17-Hydroxypregnenolone, LC/MS/MS

The 17-Hydroxypregnenolone, LC/MS/MS test contains 1 test with 1 biomarker.

Brief Description: The 17-Hydroxypregnenolone test is a blood test that measures the levels of 17-Hydroxypregnenolone, a steroid hormone produced in the adrenal glands and a precursor in the synthesis of other hormones, including cortisol and sex steroids. This hormone is a crucial player in the chain of biochemical reactions that lead to the formation of vital hormones in the body.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why a 17-Hydroxypregnenolone Test May Be Ordered

Healthcare providers might order this test when they suspect:

1. Congenital Adrenal Hyperplasia (CAH): An inherited condition affecting the adrenal glands, which can result in ambiguous genitalia, early puberty, or other endocrine abnormalities.
2. Adrenal Tumor or Cancer: To detect tumors or cancers that might be producing 17-Hydroxypregnenolone or other related hormones.
3. Fertility Issues: Elevated or decreased levels of 17-Hydroxypregnenolone can be linked to fertility problems.

What the 17-Hydroxypregnenolone Test Checks For

The test assesses the levels of 17-Hydroxypregnenolone in the blood. Elevated levels might suggest an enzyme deficiency or blockage in the hormone production pathway, while decreased levels might indicate adrenal insufficiency or a problem with the production of adrenal hormones.

Other Lab Tests Ordered Alongside the 17-Hydroxypregnenolone Test

When a 17-Hydroxypregnenolone test is ordered, it's typically part of a broader endocrine evaluation. Here are some tests commonly ordered alongside it:

1. Cortisol Level:

   • Purpose: To measure the level of cortisol, a hormone produced by the adrenal glands.
   • Why Is It Ordered: To evaluate adrenal gland function and assess for conditions such as Addison's disease, Cushing's syndrome, or adrenal insufficiency.

2. ACTH (Adrenocorticotropic Hormone) Test:

   • Purpose: To measure the level of ACTH, a hormone that stimulates the adrenal glands to produce cortisol.
   • Why Is It Ordered: To help diagnose adrenal gland disorders and differentiate between primary and secondary adrenal insufficiency.

3. DHEA-Sulfate (DHEA-S) Test:

   • Purpose: To measure the level of DHEA-S, a hormone produced by the adrenal glands.
   • Why Is It Ordered: To evaluate adrenal function, particularly in cases of suspected adrenal tumors or congenital adrenal hyperplasia.

4. Androstenedione Level:

   • Purpose: To measure the level of androstenedione, a steroid hormone that serves as a precursor to testosterone and estrogens.
   • Why Is It Ordered: To assess adrenal and ovarian function and to help diagnose conditions affecting steroid hormone production.

5. Plasma Renin Activity and Aldosterone:

   • Purpose: To measure the levels of renin and aldosterone, which are involved in blood pressure regulation.
   • Why Is It Ordered: To evaluate adrenal function related to the renin-angiotensin-aldosterone system, particularly in cases of hypertension or suspected adrenal insufficiency.

6. Total and Free Testosterone Levels:

   • Purpose: To measure the levels of testosterone, a key androgen hormone.
   • Why Is It Ordered: In cases of suspected androgen excess or deficiency, which may be related to adrenal gland disorders.

7. LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone):

   • Purpose: To measure the levels of these pituitary hormones that regulate the reproductive system.
   • Why Is It Ordered: To assess pituitary function and its interaction with the adrenal glands, particularly in cases of suspected reproductive or endocrine disorders.

These tests, when ordered alongside a 17-Hydroxypregnenolone test, provide a comprehensive evaluation of adrenal and endocrine function. They are crucial for diagnosing and managing conditions affecting steroid hormone synthesis, adrenal gland function, and related endocrine disorders. The specific combination of tests will depend on the individual’s symptoms, medical history, and the clinical context of the testing.

Conditions or Diseases that Require a 17-Hydroxypregnenolone Test

The test is primarily used in the evaluation and diagnosis of:

• Congenital Adrenal Hyperplasia (CAH)
• Adrenal Tumors or Cancers
• Polycystic Ovary Syndrome (PCOS): Though it is not the primary test, it can be useful in conjunction with other tests.
• Adrenal Insufficiency

Usage of Results from the 17-Hydroxypregnenolone Test by Health Care Providers

A healthcare provider will interpret the results in the context of the clinical presentation and other diagnostic tests:

• Elevated Levels: Might suggest a blockage or deficiency in an enzyme involved in the steroid hormone synthesis pathway, often indicating CAH.
• Decreased Levels: Might point towards adrenal insufficiency or a decreased production of adrenal hormones.

The results of the test can guide treatment decisions, including hormone replacement therapy, surgical interventions, or other therapeutic measures, depending on the underlying condition.

In summary, the 17-Hydroxypregnenolone test is an essential tool for diagnosing and managing a range of endocrine disorders, providing valuable insights into adrenal function and the body's hormonal health.

Most Common Questions About the 17-Hydroxypregnenolone test:

Purpose and Clinical Indications

Why is the 17-Hydroxypregnenolone test conducted?

The 17-Hydroxypregnenolone test is used to evaluate the function of the adrenal glands and to diagnose congenital adrenal hyperplasia (CAH), a group of inherited disorders affecting the adrenal glands. Elevated levels of 17-Hydroxypregnenolone can indicate a specific form of CAH.

Who should consider taking the 17-Hydroxypregnenolone test?

Individuals with symptoms suggesting adrenal insufficiency or an adrenal tumor might consider undergoing this test. It's also relevant for infants and children showing signs of abnormal sex organ development, premature puberty, or other symptoms consistent with CAH.

Interpretation of Results

What do elevated levels in the 17-Hydroxypregnenolone test indicate?

Elevated levels of 17-Hydroxypregnenolone often suggest the presence of congenital adrenal hyperplasia or another adrenal gland disorder. Specifically, increased levels may be associated with the nonclassic form of 21-hydroxylase deficiency, which is a type of CAH.

If the 17-Hydroxypregnenolone test shows low levels, what does it imply?

Low levels of 17-Hydroxypregnenolone might suggest decreased adrenal gland function or a possible defect in the enzymes involved in adrenal steroid synthesis. It can also be a sign of adrenal insufficiency or damage to the adrenal glands.

Implications and Medical Management

How do healthcare providers use the results of the 17-Hydroxypregnenolone test for treatment decisions?

The results of this test can guide healthcare providers in diagnosing adrenal gland disorders, determining the cause, and formulating a treatment plan. For instance, if CAH is diagnosed, treatment may involve hormone replacement. Regular monitoring using the 17-Hydroxypregnenolone test and other relevant tests can also be employed to adjust treatment as needed.

Should individuals with abnormal 17-Hydroxypregnenolone test results see an endocrinologist?

Yes, individuals with abnormal results should ideally consult with an endocrinologist. These specialists have expertise in hormonal disorders, including those related to the adrenal glands. They can provide more specific insights, diagnostic tests, and targeted treatments.

Post-Test Management

If the 17-Hydroxypregnenolone test indicates an adrenal gland disorder, how often should one be re-tested?

The frequency of re-testing depends on the specific diagnosis and the treatment provided. Individuals diagnosed with CAH or other chronic adrenal conditions may need regular monitoring to adjust treatment. The endocrinologist or treating physician will determine the appropriate frequency based on individual needs.

Can lifestyle or dietary changes impact the levels of 17-Hydroxypregnenolone in the body?

While lifestyle and dietary factors can influence overall adrenal function and health, they may not have a direct and significant impact on 17-Hydroxypregnenolone levels, especially in cases of genetic or congenital disorders like CAH. However, maintaining overall health through a balanced diet, stress management, and regular exercise can support adrenal health.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.