The PSA, Free and Total test contains 1 test with 3 biomarkers.
Description: PSA Free and Total is a test that is used to measure the total amount of PSA in the blood along with the amount of free PSA. There are two types of PSA, complex and free. This test is used to measure both and to calculate the PSA ratios.
Also Known As: Prostate Specific Antigen Test, PSA Free and Total Test, PSA Free Test, PSA Total Test, PSA Blood Test
Collection Method: Blood Draw
Specimen Type: Serum
Test Preparation: No preparation required
When is a PSA Free and Total test ordered?
The American Cancer Society recommends that healthy men of average risk wait until age 50 to be screened for prostate cancer, whereas the American Urological Association suggests screening for men between the ages of 55 and 69, with no routine screening after age 70.
The guideline is to start testing at age 40 or 45 for people at high risk, such as African-American men and those with a family medical history of the condition.
When a man develops symptoms that could be caused by prostate cancer, such as difficult, painful, and/or frequent urination, back discomfort, and/or pelvic pain, a total PSA test and digital rectal exam may be prescribed.
A healthcare professional may schedule a repeat test a few weeks later if the total PSA level is elevated to see if the PSA concentrations have returned to normal.
When a man's total PSA is significantly elevated, a free PSA is usually ordered. The results provide further information to the healthcare professional regarding whether the person is at an elevated risk of prostate cancer and aid in the choice to biopsy the prostate.
The total PSA may be conducted at regular intervals during the treatment of men who have been diagnosed with prostate cancer, as well as when a man is on "watchful waiting" and not currently being treated for his cancer.
What does a PSA Free and Total blood test check for?
Prostate specific antigen is a protein produced predominantly by cells in the prostate, a tiny gland that surrounds the urethra in males and generates a fluid that is part of the sperm. The majority of PSA produced by the prostate is discharged into this fluid, but minor amounts can also be found in the bloodstream. This test determines how much PSA is present in the blood.
The PSA test is used to screen for and monitor prostate cancer as a tumor marker. It's a good tool, but it's not perfect, and most experts agree that asymptomatic men should only be screened after having a detailed discussion with their healthcare professionals about the benefits and dangers, and after making an informed decision to do so. PSA levels that are higher than normal are linked to prostate cancer, but they can also be detected in prostatitis and benign prostatic hyperplasia. PSA levels rise with age in all men, but men of African American ancestry may have greater levels than other men, even at a younger age.
PSA is not a cancer indicator. The prostate biopsy, which involves taking small samples of prostate tissue and examining them under a microscope for abnormal cells, is the gold standard for detecting prostate cancer. The total PSA test and the digital rectal exam are combined to help determine whether a prostate biopsy is necessary.
The purpose of prostate cancer screening is to discover the disease when it is still contained within the prostate. Once the diagnosis of prostate cancer has been verified by biopsy, a treatment decision must be determined. As men get older, prostate cancer becomes more common, and many, if not all, of the tumors are slow-growing. While prostate cancer is the second leading cause of mortality in men, slow-growing prostate cancer is a rare cause of death. A pathologist may be able to tell the difference between cancers that grow slowly and spread to other regions of the body and cancers that grow quickly and spread to other parts of the body.
Overdiagnosis and overtreatment are two challenges that health professionals are currently dealing with. In certain situations, the treatment is worse than the cancer, with substantial side effects including as incontinence and erectile dysfunction possible. In general, neither the PSA test nor the DRE can indicate how a person's condition will progress.
PSA is found in the blood in two forms: complexed and free. The total PSA test, which analyzes the sum of complexed and free PSA in the blood, is the most often used PSA test.
When the total PSA is only slightly raised, the free PSA test is occasionally used to help assess whether a biopsy should be performed. PSA is an enzyme that is inactivated by circulating proteins that bind to it when it is released into the bloodstream. In BPH, benign prostate cells emit PSA that is not active, but malignant prostate cells release PSA that is already coupled to a protein.
As a result, men with BPH tend to have greater levels of free PSA, while men with prostate cancer have lower levels. Even if total PSA is not dramatically raised, a relatively low amount of free PSA raises the chances of cancer.
Lab tests often ordered with a PSA Free and Total test:
Conditions where a PSA Free and Total test is recommended:
- Prostate Cancer
- Benign Prostatic Hypertrophy
How does my health care provider use a PSA Free and Total test?
Both the PSA test and the digital rectal exam can be used to screen for prostate cancer in both asymptomatic and symptomatic individuals. PSA is a protein produced predominantly by prostate cells. The majority of PSA is released into the sperm, although minor amounts are also released into the blood. PSA is found in the blood in two forms: free and complexed. PSA levels can be measured in the lab as either free or total PSA.
Some organizations, such as the United States Preventive Services Task Force, believe that the risks of over-diagnosis and over-treatment outweigh the potential advantages of PSA screening in healthy men of any age, and advise against using PSA to test for prostate cancer in healthy men of any age. Before deciding whether or not to be screened for prostate cancer, the American Cancer Society and the American Urological Association urge that men consider the benefits and drawbacks of PSA-based screening with their healthcare professional.
While elevated PSA levels are linked to cancer, they can also be produced by disorders like benign prostatic hyperplasia and prostate inflammation. A biopsy may be required in the case of an increased PSA, which carries the risk of consequences such as discomfort, fever, blood in the urine, and urinary tract infection.
Even though prostate cancer is the second most frequent cancer in males and the second leading cause of death, many prostate tumors grow slowly. These slow-growing kinds may never create symptoms or pose a threat to one's life. Prostate cancer discovered by screening, on the other hand, may be treated with surgery or radiation therapy, which can have major side effects like incontinence or erectile dysfunction.
Because the total PSA test might be temporarily raised for a variety of causes, if an initial PSA is elevated, a follow-up PSA may be performed a few weeks later to see if the PSA is still elevated. If the repeat test shows an elevated level, a healthcare professional may suggest taking a series of PSAs over time to see if the level drops, stays elevated, or rises. When a cancer looks to be slow-growing, the healthcare professional and patient may decide to watch its progress rather than treat it right away.
A free PSA test can be done to look at the ratio of free to total PSA if the DRE is normal but the PSA is considerably increased. This can assist distinguish between prostate cancer and other sources of increased PSA that aren't cancer.
If the PSA or DRE are abnormal, other testing may be ordered. A urinalysis, for example, can be used to screen for a urinary tract infection, and imaging tests like an ultrasound can be used to inspect the prostate.
The total PSA test may be used as a monitoring tool to help determine the success of treatment if prostate cancer is diagnosed. It may also be ordered following therapy at regular intervals to identify cancer recurrence.
What do my PSA test results mean?
PSA test results can be interpreted in a variety of ways, and the cutoff values used by different laboratories may differ.
Total PSA levels below 4.0 ng/ml are considered unlikely to indicate the existence of prostate cancer. Some argue that this limit should be reduced to 2.5 ng/ml in order to detect more prostate cancer cases. Others contend that this might result in more malignancies being diagnosed and treated that aren't clinically important.
Men with a total PSA level of more than 10.0 ng/ml are thought to be at a higher risk of prostate cancer.
Prostate cancer, benign prostate hyperplasia, or inflammation can all be indicated by total PSA readings between 4.0 and 10.0 ng/ml. These problems, as well as an increase in PSA levels, are more common among the elderly. The "gray zone" is defined as total PSA levels between 4.0 and 10.0 ng/ml. The free PSA may be beneficial in this range.
Prostate cancers generally produce a lot of complexed PSA rather than free PSA. Prostate cancer cells create more free PSA, which does not bind to proteins. As a result, when men in the gray zone have lower levels of free PSA, they have higher levels of cPSA and a higher risk of prostate cancer. When individuals have high amounts of free PSA but low cPSA, however, the danger is reduced. The ratio of free to total PSA can assist the patient and his healthcare professional in determining whether or not a prostate biopsy is necessary.
We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.