The Estradiol and Testosterone Total (Male) panel contains 2 tests with 2 biomarkers.
Brief Description: The Estradiol and Testosterone Total (Male) test is a specialized blood test designed to measure the levels of two crucial hormones in the male body: estradiol, a form of estrogen, and testosterone. While testosterone is the primary male sex hormone responsible for the development of male reproductive tissues and the manifestation of male secondary sexual characteristics, estradiol, albeit present in lower quantities in males than females, still plays a vital role in modulating libido, erectile function, and the production of sperm.
Please note: Testosterone, Total, Males (Adult) Only #873 is for Adult (18 years of age or older) male patients only. If this panel is ordered for a pediatric or female patient, the lab will automatically change the test code for testosterone to Testosterone, Total, MS #15983 and charge for it.
Collection Method: Blood Draw
Specimen Type: Serum
Test Preparation: No preparation required
When and Why the Estradiol and Testosterone Total (Male) Test May Be Ordered
This test can be ordered for a variety of reasons:
Hormonal Imbalance Suspicions: If a male exhibits symptoms suggesting a hormonal imbalance, such as changes in sex drive, erectile dysfunction, or infertility.
Gynecomastia: In cases where males develop enlarged breast tissues, measuring estradiol can help determine the cause.
Testosterone Replacement Therapy (TRT): For males undergoing TRT, it's crucial to monitor testosterone levels to ensure they're in the desired range and to check estradiol levels, which can increase as a result of testosterone being aromatized (converted) to estradiol in the body.
Puberty Concerns: In younger males, if there are signs of delayed or early puberty, this test can provide insights into hormonal activity.
What the Estradiol and Testosterone Total (Male) Test Checks For
Estradiol: This hormone, predominant in females but also found in males, is crucial for sexual function and sperm maturation in men. In males, most estradiol is derived from the conversion (aromatization) of testosterone.
Testosterone Total (for Adult Males): This measures the total amount of testosterone in the blood, including both free (unbound) testosterone and testosterone that's bound to proteins (mainly sex hormone-binding globulin). Testosterone plays a pivotal role in muscle mass, bone density, hair growth, mood regulation, and overall male reproductive health.
Other Lab Tests Often Ordered Alongside an Estradiol and Testosterone Total Panel
When an Estradiol and Adult Male Testosterone Total panel is ordered, it typically indicates an evaluation of hormonal status and balance, particularly focusing on reproductive and sexual health. In men, both estradiol (a form of estrogen) and testosterone play crucial roles in health and well-being. Additional tests may be ordered to provide a comprehensive assessment of endocrine function and related health issues. Here are some tests commonly ordered alongside this panel:
Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH):
- Purpose: To measure the levels of these pituitary hormones that regulate the production of sex hormones.
- Why Is It Ordered: To evaluate the function of the testes and the balance of the hypothalamic-pituitary-gonadal axis, especially in cases of suspected hypogonadism or infertility.
Sex Hormone Binding Globulin (SHBG):
- Purpose: To measure SHBG, which binds to sex hormones, affecting their bioavailability.
- Why Is It Ordered: To assess the amount of free (biologically active) testosterone and estradiol, which can be different from the total levels.
- Purpose: To measure prolactin levels, which can affect sexual function and hormone production.
- Why Is It Ordered: Elevated prolactin can cause testosterone deficiency and erectile dysfunction.
Dehydroepiandrosterone Sulfate (DHEA-S):
- Purpose: To measure DHEA-S, an androgen precursor produced by the adrenal glands.
- Why Is It Ordered: To evaluate adrenal gland function and its contribution to androgen levels.
Complete Blood Count (CBC):
- Purpose: To evaluate overall blood health.
- Why Is It Ordered: Testosterone can influence red blood cell production, so it’s important to monitor for conditions like polycythemia.
Prostate-Specific Antigen (PSA):
- Purpose: To screen for prostate health.
- Why Is It Ordered: Testosterone can influence prostate growth; monitoring PSA is important, especially in older men or those receiving testosterone replacement therapy.
- Purpose: To measure cholesterol and triglycerides.
- Why Is It Ordered: Hormonal imbalances can impact cardiovascular health and lipid metabolism.
Liver Function Test:
- Purpose: To assess liver enzyme levels and overall liver function.
- Why Is It Ordered: The liver metabolizes hormones; liver function can influence hormone levels.
Thyroid Function Tests:
- Purpose: To assess thyroid gland function.
- Why Is It Ordered: Thyroid disorders can affect sexual health and hormone levels.
These tests, when ordered alongside an Estradiol and Adult Male Testosterone Total panel, provide a comprehensive evaluation of hormonal health in men. They are crucial for diagnosing conditions like hypogonadism, erectile dysfunction, infertility, and assessing the risk of hormone-related issues such as polycythemia and prostate enlargement. The specific combination of tests will depend on the individual's symptoms, clinical history, and the reason for testing.
Conditions or Diseases the Estradiol and Testosterone Total (Male) Test Can Check For
Hypogonadism: A condition where the body doesn't produce enough testosterone.
Gynecomastia: Abnormal breast tissue enlargement in males, which can be due to elevated estradiol levels.
Pituitary gland disorders: The pituitary gland regulates the production of testosterone. Abnormal results might suggest issues with this gland.
Testicular tumors: Some tumors can lead to elevated testosterone levels.
Aromatase excess syndrome: A condition where there's an excessive conversion of testosterone to estradiol in males, leading to feminizing features.
In conclusion, the Estradiol and Testosterone Total (Male) test is a fundamental tool in understanding a man's hormonal health. By evaluating both testosterone and estradiol levels, healthcare professionals can diagnose, treat, and manage a variety of conditions, ensuring optimal male health and well-being.
We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.