Aplastic Anemia Test

Aplastic anemia is a rare and serious disease that is caused by damage to bone marrow and can be very dangerous. Bone marrow is where new blood cells are made. 

Platelets die every six days, and red and white blood cells die after 120 days. Healthy persons are unaffected by blood cell loss because their bone marrow produces new cells to replace the ones that have died. When the bone marrow is injured, however, it stops producing new blood cells, resulting in a low blood cell count. This failure to produce new blood cells manifests itself in a variety of ways, including a blood illness known as aplastic anemia.  

The aplastic anemia test may be found here if you want to know how many blood cells you have. Several aspects of your blood will be examined during this test, including your hemoglobin and hematocrit levels. Ulta Lab Tests has tests that can help you figure out whether you're anemic. 

On this page, you may select from a variety of lab tests. You can order them, have your specimen collected, and find out your results in 1 to 2 business days for most of them. 

guide to lab tests for aplastic anemia is below a list of anemia tests. You can read it to learn more about the tests.


Name Matches

A Complete Blood Count (CBC) Panel is used as a screening test for various disease states including anemia, leukemia, and inflammatory processes.

A CBC blood test includes the following biomarkers: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet count, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)

NOTE: Only measurable biomarkers will be reported.

Reflex Parameters for Manual Slide Review
  Less than  Greater Than 
WBC  1.5 x 10^3  30.0 x 10^3 
Hemoglobin  7.0 g/dL  19.0 g/dL 
Hematocrit  None  75%
Platelet  100 x 10^3  800 x 10^3 
MCV  70 fL  115 fL 
MCH  22 pg  37 pg 
MCHC  29 g/dL  36.5 g/dL 
RBC  None  8.00 x 10^6 
RDW  None  21.5
Relative Neutrophil %  1% or ABNC <500  None 
Relative Lymphocyte %  1% 70%
Relative Monocyte %  None  25%
Eosinophil  None  35%
Basophil  None  3.50%
     
Platelet  <75 with no flags,
>100 and <130 with platelet clump flag present,
>1000 
Instrument Flags Variant lymphs, blasts,
immature neutrophils,  nRBC’s, abnormal platelets,
giant platelets, potential interference
     
The automated differential averages 6000+ cells. If none of the above parameters are met, the results are released without manual review.
CBC Reflex Pathway

Step 1 - The slide review is performed by qualified Laboratory staff and includes:

  • Confirmation of differential percentages
  • WBC and platelet estimates, when needed
  • Full review of RBC morphology
  • Comments for toxic changes, RBC inclusions, abnormal lymphs, and other
  • significant findings
  • If the differential percentages agree with the automated counts and no abnormal cells are seen, the automated differential is reported with appropriate comments

Step 2 - The slide review is performed by qualified Laboratory staff and includes: If any of the following are seen on the slide review, Laboratory staff will perform a manual differential:

  • Immature, abnormal, or toxic cells
  • nRBC’s
  • Disagreement with automated differential
  • Atypical/abnormal RBC morphology
  • Any RBC inclusions

Step 3 If any of the following are seen on the manual differential, a Pathologist will review the slide:

  • WBC<1,500 with abnormal cells noted
  • Blasts/immature cells, hairy cell lymphs, or megakaryocytes
  • New abnormal lymphocytes or monocytes
  • Variant or atypical lymphs >15%
  • Blood parasites
  • RBC morphology with 3+ spherocytes, RBC inclusions, suspect Hgb-C,
  • crystals, Pappenheimer bodies or bizarre morphology
  • nRBC’s

Vitamin B12 is decreased in pernicious anemia, total or partial gastrectomy, malabsorption and certain congenital and biochemical disorders


Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. 

Reflex Information: If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge.


Epstein-Barr Virus (EBV) Antibody Panel

Includes: Epstein-Barr Virus VCA Antibody (IgM), Epstein-Barr Virus VCA Antibody (IgG), Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

Clinical Significance: Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgM is typically detectable at clinical presentation, then declines to undetectable levels within a month in young children and within 3 months in other individuals. VCA-IgG is typically detectable at clinical presentation, and persists for life. EBNA IgG typically appears during convalescence (3-4 months after clinical presentation) and remains detectable for life.

EBV-VCA IgG/IgM (viral capsid antigen): A positive IgG means you’ve had or currently have the infection; A positive IgM means the virus has been reactivated.

EBV-EBNA IgG (nuclear antigen): A positive test result is usually associated with past infections.

Reference Range(s)

Epstein-Barr Virus VCA Antibody (IgM)

U/mLInterpretation

  • <36.00 Negative
  • 36.00-43.99Equivocal
  • >43.99Positive


Epstein-Barr Virus VCA Antibody (IgG)

U/mLInterpretation

  • <18.00 Negative
  • 18.00-21.99Equivocal
  • >21.99Positive


Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

U/mLInterpretation

  • <18.00 Negative
  • 18.00-21.99Equivocal
  • >21.99Positive

Alternative Name(s)

EBV Comprehensive,Infectious Mononucleosis Panel

 


Most Popular

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Use in evaluating erythropoietic activity.

This assay is used to monitor exposure to arsenic, wellness, and therapy during treatment of chronic myelocytic leukemia.

CMV infections are common and usually asymptomatic. In patients who are immunocompromised, CMV may cause disseminated, severe disease. CMV may cause birth defects in a minority of infected newborns. Antibody IgG may represent prior exposure or recent infection if there is a significant change in titer between acute and convalescent specimens.

CMV infections are common and usually asymptomatic. In patients who are immunocompromised, CMV may cause disseminated, severe disease. CMV may cause birth defects in a minority of infected newborns.

Epstein-Barr Virus DNA, Real-Time PCR is useful in assessing active disease. Central nervous system infections can be diagnosed with CSF specimens.

Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgG is typically detectable at clinical presentation, and persists for life. Absence of VCA-IgG usually indicates the patient is susceptible to EBV infection.

Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgM is typically detectable at clinical presentation, then declines to undetectable levels within a month in young children and within 3 months in other individuals.

Test not available in the following States: CA, MD, NY, PA and RI.



Your body is a complex machine, and sometimes things can go wrong that are not easy to spot from the outside. There are some diseases, illnesses, and other conditions which require lab tests to confirm what exactly is going on inside of the body. An example of a condition that must be diagnosed through a blood test is aplastic anemia. 

What is Aplastic Anemia?

Aplastic anemia is a rare and serious disease caused by damage to bone marrow. Bone marrow is responsible for the production of new blood cells.

Blood cells die naturally after 120 days for red/white cells and every 6 days for platelets. In a healthy person, the death of a blood cell is not a concern because the bone marrow simply creates new cells to replace the dead ones.

However, when damage is done to the bone marrow, the damage prevents the bone marrow from making new blood cells, leading to a reduced blood cell count. This inability to produce new blood cells causes a wide range of symptoms and complications.

Risk Factors of Aplastic Anemia

As stated above, aplastic anemia is caused by damaged bone marrow that is unable to produce enough new blood cells. Factors that increase the risk of damaging bone marrow and developing aplastic anemia include:

  • Radiation exposure, including chemotherapy treatments
  • Autoimmune diseases
  • Pregnancy
  • Exposure to toxic chemicals or consumption of some medications
  • Family history of the disease

Aplastic anemia can develop at any age, and it occurs equally in men and women. The disease is 2-3 times more prevalent in Asian countries.

Causes of Aplastic Anemia

Possible causes of aplastic anemia include:

  • Exposure to toxins, such as benzene, arsenic, and pesticides.
  • Exposure to chemotherapy and radiation (used to treat cancer).
  • A side-effect of certain medicines, such as chloramphenicol (an antibiotic not common in the U.S.).
  • Suffering from other infectious diseases such as hepatitis and HIV.
  • Suffering from other autoimmune disorders, such as lupus and rheumatoid arthritis.
  • Pregnancy (usually temporary in nature)
  • Cancer from another part of the body has spread to the bone marrow

The cause of someone's aplastic anemia is not always known, and scientists are not sure of all the reasons the disease occurs.

Symptoms of Aplastic Anemia

The symptoms of aplastic anemia can appear at any age, and they can develop rapidly or slowly over time. Most symptoms are all associated with the loss of blood cells, and the exact symptoms depend on which blood cell types are affected. Common symptoms include:

  • Loss of red blood cells: fatigue, dizziness, shortness of breath, rapid, irregular heartbeat
  • Loss of white blood cells: reoccurring infections, lingering flu-like symptoms
  • Loss of platelets: Excessive bruising and bleeding, bleeding gums, blood in stool 

Other symptoms not directly associated with low blood counts include nausea and skin rashes. 

Diagnosis of Aplastic Anemia

Diagnosing aplastic anemia can be difficult given the varying speeds that symptoms may appear and the fact these symptoms overlap with so many other disorders. 

The most common method of confirming an aplastic anemia diagnosis is to conduct blood tests. Depending on blood test results, a doctor may also take a bone marrow sample for further testing.

Lab Tests for Aplastic Anemia

The most common blood lab tests for aplastic anemia are:

This is usually one of the first blood tests used to check for aplastic anemia. The test measures 33 different biomarkers to provide a very thorough assessment of what is in the blood. This test provides data such as:

- the amount of hemoglobin, a protein in your red blood cells that carries oxygen to your body
- the number of red blood cells and platelets
- the number and types of white blood cells

A blood smear examines the size, shape, and number of blood cells in the blood.

Treatment for Aplastic Anemia

There is no cure for aplastic anemia. There are several treatment options to relieve symptoms, depending on the exact cause, symptoms, and severity of the illness. 

Minor cases of aplastic anemia are often focused on increasing blood counts and treating anemia. Vitamins such as B12, folic acid, and iron can be increased through dietary changes, dietary supplements. Doctors can also prescribe medicines such as:

  • A man-made version of the hormone erythropoietin, which can stimulate the production of more red blood cells. 
  • Immunosuppressants to stop the immune system from attacking its own red blood cells.

In severe cases, more aggressive treatment options are considered, including:

  • Blood and plasma transfusions to provide more blood cells
  • High doses of Cyclophosphamide (a chemotherapy drug)
  • Immunosuppressive drug therapy to suppress an overactive immune system

In severe cases, and where drug therapy has failed to provide relief, a patient may have to undergo a bone marrow transplant.

Order Your Aplastic Anemia Tests with Ulta Lab Tests

If you are suffering symptoms of aplastic anemia, a lab test can help confirm or rule out an aplastic anemia diagnosis.

Ulta Lab Tests offers tests that are highly accurate and reliable, so you can make informed decisions about your health.

  • Secure and confidential results
  • No insurance referral is needed
  • Affordable pricing
  • 100% satisfaction guarantee

Order your aplastic anemia lab tests today, and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control of your health today with Ulta Lab Tests.