Travelers' Diseases

Travel exposes you to infections that are uncommon at home. Travelers’ Diseases Tests help identify causes of fever, diarrhea, jaundice, rash, and respiratory illness after you return—or provide documentation for programs that require screening.

A proactive plan focuses on what you need to answer now: fever from a malaria area (urgent malaria testing), diarrhea after street food (stool pathogen panel), fever with rash (dengue/chikungunya/Zika testing), or jaundice (hepatitis labs). Add TB blood tests (IGRAs) for long-term travelers, and parasite serology (e.g., schistosomiasis, strongyloidiasis) when exposures fit. These labs support screeningdiagnostic triage, and monitoring, but they do not replace a clinician’s exam, imaging, or emergency care for severe symptoms.

Signs, Symptoms & Related Situations

  • Fever (especially within 1–4 weeks of return): consider malariadenguetyphoid/enteric feverrickettsial illnesses

  • Gastrointestinal: acute or persistent diarrhea, cramps, nausea, vomiting—think traveler’s diarrhea pathogensGiardiaEntamoeba histolytica

  • Jaundice or dark urine: consider hepatitis A/Emalarialeptospirosis

  • Rash/arthralgia: consider denguechikungunyaZika (pregnancy considerations)

  • Respiratory: cough, sore throat, shortness of breath—consider influenza/COVID-19/RSVatypical bacteria

  • Eosinophilia or itchy rash after freshwater/soil exposure: consider schistosomiasis or strongyloidiasis

  • Program screening: long-term or high-risk travel may require TB blood testing or immunity titers
    Seek urgent care now for high fever after travel to malaria areas, breathing difficulty, confusion, severe abdominal pain, bleeding/bruising, fainting, or signs of dehydration.

Symptoms require evaluation by a qualified clinician.

Why These Tests Matter

What testing can do

  • Pinpoint likely causes of post-travel illness (malaria, dengue/Zika/chikungunya, typhoid, hepatitis, GI pathogens)

  • Guide next steps (confirmatory testing, isolation guidance, imaging) and establish baselines to monitor trends

  • Provide documentation for employment, education, or public-health requests

What testing cannot do

  • Diagnose from one early test alone—many infections have window periods

  • Replace a clinician’s judgment, vaccines/prophylaxis decisions, or emergency care

  • Guarantee immunity or contagiousness status

What These Tests Measure (at a glance)

  • Malaria testing:

    • Thick/thin blood smears (parasite ID and % parasitemia) and rapid antigen testsPCR adds sensitivity/typing where available. Positive results require urgent clinician review.

  • Arboviruses (mosquito-borne):

    • Dengue: NS1 antigen (early), IgM/IgG, or PCR. Platelets/WBC often low.

    • Chikungunya: IgM/IgG or PCR early in illness.

    • Zika: NAAT (PCR) in acute phase; IgM can cross-react with dengue, so confirmatory testing may be needed in select cases.

  • Typhoid/Enteric fever:

    • Blood culture (early), stool culture (later); some labs offer molecular tests. Antibody screens (e.g., Widal) are not recommended for diagnosis.

  • Hepatitis after travel:

    • Hepatitis A IgMHepatitis E IgMHepatitis B panel (HBsAg, anti-HBc IgM, anti-HBs)Hepatitis C Ab with reflex RNA.

  • Traveler’s diarrhea & parasites:

    • Stool multiplex PCR (bacteria/viruses/protozoa), stool cultureova & parasite examGiardia/Cryptosporidium antigenEntamoeba histolytica antigen/PCR.

  • Helminth exposures:

    • Schistosoma IgGStrongyloides IgGCBC with differential for eosinophilia.

  • Respiratory pathogens:

    • Multiplex PCR for flu/COVID-19/RSV ± atypicalsprocalcitonin/CRP for context.

  • Tuberculosis screening:

    • IGRAs (QuantiFERON-TB Gold Plus or T-SPOT.TB) for long-term travelers or exposure settings.

Note: Some specialized tests (e.g., confirmatory arbovirus assays) are clinician-directed and may be coordinated with public-health laboratories.

Quick Build Guide

Clinical goal Start with Add if needed
Fever after malaria-area travel (urgent) Malaria smears + rapid antigen • CBC • CMP Malaria PCR • Blood cultures • Dengue NS1/IgM
Fever + rash/aches (tropics) Dengue NS1 ± PCR • Dengue IgM/IgG • Chikungunya IgM/IgG or PCR Zika NAAT/IgM (pregnancy/sexual exposure context) • Platelets/WBC • LFTs
Persistent diarrhea (>7–10 days) Stool multiplex GI PCR • Giardia/Crypto antigen Stool culture • Ova & Parasite exam (×2) • E. histolytica antigen/PCR
Typhoid-like fever Blood cultures (×2) Stool culture • Hepatitis labs • Malaria testing based on exposures
Jaundice after travel Hepatitis A IgM • Hepatitis E IgM • HBV panel Malaria testing • Leptospira IgM (clinician-directed)
Freshwater exposure (snails/estuaries) Schistosoma IgG • CBC (eosinophils) Urine/stool ova (clinical collection)
Before steroids or transplant; soil exposure Strongyloides IgG Repeat serology if high-risk; eosinophil count
Long-term stay or exposure screening TB IGRA CXR per clinician; immunity titers if required

How the Testing Process Works

  1. Match tests to exposure and symptoms: use the Quick Build Guide to choose targeted panels.

  2. Provide samples: blood draw; stool/urine collections when indicated; nasal/throat swabs for respiratory PCR. Follow collection instructions closely.

  3. Timing matters: some antibodies appear after 1–3 weeks; PCR/antigen tests detect earlier. Your clinician may schedule repeat testing if early results are negative but suspicion remains.

  4. Results & review: most results post within a few days; cultures may take longer. Discuss results with your clinician to plan imaging, follow-up, or specialist referral.

  5. Monitor trends: repeat key markers (e.g., platelets in dengueparasitemia in malaria) as your clinician directs.

Interpreting Results (General Guidance)

  • Malaria positive (smear/antigen/PCR): consistent with malaria—urgent clinical evaluation is required.

  • Dengue: NS1 positive earlyIgM/IgG help later. Low platelets and WBC often accompany dengue.

  • Zika: PCR is best in the first week; IgM may cross-react with dengue—confirmatory testing may be needed.

  • Typhoid: Positive blood culture supports diagnosis; antibody-only screens are unreliable.

  • GI PCR/culture: identifies pathogens; some results reflect colonization—interpret with symptoms and travel history.

  • Schistosoma/Strongyloides IgG: suggests exposure; serology does not show worm burden.

  • TB IGRA positive: indicates TB infection (latent or active); needs clinician evaluation.
    Always interpret results with a qualified healthcare professional; patterns, timing, and exposure history matter more than any single value.

Choosing Panels vs. Individual Tests

  • Targeted illness: choose malaria testingdengue/chikungunya/Zika, or hepatitis panels based on symptoms.

  • GI focus: stool multiplex PCR plus Giardia/Crypto antigen; add O&P for prolonged symptoms or parasite exposure.

  • Screening/documentation: TB IGRAimmunity titers as requested by programs.

  • Monitoring: repeat the same method over time for consistent comparisons.

FAQs

When should I test after returning?
Test as soon as symptoms start. Some infections need repeat testing due to window periods.

Is malaria testing urgent?
Yes—any fever after travel to malaria areas needs same-day malaria testing and clinician review.

Do I need to fast?
No. Most infectious-disease tests do not require fasting. Follow any collection instructions for stool or urine.

Can I do one test for all causes?
No single test covers everything. Multiplex panels help for GI or respiratory illness, but many conditions need targeted labs.

Are antibody tests enough?
Early illness may require PCR or antigen tests. Antibodies often rise after 1–3 weeks.

What if my first test is negative?
You may have tested too early or need a different sample type. Your clinician may repeat or add tests based on risk.

Can travel vaccines or malaria pills affect results?
Vaccines don’t cause positive pathogen tests. Prophylaxis can lower parasite levels, so high-quality malaria testing is still important if you have fever.

Related Categories & Key Tests

  • Infectious Disease Tests Hub

  • Immunity & Titer Tests • TB & QuantiFERON Tests • Respiratory Tests • Hepatitis Panels • Stool & GI Pathogen Tests • Dengue/Chikungunya/Zika • Malaria Tests

  • Key Tests: Malaria thick/thin smears • Malaria rapid antigen • Malaria PCR • Dengue NS1/IgM/IgG (± PCR) • Chikungunya IgM/IgG (± PCR) • Zika NAAT/IgM • Blood cultures • Stool multiplex PCR • Stool culture • Ova & Parasite exam • Giardia/Cryptosporidium antigen • E. histolytica antigen/PCR • Hepatitis A IgM • Hepatitis E IgM • HBV panel • HCV Ab±RNA • Schistosoma IgG • Strongyloides IgG • CBC/CMP • TB IGRA • Respiratory multiplex PCR

References

  • CDC Yellow Book — Health Information for International Travel.
  • World Health Organization — Guidelines on malaria, dengue, and travel-related illnesses.
  • Infectious Diseases Society of America — Practice guidelines for infectious diarrhea and fever in returning travelers.
  • American Society of Tropical Medicine and Hygiene — Evaluation of post-travel illness.
  • Clinical microbiology reviews on arboviral diagnostics and stool PCR panels.
  • Public-health laboratory guidance on confirmatory arbovirus testing.

Available Tests & Panels

Your Travelers’ Diseases Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to build the right package—malaria testingarbovirus panels (dengue/chikungunya/Zika)hepatitis labsstool GI PCR/culture/O&Pparasite serologyrespiratory PCR, and TB IGRAs for screening needs. Follow collection instructions carefully and review results with your clinician to plan imaging, follow-up, and monitoring.

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The QuantiFERON-TB Gold Plus Test is a blood test that detects latent or active tuberculosis (TB) infection by measuring the immune response to TB antigens. It offers greater accuracy than the traditional skin test and avoids false positives from prior BCG vaccination. Doctors use it for TB screening, diagnosis, and monitoring in high-risk individuals. The QFT-Plus test is recommended for healthcare workers, travelers, and those exposed to TB.

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Also Known As: TB Test, Tuberculosis Test, IGRA Test



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The Measles IgG IgM Antibodies Test measures immune response to the measles virus by detecting IgM for recent or acute infection and IgG for past exposure or vaccine immunity. This test helps confirm suspected measles cases in patients with fever, rash, cough, or conjunctivitis, and evaluates immunity in those with uncertain vaccination history, supporting diagnosis, outbreak control, and public health monitoring.

Also Known As: Rubeola Test, Measles Virus Test, Measles Titer test, Measles Infection Test

The Measles IgG Antibody Test measures IgG antibodies to determine immunity from past infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility to measles. Doctors use this blood test to confirm immune status, evaluate vaccination records, or meet school, travel, or employment requirements. It provides valuable insight into measles protection and public health safety.

Blood
Blood Draw
Also Known As: Rubeola Test, Measles Virus Test, Measles Titer Test

The Measles IgM Antibody Test detects IgM antibodies specific to the measles virus, providing evidence of recent or acute infection. IgM antibodies typically appear shortly after exposure and indicate an active immune response. This test is used to confirm measles in symptomatic patients, support outbreak investigations, and distinguish between current infection and prior immunity, aiding timely clinical and public health decisions.

Blood
Blood Draw
Also Known As: Rubeola Test, Measles Virus Test, Measles Infection Test

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The MMR Titer Test is a quantitative blood test that measures antibody levels to measles, mumps, and rubella. Results provide exact antibody values to confirm prior infection or response to vaccination. Low levels suggest lack of protection, while higher levels indicate adequate response. Doctors order this test for school, employment, or travel requirements and to guide revaccination decisions, ensuring accurate evaluation of immune status against these viral diseases.

Also Known As: MMR Immunity Test, Measles Mumps Rubella Titer, Measles Mumps Rubella IgG Antibodies

The Mumps Virus Titer Test measures IgG antibodies to determine immunity from prior infection or vaccination. A positive result indicates protective immunity, while a negative result suggests susceptibility to mumps. Doctors use this blood test to confirm immune status, check vaccine response, or meet school, travel, or employment requirements. It provides valuable information for individual protection and public health safety.

Blood
Blood Draw
Also Known As: Mumps Virus IgG Antibody Test, Mumps Virus Test

The Zika Virus RNA Qualitative Test detects the genetic material of the Zika virus in blood or other specimens using molecular amplification. This test identifies active infection during the acute phase, helping confirm Zika virus exposure and guide clinical management. It is especially useful in evaluating febrile illness, pregnancy-related risk, and travel-associated viral infections.

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The term “travelers’ diseases” is an inclusive category for any sort of infection or illness that one might acquire while traveling, particularly when going from a well-developed region into a less-developed one. There are specific health risks associated with any given travel destination. Whenever you plan a trip to a different country or region, take the time to learn about potential health issues related to the places you’ll be visiting.

You may want to meet with your healthcare provider to discuss any or all the following topics: 

  • Any diseases that are known to pose a threat at your destination(s) 
  • The length of time you plan to stay at your destination(s) 
  • The activities you plan on engaging in during your trip 

Most travelers’ diseases can be prevented with proper preparation and planning. Common precautions include: 

  • Taking appropriate precautions in areas with known disease-carrying insects or animals 
  • Verifying the safety of food and water 
  • Avoiding risky behaviors that may result in infections 
  • Getting vaccines and/or taking preventative treatments as recommended 

Various travelers’ diseases are found in every part of the world. Travelers’ diseases can, in some instances, cause permanent health problems. Childhood illnesses are especially troublesome without appropriate vaccinations. There are many nationwide vaccination programs designed to reduce the risk of contracting diseases like measles, mumps, polio, and rubella (German measles). These conditions may be greater threats in nations or regions where high vaccination rates have not been achieved. Without adequate local vaccination, such disease can be endemic or break out into epidemics. Such infections pose a serious threat to travelers who lack the appropriate vaccinations, children who have not completed their immunizations, and people with compromised immune systems. 

What Are the Common Causes of Travelers’ Diseases? 

The travelers’ diseases that are caused by infectious microbes (viruses, bacteria, and parasites) may become problems in many ways. Contact with contaminated food or water, soil, or animal droppings may transmit the microbes. Bites and stings from infected animals and insects can cause infection. Even animal hides may pose a risk. Insects that commonly carry travelers’ diseases include mosquitoes, ticks, fleas, and flies. Some travelers’ diseases are water-borne, posing a risk to individuals who swim in contaminated water or walk barefoot. There are also travelers’ diseases that can pass directly from person to person through blood or body fluid contact. 

Signs and Symptoms 

Some travelers’ diseases cause relatively mild symptoms that may resolve without treatment. In some cases, no symptoms may develop until after a traveler returns home, after which they may grow worse, linger, resolve themselves, or disappear and reappear. A few travelers’ diseases can cause serious, permanent complications without treatment, including organ failure, blindness, coma, and even death. Check yourself as thoroughly as possible for the development of new signs and symptoms during and after your trip.

You should speak to a healthcare practitioner if you experience any of the following symptoms: 

  • Fever or flu-like symptoms. If you develop a fever or flu-like symptoms within six months of traveling to a region with malaria, it is especially important to seek medical attention. 
  • Persistent (lasting two weeks or more) diarrhea or recurring diarrhea 
  • Persistent fatigue 
  • Inexplicable weight loss 
  • A yellow coloration on the skin or in the whites of your eyes (may indicate jaundice)  
  • Inexplicable rashes or sores on the skin 

World Health Organization (WHO) recommendations suggest that travelers should get a medical exam if they experience any symptoms within a few weeks of returning home. An exam is particularly important if a traveler has a fever after visiting a region where malaria is present. 

Travelers who have been abroad for more than three months, those that know they were exposed to an infectious disease, and those with chronic medical conditions should all have a medical exam after returning home, whether or not they experience any unusual symptoms. 

Testing for Travelers’ Diseases 

Identifying the cause of travelers’ diseases is very important both to treat the infected individual and to prevent transmission of the specific disease involved. Identifying the disease is also part of documenting the disease’s presence in both the traveler’s home country and the countries they visited. 

The specific tests used to diagnose travelers’ diseases will depend on the signs and symptoms the sufferer displays. Returning travelers who experience symptoms should consult with their regular healthcare provider; their case may be referred to or consulted on by a specialist in infectious and/or tropical diseases. 

Tests – Digestive Tract Symptoms 

Infections that commonly cause symptoms in the digestive tract (such as travelers’ diarrhea) may be tested for with (among others) the tests described below: 

  • Molecular Tests 

These tests seek out foreign genetic material (DNA & RNA) in the digestive tract to diagnose the presence of specific microbes. Molecular testing is growing more common, but it is not available everywhere. 

  • GI Pathogens Panel 

This battery of tests analyzes a stool sample for the presence of multiple disease-causing microbes. A pathogen panel can identify microbes that might be overlooked in less-comprehensive testing. A GI pathogen panel is also useful for identifying co-infections where a patient is infected with more than one microbe. 

  • Stool Culture 

This is a traditional test that is used less often but may still be helpful. It can identify bacterial infections causing diarrhea. 

  • O&P (Ova and Parasite) Stool Test 

This test identifies disease-causing parasites by finding the parasites or their eggs in a stool sample. Samples for an O&P test can be either fresh or preserved. 

There are disease-specific antigen tests available for some digestive parasites. These identify proteins associated with a given strain of the parasite. Examples include Cryptosporidium, Giardia intestinalis (lamblia), and Entamoeba histolytica. 

In cases where diarrhea is caused by a viral infection, identifying the virus responsible can be complicated. Identification is rarely undertaken except in situations where large numbers of people are infected by the same viral strain, such as a norovirus outbreak on a cruise ship. 

Tests for Insect-Born Infections 

  • Malaria 

Malaria is carried by the red blood cells in infected animals and humans. A blood sample can be prepared specifically for examination under a microscope where the responsible parasite can be seen. There is also a rapid antigen assay test that can detect malaria parasites without the need for microscopic examination. 

Testing for specific insect-borne viruses is performed based on where an individual has traveled. Viruses that may be checked for include: 

Tests for Respiratory Illness 

Testing for respiratory infection will be based on symptoms, travel history, and an individual’s vaccination history. Common examples include: 

A basic TB screening test can determine whether you were exposed to the disease. If an infection is suspected, further testing (AFB testing) will be done. 

Several infections are normally prevented by vaccination. If you present the appropriate signs and symptoms, and your immunity is in doubt, your healthcare provider may want to test for: