HH-2. Hormone Health - Women

There are no preparation instructions.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Dehydroepiandrosterone Sulfate, DHEA SO4, DHEA Sulfate Immunoassay, DHEAS, Transdehydroandrosterone


DHEA-sulfate test measures the amount of DHEA-sulfate in the blood. DHEA-sulfate is a weak male hormone (androgen) produced by the adrenal gland in both men and women.


Estradiol (estradiol-17 beta, E2) is part of an estrogen that is a group of steroids that regulate the menstrual cycle and function as the main female sex hormones. Estrogens are responsible for the development of female sex organs and secondary sex characteristics and are tied to the menstrual cycle and pregnancy. They are considered the main sex hormones in women and are present in small quantities in men. Estradiol (E2) is the predominant form of estrogen and is produced primarily in the ovaries with additional amounts produced by the adrenal glands in women and in the testes and adrenal glands in men. Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea – for example, to determine whether the cause is menopause, pregnancy, or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy.

Also known as: Estrogen Total Serum

Estrogen, Total, Serum

Estrogen is a group of steroids that regulate the menstrual cycle and function as the main female sex hormones. Estrogens are responsible for the development of female sex organs and secondary sex characteristics and are tied to the menstrual cycle and pregnancy. They are considered the main sex hormones in women and are present in small quantities in men.

Also known as: Estrone LCMSMS

Estrone, LC/MS/MS

Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women. Estrone levels may be elevated in patients with polycystic ovarian syndrome and endometriosis. Tests may be used to aid in the diagnosis of an ovarian tumor, Turner syndrome, and hypopituitarism. In males, it may help in the diagnosis of the cause of gynecomastia or in the detection of estrogen-producing tumors.

Also known as: Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), Follicle Stimulating Hormone and Luteinizing Hormone



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The HH-2. Hormone Health - Women panel contains 5 tests with 6 biomarkers.

Brief Description: The HH-2 Hormone Health - Women panel offers an expanded range of tests designed to provide a more comprehensive understanding of a woman's hormonal health. This panel includes tests for DHEA Sulfate, Estradiol, Estrogen Total, Estrone, Follicle Stimulating Hormone (FSH), and Luteinizing Hormone (LH). This panel is designed to offer insights into a woman's reproductive health, hormone balance, and overall well-being.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the HH-2 Panel May Be Ordered

The HH-2 Hormone Health - Women panel may be ordered for women experiencing symptoms indicative of hormonal imbalances, fertility issues, menstrual irregularities, or those undergoing evaluation for menopause or perimenopause. It's also useful for monitoring the effectiveness of hormone therapy and for women wanting a deeper understanding of their hormonal health as part of a comprehensive health checkup.

What the HH-2 Panel Checks For

  • DHEA Sulfate: This test measures the concentration of DHEA sulfate, a hormone involved in producing sex hormones. It's important for assessing adrenal gland function and overall vitality.

  • Estradiol: Estradiol, the most potent form of estrogen, is crucial for reproductive and sexual health. This test is essential for evaluating ovarian function, menstrual cycle issues, and fertility.

  • Estrogen Total: Measuring the total estrogen levels, including estradiol, gives a broader view of a woman's estrogen status, impacting various aspects of health from bone density to menstrual cycle regulation.

  • Estrone: Estrone, a weaker form of estrogen, becomes more prominent after menopause. Testing for estrone can help evaluate menopausal status and estrogen's overall impact on the body.

  • Follicle Stimulating Hormone (FSH): FSH is pivotal in regulating the menstrual cycle and egg production. High levels may indicate reduced ovarian reserve or approaching menopause.

  • Luteinizing Hormone (LH): LH plays a critical role in triggering ovulation. An LH test can help diagnose disorders of the ovaries or pituitary gland and is often used in fertility assessments.

Beyond the Basics: Advanced Hormonal Health Insights

For those who seek to delve deeper into their hormonal health, the HH-3 and HH-4 Hormone Health - Women panels offer further insights by adding key tests to the foundational HH-2 panel.

HH-3 Hormone Health - Women Panel

The HH-3 panel builds upon the HH-2 by including tests for Insulin-like Growth Factor-1 (IGF-1), Pregnenolone, and Progesterone. These additions are invaluable for assessing fertility, adrenal function, and the health of the menstrual cycle, providing a more nuanced understanding of hormonal balance.

HH-4 Hormone Health - Women Panel

The comprehensive HH-4 panel encompasses all the tests in HH-3 and further includes Prolactin, Sex Hormone Binding Globulin (SHBG), and Testosterone Free and Total. This panel offers an exhaustive overview of a woman's hormonal landscape, aiding in the diagnosis and management of conditions like PCOS, thyroid disorders, and hormonal imbalances affecting overall health.

Conditions Detected by the HH-2 Panel

The HH-2 Hormone Health - Women panel is instrumental in detecting a range of conditions that affect women's health:

  • Menopause and Perimenopause: Fluctuations in FSH, estradiol, and estrone levels can indicate the transition to menopause, helping women and healthcare providers manage symptoms and health risks associated with this life stage.

  • Polycystic Ovary Syndrome (PCOS): Irregularities in LH, FSH, and estradiol levels can suggest PCOS, a condition characterized by hormonal imbalances and metabolic issues affecting women's health and fertility.

  • Ovarian Reserve and Fertility: FSH and estradiol levels can provide insights into a woman's ovarian reserve and overall fertility, guiding treatment for those struggling with conception.

Utilizing HH-2 Panel Results in Treatment and Monitoring

Healthcare professionals leverage the results from the HH-2 Hormone Health - Women panel to personalize treatment strategies and monitor the progress of interventions for the detected conditions:

  • Menopause Management: Tailoring hormone replacement therapies or recommending lifestyle adjustments based on hormone levels can alleviate menopausal symptoms and protect long-term health.

  • PCOS Treatment: Hormone level insights can guide the management of PCOS through lifestyle changes, medications, or fertility treatments, addressing both symptoms and underlying metabolic concerns.

  • Fertility Interventions: Understanding hormonal status can inform fertility treatments, such as in vitro fertilization (IVF) or ovulation induction, improving chances of conception.

The HH-2 Hormone Health - Women panel offers valuable insights into a woman's hormonal health, providing a deeper understanding of reproductive health, menopausal status, and potential hormonal imbalances. By leveraging the detailed information provided by this panel, healthcare providers can offer personalized care, helping women manage their health more effectively and make informed decisions about treatments and lifestyle changes.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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