Prostate Cancer

A proactive plan for prostate health starts with the PSA blood test and smart follow-ups. Most men talk with a clinician about PSA screening between ages 55–69. Some urology groups offer testing every 2–4 years in ages 50–69. Men at higher risk (for example, Black men, those with a strong family history, or a BRCA2 variant) may consider a baseline PSA at 40–45. After an elevated PSA, today’s care often uses multiparametric MRI (mpMRI) and targeted biomarkers to focus on clinically significant cancers and avoid unnecessary biopsies.
Ulta Lab Tests provides fast access to PSA and follow-up biomarkers your clinician can use to guide clear next steps.


When to Consider Testing (Proactive Triggers)

  • Screening discussion:

    • Most men: ages 55–69

    • High-risk men: 40–45 baseline, then personalized follow-up

  • Symptoms that need evaluation: weak stream, frequent urination (especially at night), blood in urine or semen, bone pain, or unintended weight loss


Why These Tests Matter

What lab testing can do

  • Find risk early so problems are addressed before they spread

  • Use biomarkers + MRI to reduce unnecessary biopsies

  • Track disease with clear trends over time

What lab testing cannot do

  • single PSA does not diagnose cancer

  • Biomarkers and MRI refine risk; they don’t replace clinical judgment or shared decision-making


What the Key Tests Measure (at a glance)

  • Total PSA: main screening blood test; changes over time help guide decisions

  • Percent-Free PSA (%fPSA): most helpful when PSA is ~4–10 ng/mLlower % = higher risk

  • PHI (Prostate Health Index): combines total PSA, free PSA, and p2PSA to improve specificity (fewer unnecessary biopsies)

  • 4Kscore®: blood panel estimating risk of clinically significant cancer (Grade Group ≥2); often used with MRI

  • PCA3 (urine): helps decide on a repeat biopsy after a prior negative biopsy

  • Context labs: general health panels (e.g., CBC/CMP). PSA “velocity/density” can add context but shouldn’t be the only reason for biopsy


How the Testing Process Works

  1. Shared decision: review age, risks, and preferences; agree on a PSA plan (often every 2–4 years if continuing)

  2. Start with PSA: if borderline or elevated, add %fPSA, PHI, or 4Kscore

  3. Use imaging before biopsy: mpMRI helps target suspicious areas and avoid unnecessary biopsy

  4. Decide next steps: combine history, exam, biomarkers, MRI, and risk calculators to choose biopsy or surveillance


Understanding Your Results

  • Normal/low PSA: continue on the agreed screening schedule

  • Borderline PSA (about 4–10): add %fPSA, PHI, or 4Kscore and get mpMRI to refine need for biopsy

  • Elevated/rising PSA: repeat to confirm; use biomarkers + mpMRI; biopsy only when risk of meaningful cancer is high

  • After a negative biopsy: PCA3PHI/4Kscore, and MRI can guide whether a repeat biopsy is needed


Choosing Panels vs. Individual Tests

  • Average risk (55–69) / 50–69 with urology guidance: periodic PSA with shared decision-making

  • Higher risk (Black ancestry, strong family history, BRCA2): baseline at 40–45 and closer follow-up

  • Borderline PSA: add %fPSA and/or PHI or 4Kscore; use mpMRI to focus decisions

  • Post-negative biopsy, ongoing concern: PCA3 ± MRI-targeted approach


FAQs (Quick Answers)

Do I automatically need a biopsy if PSA is high?
No. Many clinicians repeat PSA, add biomarkers, and order mpMRI before biopsy.

Is a digital rectal exam (DRE) required?
No. DRE is optional for screening and often used after an elevated PSA.

Can biomarkers really cut down on biopsies?
Yes. %fPSA, PHI, and 4Kscore improve specificity and, with mpMRI, can help avoid unnecessary biopsy.

When should I start testing if I’m high-risk?
Discuss a baseline PSA at 40–45 and set a personalized plan with your clinician.


Internal Links & Cross-References

  • Cancer Screening Hub

  • Men’s Cancer & Tumor Markers

  •  Colorectal Cancer

  • Multi-Cancer Early Detection (MCED)

  • Key Lab Tests: PSA • Percent-Free PSA • PHI • 4Kscore • PCA3 • mpMRI (Clinical Imaging)

 

 

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Name Matches

The PSA Free and Total Test measures prostate-specific antigen in blood, reporting both free and total PSA to help evaluate prostate health. It is used to screen for prostate cancer, differentiate between cancer and benign conditions like prostatitis or enlarged prostate (BPH), and monitor treatment. Doctors order this test for men with urinary symptoms or at risk of prostate disease. Results provide key insight into prostate function and overall men’s health.

Blood
Blood Draw
Also Known As: Prostate Specific Antigen Test, PSA Blood Test

The PSA Total and Testosterone Total Males Panel is a specialized set of blood tests tailored for men to evaluate prostate health and testosterone levels. This panel combines two crucial markers: the Prostate-Specific Antigen (PSA) and total testosterone levels, making it an essential tool for assessing men's health, particularly in the areas of reproductive health and prostate function.
Blood
Blood Draw

Most Popular

The PSA Total Test measures prostate-specific antigen levels in blood to evaluate prostate health. Elevated PSA may indicate prostate cancer, benign prostatic hyperplasia (BPH), or prostatitis. Doctors use this test for early detection of prostate cancer, monitoring treatment, or assessing recurrence risk. Commonly recommended for men over 50 or those at higher risk, the PSA test supports diagnosis, prevention, and long-term prostate care.

Blood
Blood Draw
Also Known As: Prostate Specific Antigen Test, PSA Test, Prostate Test

The Urinalysis Complete Test evaluates urine for physical, chemical, and microscopic properties to assess kidney health, urinary tract infections, diabetes, and metabolic disorders. It measures appearance, concentration, pH, protein, glucose, ketones, blood, bilirubin, nitrites, leukocyte esterase, and microscopic cells or crystals. Doctors use this test in routine exams, to diagnose urinary symptoms, and to monitor chronic kidney or metabolic disease.

Urine
Urine Collection
Also Known As: Urine Analysis Test, UA Test, Complete Urinalysis Test

The Culture Urine Routine Test detects and identifies bacteria or yeast in urine that cause urinary tract infections (UTIs). By growing microorganisms in a lab, this test determines the type of infection and guides effective treatment. Doctors use it to evaluate symptoms such as painful urination, frequent urges, or fever and to monitor recurrent UTIs. Results provide critical insight for diagnosis, antibiotic selection, and urinary health management.

Urine
Urine Collection
Also Known As: Urine Culture Test, Urine Culture and Sensitivity, UTI test

The BUN Creatinine Ratio Test compares blood urea nitrogen (BUN) to creatinine levels to assess kidney function and hydration status. A high ratio may indicate dehydration, gastrointestinal bleeding, or high protein intake, while a low ratio can suggest liver disease or malnutrition. Doctors order this test with kidney panels to evaluate fatigue, swelling, or abnormal lab results. Results help diagnose renal issues and guide treatment planning.

Blood
Blood Draw
Also Known As: Blood Urea Nitrogen to Creatinine Ratio

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

Blood
Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

Most Popular

The Creatinine Test measures creatinine levels in blood to evaluate kidney function and filtration efficiency. Elevated levels may indicate kidney disease, dehydration, or muscle disorders, while low levels may reflect reduced muscle mass. Doctors use this test to monitor chronic kidney disease (CKD), assess treatment response, and detect early signs of renal impairment. It provides key insight into kidney health, metabolic balance, and overall renal function.

Blood
Blood Draw
Also Known As: Blood Creatinine Test, Serum Creatinine Test

The Prostatic Acid Phosphatase Test detects PAP, an enzyme produced in the prostate, to provide information about prostate health and possible disease. Abnormal levels may suggest prostate cancer, metastatic spread, or benign prostate conditions. This test supports assessment of prostate function, systemic effects, and urologic health, offering insight into disease monitoring and progression.

Blood
Blood Draw
Also Known As: PAP Test

The Post-Prostatectomy PSA Test measures prostate-specific antigen levels in blood after surgical removal of the prostate. PSA should drop to very low or undetectable levels following surgery. Rising or persistent PSA may indicate recurrence of prostate cancer. Doctors use this test to closely monitor recovery, detect early signs of cancer return, and guide further treatment decisions, making it an essential tool for long-term prostate cancer management.

Also Known As: Prostate Specific Antigen Test, PSA Test, Prostate Test, PSA Total Test

The PSA Post Prostatectomy Test with HAMA Treatment measures prostate-specific antigen (PSA) levels following prostate removal surgery. This test uses Heterophilic Antibody Blocking (HAMA) treatment to eliminate antibody interference, ensuring accurate detection of residual or recurrent prostate cancer and improving post-surgical monitoring precision.

Blood
Blood Draw

The PSA Total Test with 2.5 ng/mL Cutoff measures prostate-specific antigen in blood to screen for prostate cancer and evaluate prostate health. A result above 2.5 ng/mL may indicate increased cancer risk or benign conditions like prostatitis or BPH. Doctors order this test for men with urinary symptoms or as part of routine screening. Results help detect cancer earlier, monitor prostate conditions, and guide decisions on further evaluation or treatment.

Blood
Blood Draw
Also Known As: Prostate Specific Antigen Test, PSA Test, Prostate test

The Testosterone Total Male Test measures testosterone levels in men to assess reproductive, sexual, and hormonal health. It helps diagnose low testosterone (hypogonadism), infertility, and erectile dysfunction. Doctors use it to evaluate fatigue, muscle loss, or low libido and to monitor testosterone therapy, hormonal balance, bone health, and overall metabolism.

Patient must be male and 18 years of age or older.
Blood
Blood Draw
Also Known As: Total Male Testosterone Test

The Blood Urea Nitrogen (BUN) Test measures urea nitrogen levels in blood to assess kidney function and how well the body removes waste. Elevated BUN may indicate kidney disease, dehydration, heart failure, or high protein intake, while low levels may suggest liver disease or malnutrition. Doctors order this test to evaluate fatigue, swelling, or abnormal lab results. Results help diagnose kidney and liver conditions and guide treatment decisions.

Blood
Blood Draw
Also Known As: BUN Test, Blood Urea Nitrogen Test

 A Urinalysis Screen test is a common diagnostic tool used in healthcare to assess and monitor various disorders by analyzing a patient's urine. This test encompasses a range of examinations including physical, chemical, and microscopic aspects of urine. It's a non-invasive, quick, and often revealing test that can provide significant insights into a person's health.
Urine
Urine Collection

Blood
Blood Draw, Phlebotomist

Every year in the United States nearly 250,000 men are diagnosed with prostate cancer. This can be an extremely daunting time for them and their loved ones. However, an early diagnosis can have a huge impact on your treatment plan and chances of survival. 

An early diagnosis can put your 5-year survival rate at more than 99%! However, as the American cancer society will tell you, this is only possible if you get tested.

So how do you get a prostate cancer test, and what does this involve? If you are concerned about getting a PSA test, read on to find out more!

What is Prostate Cancer? 

Your prostate is an integral part of your body's reproductive system and produces the seminal fluid that transports sperm. It is a small gland that sits just below your bladder and in front of your rectum. 

Prostate cancer is one of the most common types of cancer in America and affects this small gland. To begin with, most people will not notice it because symptoms can take a while to show up. Prostate cancer is a condition characterized by the uncontrolled growth of cells around and in the prostate gland. This is the organ responsible for producing prostate fluid, which makes part (70%) of semen produced in the testes.  This type of cancer affects cells responsible for generating the prostate fluid- hence known as adenocarcinomas.

While most types of prostate cancer are slow-growing, some types grow and spread at a faster rate, hence more dangerous.  Slow-Growing cancer does not, however, pose a significant risk to most men.  Many older men, and even some younger ones, who died of other causes, also had slow-growing prostate cancer, according to the American Cancer Society. Most of these men had no idea they had prostate cancer in the first place.

However, over time it can have a huge effect on your reproductive system. It can also alter the prostate-specific antigen (PSA) level in your blood. Without treatment, this cancer can spread and become fatal.

So why do some men develop prostate cancer?

What are the Causes of and Risk Factors for Prostate Cancer?

There can be several different things that cause prostate cancer. Changes to your DNA as you age can increase your likelihood of developing it. This is why prostate cancer is especially common in men over the age of 60. 

Your diet can also affect your likelihood of developing prostate cancer. Fatty foods stimulate hormones that support the growth of prostate cancer. So, watching what you eat can help protect your prostate. 

You may also have a higher chance of developing prostate cancer if you: 

  • Have a family history of it
  • Are overweight or obese
  • Are a smoker
  • Have a high calcium intake 
  • Are of black ethnic origins
  • Are over the age of 50

Even if you do not fall into any of these categories, it is a good idea to check your prostate regularly, especially as you get older.

Signs and Symptoms of Prostate Cancer

It is not always possible to spot cancer affecting your prostate gland immediately. However, as prostate cancer develops, you will start to notice more symptoms. These can include: 

  • Having to urinate more frequently
  • Difficulty emptying your bladder or weak urine flow
  • The urge to urinate more frequently at night
  • Blood in your urine
  • Erectile dysfunction (that is newly onset)
  • Pain when urinating
  • Discomfort when sitting

If your cancer has spread, you may also experience pain across your back, hips, or thighs. You may also lose a lot of weight and find that you're more tired than usual.

If you are experiencing any of these symptoms, it is a good idea to get a prostate cancer screening as soon as possible. There are several ways to do this.

PSA Lab Test for Prostate Cancer

A PSA test is a type of blood test that checks the amount of PSA in your blood. PSA, or Prostate-Specific Antigen, is a type of protein that your prostate gland produces. Even when you are healthy, some PSA leaks into your bloodstream. 

  • Total Prostate Specific Antigen – The tests are done to detect and monitor prostate cancer.  The health expert must evaluate tests based on the volume of the patient’s prostate and PSA levels in the blood.
  • Free PSA – There are two types of PSA in the blood: free PSA (fPSA), which isn’t bound, and complexed PSA (cPSA), which is linked to other proteins. Health experts test for fPSA to determine the need for biopsy to be done. The biopsy can only be done when the total PSA is slightly elevated. Most men with BPH will have higher levels of fPSA, while those with prostate cancer will have relatively lower amounts of the same. Low levels of fPSA increase the risk of cancer despite normal PSA levels.

A raised PSA result can be a useful way of detecting prostate cancer. This is a quick way to spot early-stage prostate cancer. However, if your PSA is raised, it is also a good idea to get some further prostate cancer tests. 

Lab tests come in handy in detecting prostate cancer, and ruling out health conditions/ailments that may make the situation worse. The tests can also be used to monitor and determine the effectiveness of the current mode of treatment.

A digital rectal examination (DRE) helps your doctor check your prostate. Because your prostate cannot be seen directly, your doctor inserts a gloved lubricated finger into your rectum to feel your prostate and check for enlargement.

If you or your doctor is concerned about your prostate, your doctor may recommend a prostate biopsy. This involves taking a small tissue sample from your prostate using a thin needle. Your doctor will then examine these under a microscope to check for cancer cells.

General Lab Tests

Additional tests may be required to ascertain the likelihood of prostate cancer, and to rule out possible other conditions with similar signs and symptoms. These include:

FAQs About the Prostate Cancer Test

Getting your prostate checked for the first time can be a daunting experience. To help, here are some common questions that people have about prostate cancer testing. 

How Do You Prepare for a PSA Test? 

To prepare for a PSA test, you should: 

  • Not ejaculate or exercise heavily within the 48 hours leading up to your test
  • Ensure that you are clear of any urinary infections
  • Make sure that it has been at least 6 weeks since your last prostate biopsy

Do PSA Tests Have Any Side Effects? 

A PSA test is just like any routine blood test, so side effects are rare. If you are taking any medication you should speak to someone about this before having your blood tested. Some doctors may recommend pausing certain medication shortly before your test.

How Long Does It Take to Get a PSA Test Result Back? 

Usually, it takes between one and two weeks to get your test result back from the lab if you go through your doctor. With Ulta Lab Tests, you will receive your test results in one to two days.

What Happens If Your PSA Level is Raised? 

If you have a raised PSA level, this doesn't necessarily mean that you have prostate cancer. This can also be an indication that you have an enlarged benign prostate.

However, it is a good idea to speak to a doctor as soon as possible to investigate this further. You should do this even if your PSA is normal but, you still have symptoms of prostate cancer. That way, if it is cancer, you can start your prostate cancer treatment early.

Get Your Prostate Checked Today

When it comes to getting a prostate cancer test you shouldn't wait around. Ulta Lab Tests offer extremely accurate and reliable testing so that you can make informed decisions about your health.

Our service provides secure and confidential results, and you don't need insurance or a medical referral. We are committed to providing affordable testing (which includes the doctor's order) and delivering a 100% satisfaction guarantee.

Order your PSA test today, and your results will be provided to you securely and confidentially online in 24 to 48 hours. Take charge of your health and track your PSA test progress with Ulta Lab Tests today.