Estrone, LC/MS/MS Most Popular

The Estrone, LC/MS/MS test contains 1 test with 1 biomarker.

Description: Estrone is one of the estrogen tests, there are three types of Estrogens that are frequently tested; estrone is one of them and the other two are estradiol and estriol. Estrone is a blood test that will measure the amount of estrone in the blood's serum. It is used in fertility treatment, hormone treatment, and can be used to help diagnose a problem with the endocrine system.

Also Known As: E1 Test, Estrogen 1 Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When is an Estrone test ordered?

Estrone testing in women and girls may be requested if:

  • The development of a girl's sex organs occur sooner or later than predicted.
  • After menopause, a woman may experiences symptoms such as abnormal vaginal bleeding or irregular or absent menstrual cycles.
  • When a woman is unable to conceive, a series of estradiol readings taken over the course of her menstrual cycle may be used to track follicle development before using in vitro fertilization procedures 
  • A woman is experiencing menopause symptoms such as hot flashes, night sweats, sleeplessness, and/or irregular or absent menstrual cycles.
  • If a menopausal woman is on hormone replacement therapy, her doctor may order estrone levels on a regular basis to check her progress.

Estrone levels in men could be requested in the following circumstances:

  • A boy's puberty is delayed, as evidenced by delayed or slow growth of penis and testicles, as well as a lack of body hair or voice deepening.
  • Signs of feminization, such as larger breasts

What does an Estrone test check for?

Estrogens are a class of steroids that have a role in the development and function of women's reproductive organs, as well as the generation of secondary sex characteristics. They help regulate the menstrual cycle, are involved in the growth of breasts and the uterus, and aid in the maintenance of a healthy pregnancy, together with another hormone, progesterone. Though they are primarily associated with women, they are also prevalent in men and play a role in bone metabolism and growth in both genders. Estrogen tests look for one of three hormones in the blood or urine: estrone, estradiol, or estriol.

Androstenedione or other androgens are directly transformed to estrone. The ovaries and placenta, as well as the testicles and adipose tissues, can all produce E1. As needed, E2 and E1 can be transformed into each other. In men and postmenopausal women, E1 is the main estrogen.

Lab tests often ordered with an Estrone test:

  • Estrogen
  • Estriol
  • Estradiol
  • Estradiol, Ultrasensitive
  • Testosterone Free and Total
  • Sex Hormone Binding Globulin
  • FSH
  • LH
  • Progesterone

Conditions where an Estrone test is recommended:

  • Infertility
  • Menopause
  • Polycystic Ovarian Syndrome (PCOS)
  • Hormone Imbalance
  • Premature or delayed puberty
  • Breast cancer

How does my health care provider use an Estrone test?

Estrone testing is used to identify a woman's estrogen insufficiency or excess, as well as to diagnose a range of illnesses linked to this imbalance. It may also be ordered to monitor the health of the growing fetus and placenta during pregnancy, as well as to help pinpoint the date of a woman's ovulation. Estrone testing can be used to determine a hormone excess and its source in men.

What do my Estrone test results mean?

The sex and age of the person being tested influence the normal estrone readings. It also depends on a woman's menstrual cycle or whether she is pregnant. The normal values indicated and the units used in reference ranges will differ slightly between laboratories.

Estrone levels can rise or fall in a variety of metabolic situations. Estrone levels change from day to day and throughout a woman's menstrual cycle, therefore interpretation of the results must be done with caution.

Rather than examining single numbers, a health practitioner monitoring a woman's hormones will look at trends in the levels, rising or falling over time in connection with the menstrual cycle or pregnancy. The findings of a test are not diagnostic of a specific ailment, but they do provide information to a health care provider regarding the possible source of a person's symptoms or status.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Estrone LCMSMS

Estrone, LC/MS/MS

Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women. Estrone levels may be elevated in patients with polycystic ovarian syndrome and endometriosis. Tests may be used to aid in the diagnosis of an ovarian tumor, Turner syndrome, and hypopituitarism. In males, it may help in the diagnosis of the cause of gynecomastia or in the detection of estrogen-producing tumors.
*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Customer Reviews