Adrenal Insufficiency and Addison Disease

Adrenal Insufficiency and Addison Disease Lab Tests and health information

Are you or someone you know suffering from adrenal insufficiency?

Our adrenal insufficiency testing can give you an accurate reading of the health of your adrenal glands, with results sent confidentially online in 1 to 2 days. 

Adrenal insufficiency is an autoimmune disease that causes the adrenal glands to stop producing enough cortisol. It can be caused by genetic mutations, autoimmune diseases, and infections. The most common symptoms of Addison's Disease are fatigue, muscle weakness, weight loss, and low blood pressure. If left untreated, it can lead to shock and death. We offer lab tests for Addison's Disease and Adrenal Insufficiency, so you can quickly understand your health!

You may need treatment if your symptoms are severe or if they last for more than a few weeks. Treatment involves replacing the hormones that your body isn't making with medications called corticosteroids such as hydrocortisone or prednisone. These drugs help control inflammation and suppress immune system activity that could otherwise damage tissues throughout your body, including organs like the kidneys and lungs. They also help regulate blood sugar levels, so you don't develop diabetes mellitus type 1 from lack of cortisol production by the adrenal gland.

If you want to learn more about adrenal insufficiency or Addison's Disease and the lab tests that can help you, click on the title of the articles below.

We understand how important it is to know if you have adrenal insufficiency or Addison disease, so we made the order process easy with affordable lab tests listed below.

You don't have to go anywhere else: You can order online today, have your specimen taken at a nearby lab, and get your results back in 1-2 business days for most tests!

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The Adrenal Complete Panel includes the following tests 

  • Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
  • Comprehensive Metabolic Panel (CMP)
  • DHEA Sulfate, Immunoassay 
  • Iron, Total
  • Lipid Panel with Ratios
  • Magnesium
  • Sex Hormone Binding Globulin (SHBG)

This panel contains both Cortisol, A.M. #4212 and Cortisol, P.M. #4213, which will require the patient to visit the patient service center twice in one day.

  • First visit between 7 a.m. - 9 a.m. to have Cortisol, A.M. #4212 drawn along with most of the panel
  • Second visit between 3 p.m. – 5 p.m. to have Cortisol, P.M. #4213 drawn.

This panel contains both Cortisol, A.M. #4212 and Cortisol, P.M. #4213, which will require the patient to visit the patient service center twice in one day.

  • First visit between 7 a.m. - 9 a.m. to have Cortisol, A.M. #4212 drawn along with most of the panel
  • Second visit between 3 p.m. – 5 p.m. to have Cortisol, P.M. #4213 drawn.

The Adrenal Insufficiency and Addison Disease Panel contains the following tests:

  • 21- Hydroxylase Antibody
  • ACTH, Plasma
  • Aldosterone, LC/MS/MS 
  • Comprehensive Metabolic Panel (CMP)
  • Cortisol, A.M.
  • Cortisol, P.M.
  • DHEA Sulfate, Immunoassay 
  • Magnesium
  • Plasma Renin Activity, LC/MS/MS

The Aldosterone-renin ratio is used to screen for primary aldosteronism

Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.

Comprehensive Metabolic Panel

Cortisol, LC/MS/MS, Saliva Collection Kit

  1. Pick up the Cortisol, LC/MS/MS, Saliva Collection Kit from the Patient Service Center that is selected when placing the order.
  2. Collection Instructions

    1. Place contents on a clean and dry surface.
    2. Firmly attach the Collection Tube (E) provided to the base (D) of the Compression tube (C) (Figure 1). In preparation for saliva collection, pool saliva in the mouth. Sample collection may now begin.
    3. Place the tip of the pad of the Collector (A) where saliva has pooled (Figure 2).
    4. The Collector (A) may be removed from the mouth periodically to read the SVAI, but resume collection immediately afterward. Collect until the appearance of the SVAI (B) changes from white to fully red (Figure 3). The collection procedure should last approximately 1-5 minutes.
    6. Place the white absorbent pad end into the Compression Tube (C) holding the Collector (A) in an upright and vertical position and firmly push the plunger downwards to transfer saliva from the absorbent pad into the Collection Tube (E). Push and hold for 30 seconds (Figure 4).
    6. Gently remove the Collection Tube (E) from the end of the Compression Tube (C). It is appropriate to remove the Collection Tube (E) during expression if necessary due to foaming. Close the lid on the tube tightly.
    7. Label the collected sample immediately, include date and time of collection and store at refrigerated temperatures for shipment.
    For Technical Support, call 1-800-642-4657 ext. 2904.

    Transport Temperature

    Room temperature


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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 7 a.m.-9 a.m.

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 3 p.m - 5 p.m.

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency).

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with Polycystic Ovarian Syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.

Elevated GGT is found in all forms of liver disease. Measurement of GGT is used in the diagnosis and treatment of alcoholic cirrhosis, as well as primary and secondary liver tumors. It is more sensitive than alkaline phosphatase, the transaminases, and leucine aminopeptidase in detecting obstructive jaundice, cholangitis, and cholecystitis. Normal levels of GGT are seen in skeletal diseases; thus, GGT in serum can be used to ascertain whether a disease, suggested by elevated alkaline phosphatase, is skeletal or hepatobiliary.

A Hemoglobin (Hb) A1c Blood Test evaluates the average amount of glucose in the blood. The A1c test will help determine whether you are at a higher risk of developing diabetes; to help diagnose diabetes and prediabetes; to monitor diabetes and to aid in treatment decisions.

To assist with control of blood glucose levels, the American Diabetes Association (ADA) has recommended glycated hemoglobin testing (HbA1c) twice a year for patients with stable glycemia, and quarterly for patients with poor glucose control. Interpretative ranges are based on ADA guidelines.

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Elevated levels of homocysteine are observed in patients at risk for coronary heart disease and stroke.

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For diagnosis and monitoring of diabetes and insulin-secreting tumors.

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Lactate Dehydrogenase (LD) (LDH)

Elevations in serum lactate dehydrogenase occur from myocardial infarction, liver disease, pernicious and megaloblastic anemia, pulmonary emboli, malignancies, and muscular dystrophy

A lipid panel includes:Total cholesterol —this test measures all of the cholesterol in all the lipoprotein particles.High-density lipoprotein cholesterol (HDL-C) — measures the cholesterol in HDL particles; often called "good cholesterol" because it removes excess cholesterol and carries it to the liver for removal.Low-density lipoprotein cholesterol (LDL-C) — calculates the cholesterol in LDL particles; often called "bad cholesterol" because it deposits excess cholesterol in walls of blood vessels, which can contribute to atherosclerosis. Usually, the amount of LDL cholesterol (LDL-C) is calculated using the results of total cholesterol, HDL-C, and triglycerides.Triglycerides — measures all the triglycerides in all the lipoprotein particles; most is in the very low-density lipoproteins (VLDL).Very low-density lipoprotein cholesterol (VLDL-C) — calculated from triglycerides/5; this formula is based on the typical composition of VLDL particles.Non-HDL-C — calculated from total cholesterol minus HDL-C.Cholesterol/HDL ratio — calculated ratio of total cholesterol to HDL-C.

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Testosterone, dihydrotestosterone and estrogens circulate in serum bound to Sex Hormone Binding Globulin (SHBG). SHBG concentrations are increased in pregnancy, hyperthyroidism, cirrhosis, oral estrogen administration and by certain drugs. Concentrations are decreased by testosterone, hypothyroidism, Cushings syndrome, acromegaly and obesity

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Serum uric acid measurements are useful in the diagnosis and treatment of numerous renal and metabolic disorders, including renal failure, gout, leukemia, psoriasis, starvation or other wasting conditions, and in patients receiving cytotoxic drugs.

Measurement of serum 25-OH vitamin D concentrations provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Lower than normal 25-OH vitamin D levels can result from a dietary deficiency, poor absorption of the vitamin or impaired metabolism of the sterol in the liver. A 25-OH vitamin D deficiency can lead to bone diseases such as rickets and osteomalacia. Above normal levels can lead hypercalcemia. This assay employs liquid chromatography tandem mass spectrometry to independently measure and report the two common forms of 25-hydroxy vitamin D: 25OH D3 - the endogenous form of the vitamin and 25OH D2 - the analog form used to treat 25OH Vitamin D3 deficiency.

Clinical Significance
11-Deoxycortisol - 11-Deoxycortisol (Compound S) is useful in diagnosing patients with 11-beta-hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.

17-Hydroxypregnenolone, LC/MS/MS

Clinical Significance

17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.


Adrenal glands are small but play a big role in everyday life. They produce several hormones, most notably cortisol. Cortisol handles the "fight or flight" response and is how the body responds to stress.

Early Adrenal Disease Tests can track your hormone levels and determine if your hormones are out of balance. These tests are convenient and provide you with the health information you need.

Understanding the Adrenal Glands

The adrenal glands are located in the midsection of the body near the top of the kidneys. Each of the two parts of the glands—the medulla and the cortex—produces a different set of hormones.

These hormones include cortisol, aldosterone, DHEA and androgenic steroids, and epinephrine, and norepinephrine.

Adrenal Insufficiency and Addison Disease

When the adrenal glands are not working correctly, several health issues can arise. These can include adrenal insufficiency, congenital adrenal hyperplasia, Cushing Disease, Hyperaldosteronism, Pheochromocytoma, or Adrenal Cancer.

When the adrenal glands do not produce the necessary level of hormones, Adrenal Insufficiency, or Addison Disease, will occur. 

Unfortunately, once a person develops Addison's Disease, it will never go away, which is why it is imperative to be proactive with lab testing. If you catch issues before they get serious, there is a better chance of healing.

Signs and Symptoms of Adrenal Insufficiency and Addison Disease

The most common signs of Addison's Disease are:

  • Loss of appetite
  • Weight loss
  • Nausea and vomiting
  • Exhaustion
  • Pain around the adrenal glands
  • Skin darkening

This rare condition is onset by:

  • Autoimmune diseases
  • Infections
  • Cancer
  • Genetics

Lab Testing for Adrenal Insufficiency and Addison Disease

Several Addison Disease Tests are available through Ulta Labs. These tests cover a wide range of biomarkers and can help create a better understanding of where your health stands.

Adrenal Complete

Adrenal Complete is a panel with 8 tests that covers 41 biomarkers. This test will measure several factors, including a metabolic panel, cortisol levels, DHEA sulfate, iron levels, and magnesium. This test uses both saliva and blood specimen.

ULTA Adrenal Function Panel

The Adrenal Function Panel is a combination of 16 tests, which will review 77 biomarkers. This test takes both a saliva and blood specimen, and patients must fast for at least nine hours before.

The test will measure C-reactive protein, blood count, a metabolic panel, cortisol levels, DHEA sulfate, gamma-glutamyl transferase, hemoglobin, homocysteine, insulin levels, lactate dehydrogenase, lipid panel, magnesium levels, phosphate levels, vitamin D, D2, and D3, and uric acid.

STTM Adrenal Panel Total

The STTM Adrenal Panel Total test is a combination of 3 tests that will review 23 biomarkers. It covers aldosterone, a comprehensive metabolic panel (CMP), and magnesium levels.

The biomarkers reviewed in the CMP are albumin, the albumin/globulin ratio, alkaline phosphatase, alanine transaminase, aspartate aminotransferase, total bilirubin, the BUN and blood creatinine ratio, calcium levels, carbon dioxide levels, chloride levels, creatinine levels, glomerular filtration rate, globulin levels, insulin tolerance test, potassium levels, total protein levels, sodium levels, and blood urea nitrogen levels (BUN).

Benefits of Adrenal Insufficiency and Addison Disease Testing

Adrenal insufficiency tests are an important step to take control of your health and life. They are easy to complete and will provide you with a wealth of knowledge.

Better Understanding Your Body

Testing for adrenal insufficiency will cover a multitude of factors in your body. Understanding these levels and how they affect your body can help you make the necessary changes to get back on top of your health.

Catching Other Health Issues

Once you receive your test results, the levels you thought would be high could be right on track, but other levels may surprise you. This can open the door to other issues that could be affecting your health and the quality of your daily life.

Prevention of Addison's Disease

If you identify early that you are on a path towards Addison's disease, you can be proactive to get things under control. Perhaps a simple lifestyle change can improve levels and resolve any issues.

If you are genetically predisposed to Addison's Disease, tests can show you which biomarkers to monitor more closely and test more often.


If the testing does result in a diagnosis of Addison's Disease, there are several treatment options available. Patients with Addison's Disease can treat the problem by taking hormones to make up for the ones that are not produced by the adrenal glands.

Lifestyle changes can dramatically alter the side effects of the disease, as well as stress, and blood pressure management.

If the disease goes untreated, an Addisonian crisis can happen. This causes low blood pressure, low blood sugar, and high levels of potassium in the blood. These issues may be life-threatening and need immediate treatment.

Feel More Confident About Your Health

Understanding what is going on internally and learning how lifestyle changes can impact that is an empowering feeling.

Having more confidence when it comes to making decisions regarding your health may require a little time upfront, but the information Ulta Lab Tests provide you with can make it very attainable.

Testing with Ulta Lab Tests

Ulta Lab Tests offers tests that are highly accurate and reliable so you can make informed decisions about your health. You can always guarantee secure and confidential results.

You do not need insurance or a doctor's referral to schedule your test. Ulta Lab Tests provides affordable pricing and 100% satisfaction guaranteed.

Order your Adrenal Insufficiency and Addison Disease Tests today. Results can be viewed online in 24 to 48 hours. Take charge of your health and track your progress with Ulta Lab Tests.