PSA, Total (2.5 ng/mL cutoff)

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Also known as: Prostate Specific Antigen, PSA, PSA Total 25 ngmL cutoff, Total PSA

Psa,Total,2.5ng/Ml Cutoff

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The PSA, Total (2.5 ng/mL cutoff) test contains 1 test with 1 biomarker.

Brief Description: The PSA Total with 2.5 ng/mL cutoff test is a specialized laboratory assay that measures the total level of prostate-specific antigen (PSA) in a patient's blood, using a cutoff value of 2.5 ng/mL as a reference point. This test plays a significant role in prostate health assessment and is especially pertinent in monitoring individuals at risk of prostate-related conditions.

For patients who are suspected of having a PSA level higher than 2.5 ng/mL, a PSA, Total #5363 test is suggested as the upper limit is 4.0 ng/mL. There are two types of PSA, complex and free, and this test will measure the total sum of both. This test does not specify how much of each. If a measure of each amount is desired the test PSA, Free and Total #31348 will be able to differentiate between each one.

Also Known As: Prostate Specific Antigen Test, PSA Test, Prostate test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When is a PSA Total test ordered?

PSA is commonly ordered as a routine test in men over the age of 55, or 40 if they have a relative who has had prostate cancer. It is used to help identify, diagnose, and monitor prostate cancer. This test should also be ordered if the patient is having difficulty urinating or it becomes painful to do so.

The guideline is to start testing at age 40 or 45 for people at high risk, such as African-American men and men with a family history of the condition.

A healthcare professional may schedule a repeat test a few weeks later if the total PSA level is elevated to see if the PSA concentrations have returned to normal.

When a man's total PSA is significantly elevated, a free PSA is usually ordered. The results provide further information to the healthcare professional regarding whether the person is at an elevated risk of prostate cancer and aid in the choice to biopsy the prostate.

The total PSA may be conducted at regular intervals during the treatment of men who have been diagnosed with prostate cancer, as well as when a man is on "watchful waiting" and not currently being treated for his cancer.

What does a PSA Total blood test check for?

PSA is a protein produced predominantly by cells in the prostate, a tiny gland that surrounds the urethra in males and generates a fluid that is a component of semen. The majority of PSA produced by the prostate is discharged into this fluid, but minor amounts can also be found in the bloodstream. This test determines how much PSA is present in the blood.

The PSA test is used to screen for and monitor prostate cancer as a tumor marker. It's a good tool, but it's not perfect, and most experts agree that asymptomatic men should only be screened after having a detailed discussion with their healthcare professionals about the benefits and dangers, and after making an informed decision to do so. PSA levels that are high are linked to prostate cancer, but they can also indicate prostatitis or benign prostatic hyperplasia. PSA levels rise with age in all men, but men of African American ancestry may have greater levels than other men, even at a younger age.

PSA is not a cancer indicator. The prostate biopsy, which involves taking small samples of prostate tissue and examining them under a microscope for abnormal cells, is the gold standard for detecting prostate cancer. The total PSA test and the digital rectal exam are used to evaluate whether a prostate biopsy is necessary.

The purpose of prostate cancer screening is to discover the disease when it is still contained within the prostate. Once the diagnosis of prostate cancer has been verified by biopsy, a treatment decision must be determined. As men get older, prostate cancer becomes more common, and many, if not all, of the tumors are slow-growing. While prostate cancer is the second leading cause of mortality in men, slow-growing prostate cancer is a rare cause of death. A pathologist may be able to tell the difference between cancers that grow slowly and spread to other regions of the body and cancers that grow quickly and spread to other parts of the body.

Overdiagnosis and overtreatment are two challenges that health professionals are currently dealing with. In certain situations, the treatment is worse than the cancer, with substantial side effects including as incontinence and erectile dysfunction possible. In general, neither the PSA test nor the DRE can indicate how a person's condition will progress.

In the blood, PSA is found in two forms: complexed and free. The total PSA test, which analyzes the sum of complexed and free PSA in the blood, is the most often used PSA test.

When the total PSA is only slightly raised, the free PSA test is occasionally used to help assess whether a biopsy should be performed. PSA is an enzyme, and when it is released into the bloodstream, some circulating proteins link to it and inactivate it. In BPH, benign prostate cells produce PSA that is not active, whereas malignant prostate cells produce PSA that is already protein-bound.

As a result, men with BPH tend to have greater levels of free PSA, while men with prostate cancer have lower levels. Even if total PSA is not dramatically raised, a relatively low amount of free PSA raises the chances of cancer.

Lab tests often ordered with a PSA Total test:

When a PSA Total test is ordered, it's often part of a broader evaluation of prostate health. Here are some tests and assessments commonly ordered alongside it:

  1. Free PSA Test:

    • Purpose: To measure the percentage of PSA in the blood that is not bound to proteins (free PSA).
    • Why Is It Ordered: A lower percentage of free PSA can be associated with prostate cancer. This test helps to distinguish prostate cancer from benign prostatic hyperplasia (BPH) when total PSA levels are in a borderline range.
  2. Complete Blood Count (CBC) and Comprehensive Metabolic Panel (CMP):

    • Purpose: To provide a broad overview of the body's overall health.
    • Why Is It Ordered: To monitor general health status, especially if the patient is receiving treatment for prostate cancer.

These tests and assessments, when ordered alongside a PSA Total test, provide a comprehensive evaluation of prostate health and are crucial for detecting and managing prostate cancer. They can help in differentiating between benign conditions and malignancy, guiding biopsy decisions, and assessing treatment efficacy. The specific combination of tests will depend on the individual’s risk factors, symptoms, and clinical history.

Conditions where a PSA Total test is recommended:

The PSA Total with 2.5 ng/mL cutoff test is crucial in assessing various prostate-related conditions:

  1. Prostate Cancer: Elevated PSA levels can be indicative of prostate cancer, prompting further diagnostic procedures such as biopsies.

  2. Prostatitis: Inflammation of the prostate gland can lead to increased PSA levels, even in the absence of cancer.

  3. Benign Prostatic Hyperplasia (BPH): BPH, a non-cancerous enlargement of the prostate, can cause elevated PSA levels due to increased prostate tissue.

How does my health care provider use a PSA Total test?

Both the PSA test and the digital rectal exam can be used to screen for prostate cancer in both asymptomatic and symptomatic men. PSA is a protein produced predominantly by prostate cells. The majority of PSA is released into the sperm, although minor amounts are also released into the blood. PSA is found in the blood in two forms: free and complexed. PSA levels can be measured in the lab as either free or total PSA.

Some organizations, such as the United States Preventive Services Task Force, believe that the risks of over-diagnosis and over-treatment outweigh the potential advantages of PSA screening in healthy men of any age, and advise against using PSA to test for prostate cancer in healthy men of any age. Before deciding whether or not to be screened for prostate cancer, the American Cancer Society and the American Urological Association urge that men consider the benefits and drawbacks of PSA-based screening with their healthcare professional.

While elevated PSA levels are linked to cancer, they can also be produced by disorders like benign prostatic hyperplasia and prostate inflammation. A biopsy may be required in the case of an increased PSA, which carries the risk of consequences such as discomfort, fever, blood in the urine, and urinary tract infection.

Even though prostate cancer is the second most frequent cancer in males and the second leading cause of death, many prostate tumors grow slowly. These slow-growing kinds may never create symptoms or pose a threat to one's life. Prostate cancer discovered by screening, on the other hand, may be treated with surgery or radiation therapy, which can have major side effects like incontinence or erectile dysfunction.

Because the total PSA test might be temporarily raised for a variety of causes, if an initial PSA is elevated, a follow-up PSA may be performed a few weeks later to see if the PSA is still elevated. If the repeat test shows an elevated level, a healthcare professional may suggest taking a series of PSAs over time to see if the level drops, stays elevated, or rises. When a cancer looks to be slow-growing, the healthcare professional and patient may decide to watch its progress rather than treat it right away.

A free PSA test can be done to look at the ratio of free to total PSA if the DRE is normal but the PSA is considerably increased. This can assist distinguish between prostate cancer and other sources of increased PSA that aren't cancer.

If either the PSA or the DRE are abnormal, other testing may be ordered. A urinalysis, for example, can be used to screen for a urinary tract infection, and imaging tests like an ultrasound can be used to inspect the prostate.

The total PSA test may be used as a monitoring tool to help determine the success of treatment if prostate cancer is diagnosed. It may also be ordered following therapy at regular intervals to identify cancer recurrence.

What do my PSA Total test results mean?

PSA test results can be interpreted in a variety of ways, and the cutoff values used by different laboratories may differ.

Total PSA levels below 4.0 ng/ml are considered unlikely to indicate the existence of prostate cancer. Some argue that this limit should be reduced to 2.5 ng/ml in order to detect more prostate cancer cases. Others contend that this might result in more malignancies being diagnosed and treated that aren't clinically important.

Men with a total PSA level of more than 10.0 ng/ml are thought to be at a higher risk of prostate cancer.

Total PSA readings of 4.0 to 10.0 ng/ml may suggest prostate cancer, benign prostatic hyperplasia, or prostate inflammation. These problems, as well as an increase in PSA levels, are more common among the elderly. The "gray zone" is defined as total PSA levels between 4.0 and 10.0 ng/ml. The free PSA may be beneficial in this range.

Prostate cancers produce primarily complexed PSA rather than free PSA. Prostate cancer cells create more free PSA, which does not bind to proteins. As a result, when men in the gray zone have lower levels of free PSA, they have higher levels of cPSA and a higher risk of prostate cancer. When individuals have high amounts of free PSA but low cPSA, however, the danger is reduced. The ratio of free to total PSA can assist the patient and his healthcare professional in determining whether or not a prostate biopsy is necessary.

Additional analyses of PSA test results are occasionally utilized to improve the total PSA's efficacy as a screening tool. They are as follows:

  • PSA velocity is the rate at which PSA concentrations fluctuate over time; if the PSA continues to climb rapidly over time, prostate cancer is more likely. If it rises quickly, the patient may be suffering from a more aggressive kind of cancer.
  • PSA doubling time is a kind of PSA velocity that quantifies the rate at which the PSA concentration doubles.
  • PSA density is a comparison of PSA concentration and prostate volume; if the PSA level is higher than one would predict given the size of the prostate, the likelihood of cancer is higher.
  • PSA ranges adapted to a man's age—Because PSA values typically rise with age, it has been advocated that normal ranges be customized to a man's age.

The PSA level should start to drop with prostate cancer treatment, and should be very low or undetectable at the end of treatment. If concentrations do not drop to extremely low levels, the treatment is ineffective. Following treatment, the PSA test is repeated at regular intervals to check for recurrence of cancer. Because even small increases can be important, persons who are impacted should have their monitoring PSA tests done by the same laboratory each time to reduce testing variation.

A test known as "ultrasensitive PSA" may be helpful in detecting cancer persistence or recurrence after therapy. PSA is detected at significantly lower levels in this test than in regular PSA tests. Increases in PSA related to the persistence or return of cancer, it has been proposed, can be detected much sooner using this test. The results of this test, however, should be regarded with caution. Because the test is so sensitive, even when no cancer is present, minor rises in PSA levels can occur from one time to the next.

Is there anything else I should know about the Prostate Specific Antigen Total test?

The blood sample is normally taken before the DRE since the DRE can induce a brief increase in PSA.

PSA levels will be dramatically elevated following prostate procedure such as biopsy or excision. Before surgery or six weeks after manipulation, a blood test should be performed.

A brief increase in PSA level can be caused by strenuous physical activity that affects the prostate, such as cycling. Ejaculation within 24 hours of a PSA test can result in higher PSA values, thus it's best to avoid it.

Some chemotherapy medicines, such as cyclophosphamide and methotrexate, can raise or lower PSA levels in high dosages.

PSA levels may briefly rise in some men as a result of other prostate problems, particularly infection. According to a research, nearly half of men with high PSA levels saw their levels return to normal after a period of time. Before taking any further action, several authorities urge that a high PSA be repeated between 6 weeks and 3 months following the initial high PSA. If there is indication that the prostate is infected, some doctors will prescribe antibiotics.

Most Common Questions About the PSA Total with 2.5 ng/mL cutoff test:

Purpose and Clinical Significance

What is the PSA Total with 2.5 ng/mL cutoff test?

The PSA Total with 2.5 ng/mL cutoff test is a blood test used to measure the concentration of prostate-specific antigen (PSA) in the blood. PSA is a protein produced by the prostate gland, and its level can be used as a marker for prostate conditions, including benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer.

Why is the PSA Total with 2.5 ng/mL cutoff test important?

This test helps in the early detection of potential prostate problems. The 2.5 ng/mL cutoff is used because studies have shown that prostate cancer becomes a more probable diagnosis above this level, especially in younger men.

Interpretation of Results

What do results above 2.5 ng/mL in the PSA Total with 2.5 ng/mL cutoff test indicate?

A PSA level above 2.5 ng/mL suggests a higher risk of prostate cancer, especially in men under age 60. However, elevated PSA levels can also be due to other factors like BPH or prostatitis. Further evaluation, often with a prostate biopsy, is recommended to determine the cause of the elevation.

If the PSA Total with 2.5 ng/mL cutoff test result is below 2.5 ng/mL, does it mean there's no risk of prostate cancer?

While a result below 2.5 ng/mL is generally considered to be in the normal range and suggests a lower risk of prostate cancer, it does not entirely rule out the disease. Other factors, such as the rate of increase of PSA over time (PSA velocity), can also be indicative of potential issues.

Disease and Complications

How does the PSA Total with 2.5 ng/mL cutoff test differ from other PSA tests?

Traditional PSA tests often use a cutoff of 4.0 ng/mL. The 2.5 ng/mL cutoff is a more aggressive threshold, leading to earlier detection in some cases. This can be particularly beneficial for younger men, where an elevated PSA is less likely to be due to benign causes.

Are there conditions other than prostate cancer that can raise PSA levels in the PSA Total with 2.5 ng/mL cutoff test?

Yes, several conditions can lead to elevated PSA levels, including BPH, prostatitis (inflammation of the prostate), and even recent sexual activity. Medications and procedures involving the prostate can also temporarily increase PSA levels.

Relation with Other Tests

Why might a doctor order both a PSA Total with 2.5 ng/mL cutoff test and a free PSA test?

The free PSA test measures the proportion of PSA that is not bound to other proteins in the blood. When used in conjunction with the total PSA test, it can help differentiate between BPH and prostate cancer, especially in situations where PSA levels are in the borderline range.

If PSA levels are elevated in the PSA Total with 2.5 ng/mL cutoff test, what are the next steps?

If PSA levels are elevated, a doctor may recommend a repeat test to confirm results, other diagnostic tests like imaging, or a prostate biopsy to determine the nature of the prostate condition.

Understanding the PSA Total with 2.5 ng/mL cutoff test results in context with other diagnostic findings and considering the patient's overall health and risk factors are essential in making informed decisions about further evaluation and treatment.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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