes 1 and 2 Test uses type-specific HSV-1/HSV-2 IgG to assess past infection and differentiate exposure to each virus. It is useful for evaluating recurrent lesions, screening asymptomatic partners, and documenting baseline status for clinical management. Because IgG can take 2–12 weeks to develop, early negatives may need repeat testing; HSV-2 reactive results reflex to an inhibition assay to verify specificity and reduce cross-reactivity.

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The Herpes 2 IgG Antibody Test detects IgG antibodies to HSV-2, the virus that most often causes genital herpes. IgG develops weeks after infection and remains for life, making this test valuable for confirming past exposure or infection history. Doctors order it for patients with genital sores, blisters, or concerns about herpes transmission. Results help confirm HSV-2 infection, guide treatment, and support counseling, prevention, and long-term care.

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Blood Draw
Also Known As: Herpes Simplex Virus 2 IgG HerpeSelect® Test with Reflex to HSV 2 Inhibition, Herpes 2 IgG Test, Genital Herpes Test

The Herpes Simplex Virus 1 and 2 IgG Type-Specific Antibody HerpeSelect® Test detects IgG antibodies to HSV-1 and HSV-2, distinguishing between the two types. A positive result indicates past exposure, as IgG develops weeks after infection and remains long-term. Doctors use this test to confirm herpes diagnosis, guide treatment, or support sexual health decisions. Results provide vital insight into HSV status, infection history, and long-term immune response.

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Blood Draw
Also Known As: Herpes 1 and 2 Test, Herpes IgG Test

The Interleukin 2 Receptor (IL-2R) Test evaluates soluble receptor levels in blood, reflecting immune system activation and regulation. Increased IL-2R may be seen in lymphoma, sarcoidosis, autoimmune conditions, and chronic inflammatory disease. This test provides insights into T-cell activation, immune dysregulation, and disease monitoring, helping guide evaluation of systemic immune health.
 

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Blood Draw

The Iron Total and Total Iron Binding Capacity (TIBC) Test measures iron levels in blood along with the blood’s ability to transport iron. It helps diagnose iron deficiency anemia, iron overload (hemochromatosis), and monitor nutritional or chronic health conditions. Low iron or high TIBC may indicate anemia, while high iron or low TIBC can suggest overload. Doctors use this test to evaluate fatigue, weakness, or other symptoms linked to iron and metabolic health.

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Blood Draw
Also Known As: Serum Iron Test, Total Iron Binding Capacity Test, TIBC Test, UIBC Test

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The Magnesium Serum Test measures magnesium levels in blood to evaluate electrolyte balance, nerve and muscle function, and overall metabolic health. Abnormal levels may indicate kidney disease, malnutrition, gastrointestinal disorders, or uncontrolled diabetes. Low magnesium can cause weakness, cramps, or irregular heartbeat, while high levels may signal kidney dysfunction. Doctors use this test to diagnose deficiencies, monitor therapy, or assess chronic health conditions.

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Blood Draw
Also Known As: Mg Test, Mag Test

The Measles IgG IgM Antibodies Test measures immune response to the measles virus by detecting IgM for recent or acute infection and IgG for past exposure or vaccine immunity. This test helps confirm suspected measles cases in patients with fever, rash, cough, or conjunctivitis, and evaluates immunity in those with uncertain vaccination history, supporting diagnosis, outbreak control, and public health monitoring.

Also Known As: Rubeola Test, Measles Virus Test, Measles Titer test, Measles Infection Test

The Measles IgG Antibody Test measures IgG antibodies to determine immunity from past infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility to measles. Doctors use this blood test to confirm immune status, evaluate vaccination records, or meet school, travel, or employment requirements. It provides valuable insight into measles protection and public health safety.

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Blood Draw
Also Known As: Rubeola Test, Measles Virus Test, Measles Titer Test

The Measles Titer Test measures IgG antibody levels to determine immunity from prior measles infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility. Doctors order this test to confirm immune status for school, healthcare, travel, or employment requirements. It is also used to verify vaccination response, ensuring individuals are protected against measles and reducing outbreak risk.

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Blood Draw
Also Known As: Rubeola Test, Measles Virus Test, Measles IgG Antibody Test

The Measles, Mumps, Rubella (MMR) Immunity Profile is a quantitative blood test that measures antibody levels to measles, mumps, and rubella. Results confirm prior infection or vaccine response and show if antibody levels are protective. Doctors order this test for school, employment, or travel requirements, to evaluate vaccine effectiveness, and to guide revaccination decisions. It provides reliable assessment of immune protection against all three viral diseases.

Also Known As: MMR Titer Test

Did you know over 200 forms of primary immune deficiency diseases affect almost 500,000 people in the United States? 

Primary immune deficiency diseases (PIDDs) are rare, costly, and can lead to disability and huge changes in your life. Immunity blood tests are critical in the diagnosis and treatment of these disorders.

If you lack immunity to common diseases and wonder about a blood test to check your immune system, you're in the right place.

Keep reading this guide to learn everything you need to know about immunity deficiencies and immunity blood tests.

What is Immune Deficiency

Immunity deficiency is categorized by a group of disorders called primary immune deficiency diseases (PIDDs). These disorders are rare, genetic, and impair your immune system. If your immune system doesn't function properly, you're subject to debilitating and chronic infections.

Over 200 forms of PIDDs can be diagnosed in infancy, ... See more