All Liver Tests

All Liver Tests brings together the core blood tests that assess liver injurybile-flow (cholestasis), and liver function, while helping uncover common causes such as viral hepatitismetabolic/fatty liver diseasealcohol-related injuryautoimmune conditions, and genetic disorders. Early liver problems are often silent, so a proactive testing plan can identify issues before symptoms start.

Start with a hepatic function panelAST, ALT, alkaline phosphatase, GGT, total/direct bilirubin, albumin, total protein (± A/G ratio)—and add PT/INRplatelets/CBC, and basic metabolic safety labs (sodium, creatinine). Based on your history and results, include hepatitis A/B/C screeningautoimmune markers, and iron/copper/alpha-1 antitrypsin studies. Noninvasive fibrosis scores calculated from routine labs (e.g., FIB-4, APRI) help estimate scarring risk. Labs support screeningdiagnosisstaging, and monitoring, but they do not replace a clinician’s exam, ultrasound/elastography, endoscopy, or urgent care for severe symptoms.

Signs, Symptoms & Related Situations

  • Often silent early: abnormal enzymes on a routine wellness panel

  • Skin/eyes & digestion: jaundice, dark urine, pale stools, itching, low appetite, nausea

  • Abdomen & fluid: bloating or ascites, rapid weight change, leg swelling

  • Bleeding/energy: easy bruising/bleeding, fatigue, weakness

  • Thinking changes: sleep reversal, confusion (possible encephalopathy)

  • Risks & exposures: viral hepatitis risks, alcohol use, metabolic syndrome (central weight, diabetes, high triglycerides), family history of iron/copper/A1AT disorders, long-term or new medications/supplements

  • Seek urgent care now: vomiting blood or black stools, severe abdominal swelling with pain/fever, confusion or extreme sleepiness, chest pain, or trouble breathing

All symptoms and risks should be evaluated by a qualified clinician.

Why These Tests Matter

What testing can do

  • Reveal injury patterns (hepatocellular vs. cholestatic) and assess synthetic function (albumin, PT/INR)

  • Suggest causes using targeted add-ons (hepatitis panels, autoimmune markers, iron/copper/A1AT)

  • Provide risk clues for scarring via platelets and fibrosis scores (FIB-4/APRI; ELF where available)

  • Track trends over time to guide follow-up and imaging

What testing cannot do

  • Confirm cirrhosis or cancer on labs alone—imaging/elastography (and sometimes biopsy) may be needed

  • Replace medication/alcohol review, lifestyle counseling, or a clinician’s examination

  • Provide treatment or dosing advice—use results to plan with your clinician

What These Tests Measure (at a glance)

  • AST & ALT: enzymes of liver-cell injury; ALT is more liver-specific. (AST can rise with muscle injury/exercise.)

  • Alkaline Phosphatase (ALP) & GGT: cholestasis markers; GGT helps confirm that elevated ALP is liver-related (vs. bone).

  • Bilirubin (total/direct): high levels cause jaundicedirect (conjugated) bilirubin rises with cholestasis/obstruction.

  • Albumin & Total Protein (± A/G ratio): reflect protein-making (synthetic) function and nutrition/inflammation context.

  • PT/INR: clotting proteins made by the liver; prolonged INR indicates reduced synthesis.

  • Platelets & CBC: low platelets may track with portal hypertension; CBC adds anemia/infection context.

  • Safety labs (BMP): sodium and creatinine/eGFR support risk assessment and MELD-type scoring.

  • Hepatitis testing: HBsAg, anti-HBs, total anti-HBcHCV Ab with reflex RNAHAV IgM/totalHDV/HEV in select settings.

  • Autoimmune markers: ANA, ASMA, AMAIgG/IgM—support autoimmune hepatitis or primary biliary cholangitis patterns.

  • Iron & genetics: Ferritin, iron/TIBC, transferrin saturation (hemochromatosis risk); HFE testing as directed.

  • Wilson/A1AT: Ceruloplasmin (± copper studies) for Wilson disease; alpha-1 antitrypsin level/phenotype for A1AT deficiency.

  • Fibrosis indicators: FIB-4, APRI from routine labs; ELF where available.

  • HCC marker (context): AFP may support surveillance with ultrasound.

Quick Build Guide

Clinical goal Start with Add if needed
Wellness baseline / risk check Hepatic function panel (AST/ALT, ALP/GGT, bilirubin, albumin/TP) PT/INR • Platelets/CBC
Abnormal enzymes on wellness panel Liver panel • PT/INR • Platelets/CBC • BMP (Na, creatinine) HBV/HCV panels • Ferritin/Iron/TIBC • A1c/Lipids
Metabolic/fatty liver risk AST/ALT • GGT • Platelets • Albumin • A1c • Lipids Calculate FIB-4/APRI; rule out HBV/HCV
Cholestatic pattern (ALP/GGT high) Liver panel • Direct bilirubin • GGT AMA • IgM (PBC context); clinician-directed imaging
Viral hepatitis screen HBV triple panel • HCV Ab with reflex RNA Hepatic panel for injury context
Autoimmune pattern suspected Liver panel • Immunoglobulins ANA • ASMA • AMA; consider IgGsubclassing
Iron overload/elevated ferritin Ferritin • Iron/TIBC • Transferrin saturation HFE genotype per clinician
Unclear cause Liver panel • PT/INR • CBC Ceruloplasmin • Alpha-1 Antitrypsin • HBV/HCV
Monitoring known cirrhosis Bilirubin • INR • Creatinine • Sodium • Albumin • Platelets AFP per surveillance; track MELD-type labs

How the Testing Process Works

  1. Pick your starting set: most users begin with a hepatic function panelPT/INRCBC/platelets, and BMP.

  2. Provide a blood sample: no routine fasting (fast only if lipids are included). List all medications and supplements.

  3. Layer cause-finding tests: add hepatitis panelsautoimmune markers, and iron/copper/A1AT studies based on patterns and history.

  4. Get results securely: most values post within a few days.

  5. Plan next steps: your clinician may recommend ultrasound/FibroScan, MRI, or endoscopy; set a monitoring schedule to trend results.

Interpreting Results (General Guidance)

  • AST/ALT predominant elevation: hepatocellular injury (e.g., viral hepatitis, metabolic/fatty liver, alcohol, medication).

  • ALP ± GGT predominant elevation: cholestasis or bile-duct disease.

  • Rising bilirubin, high INR, low albumin: reduced synthetic function—requires closer follow-up.

  • Low platelets: may signal portal hypertension; correlate with imaging and exam.

  • High ferritin + high transferrin saturation: consider iron overload; discuss HFE testing.

  • High FIB-4/APRI: suggests advanced fibrosis; confirm with elastography.
    Always interpret patterns and trends with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Core liver set (most adults): AST • ALT • ALP • GGT • Total/Direct Bilirubin • Albumin • Total Protein (± A/G)

  • Function/severity add-ons: PT/INR • Platelets/CBC • Sodium • Creatinine

  • Cause-finding add-ons: HBV/HCV panels • ANA/ASMA/AMA • Ferritin/Iron/TIBC • Ceruloplasmin • Alpha-1 Antitrypsin • A1c/Lipids

  • Fibrosis assessment: calculate FIB-4/APRI (± ELF where available); imaging/elastography remains key

  • Monitoring: repeat the same markers on the same method to compare trends reliably.

FAQs

Do I need to fast for liver tests?
No. Fast only if your order includes lipids.

Can medicines or supplements affect results?
Yes. Many drugs and some supplements alter enzymes. List everything you take on the order.

Are normal liver tests a clean bill of health?
Not always. Compensated disease can test near normal; risk-based screening still matters.

What is the difference between LFTs and “liver function”?
“LFTs” include injury markers (AST/ALT, ALP/GGT) and function markers (albumin, PT/INR)—both are important.

When should I add hepatitis or autoimmune testing?
When enzymes are persistently abnormal or risk/history suggests infection or autoimmune disease.

What is FIB-4?
noninvasive fibrosis score using age, AST, ALT, and platelets; high values suggest more scarring and prompt elastography.

How often should I recheck labs?
It depends on results and risk. Many people recheck every 3–12 months—follow your clinician’s plan.

Related Categories & Key Tests

  • Liver & Gallbladder Tests Hub

  • Hepatic Function Tests • Hepatitis Screening Tests • Hepatitis Tests • Cirrhosis Tests • Fatty Liver (Metabolic) • Autoimmune Liver Disease

  • Key Tests: AST • ALT • Alkaline Phosphatase • GGT • Total/Direct Bilirubin • Albumin • Total Protein • A/G Ratio • PT/INR • Platelets/CBC • Sodium • Creatinine/eGFR • HBsAg • Anti-HBs • Anti-HBc • HCV Ab ± RNA • ANA • ASMA • AMA • Ferritin • Iron/TIBC • Transferrin Saturation • Ceruloplasmin • Alpha-1 Antitrypsin Level/Phenotype • A1c • Lipid Panel • FIB-4/APRI (calculated) • ELF (where available) • AFP

References

  • American Association for the Study of Liver Diseases (AASLD) — Guidance on evaluation of abnormal liver chemistries and chronic liver diseases.
  • AASLD — Guidance on MASLD/NAFLD, autoimmune liver disease, and cholestatic disease.
  • European Association for the Study of the Liver (EASL) — Clinical practice guidelines on liver disease assessment and fibrosis.
  • World Health Organization — Hepatitis B and C testing guidelines.
  • U.S. Preventive Services Task Force — Screening for Hepatitis B and C.
  • Clinical reviews on noninvasive fibrosis scores (FIB-4, APRI, ELF) and laboratory monitoring in liver disease.

Available Tests & Panels

Your All Liver Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to build the right package—hepatic function panelPT/INRCBC/plateletsBMP, plus hepatitis panelsautoimmune markersiron/copper/A1ATstudies, and fibrosis scoring support. Review results with your clinician to set imaging, follow-up timing, and an ongoing monitoring plan.

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The Sed Rate Test, also called the ESR Test, measures how quickly red blood cells settle in a sample of blood. A faster rate may signal inflammation caused by infections, autoimmune diseases, arthritis, or other chronic conditions. Doctors use this test to investigate unexplained fever, joint pain, or muscle aches, and to monitor inflammatory disorders such as lupus or rheumatoid arthritis. The Sed Rate Test provides important insight into overall inflammatory activity.

Blood
Blood Draw
Also Known As: Erythrocyte Sedimentation Rate Test, ESR Test, Sedimentation Rate Test, Westergren Sedimentation Rate Test

The Sedimentation Rate Blood Test, also called the Erythrocyte Sedimentation Rate (ESR) Test, measures how quickly red blood cells settle in a sample. A faster rate can signal inflammation linked to arthritis, autoimmune disease, or infection. Doctors order this test when patients have symptoms like joint pain, fever, or fatigue. While not diagnostic alone, results provide valuable insight into inflammatory activity and help guide further evaluation and treatment.

Blood
Blood Draw
Also Known As: Sed Rate Test

The Serum Protein Electrophoresis (SPEP) Test separates proteins in blood into albumin and globulin fractions to detect abnormal patterns. Doctors order this test to evaluate multiple myeloma, Waldenström’s macroglobulinemia, amyloidosis, or chronic infections. Abnormal results may indicate monoclonal gammopathy or immune disorders. Results provide essential insight into protein balance, immune function, and blood-related cancers, guiding diagnosis and monitoring.

Also Known As: SPEP Test, Protein Total and Electrophoresis Test, Protein ELP Test, SPE Test, Serum Protein Electrophoresis Test

The Sex Hormone Binding Globulin (SHBG) Test measures SHBG, a protein that binds testosterone and estrogen, to assess how much active hormone is available in the body. Abnormal levels may indicate PCOS, infertility, low testosterone, liver disease, or thyroid disorders. Doctors order this test to investigate symptoms like low libido, irregular periods, acne, or hair loss and to evaluate hormone balance, endocrine function, and metabolic health in men and women.

Blood
Blood Draw
Also Known As: SHBG Test, TeBG Test, Testosterone-Estrogen Binding Globulin Test

The Sjögren’s SS-A and SS-B Antibodies Test detects autoantibodies linked to Sjögren’s syndrome, an autoimmune disorder affecting tear and saliva glands. High levels are also associated with lupus and other connective tissue diseases. Doctors order this test for patients with dry eyes, dry mouth, joint pain, or fatigue. Results help confirm diagnosis, distinguish autoimmune conditions, and guide long-term management and treatment planning.

Blood
Blood Draw
Also Known As: Sjögren’s Antibodies Test

The Sjögren's SS-A Antibody Test detects SS-A (Ro) antibodies often linked to Sjögren’s syndrome, lupus, and other autoimmune disorders. These antibodies are associated with dry eyes, dry mouth, joint pain, and systemic inflammation. By measuring SS-A levels, the test supports evaluation of autoimmune activity, connective tissue disease, and overall immune system health in patients with persistent symptoms.

Blood
Blood Draw

The Sjögren's SS-B Antibody Test measures antibodies targeting the SS-B/La antigen, aiding diagnosis of Sjögren’s syndrome and differentiating it from other autoimmune conditions. Detected most often with SS-A/Ro antibodies, SS-B positivity can guide clinicians in assessing disease activity, organ involvement, and systemic features. This test supports evaluation of patients with chronic dryness, fatigue, or suspected connective tissue disease.

Blood
Blood Draw

The Sm and Sm/RNP Antibodies Test detects autoantibodies associated with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Sm antibodies are highly specific for lupus, while Sm/RNP antibodies appear in MCTD and sometimes overlap syndromes. Physicians use this test to support diagnosis, evaluate autoimmune activity, and guide monitoring alongside other clinical findings and laboratory markers.

Blood
Blood Draw

The Sm Antibody Test measures antibodies against Smith antigens, strongly associated with systemic lupus erythematosus. It helps identify autoimmune activity, connective tissue disorders, and systemic inflammation. This test provides information about persistent symptoms including fatigue, arthritis, rash, or kidney involvement, supporting evaluation of lupus and related autoimmune disease.

Blood
Blood Draw

Blood
Blood Draw

The Systemic Lupus Erythematosus (SLE) Comprehensive Diagnostic Panel measures key autoimmune markers to aid in lupus diagnosis and monitoring. This panel includes ANA Screen with reflex, dsDNA, chromatin, Sm, RNP, Sjögren’s (SS-A, SS-B), and complement levels (C3c, C4c, CH50). Doctors order this test for patients with fatigue, joint pain, rash, or organ involvement. Results provide critical insight into immune activity, disease severity, and treatment guidance.

Also Known As: Lupus Panel with ANA Screen IFA with Reflex to Titer and Pattern, SLE Antibody Panel

The Systemic Lupus Erythematosus Disease Activity Panel assesses key lupus markers, including complement proteins, autoantibodies, and inflammatory indicators. It supports detection of lupus flares, monitoring of renal and systemic involvement, and evaluation of immune system dysregulation. This panel aids in tracking lupus severity, disease activity, and response to ongoing management.

Also Known As: SLE Disease Activity Test

Most Popular

The T3 Uptake Test estimates thyroid hormone-binding capacity by measuring how well proteins in the blood bind triiodothyronine (T3). It does not measure T3 directly but helps assess thyroid function when combined with Total T4. Abnormal results may indicate hyperthyroidism, hypothyroidism, pregnancy, or protein-binding disorders. Doctors use this test to investigate fatigue, weight changes, or irregular heartbeat and to guide thyroid treatment decisions.

Blood
Blood Draw

The Thyroxine Binding Globulin (TBG) Test measures levels of TBG, the protein that carries thyroid hormones T4 and T3 in the blood. Abnormal levels can affect total thyroid hormone measurements and may indicate liver disease, genetic conditions, pregnancy, or medication effects. Doctors use this test to evaluate unexplained thyroid function results, distinguish true thyroid disorders from binding protein abnormalities, and guide treatment decisions.

Blood
Blood Draw
Also Known As: Thyroxine Binding Globulin Test


The Cholesterol Total Test measures the overall amount of cholesterol in blood, combining LDL and HDL, to evaluate cardiovascular health. High cholesterol is a major risk factor for heart disease, atherosclerosis, and stroke, while low levels may also affect health. Doctors use this test for routine screening, monitoring treatment, and assessing heart risk. Results provide key insight into lipid balance, helping guide lifestyle changes and therapy decisions.

Blood
Blood Draw
Also Known As: Blood Cholesterol Test

Most Popular

The Transferrin Test measures transferrin, a blood protein that transports iron, to evaluate iron status and nutritional health. High levels may suggest iron deficiency anemia, while low levels may indicate liver disease, malnutrition, or chronic illness. Doctors use this test alongside iron and TIBC to investigate fatigue, weakness, or anemia symptoms. Results provide vital insight into iron balance, red blood cell production, and overall metabolic function.

Blood
Blood Draw

The Triglycerides Test measures triglyceride levels in blood to evaluate heart health and metabolic function. High levels may increase risk for cardiovascular disease, atherosclerosis, or pancreatitis, while low levels may reflect nutritional issues. Doctors use this test as part of lipid screening to assess patients with obesity, diabetes, or high cholesterol. Results provide vital insight into fat metabolism, cardiovascular risk, and overall wellness management.

Blood
Blood Draw
Also Known As: TG Test, TRIG Test

The Urea Nitrogen 24 Hour Urine Test measures nitrogen excreted over a full day to evaluate protein metabolism and kidney function. Elevated levels may reflect high protein intake, catabolic states, or certain metabolic conditions, while decreased levels can indicate malnutrition, liver disease, or impaired renal function. This test provides valuable insight into nutritional balance, metabolic health, and renal performance.

Urine
Urine Collection
Also Known As: 24 Hour Urine Urea Nitrogen Test

The Blood Urea Nitrogen (BUN) Test measures urea nitrogen levels in blood to assess kidney function and how well the body removes waste. Elevated BUN may indicate kidney disease, dehydration, heart failure, or high protein intake, while low levels may suggest liver disease or malnutrition. Doctors order this test to evaluate fatigue, swelling, or abnormal lab results. Results help diagnose kidney and liver conditions and guide treatment decisions.

Blood
Blood Draw
Also Known As: BUN Test, Blood Urea Nitrogen Test

 A Urinalysis Screen test is a common diagnostic tool used in healthcare to assess and monitor various disorders by analyzing a patient's urine. This test encompasses a range of examinations including physical, chemical, and microscopic aspects of urine. It's a non-invasive, quick, and often revealing test that can provide significant insights into a person's health.
Urine
Urine Collection

The Vitamin D 25-Hydroxy Total Test measures levels of 25-hydroxyvitamin D in blood to evaluate vitamin D status, bone health, and calcium balance. It helps detect deficiency, insufficiency, or toxicity, which can affect immune function, muscle strength, and risk of osteoporosis. Doctors use this test to assess overall nutritional health, monitor supplementation, and support diagnosis of metabolic or endocrine disorders linked to vitamin D.

Blood
Blood Draw
Also Known As: 25-hydroxyvitamin D Test, Vitamin D 25-OH Test, Total 25-OH D Test

Blood
Blood Draw

The Zinc Protoporphyrin (ZPP) Test measures ZPP levels in red blood cells to detect iron deficiency and lead exposure. When iron is low or lead interferes with hemoglobin production, ZPP accumulates, making it a sensitive early marker. Doctors use this test to screen for iron-deficiency anemia, monitor occupational lead exposure, and evaluate unexplained anemia, helping guide diagnosis, prevention, and treatment strategies.

Blood
Blood Draw
Also Known As: ZPP Test, ZP Test, Free Erythrocyte Protoporphyrin Test, FEP Test

Nearly 4.5 million Americans — almost 1 in every 50 — live with liver disease. Are you one of them? If you're not sure, it might be time to order a liver function test.

A hepatic function panel tests how well your liver is working. Taking the initiative to check your liver function before noticing a problem could help you avoid serious health issues. 

Keep reading to learn what a hepatic function panel is, how it can help you catch health issues early, and how you can order it yourself online. 

What is a Decline in Hepatic Function?

Your liver is your body's hard-working multitasker. It performs many crucial functions, including:

  • Monitoring and regulating chemicals in your blood
  • Cleaning toxins from your blood
  • Performing functions with your immune system
  • Storing energy in the form of glycogen
  • Helping break down fatty food
  • Breaking down old red blood cells

Your liver is important to almost every function in your body. When your liver works poorly, your whole body can be affected. In medicine, this is known as a decline in hepatic function. 

Declining hepatic function can lead to serious health complications. That's why it's important to check your liver health as soon as you suspect that there may be a problem. 

Risk Factors for a Decline in Hepatic Function

You should watch for signs of liver problems if you have any risk factors for liver damage, including:

  • Traveling without being vaccinated against Hepatitis
  • Drinking more than the recommended maximum amount of alcohol per day
  • Being in contact with needles that aren't clean
  • Taking more than the recommended amount of medication that can harm your liver

While none of these risk factors guarantee that you will have a decline in hepatic function, they make it more likely that you will have liver problems.

Causes of a Decline in Hepatic Function

A decline in hepatic function is usually caused by liver damage or disease, such as:

  • A virus that damages the liver (such as Hepatitis A, B, and C)
  • Naturally occurring toxins
  • Excessive drug use (both street drugs and prescribed drugs)
  • Alcohol-related liver damage (alcoholic cirrhosis)
  • Liver cancer

A chronic disease like alcoholism can damage your liver slowly over a long period of time. Other diseases, such as viruses, can damage your liver quickly and leave you with lasting liver problems.

Signs and Symptoms of a Decline in Hepatic Function

If your liver is damaged, you'll need to get help immediately. Symptoms of low hepatic function include:

  • Jaundice (yellow color of your skin and eyes)
  • Light-colored stool and dark-colored urine
  • Nausea, vomiting, and diarrhea
  • Pain in your lower abdomen
  • Fatigue

If you see any of these symptoms of liver failure develop, you could be at risk for serious illness from liver damage and should have your liver function assessed right away.  

How is Decline in Hepatic Function Diagnosed?

A lab can analyze your hepatic function using blood tests. When you order your liver test online, you'll go to a patient service center to get a blood draw. They will take a sample of blood on which to perform tests.

Lab Tests to Screen, Diagnose, and Monitor Decline in Hepatic Function

Because your liver performs so many functions, a hepatic function panel includes a wide range of tests. These blood tests check how well your liver is doing its various tasks.

There are so many possible liver function tests that they are usually bundled together into a liver function panel. The most common tests included in a liver function panel are:

  • Aspartate transaminase (AST)
  • Alanine transaminase (ALT)
  • Bilirubin
  • Albumin and total protein
  • Blood creatinine 
  • Ammonia

Once you've been diagnosed with a decline in hepatic function, you can continue to order liver function panels to monitor your liver's status. 

You can also get lab tests to diagnose the cause of your liver problems, including:

These tests can help you narrow down the source of damage to your liver.

Frequently Asked Questions About Decline in Hepatic Function

Fortunately, testing hepatic function involves straightforward tests. However, you may still have questions. 

Are There Any Risks Involved in a Hepatic Function Panel?

When you get your hepatic function tested, the only risks involved are the normal side effects of getting a blood test. You may see some bleeding and bruising around the blood test site. To minimize bruising, put a bandage over the site and hold it on with firm pressure for several minutes after the blood test. 

Should I Fast Before My Hepatic Function Tests?

It depends on which tests you order. Some tests do not require you to fast before you have your blood drawn, but others do. Make sure to ask your doctor or online medical professional about the specific tests that you have ordered.

Keep in mind that you may want to order other tests in addition to your hepatic function panel, like a comprehensive metabolic panel, and have them all done at once. If you are ordering other tests, you may need to fast for those ones, even if you don't have to fast for your hepatic function tests.

To fast, avoid eating for 12 hours before the test. Avoid drinking anything other than water. 

Do I Have To Wait For a Doctor to Order Hepatic Function Tests For Me?

When you order your lab test online, you don't have to wait for a doctor's referral. This saves you time and money.

Catch Liver Disease Early With a Hepatic Function Panel

Your liver is one of the most essential organs in your body. If your liver is damaged, you should know about it right away. 

Ulta Lab Tests lets you order lab tests with no need for a physician referral, so you can be proactive about your health. You'll get your confidential results in as little as 24 to 48 hours.

Take control of your liver health today with a hepatic function panel test from Ulta Lab Tests.

Jaundice, also called icterus, is a condition where the skin, the whites of the eyes, and even body fluids turn significantly yellow following an increase in the levels of bilirubin in the blood. Bilirubin is a yellowish substance that forms from the normal breakdown of red blood cells (or RBCs). Red blood cells normally live for about 120 days before being broken down by the body, a process that results in the formation of bilirubin. Bilirubin is then transported to the liver where it is metabolized and excreted in bile. Bile is a yellow-green-to-brown fluid that is released into the duodenum to help in the digestion of lipids and the elimination of waste substances like bilirubin and excess cholesterol. Changes to the normal metabolism process or overproduction of bilirubin may lead to jaundice. 

Jaundice is not an illness, per se. Rather, it is a medical condition that may indicate an underlying liver, pancreas, or gallbladder problem. Jaundice can be caused by several factors, including infections, cancer, use of certain drugs, gallstones, blood disorders, inherited conditions, congenital disabilities, among other medical conditions.

Generally, the causes of jaundice may be categorized into these three groups: 

  • Conditions that arise from the inability of the liver to metabolize and eliminate bilirubin 
  • Conditions that cause shortened life for red blood cells, which in turn leads to increased levels of bilirubin 
  • Conditions that inhibit the elimination of bilirubin from the body 

Common Causes of Jaundice 

Acute hepatitis: inflammation of the liver due to various reasons, including hepatitis A, B, C, D, and E, alcohol abuse, viral infections, toxins, and some medicines such as acetaminophen. 

Blockage of the bile duct, which may be caused by: 

  • Damage and Scarring 
  • Biliary atresia, a congenital condition linked to the abnormal development of the bile duct, which results in the backup and pooling of bile and an increase in the level of bilirubin in the blood. 
  • Gallstones 
  • Pancreatic cancer may sometimes lead to the blockage of the bile duct. 

Conditions that result in a significant increase in the rate of red blood cell destruction cause an increase in bilirubin production. Such conditions include hemolytic anemia, due to an abnormal variant of hemoglobin, autoimmune disorders, malaria, or hemolytic disease of the newborn (or HDN). 

Gilbert syndrome: an inherited condition that is associated with reduced bilirubin metabolism due to decreased enzyme activity. Individuals with Gilbert syndrome may have passing jaundice during times of sickness or stress and times of increased levels of unconjugated bilirubin. 

Cirrhosis: jaundice can occur in the late stages of cirrhosis. 

Laboratory Tests 

Some of the tests used to assess liver function and detect liver damage include: 

Liver panel, which often comprises: 

ALT (or Alanine aminotransferase) 

AST (or Aspartate aminotransferase) 

ALP (or Alkaline phosphatase) 

Bilirubin, Total (conjugated and unconjugated), Direct (conjugated) and Indirect (unconjugated) 

GGT (or Gamma-glutamyl transferase) 

Albumin 

Prothrombin time (or PT): the liver produces essential proteins for blood clotting/coagulation. The PT measures the clotting function, which may indicate liver damage if abnormal. 

Urine bilirubin, which often falls under a urinalysis 

Some tests are important for the detection of infections that affect the liver, including: 

Tests that come in handy in detecting reduced red blood cell survival include: