Adrenal Fatigue Tests

Adrenal glands are quite small but play a crucial role in your life. These glands produce several hormones, including the most notable cortisol hormone, which handles the fight-or-flight response. Early adrenal disease tests help track your hormonal levels and see if they are out of balance. Adrenal disease tests are quite convenient and provide you with the necessary health information you require. 

Our tests are highly accurate and reliable so that you can make informed decisions about your health. We also guarantee confidential and secure results. With Ulta Lab Tests, you don't need a doctor's referral or insurance to order lab tests. We offer affordable pricing as well as a 100% satisfaction guarantee. 

Order your Adrenal fatigue tests now. You can view the results online in 24 to 48 hours for most tests. 


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17-Hydroxypregnenolone, LC/MS/MS

Clinical Significance

17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.

 


17-hydroxyprogesterone is elevated in patients with congenital adrenal hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.

Clinical Significance

21- Hydroxylase Antibody - 21-Hydroxylase Antibody is present in patients with autoimmune destruction of the adrenal glands, leading to Addison's disease. Antibody is also seen in autoimmune polyglandular syndrome.


Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's disease, Cushing's syndrome, adrenal carcinoma, ectopic ACTH syndrome, and adrenal nodular hyperplasia.

Determination of aldosterone is useful in the diagnosis and evaluation of primary aldosteronism, selective hypoaldosteronism, edematous states, and other conditions of electrolyte imbalance

Androstenedione is useful when evaluating patients with androgen excess and managing patients with Congenital Adrenal Hyperplasia (CAH).

Antiadrenal Antibody Screen With Reflex To Titer

This is a reflex test that may require additional tests to be run at additional cost to the patient.

If  Adrenal Antibody Screen is positive, Adrenal Antibody Titer will be performed at an additional charge (CPT code(s): 86256).


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Serum calcium is involved in the regulation of neuromuscular and enzyme activity, bone metabolism and blood coagulation. Calcium blood levels are controlled by a complex interaction of parathyroid hormone, vitamin D, calcitonin and adrenal cortical steroids. Calcium measurements are useful in the diagnosis of parathyroid disease, some bone disorders and chronic renal disease. A low level of calcium may result in tetany.

Cortisol, LC/MS/MS, Saliva Collection Kit

  1. Pick up the Cortisol, LC/MS/MS, Saliva Collection Kit from the Patient Service Center that is selected when placing the order.
  2. Collection Instructions

    1. Place contents on a clean and dry surface.
    2. Firmly attach the Collection Tube (E) provided to the base (D) of the Compression tube (C) (Figure 1). In preparation for saliva collection, pool saliva in the mouth. Sample collection may now begin.
    3. Place the tip of the pad of the Collector (A) where saliva has pooled (Figure 2).
    4. The Collector (A) may be removed from the mouth periodically to read the SVAI, but resume collection immediately afterward. Collect until the appearance of the SVAI (B) changes from white to fully red (Figure 3). The collection procedure should last approximately 1-5 minutes.
    6. Place the white absorbent pad end into the Compression Tube (C) holding the Collector (A) in an upright and vertical position and firmly push the plunger downwards to transfer saliva from the absorbent pad into the Collection Tube (E). Push and hold for 30 seconds (Figure 4).
    6. Gently remove the Collection Tube (E) from the end of the Compression Tube (C). It is appropriate to remove the Collection Tube (E) during expression if necessary due to foaming. Close the lid on the tube tightly.
    7. Label the collected sample immediately, include date and time of collection and store at refrigerated temperatures for shipment.
    For Technical Support, call 1-800-642-4657 ext. 2904.

    Transport Temperature

    Room temperature

     


Cortisol is increased in Cushing's disease and decreased in Addison's disease (adrenal insufficiency).

Cortisol is increased in Cushing's disease and decreased in Addison's disease (adrenal insufficiency).

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 7 a.m.-9 a.m.


Urinary Free Cortisol is useful in the detection of patients with Cushing's syndrome for whom Free Cortisol concentrations are elevated.

Free cortisol is useful in the detection of patients with Cushing's syndrome for whom free cortisol concentrations are elevated.

Reference Range(s)

Adult    
8:00 A.M.-10:00 A.M. 0.07-0.93 µg/dL
4:00 P.M.-6:00 P.M. 0.04-0.45 µg/dL
10:00 P.M.-11:00 P.M. 0.04-0.35 µg/dL

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency).

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency).

Deoxycorticosterone (DOC) is a weak mineralocorticoid derived from 21-hydroxylation of progesterone in the adrenal cortex.

Dexamethasone

 

Clinical Significance

Test used in the differential diagnosis of Cushing's syndrome.


DHEA is a weakly androgenic steroid that is useful when congenital adrenal hyperplasia is suspected. It is also useful in determining the source of androgens in hyperandrogenic conditions, such as polycystic ovarian syndrome and adrenal tumors.

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with polycystic ovarian syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with Polycystic Ovarian Syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.


Estrogens are secreted by the gonads, adrenal glands, and placenta. Total estrogens provide an overall picture of estrogen status for men and women.

Potassium measurements are useful in monitoring electrolyte balance in the diagnosis and treatment of disease conditions characterized by low or high blood potassium levels. Potassium is elevated in adrenal cortical insufficiency, acute renal failure and in some cases of diabetic acidosis. Potassium is decreased in diuretic administration and renal tubular acidosis.

Sodium measurements are useful in the diagnosis and treatment of aldosteronism, diabetes insipidus, adrenal hypertension, Addison's Disease, dehydration, inappropriate antidiuretic hormone secretion, or other diseases involving electrolyte imbalance.

This panel identifies all major adrenal steroid hormones and facilitates the diagnosis of the four enzymatic defects associated with congenital adrenal hyperplasia (CAH).


Adrenal glands are quite small but play a crucial role in your life. These glands produce several hormones, including the most notable cortisol hormone, which handles the fight-or-flight response. Early adrenal disease tests help track your hormonal levels and see if they are out of balance. Adrenal disease tests are quite convenient and provide you with the necessary health information you require. 

The Adrenal Glands

The adrenal glands are located on top of the kidneys in the midsection of the body. There are two parts of each gland (medulla and cortex) responsible for producing a different set of hormones. The hormones produced by these glands include: 

  • Aldosterone
  • Cortisol
  • Epinephrine
  • Androgenic steroids
  • DHEA
  • Norepinephrine. 

Adrenal Inefficiency

Various health issues may arise when your adrenal glands are not functioning properly, including: 

  • Congenital adrenal hyperplasia
  • Adrenal insufficiency 
  • Hyperaldosteronism
  • Cushing disease
  • Adrenal cancer
  • Pheochromocytoma. 

Addison's disease or adrenal insufficiency is the result of low hormone levels produced by the adrenal glands. But when a person develops Addison's disease, it never goes away. That is why proactive lab testing is so important. There is a better chance of treating a condition if you catch it before it gets serious. 

Symptoms Of Adrenal Insufficiency

Some of the most common signs and symptoms of adrenal insufficiency include:

  • Weight loss
  • Loss of appetite
  • Exhaustion
  • Nausea & Vomiting
  • Skin darkening
  • Pain near the adrenal glands

This rare condition can be onset by:

  • Infections
  • Cancer
  • Genetics
  • Autoimmune diseases

Lab Tests for Adrenal Insufficiency

Ulta Lab Tests offers several Addison's disease test panels that cover a wide range of biomarkers. These tests will help you get a better understanding of your hormone health.

Adrenal Complete

Adrenal Complete includes eight tests that cover 41 biomarkers. It helps measure several factors such as cortisol levels, a metabolic panel, iron levels, DHEA sulfate, and magnesium. The panel is performed using both blood and saliva samples.

ULTA Adrenal Function Panel

The Adrenal Function Panel has a combination of 16 tests to review 77 biomarkers. The test is done using both blood specimens and saliva. The patient should fast for at least 9 hours before taking the test. This test measures: 

  • Blood count
  • C-reactive protein
  • Cortisol levels
  • Metabolic health
  • DHEA sulfate
  • Vitamins D
  • Uric acid
  • Lipid health
  • Insulin level
  • Homocysteine
  • Hemoglobin A1c
  • Gamma-glutamyl transferase
  • Lactate dehydrogenase
  • Magnesium level
  • Phosphate level 

STTM Adrenal Panel Total

This is a combination of 3 tests that review 23 biomarkers. The test will cover a comprehensive metabolic panel (CMP), aldosterone levels, and magnesium levels. The biomarkers that are reviewed in the CMP include:

  • Albumin 
  • Globulin
  • Alanine transaminase
  • Alkaline phosphatase
  • Aspartate aminotransferase
  • Total bilirubin
  • Carbon dioxide levels
  • Calcium level
  • Creatinine level
  • Chloride level
  • Glomerular filtration rate
  • Total protein level
  • Potassium level
  • Sodium level
  • Blood urea nitrogen levels (BUN)

Benefits Of Adrenal Insufficiency Tests

Adrenal insufficiency tests help you take full control of your health and life. These tests are quite easy to perform and provide a wealth of knowledge about your current adrenal health status.

Better Understanding of Your Body

Adrenal insufficiency covers a multitude of factors in your body. You should understand these levels and how they affect the body to make the necessary changes and regain optimal health.

Catching Other Health Issues Early On

Once you get the results of your adrenal health tests, the results can surprise you. The levels you thought were on track could be high, and those you thought were off-track may be on track. It may reveal other issues that could be affecting your health and quality of life. 

Prevention Of Addison's Disease

When you know that you are on the path towards Addison's disease, you can take action to get things under control. For example, simple lifestyle changes can easily help improve levels and resolve any health issues. If you have a genetic cause for Addison's disease, these tests will reveal which biomarkers should be closely monitored and tested more often.

Treatments

If the tests reveal that you have Addison's disease, there are many treatment options for you. You can treat the issue with hormone therapy to make up for the hormones that are not being produced by the adrenal glands. Lifestyle changes can dramatically alter the side effects of the condition. It can also help manage your stress and blood pressure levels. Addisonian Crisis is the result of untreated Addison's disease. It causes low blood sugar, low blood pressure, as well as high levels of potassium in the blood. These issues need immediate treatment since they can be life-threatening. 

Feel More Confident About Your Health

Understanding what is going on in your body and adopting lifestyle changes can impact your health and well-being in a big way. The information provided by Ulta Lab Tests helps you make the correct decisions about your health and well-being.

Testing With Ulta Lab Tests

Our tests are highly accurate and reliable so that you can make informed decisions about your health. We also guarantee confidential and secure results. With Ulta Lab Tests, you don't need a doctor's referral or insurance to order lab tests. We offer affordable pricing as well as a 100% satisfaction guarantee. 

Order your Adrenal Insufficiency lab tests now. You can view the results online in 24 to 48 hours for most tests. 

Take charge of your health today with Ulta Lab Tests.