Estrogen Dominance Panel Non-Cycling Women

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.


Estradiol (estradiol-17 beta, E2) is part of an estrogen that is a group of steroids that regulate the menstrual cycle and function as the main female sex hormones. Estrogens are responsible for the development of female sex organs and secondary sex characteristics and are tied to the menstrual cycle and pregnancy. They are considered the main sex hormones in women and are present in small quantities in men. Estradiol (E2) is the predominant form of estrogen and is produced primarily in the ovaries with additional amounts produced by the adrenal glands in women and in the testes and adrenal glands in men. Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea – for example, to determine whether the cause is menopause, pregnancy, or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy.

Also known as: Estriol LCMSMS Serum

Estriol, LC/MS/MS, Serum

Estriol may sometimes be ordered serially to help monitor a high risk pregnancy. When it is used this way, each sample should be drawn at the same time each day. An unconjugated estriol test, one that measures estriol that is not bound to a protein, is one of the components of the triple or quad screen. Decreased levels have been associated with various genetic disorders including Down syndrome, neural tube defects, and adrenal abnormalities. It is ordered during pregnancy, along with maternal alpha-fetoprotein (AFP maternal), human chorionic gonadotropin (hCG), and inhibin-A tests, to assess the risk of carrying a fetus with certain abnormalities.

Also known as: Estrone LCMSMS

Estrone, LC/MS/MS

Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women. Estrone levels may be elevated in patients with polycystic ovarian syndrome and endometriosis. Tests may be used to aid in the diagnosis of an ovarian tumor, Turner syndrome, and hypopituitarism. In males, it may help in the diagnosis of the cause of gynecomastia or in the detection of estrogen-producing tumors.

Also known as: Progesterone Immunoassay


Serum progesterone is a test to measure the amount of progesterone in the blood. Progesterone is a hormone produced mainly in the ovaries. In women, progesterone plays a vital role in pregnancy. After an egg is released by the ovaries (ovulation), progesterone helps make the uterus ready for implantation of a fertilized egg. It prepares the womb (uterus) for pregnancy and the breasts for milk production. Men produce some amount of progesterone, but it probably has no normal function except to help produce other steroid hormones.
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The Estrogen Dominance Panel Non-Cycling Women panel contains 4 tests with 4 biomarkers.

Brief Description: The Estrogen Dominance Panel for Non-Cycling Women is designed to evaluate the balance of estrogen and progesterone levels in women who are not menstruating, whether due to menopause, surgical removal of reproductive organs, or other health conditions. This panel is crucial for assessing hormonal status and addressing symptoms related to hormonal imbalances, which can significantly impact a woman's quality of life and overall health.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the Estrogen Dominance Panel Non-Cycling Women Panel May Be Ordered

This panel is typically ordered for women experiencing symptoms suggestive of hormonal imbalance, such as hot flashes, mood swings, weight gain, or changes in libido, particularly in the post-menopausal phase. Healthcare providers may also recommend this panel for women with a history of hormonal disorders or those undergoing hormone replacement therapy to monitor treatment effects and ensure hormonal balance is achieved and maintained.

What the Estrogen Dominance Panel Non-Cycling Women Panel Checks For

The panel includes several key hormone tests that together provide a comprehensive view of a woman's hormonal status:

  • Estradiol: This test measures the level of estradiol, the primary form of estrogen in women. Estradiol is crucial for many body functions, including bone health and the regulation of cholesterol. It helps assess estrogen's role in the body post-menopause or in non-cycling conditions.

  • Estriol: Often checked during pregnancy, estriol can also provide valuable information about estrogen activity in non-pregnant, non-cycling women, particularly related to certain health risks like breast cancer.

  • Estrone: Estrone is a weaker form of estrogen that becomes more dominant post-menopause. Elevated levels can indicate an increased risk of breast and endometrial cancer in non-cycling women.

  • Progesterone: Progesterone levels are tested to evaluate its balance with estrogen levels. In non-cycling women, progesterone is typically low, and its ratio to estrogen is crucial for assessing the risk of developing estrogen dominance-related conditions.

Conditions and Diseases Detected by the Estrogen Dominance Panel Non-Cycling Women Panel

This panel is instrumental in detecting and managing conditions related to hormonal imbalances:

  • Estrogen Dominance: This occurs when the ratio of estrogen to progesterone is higher than normal, which can lead to various symptoms like weight gain, mood swings, and increased risk of hormonal cancers.

  • Hormonal Imbalances in Menopause: Fluctuating or high estrogen levels coupled with low progesterone can exacerbate menopausal symptoms and contribute to conditions such as osteoporosis.

  • Risk of Hormonal Cancers: Elevated levels of estrone and estradiol in the absence of adequate progesterone may increase the risk of breast and endometrial cancers.

Using the Results of the Estrogen Dominance Panel Non-Cycling Women Panel

Healthcare professionals use the results from this panel to:

  • Customize Hormone Replacement Therapy (HRT): By understanding the specific hormonal imbalance, treatment can be tailored to achieve hormonal equilibrium, improve symptoms, and reduce the risk of long-term complications.

  • Monitor Hormonal Therapy: Regular testing allows for adjustments in therapy to ensure optimal outcomes and minimize side effects.

  • Preventive Health Measures: Identifying risks related to hormonal imbalances can guide preventive strategies against conditions like osteoporosis and hormonal cancers.

The Estrogen Dominance Panel Non-Cycling Women Panel is a vital diagnostic resource for assessing hormone levels in women who no longer menstruate. By providing detailed insights into estrogen and progesterone levels, this panel aids in diagnosing hormonal imbalances, guiding effective treatment, and improving the management of menopausal symptoms and related health risks. It empowers healthcare providers to deliver personalized care that addresses the unique hormonal needs of non-cycling women, enhancing their health and well-being.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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