Syphilis (RPR)

If you're struggling with troubling syphilis symptoms, such as new sores or rashes on your body, testing with Ulta Lab Tests can put your mind at ease.


Name Matches

RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing

IMPORTANT:  NOTE THIS IS A REFLUX TEST - The price charged for this test is only for the RPR. ADDITIONAL CHARGES WILL OCCUR FOR THE REFLUX TO TITER AND CONFIRMATION TESTING .

Clinical Significance

This is a non-treponemal screening test for syphilis. False positive results may occur due to systemic lupus erythematosus, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy. Monitoring of RPR is helpful in assessing effectiveness of therapy.

Limitations

False-positive results have been associated in patients with infections, pregnancy, autoimmune disease, old age, Gaucher disease, and malignancy.

Alternative Name(s) 

Premarital RPR,Syphilis Serology Screen, Blood,ART,Rapid Plasma Reagin,Automated Reagin Test


RPR (Monitor) with Reflex to Titer 

Reference Range(s)

  • Non-Reactive

Clinical Significance

This is a non-treponemal screening test for syphilis. False positive results may occur due to systemic lupus erythematosus, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy. Monitoring of RPR is helpful in assessing effectiveness of therapy.

IMPORTANT

A positive RPR screen must be followed by a specific treponemal antibody test (e.g., FTA-ABS):

A positive result on the second method confirms the screening result and the affected person is diagnosed with syphilis.

A negative result on the treponemal test may mean that the initial RPR test was falsely positive. Further testing and investigation may be done to determine the cause of the false positive.

Limitations

False-positive results have been associated in patients with infections, pregnancy, autoimmune disease, old age, Gaucher disease, and malignancy.

Alternative Name(s) 

Syphilis


Syphilis FTA-ABS (Confirmation for Syphilis RPR test)

FTA-ABS - Treponema pallidum Ab

Clinical Significance

The FTA-ABS is a specific treponemal assay to detect antibody to t. Pallidum. The FTA-ABS becomes reactive 4-6 weeks after infection. Unlike the nontreponemal tests, once the FTA-ABS test becomes reactive, it will remain reactive for many years. Since the reactivity found with the FTA-ABS does not indicate response to therapy, it is not suitable for monitoring treatment. The FTA-ABS test does not distinguish between syphillis and other treponematoses such as yaws, pinta and bejil.

The treponemal antibody test (FTA-ABS) is often used as an initial test. A positive result indicates the presence of syphilis antibodies in the blood, but since treponemal antibodies remain positive even after an infection has been treated, it does not indicate whether the person has a current infection or was infected in the past. Conversely, nontreponemal antibodies as detected with an RPR typically disappear in an adequately treated person after about 3 years. Thus, if an initial treponemal test is positive, an RPR can be performed to differentiate between an active or past infection. In this case, a positive RPR would confirm that the person has been exposed to syphilis and, if not treated previously, has an active infection or, if treatment had occurred more than 3 years ago, possible re-infection.

Alternative Name(s) 

Treponemal pallidum, Fluorescent Treponemal Antigen, Syphilis


Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2-Glycoprotein 1 Antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Includes

  • CBC (includes Differential and Platelets)
  • Antibody Screen, RBC with Reflex to Identification, Titer, and Antigen Typing 
  • ABO Group and Rh Type
  • RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing
  • Hepatitis B Surface Antigen with Reflex Confirmation*
  • Rubella Antibody (IgG), Immune Status
  •  
  • If Antibody Screen is positive, Antibody Identification, Titer, and Antigen Typing will be performed at an additional charge (CPT code(s): 86870, 86886, 86905).
  • If RPR screen is reactive, RPR Titer and FTA Confirmatory testing will be performed at an additional charge (CPT code(s): 86593, 86780).
  • If Hepatitis B Surface Antigen is positive, confirmatory testing based on the manufacturer's FDA approved recommendations will be performed at an additional charge (CPT code(s): 87341).
  •  

The major proteins seen in the serum are albumin and globulin-the latter being primarily alpha 1 and alpha 2 globulin, beta globulin and gamma globulin. Albumin accounts for more than 50% of the total serum proteins. The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. The normal A/G ratio is 0.8-2.0. The A/G ratio can be decreased in response to a low albumin or to elevated globulins. Total globulins may be increased in some chronic inflammatory diseases (TB, syphilis) multiple myeloma, collagen disease, and rheumatoid arthritis. Decreased levels are seen in hepatic dysfunction, renal disease and various neoplasms.

Most Popular
Elevated RF is found in collagen vascular diseases such as SLE, rheumatoid arthritis, scleroderma, Sjögren's Syndrome, and in other conditions such as leprosy, tuberculosis, syphilis, malignancy, thyroid disease and in a significant percentage of otherwise normal elderly patients.

The Tissue Plasminogen Activator assay is used to detect disorders of the fibrinolytic system.

Clinical Significance
VDRL, Serum - The serum VDRL test is an aid in the diagnosis of syphilis. The predictive value of a reactive VDRL is increased when combined with a treponemal-specific test such as FTA or TP-PA. A reactive VDRL test on CSF, free of blood or other contaminants, usually suggests past or present syphilis infection of the central nervous system.



Syphilis is an unwanted intruder that has hung around the human species for several thousand years. It's a sexually transmitted infection that appears in different stages. If it's not treated early, the consequences can be life-threatening.

Syphilis tests are the key to early diagnosis, treatment, and recovery. But how can you avoid catching syphilis? Is it curable? How long will symptoms last?

Let's take a closer look at syphilis testing to answer these questions and more.

What Is Syphilis?

Syphilis is a sexually transmitted disease (STD). According to the Centers for Disease Control, it is common, and the infection rate has been increasing in recent years. The Treponema pallidum bacterium causes syphilis.

Syphilis is one of the infectious diseases that a pregnant woman can pass on to her unborn child, known as congenital syphilis.

Risk Factors for Syphilis

Syphilis is almost always spread through sexual contact. During sex, transmission occurs through coming in contact with an infected person's sore.

The most common ways of contracting syphilis are through:

  • Unprotected sex
  • Sex with multiple partners
  • Men who have sex with men
  • Already having an HIV infection

All forms of sexual activity can put you at risk of catching syphilis. Men who have sex with men are at the highest risk of catching syphilis.

Causes of Syphilis

Syphilis is a bacterial infection. When an uninfected person comes into contact with a chancre, an ulcer on the genitals, they can catch the disease. This typically happens through the mucus membranes or minor cuts on the body.

What Are the Signs and Symptoms of Syphilis?

Syphilis has four main stages if left untreated. It can be hard to diagnose syphilis without screening tests, as it can look like other diseases.

Primary Stage

Syphilis first shows itself with a single chancre - a small painless ulcer. This can appear on the penis, scrotum, vagina, anus, or mouth. This is highly contagious and even kissing can spread the disease at this stage. 

Although a single chancre is common, sufferers can get many sores. If untreated, it will develop into the secondary stage.

Secondary Stage

The secondary stage shows up with skin rashes and lesions in the mouth, vagina, or anus. The skin rashes can appear on any part of the body. They may be painless, but are rough and have a red appearance. 

Other symptoms include:

  • Headaches
  • Swollen glands
  • Lesions in the groin, mouth, or under the arms
  • Muscle aches
  • Weight loss

As with the primary stage, these symptoms will pass in time. But the body cannot cure itself of syphilis. If you do not get treatment, it will move into the latent or tertiary stage.

Latent Syphilis

Once the secondary stage is over, the syphilis infection may lie dormant for a period of time. This stage can last for years.

Tertiary Syphilis

Tertiary syphilis can occur many years after the initial infection. The bacteria now start to affect organ systems, such as the liver, heart, vascular system, or joints. It can also affect the brain and the nervous system.

At any stage in the infection, syphilis can turn into neurosyphilis or ocular syphilis. These forms affect the nervous system and eyes respectively.

How Is Syphilis Diagnosed?

Syphilis is diagnosed using three methods. First, a physical examination checking the outward symptoms of the disease.

Secondly, syphilis tests will be run. Positive results on a syphilis blood test will show whether you have an active infection or have had syphilis in the past. Finally, if you have a chancre, your doctor may take a sample of fluid for testing.

The Lab Tests to Screen, Diagnose, and Monitor Syphilis

The key screening test for syphilis is the RPR (Monitor) test. This looks for the presence of antibodies and can detect syphilis in people who have the disease. This can also be used for monitoring the disease and detecting reinfection in the future.

Another test that is often used in conjunction with RPR is the FTA-ABS #4112. This test is not suitable for monitoring the effectiveness of treatment. However, it can be useful for initial diagnosis.

Frequently Asked Questions About Syphilis and Lab Testing for Syphilis

There are lots of rumors and stories online about syphilis. The most frequently asked questions about syphilis and syphilis lab tests include:

  • What should you not do if you have syphilis?

If you have syphilis, you should avoid any activity that could pass it on to another person. This would include having unprotected sex. You should also avoid using recreational drugs.

  • Is syphilis 100% curable?

It is possible to rid the body of the bacteria that causes the syphilis infection. In this way, it is 100% curable. That said, the treatment to clear the infection will not reverse the damage the condition has already done.

  • How long does it take for syphilis to go away after treatment?

If syphilis is detected early, it can be treated with a single injection of penicillin. If your doctor suspects that you have more long-term syphilis, a longer and more potent course of treatment may be needed. You will need to have further syphilis tests to check whether the infection has been cured.

Get Answers Fast With Syphilis Tests from Ulta Lab Tests

The only accurate way to know if you have this disease is through syphilis tests. They are quick, with results coming back in 2-4 days. Syphilis lab tests can help you know what you're dealing with, so you can start the right treatment as soon as possible.

Benefits of Syphilis Lab Testing with Ulta Lab Tests

Ulta Lab Tests offers syphilis tests that are highly accurate and reliable so you can make informed decisions about your health. Here are a few great things to love about Ulta Lab Tests:

  • You'll get secure and confidential results
  • You don't need health insurance
  • You don't need a physician's referral
  • You'll get affordable pricing
  • We offer a 100% satisfaction guarantee

Order your syphilis lab tests today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control with Ulta Lab Tests today!