Adrenal Insufficiency and Addison Disease

The adrenal insufficiency tests can give you an accurate reading of the health of your adrenal glands, with results sent confidentially online in one to two days. Order from Ulta Lab Tests today!

Do you think you live with adrenal insufficiency or Addison Disease? Read below to learn more about the benefits of Addison Disease tests.

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Clinical Significance
11-Deoxycortisol - 11-Deoxycortisol (Compound S) is useful in diagnosing patients with 11-beta-hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.

17-Hydroxypregnenolone, LC/MS/MS

Clinical Significance

17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.


Clinical Significance

21- Hydroxylase Antibody - 21-Hydroxylase Antibody is present in patients with autoimmune destruction of the adrenal glands, leading to Addison's disease. Antibody is also seen in autoimmune polyglandular syndrome.

Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's disease, Cushing's syndrome, adrenal carcinoma, ectopic ACTH syndrome, and adrenal nodular hyperplasia.

The Adrenal Complete Panel includes the following tests 

  • Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
  • Comprehensive Metabolic Panel (CMP)
  • DHEA Sulfate, Immunoassay 
  • Iron, Total
  • Lipid Panel with Ratios
  • Magnesium
  • Sex Hormone Binding Globulin (SHBG)

Adrenal Insufficiency and Addison Disease Panel

  • 21- Hydroxylase Antibody
  • ACTH, Plasma
  • Aldosterone, LC/MS/MS 
  • Comprehensive Metabolic Panel (CMP)
  • Cortisol, 2 Specimens
  • Cortisol, Total
  • DHEA Sulfate, Immunoassay 
  • Magnesium
  • Plasma Renin Activity, LC/MS/MS

Determination of aldosterone is useful in the diagnosis and evaluation of primary aldosteronism, selective hypoaldosteronism, edematous states, and other conditions of electrolyte imbalance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentration for aldosterone.

The Aldosterone-renin ratio is used to screen for primary aldosteronism

Antiadrenal Antibody Screen With Reflex To Titer

This is a reflex test that may require additional tests to be run at additional cost to the patient.

If  Adrenal Antibody Screen is positive, Adrenal Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

Clinical Significance

Urine chloride excretion approximates the dietary intake. The chloride content of most foods parallel that of sodium. An increase in urine chloride may result from water deficient dehydration, diabetic acidosis, Addison's disease, and salt-losing renal disease. Decreased urine levels are seen in congestive heart failure, severe diaphoresis and in hypochloremic metabolic alkalosis due to prolonged vomiting.

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Cortisol, LC/MS/MS, Saliva Collection Kit

  1. Pick up the Cortisol, LC/MS/MS, Saliva Collection Kit from the Patient Service Center that is selected when placing the order.
  2. Collection Instructions

    1. Place contents on a clean and dry surface.
    2. Firmly attach the Collection Tube (E) provided to the base (D) of the Compression tube (C) (Figure 1). In preparation for saliva collection, pool saliva in the mouth. Sample collection may now begin.
    3. Place the tip of the pad of the Collector (A) where saliva has pooled (Figure 2).
    4. The Collector (A) may be removed from the mouth periodically to read the SVAI, but resume collection immediately afterward. Collect until the appearance of the SVAI (B) changes from white to fully red (Figure 3). The collection procedure should last approximately 1-5 minutes.
    6. Place the white absorbent pad end into the Compression Tube (C) holding the Collector (A) in an upright and vertical position and firmly push the plunger downwards to transfer saliva from the absorbent pad into the Collection Tube (E). Push and hold for 30 seconds (Figure 4).
    6. Gently remove the Collection Tube (E) from the end of the Compression Tube (C). It is appropriate to remove the Collection Tube (E) during expression if necessary due to foaming. Close the lid on the tube tightly.
    7. Label the collected sample immediately, include date and time of collection and store at refrigerated temperatures for shipment.
    For Technical Support, call 1-800-642-4657 ext. 2904.

    Transport Temperature

    Room temperature


Cortisol is increased in Cushing's disease and decreased in Addison's disease (adrenal insufficiency).

Cortisol is increased in Cushing's disease and decreased in Addison's disease (adrenal insufficiency).

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency). Patient needs to have the specimen collected between 7 a.m.-9 a.m.

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency).

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Cortisol is increased in Cushing's Disease and decreased in Addison's Disease (adrenal insufficiency).

DHEA-S is the sulfated form of DHEA and is the major androgen produced by the adrenal glands. This test is used in the differential diagnosis of hirsute or virilized female patients and for the diagnosis of isolated premature adrenarche and adrenal tumors. About 10% of hirsute women with Polycystic Ovarian Syndrome (PCOS) have elevated DHEA-S but normal levels of other androgens.

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Serum glucose levels may be abnormally high (hyperglycemia) or abnormally low (hypoglycemia). Glucose measurements are used in the diagnosis and treatment of carbohydrate metabolic disorders including diabetes mellitus, idiopathic hypoglycemia, and pancreatic islet cell neoplasm.

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A lipid panel includes:Total cholesterol —this test measures all of the cholesterol in all the lipoprotein particles.High-density lipoprotein cholesterol (HDL-C) — measures the cholesterol in HDL particles; often called "good cholesterol" because it removes excess cholesterol and carries it to the liver for removal.Low-density lipoprotein cholesterol (LDL-C) — calculates the cholesterol in LDL particles; often called "bad cholesterol" because it deposits excess cholesterol in walls of blood vessels, which can contribute to atherosclerosis. Usually, the amount of LDL cholesterol (LDL-C) is calculated using the results of total cholesterol, HDL-C, and triglycerides.Triglycerides — measures all the triglycerides in all the lipoprotein particles; most is in the very low-density lipoproteins (VLDL).Very low-density lipoprotein cholesterol (VLDL-C) — calculated from triglycerides/5; this formula is based on the typical composition of VLDL particles.Non-HDL-C — calculated from total cholesterol minus HDL-C.Cholesterol/HDL ratio — calculated ratio of total cholesterol to HDL-C.

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Identifying patients who have metabolic syndrome and who are thus at higher risk of diabetes, coronary heart disease or stroke. Identifying patients who are insulin resistant (fasting insulin at or above the 75th percentile) and who are thus at higher risk of diabetes, coronary heart disease, stroke, or liver disease. Monitoring of risk factors and insulin levels after life style change, medication use, or both.

Renin plays a central role in maintaining blood pressure by enzymatically converting angiotensinogen to angiotensin I, which is then cleaved by angiotensin converting enzyme to form angiotensin II. Angiotensin II increases blood pressure directly through vasoconstriction and indirectly by stimulating secretion of aldosterone, a hormone that promotes sodium retention and potassium loss. Renin secretion is inhibited by high blood pressure and stimulated by factors that lower blood pressure, such as upright posture and sodium deprivation. A variety of drug classes also physiologically affect plasma renin activity (PRA) levels (Table). PRA is typically used in conjunction with the measurement of aldosterone, sodium, and potassium levels in plasma and/or urine.

Adrenal glands are small but play a big role in everyday life. They produce several hormones, most notably cortisol. Cortisol handles the "fight or flight" response and is how the body responds to stress.

Early Adrenal Disease Tests can track your hormone levels and determine if your hormones are out of balance. These tests are convenient and provide you with the health information you need.

Understanding the Adrenal Glands

The adrenal glands are located in the midsection of the body near the top of the kidneys. Each of the two parts of the glands—the medulla and the cortex—produces a different set of hormones.

These hormones include cortisol, aldosterone, DHEA and androgenic steroids, and epinephrine, and norepinephrine.

Adrenal Insufficiency and Addison Disease

When the adrenal glands are not working correctly, several health issues can arise. These can include adrenal insufficiency, congenital adrenal hyperplasia, Cushing Disease, Hyperaldosteronism, Pheochromocytoma, or Adrenal Cancer.

When the adrenal glands do not produce the necessary level of hormones, Adrenal Insufficiency, or Addison Disease, will occur. 

Unfortunately, once a person develops Addison's Disease, it will never go away, which is why it is imperative to be proactive with lab testing. If you catch issues before they get serious, there is a better chance of healing.

Signs and Symptoms of Adrenal Insufficiency and Addison Disease

The most common signs of Addison's Disease are:

  • Loss of appetite
  • Weight loss
  • Nausea and vomiting
  • Exhaustion
  • Pain around the adrenal glands
  • Skin darkening

This rare condition is onset by:

  • Autoimmune diseases
  • Infections
  • Cancer
  • Genetics

Lab Testing for Adrenal Insufficiency and Addison Disease

Several Addison Disease Tests are available through Ulta Labs. These tests cover a wide range of biomarkers and can help create a better understanding of where your health stands.

Adrenal Complete

Adrenal Complete is a panel with 8 tests that covers 41 biomarkers. This test will measure several factors, including a metabolic panel, cortisol levels, DHEA sulfate, iron levels, and magnesium. This test uses both saliva and blood specimen.

ULTA Adrenal Function Panel

The Adrenal Function Panel is a combination of 16 tests, which will review 77 biomarkers. This test takes both a saliva and blood specimen, and patients must fast for at least nine hours before.

The test will measure C-reactive protein, blood count, a metabolic panel, cortisol levels, DHEA sulfate, gamma-glutamyl transferase, hemoglobin, homocysteine, insulin levels, lactate dehydrogenase, lipid panel, magnesium levels, phosphate levels, vitamin D, D2, and D3, and uric acid.

STTM Adrenal Panel Total

The STTM Adrenal Panel Total test is a combination of 3 tests that will review 23 biomarkers. It covers aldosterone, a comprehensive metabolic panel (CMP), and magnesium levels.

The biomarkers reviewed in the CMP are albumin, the albumin/globulin ratio, alkaline phosphatase, alanine transaminase, aspartate aminotransferase, total bilirubin, the BUN and blood creatinine ratio, calcium levels, carbon dioxide levels, chloride levels, creatinine levels, glomerular filtration rate, globulin levels, insulin tolerance test, potassium levels, total protein levels, sodium levels, and blood urea nitrogen levels (BUN).

Benefits of Adrenal Insufficiency and Addison Disease Testing

Adrenal insufficiency tests are an important step to take control of your health and life. They are easy to complete and will provide you with a wealth of knowledge.

Better Understanding Your Body

Testing for adrenal insufficiency will cover a multitude of factors in your body. Understanding these levels and how they affect your body can help you make the necessary changes to get back on top of your health.

Catching Other Health Issues

Once you receive your test results, the levels you thought would be high could be right on track, but other levels may surprise you. This can open the door to other issues that could be affecting your health and the quality of your daily life.

Prevention of Addison's Disease

If you identify early that you are on a path towards Addison's disease, you can be proactive to get things under control. Perhaps a simple lifestyle change can improve levels and resolve any issues.

If you are genetically predisposed to Addison's Disease, tests can show you which biomarkers to monitor more closely and test more often.


If the testing does result in a diagnosis of Addison's Disease, there are several treatment options available. Patients with Addison's Disease can treat the problem by taking hormones to make up for the ones that are not produced by the adrenal glands.

Lifestyle changes can dramatically alter the side effects of the disease, as well as stress, and blood pressure management.

If the disease goes untreated, an Addisonian crisis can happen. This causes low blood pressure, low blood sugar, and high levels of potassium in the blood. These issues may be life-threatening and need immediate treatment.

Feel More Confident About Your Health

Understanding what is going on internally and learning how lifestyle changes can impact that is an empowering feeling.

Having more confidence when it comes to making decisions regarding your health may require a little time upfront, but the information Ulta Lab Tests provide you with can make it very attainable.

Testing with Ulta Lab Tests

Ulta Lab Tests offers tests that are highly accurate and reliable so you can make informed decisions about your health. You can always guarantee secure and confidential results.

You do not need insurance or a doctor's referral to schedule your test. Ulta Lab Tests provides affordable pricing and 100% satisfaction guaranteed.

Order your Adrenal Insufficiency and Addison Disease Tests today. Results can be viewed online in 24 to 48 hours. Take charge of your health and track your progress with Ulta Lab Tests.