All Liver Tests

All Liver Tests brings together the core blood tests that assess liver injurybile-flow (cholestasis), and liver function, while helping uncover common causes such as viral hepatitismetabolic/fatty liver diseasealcohol-related injuryautoimmune conditions, and genetic disorders. Early liver problems are often silent, so a proactive testing plan can identify issues before symptoms start.

Start with a hepatic function panelAST, ALT, alkaline phosphatase, GGT, total/direct bilirubin, albumin, total protein (± A/G ratio)—and add PT/INRplatelets/CBC, and basic metabolic safety labs (sodium, creatinine). Based on your history and results, include hepatitis A/B/C screeningautoimmune markers, and iron/copper/alpha-1 antitrypsin studies. Noninvasive fibrosis scores calculated from routine labs (e.g., FIB-4, APRI) help estimate scarring risk. Labs support screeningdiagnosisstaging, and monitoring, but they do not replace a clinician’s exam, ultrasound/elastography, endoscopy, or urgent care for severe symptoms.

Signs, Symptoms & Related Situations

  • Often silent early: abnormal enzymes on a routine wellness panel

  • Skin/eyes & digestion: jaundice, dark urine, pale stools, itching, low appetite, nausea

  • Abdomen & fluid: bloating or ascites, rapid weight change, leg swelling

  • Bleeding/energy: easy bruising/bleeding, fatigue, weakness

  • Thinking changes: sleep reversal, confusion (possible encephalopathy)

  • Risks & exposures: viral hepatitis risks, alcohol use, metabolic syndrome (central weight, diabetes, high triglycerides), family history of iron/copper/A1AT disorders, long-term or new medications/supplements

  • Seek urgent care now: vomiting blood or black stools, severe abdominal swelling with pain/fever, confusion or extreme sleepiness, chest pain, or trouble breathing

All symptoms and risks should be evaluated by a qualified clinician.

Why These Tests Matter

What testing can do

  • Reveal injury patterns (hepatocellular vs. cholestatic) and assess synthetic function (albumin, PT/INR)

  • Suggest causes using targeted add-ons (hepatitis panels, autoimmune markers, iron/copper/A1AT)

  • Provide risk clues for scarring via platelets and fibrosis scores (FIB-4/APRI; ELF where available)

  • Track trends over time to guide follow-up and imaging

What testing cannot do

  • Confirm cirrhosis or cancer on labs alone—imaging/elastography (and sometimes biopsy) may be needed

  • Replace medication/alcohol review, lifestyle counseling, or a clinician’s examination

  • Provide treatment or dosing advice—use results to plan with your clinician

What These Tests Measure (at a glance)

  • AST & ALT: enzymes of liver-cell injury; ALT is more liver-specific. (AST can rise with muscle injury/exercise.)

  • Alkaline Phosphatase (ALP) & GGT: cholestasis markers; GGT helps confirm that elevated ALP is liver-related (vs. bone).

  • Bilirubin (total/direct): high levels cause jaundicedirect (conjugated) bilirubin rises with cholestasis/obstruction.

  • Albumin & Total Protein (± A/G ratio): reflect protein-making (synthetic) function and nutrition/inflammation context.

  • PT/INR: clotting proteins made by the liver; prolonged INR indicates reduced synthesis.

  • Platelets & CBC: low platelets may track with portal hypertension; CBC adds anemia/infection context.

  • Safety labs (BMP): sodium and creatinine/eGFR support risk assessment and MELD-type scoring.

  • Hepatitis testing: HBsAg, anti-HBs, total anti-HBcHCV Ab with reflex RNAHAV IgM/totalHDV/HEV in select settings.

  • Autoimmune markers: ANA, ASMA, AMAIgG/IgM—support autoimmune hepatitis or primary biliary cholangitis patterns.

  • Iron & genetics: Ferritin, iron/TIBC, transferrin saturation (hemochromatosis risk); HFE testing as directed.

  • Wilson/A1AT: Ceruloplasmin (± copper studies) for Wilson disease; alpha-1 antitrypsin level/phenotype for A1AT deficiency.

  • Fibrosis indicators: FIB-4, APRI from routine labs; ELF where available.

  • HCC marker (context): AFP may support surveillance with ultrasound.

Quick Build Guide

Clinical goal Start with Add if needed
Wellness baseline / risk check Hepatic function panel (AST/ALT, ALP/GGT, bilirubin, albumin/TP) PT/INR • Platelets/CBC
Abnormal enzymes on wellness panel Liver panel • PT/INR • Platelets/CBC • BMP (Na, creatinine) HBV/HCV panels • Ferritin/Iron/TIBC • A1c/Lipids
Metabolic/fatty liver risk AST/ALT • GGT • Platelets • Albumin • A1c • Lipids Calculate FIB-4/APRI; rule out HBV/HCV
Cholestatic pattern (ALP/GGT high) Liver panel • Direct bilirubin • GGT AMA • IgM (PBC context); clinician-directed imaging
Viral hepatitis screen HBV triple panel • HCV Ab with reflex RNA Hepatic panel for injury context
Autoimmune pattern suspected Liver panel • Immunoglobulins ANA • ASMA • AMA; consider IgGsubclassing
Iron overload/elevated ferritin Ferritin • Iron/TIBC • Transferrin saturation HFE genotype per clinician
Unclear cause Liver panel • PT/INR • CBC Ceruloplasmin • Alpha-1 Antitrypsin • HBV/HCV
Monitoring known cirrhosis Bilirubin • INR • Creatinine • Sodium • Albumin • Platelets AFP per surveillance; track MELD-type labs

How the Testing Process Works

  1. Pick your starting set: most users begin with a hepatic function panelPT/INRCBC/platelets, and BMP.

  2. Provide a blood sample: no routine fasting (fast only if lipids are included). List all medications and supplements.

  3. Layer cause-finding tests: add hepatitis panelsautoimmune markers, and iron/copper/A1AT studies based on patterns and history.

  4. Get results securely: most values post within a few days.

  5. Plan next steps: your clinician may recommend ultrasound/FibroScan, MRI, or endoscopy; set a monitoring schedule to trend results.

Interpreting Results (General Guidance)

  • AST/ALT predominant elevation: hepatocellular injury (e.g., viral hepatitis, metabolic/fatty liver, alcohol, medication).

  • ALP ± GGT predominant elevation: cholestasis or bile-duct disease.

  • Rising bilirubin, high INR, low albumin: reduced synthetic function—requires closer follow-up.

  • Low platelets: may signal portal hypertension; correlate with imaging and exam.

  • High ferritin + high transferrin saturation: consider iron overload; discuss HFE testing.

  • High FIB-4/APRI: suggests advanced fibrosis; confirm with elastography.
    Always interpret patterns and trends with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Core liver set (most adults): AST • ALT • ALP • GGT • Total/Direct Bilirubin • Albumin • Total Protein (± A/G)

  • Function/severity add-ons: PT/INR • Platelets/CBC • Sodium • Creatinine

  • Cause-finding add-ons: HBV/HCV panels • ANA/ASMA/AMA • Ferritin/Iron/TIBC • Ceruloplasmin • Alpha-1 Antitrypsin • A1c/Lipids

  • Fibrosis assessment: calculate FIB-4/APRI (± ELF where available); imaging/elastography remains key

  • Monitoring: repeat the same markers on the same method to compare trends reliably.

FAQs

Do I need to fast for liver tests?
No. Fast only if your order includes lipids.

Can medicines or supplements affect results?
Yes. Many drugs and some supplements alter enzymes. List everything you take on the order.

Are normal liver tests a clean bill of health?
Not always. Compensated disease can test near normal; risk-based screening still matters.

What is the difference between LFTs and “liver function”?
“LFTs” include injury markers (AST/ALT, ALP/GGT) and function markers (albumin, PT/INR)—both are important.

When should I add hepatitis or autoimmune testing?
When enzymes are persistently abnormal or risk/history suggests infection or autoimmune disease.

What is FIB-4?
noninvasive fibrosis score using age, AST, ALT, and platelets; high values suggest more scarring and prompt elastography.

How often should I recheck labs?
It depends on results and risk. Many people recheck every 3–12 months—follow your clinician’s plan.

Related Categories & Key Tests

  • Liver & Gallbladder Tests Hub

  • Hepatic Function Tests • Hepatitis Screening Tests • Hepatitis Tests • Cirrhosis Tests • Fatty Liver (Metabolic) • Autoimmune Liver Disease

  • Key Tests: AST • ALT • Alkaline Phosphatase • GGT • Total/Direct Bilirubin • Albumin • Total Protein • A/G Ratio • PT/INR • Platelets/CBC • Sodium • Creatinine/eGFR • HBsAg • Anti-HBs • Anti-HBc • HCV Ab ± RNA • ANA • ASMA • AMA • Ferritin • Iron/TIBC • Transferrin Saturation • Ceruloplasmin • Alpha-1 Antitrypsin Level/Phenotype • A1c • Lipid Panel • FIB-4/APRI (calculated) • ELF (where available) • AFP

References

  • American Association for the Study of Liver Diseases (AASLD) — Guidance on evaluation of abnormal liver chemistries and chronic liver diseases.
  • AASLD — Guidance on MASLD/NAFLD, autoimmune liver disease, and cholestatic disease.
  • European Association for the Study of the Liver (EASL) — Clinical practice guidelines on liver disease assessment and fibrosis.
  • World Health Organization — Hepatitis B and C testing guidelines.
  • U.S. Preventive Services Task Force — Screening for Hepatitis B and C.
  • Clinical reviews on noninvasive fibrosis scores (FIB-4, APRI, ELF) and laboratory monitoring in liver disease.

Available Tests & Panels

Your All Liver Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to build the right package—hepatic function panelPT/INRCBC/plateletsBMP, plus hepatitis panelsautoimmune markersiron/copper/A1ATstudies, and fibrosis scoring support. Review results with your clinician to set imaging, follow-up timing, and an ongoing monitoring plan.

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The LH-1 Liver Health panel is a focused diagnostic tool designed to assess the overall health and functionality of the liver. This panel includes tests for Gamma Glutamyl Transferase (GGT), Hepatic Function Panel, Lactate Dehydrogenase (LDH), and Prothrombin Time with INR, offering a snapshot of liver function, potential liver damage, and the liver's ability to synthesize proteins necessary for blood clotting.
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Blood Draw

The LH-2 Liver Health panel is a comprehensive suite of tests designed to evaluate liver function, identify liver damage, and screen for specific liver disorders. This panel includes Quantitative Alpha-1-Antitrypsin, Alpha-Fetoprotein and AFP-L3, Fractionated Bilirubin (Direct, Indirect, and Total), Ceruloplasmin, Comprehensive Metabolic Panel, Gamma Glutamyl Transferase, Iron and Total Iron Binding Capacity, Lactate Dehydrogenase, and Prothrombin Time with INR. Each of these tests offers valuable insights into liver health, potential liver disease, and the liver's capacity to perform its vital functions.
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Blood Draw

The LH-3 Liver Health panel is an extensive diagnostic tool designed to provide a comprehensive assessment of liver health. This panel includes a wide range of tests that evaluate liver function, screen for liver infections, and assess liver damage. It comprises Quantitative Alpha-1-Antitrypsin, Alpha-Fetoprotein and AFP-L3, Fractionated Bilirubin, Ceruloplasmin, Comprehensive Metabolic Panel, Copper, Gamma Glutamyl Transferase, Hepatitis A, B, and C antibodies and antigens, Iron and Total Iron Binding Capacity, Lactate Dehydrogenase, and Prothrombin Time with INR.
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Blood Draw, Phlebotomist

The LH-4 Liver Health panel is the most comprehensive suite of tests tailored to provide an in-depth evaluation of liver health, function, and the presence of liver diseases, including liver cancer and viral hepatitis. It encompasses a broad spectrum of markers, from liver enzymes and proteins to specific tests for genetic conditions, liver cancer markers, and comprehensive screening for hepatitis infections.
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Blood Draw, Phlebotomist

The Liver Health - Basic panel is a targeted set of tests designed to evaluate the essential functions and overall health of the liver. This panel includes Fractionated Bilirubin (Direct, Indirect, and Total), Comprehensive Metabolic Panel, Gamma Glutamyl Transferase (GGT), and the Lipid Panel with Ratios. These tests provide crucial information about liver function, bile production and flow, liver enzyme levels, and the liver's impact on lipid metabolism.
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Blood Draw, Phlebotomist

The Liver Health - Basic Plus panel expands upon the foundation of liver function testing by adding a Complete Blood Count with Differential and Platelets and Lactate Dehydrogenase (LDH) to the core tests of Fractionated Bilirubin, Comprehensive Metabolic Panel, Gamma Glutamyl Transferase (GGT), and Lipid Panel with Ratios. This enhanced panel provides a more detailed overview of liver health, including liver enzyme levels, bilirubin processing, and the potential impact on blood cells and lipid metabolism.
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Blood Draw, Phlebotomist

The Liver Health - Advanced panel is a comprehensive diagnostic tool designed for a deep dive into liver health, offering an extensive array of tests that evaluate liver function, screen for viral hepatitis, and assess related metabolic and systemic effects. This panel includes Fractionated Bilirubin (Direct, Indirect, and Total), C-Reactive Protein (CRP), Complete Blood Count with Differential and Platelets, Comprehensive Metabolic Panel (CMP), Ferritin, Gamma Glutamyl Transferase (GGT), a full suite of hepatitis markers, Iron and Total Iron Binding Capacity (TIBC), Lactate Dehydrogenase (LDH), and a Lipid Panel with Ratios.
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Blood Draw, Phlebotomist

The Liver Health - Comprehensive panel is the most inclusive test suite for evaluating liver function and health, designed to provide a thorough analysis of liver enzymes, bilirubin levels, liver's impact on blood and iron metabolism, and screening for common viral hepatitis infections. It combines a wide range of tests, including Fractionated Bilirubin, C-Reactive Protein (CRP), Complete Blood Count with Differential and Platelets, Comprehensive Metabolic Panel (CMP), Ferritin, Gamma Glutamyl Transferase (GGT), hepatitis panels, Iron and Total Iron Binding Capacity (TIBC), Lactate Dehydrogenase (LDH), Lipid Panel with Ratios, Prealbumin, Prothrombin Time with INR, and Transferrin.
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Blood Draw, Phlebotomist

The LKM-1 IgG Antibody Test measures antibodies targeting liver kidney microsomal antigen 1, often linked to autoimmune hepatitis type 2 and liver dysfunction. It helps identify autoimmune activity, chronic hepatitis, and unexplained liver inflammation. This test provides valuable information about immune response, hepatic health, and systemic risks related to autoimmune-mediated liver disease.

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Blood Draw

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Blood Draw, Phlebotomist

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Blood Draw

The Acetaminophen Test measures the level of acetaminophen (paracetamol) in the blood to evaluate potential overdose, toxicity, or therapeutic monitoring. It helps clinicians assess liver function, determine the extent of drug exposure, and guide timely treatment decisions in cases of suspected acetaminophen poisoning or impaired medication clearance.

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Blood Draw

The Acetylcholine Receptor Binding Antibody Test detects antibodies targeting acetylcholine receptors, a hallmark of myasthenia gravis. This autoimmune disorder affects nerve-to-muscle communication, causing weakness and fatigue. The test helps confirm diagnosis, differentiate from other neuromuscular diseases, and guide treatment. Elevated antibody levels support early detection and ongoing management of myasthenia gravis.

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Blood Draw

The Acetylcholine Receptor Blocking Antibody Test evaluates autoantibodies that block acetylcholine receptors, impairing nerve-to-muscle signaling. It is commonly ordered in the workup of suspected myasthenia gravis, where these antibodies contribute to muscle fatigue and weakness. This test, often performed with AChR binding and modulating antibody assays, provides valuable insight into autoimmune mechanisms affecting neuromuscular transmission.

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Blood Draw

The Acetylcholine Receptor Modulating Antibody Test measures autoantibodies that cause loss or alteration of acetylcholine receptors on muscle cells, impairing nerve transmission. Elevated levels are commonly linked to myasthenia gravis, an autoimmune disorder causing muscle weakness. This test aids in identifying immune-mediated neuromuscular disease and helps evaluate disease severity.

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Blood Draw

The Actin Smooth Muscle IgG Antibody Test detects autoantibodies against smooth muscle actin, often linked to autoimmune hepatitis and chronic liver disease. Elevated levels may indicate liver inflammation, cirrhosis, or other autoimmune conditions. Doctors use this blood test with liver panels and additional antibody tests to aid in diagnosis, monitor disease progression, and guide treatment decisions for patients with suspected autoimmune liver disorders.

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Blood Draw
Also Known As: Actin IgG Antibody Test

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Blood Draw, Phlebotomist

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Blood Draw, Phlebotomist

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Blood Draw, Phlebotomist

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Blood Draw, Phlebotomist

The Albumin Test measures albumin, the main protein made by the liver that maintains fluid balance and transports hormones, vitamins, and medications. Low albumin may indicate liver disease, kidney problems, malnutrition, or chronic inflammation, while high levels may reflect dehydration. Doctors order this test to evaluate swelling, fatigue, or abnormal labs. Results provide key insight into nutritional status, liver and kidney function, and overall metabolic health.

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Blood Draw
Also Known As: ALB Test

The Aldolase Test measures levels of aldolase, an enzyme involved in breaking down glucose for energy. Elevated levels may indicate muscle damage, muscular dystrophy, polymyositis, dermatomyositis, or certain liver diseases. Doctors use this blood test to help diagnose and monitor muscle disorders, evaluate unexplained weakness, and track treatment response. It is often ordered alongside CK and other enzyme tests for a complete evaluation of muscle health.

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Blood Draw

The ALP Test measures alkaline phosphatase enzyme levels in blood to evaluate liver, bone, and bile duct health. High ALP may indicate liver disease, bile duct obstruction, bone disorders, or certain cancers, while low levels may suggest malnutrition or deficiency. Doctors order this test to investigate symptoms like fatigue, abdominal pain, or bone pain and often pair it with other liver function tests. Results provide key insight into metabolic and organ health.

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Blood Draw
Also Known As: Alkaline Phosphatase Test, Alk Phos Test, Alkp Test

The Alkaline Phosphatase Isoenzymes Test measures different forms of alkaline phosphatase (ALP) in the blood to determine their source, such as liver, bone, intestine, or placenta. Doctors use this test to evaluate abnormal ALP results, identify liver disease, bile duct obstruction, bone disorders like Paget’s disease, or certain cancers. It helps distinguish between conditions and guides accurate diagnosis and treatment planning.


The Alpha-1 Antitrypsin Random Feces Test measures levels of alpha-1 antitrypsin, a protein that normally remains in the bloodstream. Elevated amounts in stool suggest protein-losing enteropathy, intestinal inflammation, or gastrointestinal conditions that impair absorption. By evaluating protein loss through the digestive tract, this test helps assess intestinal integrity and overall digestive health.

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Phlebotomist
Also Known As: Alpha-1 Antitrypsin Test, A1AT Test, AAT Test, Alpha-1 Antitrypsin Feces Test

Nearly 4.5 million Americans — almost 1 in every 50 — live with liver disease. Are you one of them? If you're not sure, it might be time to order a liver function test.

A hepatic function panel tests how well your liver is working. Taking the initiative to check your liver function before noticing a problem could help you avoid serious health issues. 

Keep reading to learn what a hepatic function panel is, how it can help you catch health issues early, and how you can order it yourself online. 

What is a Decline in Hepatic Function?

Your liver is your body's hard-working multitasker. It performs many crucial functions, including:

  • Monitoring and regulating chemicals in your blood
  • Cleaning toxins from your blood
  • Performing functions with your immune system
  • Storing energy in the form of glycogen
  • Helping break down fatty food
  • Breaking down old red blood cells

Your liver is important to almost every function in your body. When your liver works poorly, your whole body can be affected. In medicine, this is known as a decline in hepatic function. 

Declining hepatic function can lead to serious health complications. That's why it's important to check your liver health as soon as you suspect that there may be a problem. 

Risk Factors for a Decline in Hepatic Function

You should watch for signs of liver problems if you have any risk factors for liver damage, including:

  • Traveling without being vaccinated against Hepatitis
  • Drinking more than the recommended maximum amount of alcohol per day
  • Being in contact with needles that aren't clean
  • Taking more than the recommended amount of medication that can harm your liver

While none of these risk factors guarantee that you will have a decline in hepatic function, they make it more likely that you will have liver problems.

Causes of a Decline in Hepatic Function

A decline in hepatic function is usually caused by liver damage or disease, such as:

  • A virus that damages the liver (such as Hepatitis A, B, and C)
  • Naturally occurring toxins
  • Excessive drug use (both street drugs and prescribed drugs)
  • Alcohol-related liver damage (alcoholic cirrhosis)
  • Liver cancer

A chronic disease like alcoholism can damage your liver slowly over a long period of time. Other diseases, such as viruses, can damage your liver quickly and leave you with lasting liver problems.

Signs and Symptoms of a Decline in Hepatic Function

If your liver is damaged, you'll need to get help immediately. Symptoms of low hepatic function include:

  • Jaundice (yellow color of your skin and eyes)
  • Light-colored stool and dark-colored urine
  • Nausea, vomiting, and diarrhea
  • Pain in your lower abdomen
  • Fatigue

If you see any of these symptoms of liver failure develop, you could be at risk for serious illness from liver damage and should have your liver function assessed right away.  

How is Decline in Hepatic Function Diagnosed?

A lab can analyze your hepatic function using blood tests. When you order your liver test online, you'll go to a patient service center to get a blood draw. They will take a sample of blood on which to perform tests.

Lab Tests to Screen, Diagnose, and Monitor Decline in Hepatic Function

Because your liver performs so many functions, a hepatic function panel includes a wide range of tests. These blood tests check how well your liver is doing its various tasks.

There are so many possible liver function tests that they are usually bundled together into a liver function panel. The most common tests included in a liver function panel are:

  • Aspartate transaminase (AST)
  • Alanine transaminase (ALT)
  • Bilirubin
  • Albumin and total protein
  • Blood creatinine 
  • Ammonia

Once you've been diagnosed with a decline in hepatic function, you can continue to order liver function panels to monitor your liver's status. 

You can also get lab tests to diagnose the cause of your liver problems, including:

These tests can help you narrow down the source of damage to your liver.

Frequently Asked Questions About Decline in Hepatic Function

Fortunately, testing hepatic function involves straightforward tests. However, you may still have questions. 

Are There Any Risks Involved in a Hepatic Function Panel?

When you get your hepatic function tested, the only risks involved are the normal side effects of getting a blood test. You may see some bleeding and bruising around the blood test site. To minimize bruising, put a bandage over the site and hold it on with firm pressure for several minutes after the blood test. 

Should I Fast Before My Hepatic Function Tests?

It depends on which tests you order. Some tests do not require you to fast before you have your blood drawn, but others do. Make sure to ask your doctor or online medical professional about the specific tests that you have ordered.

Keep in mind that you may want to order other tests in addition to your hepatic function panel, like a comprehensive metabolic panel, and have them all done at once. If you are ordering other tests, you may need to fast for those ones, even if you don't have to fast for your hepatic function tests.

To fast, avoid eating for 12 hours before the test. Avoid drinking anything other than water. 

Do I Have To Wait For a Doctor to Order Hepatic Function Tests For Me?

When you order your lab test online, you don't have to wait for a doctor's referral. This saves you time and money.

Catch Liver Disease Early With a Hepatic Function Panel

Your liver is one of the most essential organs in your body. If your liver is damaged, you should know about it right away. 

Ulta Lab Tests lets you order lab tests with no need for a physician referral, so you can be proactive about your health. You'll get your confidential results in as little as 24 to 48 hours.

Take control of your liver health today with a hepatic function panel test from Ulta Lab Tests.

Jaundice, also called icterus, is a condition where the skin, the whites of the eyes, and even body fluids turn significantly yellow following an increase in the levels of bilirubin in the blood. Bilirubin is a yellowish substance that forms from the normal breakdown of red blood cells (or RBCs). Red blood cells normally live for about 120 days before being broken down by the body, a process that results in the formation of bilirubin. Bilirubin is then transported to the liver where it is metabolized and excreted in bile. Bile is a yellow-green-to-brown fluid that is released into the duodenum to help in the digestion of lipids and the elimination of waste substances like bilirubin and excess cholesterol. Changes to the normal metabolism process or overproduction of bilirubin may lead to jaundice. 

Jaundice is not an illness, per se. Rather, it is a medical condition that may indicate an underlying liver, pancreas, or gallbladder problem. Jaundice can be caused by several factors, including infections, cancer, use of certain drugs, gallstones, blood disorders, inherited conditions, congenital disabilities, among other medical conditions.

Generally, the causes of jaundice may be categorized into these three groups: 

  • Conditions that arise from the inability of the liver to metabolize and eliminate bilirubin 
  • Conditions that cause shortened life for red blood cells, which in turn leads to increased levels of bilirubin 
  • Conditions that inhibit the elimination of bilirubin from the body 

Common Causes of Jaundice 

Acute hepatitis: inflammation of the liver due to various reasons, including hepatitis A, B, C, D, and E, alcohol abuse, viral infections, toxins, and some medicines such as acetaminophen. 

Blockage of the bile duct, which may be caused by: 

  • Damage and Scarring 
  • Biliary atresia, a congenital condition linked to the abnormal development of the bile duct, which results in the backup and pooling of bile and an increase in the level of bilirubin in the blood. 
  • Gallstones 
  • Pancreatic cancer may sometimes lead to the blockage of the bile duct. 

Conditions that result in a significant increase in the rate of red blood cell destruction cause an increase in bilirubin production. Such conditions include hemolytic anemia, due to an abnormal variant of hemoglobin, autoimmune disorders, malaria, or hemolytic disease of the newborn (or HDN). 

Gilbert syndrome: an inherited condition that is associated with reduced bilirubin metabolism due to decreased enzyme activity. Individuals with Gilbert syndrome may have passing jaundice during times of sickness or stress and times of increased levels of unconjugated bilirubin. 

Cirrhosis: jaundice can occur in the late stages of cirrhosis. 

Laboratory Tests 

Some of the tests used to assess liver function and detect liver damage include: 

Liver panel, which often comprises: 

ALT (or Alanine aminotransferase) 

AST (or Aspartate aminotransferase) 

ALP (or Alkaline phosphatase) 

Bilirubin, Total (conjugated and unconjugated), Direct (conjugated) and Indirect (unconjugated) 

GGT (or Gamma-glutamyl transferase) 

Albumin 

Prothrombin time (or PT): the liver produces essential proteins for blood clotting/coagulation. The PT measures the clotting function, which may indicate liver damage if abnormal. 

Urine bilirubin, which often falls under a urinalysis 

Some tests are important for the detection of infections that affect the liver, including: 

Tests that come in handy in detecting reduced red blood cell survival include: