Estradiol and Testosterone Total (Male) Most Popular

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.


Estradiol (estradiol-17 beta, E2) is part of an estrogen that is a group of steroids that regulate the menstrual cycle and function as the main female sex hormones. Estrogens are responsible for the development of female sex organs and secondary sex characteristics and are tied to the menstrual cycle and pregnancy. They are considered the main sex hormones in women and are present in small quantities in men. Estradiol (E2) is the predominant form of estrogen and is produced primarily in the ovaries with additional amounts produced by the adrenal glands in women and in the testes and adrenal glands in men. Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea – for example, to determine whether the cause is menopause, pregnancy, or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy.

Also known as: Testosterone Total Males, Testosterone, Total


A testosterone test measures the amount of the male hormone, testosterone, in the blood. Both men and women produce this hormone. In males, the testicles produce most of the testosterone in the body. Levels are most often checked to evaluate signs of low testosterone: In boys -- early or late puberty and in men -- impotence, low level of sexual interest, infertility, thinning of the bones In females, the ovaries produce most of the testosterone and levels are most often checked to evaluate signs of higher testosterone levels, such as: decreased breast size, excess hair growth, increased size of the clitoris. irregular or absent menstrual periods and male-pattern baldness or hair thinning.
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The Estradiol and Testosterone Total (Male) panel contains 2 tests with 2 biomarkers.

Brief Description: The Estradiol and Testosterone Total (Male) test is a specialized blood test designed to measure the levels of two crucial hormones in the male body: estradiol, a form of estrogen, and testosterone. While testosterone is the primary male sex hormone responsible for the development of male reproductive tissues and the manifestation of male secondary sexual characteristics, estradiol, albeit present in lower quantities in males than females, still plays a vital role in modulating libido, erectile function, and the production of sperm.

Please note: Testosterone, Total, Males (Adult) Only #873 is for Adult (18 years of age or older) male patients only. If this panel is ordered for a pediatric or female patient, the lab will automatically change the test code for testosterone to Testosterone, Total, MS #15983 and charge for it.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the Estradiol and Testosterone Total (Male) Test May Be Ordered

This test can be ordered for a variety of reasons:

  1. Hormonal Imbalance Suspicions: If a male exhibits symptoms suggesting a hormonal imbalance, such as changes in sex drive, erectile dysfunction, or infertility.

  2. Gynecomastia: In cases where males develop enlarged breast tissues, measuring estradiol can help determine the cause.

  3. Testosterone Replacement Therapy (TRT): For males undergoing TRT, it's crucial to monitor testosterone levels to ensure they're in the desired range and to check estradiol levels, which can increase as a result of testosterone being aromatized (converted) to estradiol in the body.

  4. Puberty Concerns: In younger males, if there are signs of delayed or early puberty, this test can provide insights into hormonal activity.

What the Estradiol and Testosterone Total (Male) Test Checks For

  • Estradiol: This hormone, predominant in females but also found in males, is crucial for sexual function and sperm maturation in men. In males, most estradiol is derived from the conversion (aromatization) of testosterone.

  • Testosterone Total (for Adult Males): This measures the total amount of testosterone in the blood, including both free (unbound) testosterone and testosterone that's bound to proteins (mainly sex hormone-binding globulin). Testosterone plays a pivotal role in muscle mass, bone density, hair growth, mood regulation, and overall male reproductive health.

Other Lab Tests Often Ordered Alongside an Estradiol and Testosterone Total Panel

When an Estradiol and Adult Male Testosterone Total panel is ordered, it typically indicates an evaluation of hormonal status and balance, particularly focusing on reproductive and sexual health. In men, both estradiol (a form of estrogen) and testosterone play crucial roles in health and well-being. Additional tests may be ordered to provide a comprehensive assessment of endocrine function and related health issues. Here are some tests commonly ordered alongside this panel:

  1. Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH):

    • Purpose: To measure the levels of these pituitary hormones that regulate the production of sex hormones.
    • Why Is It Ordered: To evaluate the function of the testes and the balance of the hypothalamic-pituitary-gonadal axis, especially in cases of suspected hypogonadism or infertility.
  2. Sex Hormone Binding Globulin (SHBG):

    • Purpose: To measure SHBG, which binds to sex hormones, affecting their bioavailability.
    • Why Is It Ordered: To assess the amount of free (biologically active) testosterone and estradiol, which can be different from the total levels.
  3. Prolactin:

    • Purpose: To measure prolactin levels, which can affect sexual function and hormone production.
    • Why Is It Ordered: Elevated prolactin can cause testosterone deficiency and erectile dysfunction.
  4. Dehydroepiandrosterone Sulfate (DHEA-S):

    • Purpose: To measure DHEA-S, an androgen precursor produced by the adrenal glands.
    • Why Is It Ordered: To evaluate adrenal gland function and its contribution to androgen levels.
  5. Complete Blood Count (CBC):

    • Purpose: To evaluate overall blood health.
    • Why Is It Ordered: Testosterone can influence red blood cell production, so it’s important to monitor for conditions like polycythemia.
  6. Prostate-Specific Antigen (PSA):

    • Purpose: To screen for prostate health.
    • Why Is It Ordered: Testosterone can influence prostate growth; monitoring PSA is important, especially in older men or those receiving testosterone replacement therapy.
  7. Lipid Profile:

    • Purpose: To measure cholesterol and triglycerides.
    • Why Is It Ordered: Hormonal imbalances can impact cardiovascular health and lipid metabolism.
  8. Liver Function Test:

    • Purpose: To assess liver enzyme levels and overall liver function.
    • Why Is It Ordered: The liver metabolizes hormones; liver function can influence hormone levels.
  9. Thyroid Function Tests:

    • Purpose: To assess thyroid gland function.
    • Why Is It Ordered: Thyroid disorders can affect sexual health and hormone levels.

These tests, when ordered alongside an Estradiol and Adult Male Testosterone Total panel, provide a comprehensive evaluation of hormonal health in men. They are crucial for diagnosing conditions like hypogonadism, erectile dysfunction, infertility, and assessing the risk of hormone-related issues such as polycythemia and prostate enlargement. The specific combination of tests will depend on the individual's symptoms, clinical history, and the reason for testing.

Conditions or Diseases the Estradiol and Testosterone Total (Male) Test Can Check For

  • Hypogonadism: A condition where the body doesn't produce enough testosterone.

  • Gynecomastia: Abnormal breast tissue enlargement in males, which can be due to elevated estradiol levels.

  • Pituitary gland disorders: The pituitary gland regulates the production of testosterone. Abnormal results might suggest issues with this gland.

  • Testicular tumors: Some tumors can lead to elevated testosterone levels.

  • Aromatase excess syndrome: A condition where there's an excessive conversion of testosterone to estradiol in males, leading to feminizing features.

In conclusion, the Estradiol and Testosterone Total (Male) test is a fundamental tool in understanding a man's hormonal health. By evaluating both testosterone and estradiol levels, healthcare professionals can diagnose, treat, and manage a variety of conditions, ensuring optimal male health and well-being.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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